Putative tyrosine phosphatase isoform

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine phosphatase isoform, putative

Species:

Leishmania mexicana

UniProt:

E9B4W8_LEIMU

TriTrypDb:

LmxM.33.1430

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005829	cytosol	2	1

Expansion

Sequence features

E9B4W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4W8

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016311	dephosphorylation	5	9
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0004725	protein tyrosine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	8
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	8	3
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	7	3
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.277
CLV_NRD_NRD_1	242	244	PF00675	0.365
CLV_NRD_NRD_1	382	384	PF00675	0.286
CLV_NRD_NRD_1	385	387	PF00675	0.298
CLV_NRD_NRD_1	398	400	PF00675	0.306
CLV_NRD_NRD_1	416	418	PF00675	0.275
CLV_NRD_NRD_1	540	542	PF00675	0.233
CLV_PCSK_FUR_1	380	384	PF00082	0.308
CLV_PCSK_KEX2_1	197	199	PF00082	0.275
CLV_PCSK_KEX2_1	242	244	PF00082	0.345
CLV_PCSK_KEX2_1	382	384	PF00082	0.262
CLV_PCSK_KEX2_1	385	387	PF00082	0.274
CLV_PCSK_KEX2_1	398	400	PF00082	0.295
CLV_PCSK_KEX2_1	416	418	PF00082	0.275
CLV_PCSK_KEX2_1	540	542	PF00082	0.326
CLV_PCSK_SKI1_1	386	390	PF00082	0.275
CLV_PCSK_SKI1_1	424	428	PF00082	0.354
CLV_PCSK_SKI1_1	445	449	PF00082	0.396
DEG_APCC_DBOX_1	385	393	PF00400	0.468
DEG_Nend_UBRbox_3	1	3	PF02207	0.659
DEG_SCF_FBW7_2	353	359	PF00400	0.442
DOC_CDC14_PxL_1	389	397	PF14671	0.490
DOC_CKS1_1	353	358	PF01111	0.422
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.442
DOC_MAPK_gen_1	105	115	PF00069	0.171
DOC_MAPK_gen_1	25	33	PF00069	0.634
DOC_MAPK_gen_1	380	389	PF00069	0.465
DOC_MAPK_HePTP_8	395	410	PF00069	0.480
DOC_MAPK_MEF2A_6	108	115	PF00069	0.173
DOC_MAPK_MEF2A_6	76	85	PF00069	0.496
DOC_PP1_RVXF_1	422	429	PF00149	0.545
DOC_PP2B_LxvP_1	518	521	PF13499	0.442
DOC_PP2B_LxvP_1	91	94	PF13499	0.347
DOC_PP4_FxxP_1	63	66	PF00568	0.648
DOC_USP7_MATH_1	265	269	PF00917	0.559
DOC_WW_Pin1_4	106	111	PF00397	0.396
DOC_WW_Pin1_4	157	162	PF00397	0.390
DOC_WW_Pin1_4	352	357	PF00397	0.437
DOC_WW_Pin1_4	6	11	PF00397	0.680
LIG_14-3-3_CanoR_1	179	183	PF00244	0.277
LIG_14-3-3_CanoR_1	247	255	PF00244	0.520
LIG_14-3-3_CanoR_1	259	263	PF00244	0.543
LIG_14-3-3_CanoR_1	266	271	PF00244	0.553
LIG_14-3-3_CanoR_1	336	341	PF00244	0.453
LIG_14-3-3_CanoR_1	424	429	PF00244	0.640
LIG_BIR_III_4	549	553	PF00653	0.388
LIG_BIR_III_4	567	571	PF00653	0.671
LIG_BRCT_BRCA1_1	108	112	PF00533	0.285
LIG_eIF4E_1	86	92	PF01652	0.347
LIG_EVH1_2	520	524	PF00568	0.442
LIG_FHA_1	211	217	PF00498	0.523
LIG_FHA_1	26	32	PF00498	0.492
LIG_FHA_1	267	273	PF00498	0.525
LIG_FHA_1	298	304	PF00498	0.479
LIG_FHA_1	40	46	PF00498	0.633
LIG_FHA_1	405	411	PF00498	0.505
LIG_FHA_1	468	474	PF00498	0.549
LIG_FHA_1	486	492	PF00498	0.511
LIG_FHA_1	7	13	PF00498	0.674
LIG_FHA_2	13	19	PF00498	0.623
LIG_FHA_2	526	532	PF00498	0.431
LIG_FHA_2	67	73	PF00498	0.559
LIG_Integrin_RGD_1	551	553	PF01839	0.194
LIG_IRF3_LxIS_1	280	285	PF10401	0.433
LIG_LIR_Apic_2	227	233	PF02991	0.455
LIG_LIR_Apic_2	60	66	PF02991	0.646
LIG_LIR_Gen_1	109	120	PF02991	0.246
LIG_LIR_Gen_1	143	153	PF02991	0.471
LIG_LIR_Gen_1	28	38	PF02991	0.589
LIG_LIR_Gen_1	402	412	PF02991	0.512
LIG_LIR_Gen_1	49	58	PF02991	0.552
LIG_LIR_Gen_1	95	104	PF02991	0.398
LIG_LIR_Nem_3	109	115	PF02991	0.267
LIG_LIR_Nem_3	143	149	PF02991	0.471
LIG_LIR_Nem_3	28	33	PF02991	0.586
LIG_LIR_Nem_3	359	364	PF02991	0.511
LIG_LIR_Nem_3	402	408	PF02991	0.513
LIG_LIR_Nem_3	49	55	PF02991	0.650
LIG_LIR_Nem_3	503	509	PF02991	0.485
LIG_LIR_Nem_3	95	101	PF02991	0.398
LIG_NRBOX	164	170	PF00104	0.317
LIG_NRBOX	95	101	PF00104	0.380
LIG_REV1ctd_RIR_1	506	514	PF16727	0.485
LIG_RPA_C_Fungi	339	351	PF08784	0.317
LIG_SH2_CRK	116	120	PF00017	0.317
LIG_SH2_NCK_1	456	460	PF00017	0.361
LIG_SH2_PTP2	52	55	PF00017	0.569
LIG_SH2_SRC	30	33	PF00017	0.554
LIG_SH2_SRC	456	459	PF00017	0.493
LIG_SH2_STAP1	116	120	PF00017	0.347
LIG_SH2_STAP1	299	303	PF00017	0.153
LIG_SH2_STAT3	324	327	PF00017	0.317
LIG_SH2_STAT5	200	203	PF00017	0.391
LIG_SH2_STAT5	211	214	PF00017	0.356
LIG_SH2_STAT5	23	26	PF00017	0.439
LIG_SH2_STAT5	245	248	PF00017	0.320
LIG_SH2_STAT5	293	296	PF00017	0.378
LIG_SH2_STAT5	299	302	PF00017	0.153
LIG_SH2_STAT5	30	33	PF00017	0.460
LIG_SH2_STAT5	321	324	PF00017	0.264
LIG_SH2_STAT5	361	364	PF00017	0.335
LIG_SH2_STAT5	420	423	PF00017	0.362
LIG_SH2_STAT5	472	475	PF00017	0.463
LIG_SH2_STAT5	52	55	PF00017	0.557
LIG_SH2_STAT5	572	575	PF00017	0.536
LIG_SH2_STAT5	73	76	PF00017	0.428
LIG_SH2_STAT5	86	89	PF00017	0.352
LIG_SH3_2	378	383	PF14604	0.434
LIG_SH3_3	350	356	PF00018	0.257
LIG_SH3_3	375	381	PF00018	0.450
LIG_SH3_3	429	435	PF00018	0.364
LIG_SH3_3	514	520	PF00018	0.347
LIG_SH3_3	52	58	PF00018	0.547
LIG_SH3_3	7	13	PF00018	0.584
LIG_SUMO_SIM_par_1	249	258	PF11976	0.385
LIG_SUMO_SIM_par_1	279	285	PF11976	0.317
LIG_SUMO_SIM_par_1	89	95	PF11976	0.189
LIG_TRAF2_1	356	359	PF00917	0.287
LIG_TYR_ITSM	26	33	PF00017	0.539
LIG_WRC_WIRS_1	283	288	PF05994	0.347
MOD_CK1_1	11	17	PF00069	0.419
MOD_CK1_1	467	473	PF00069	0.546
MOD_CK2_1	12	18	PF00069	0.541
MOD_CK2_1	525	531	PF00069	0.271
MOD_CK2_1	570	576	PF00069	0.578
MOD_GlcNHglycan	329	332	PF01048	0.327
MOD_GlcNHglycan	466	469	PF01048	0.692
MOD_GSK3_1	243	250	PF00069	0.513
MOD_GSK3_1	254	261	PF00069	0.392
MOD_GSK3_1	336	343	PF00069	0.388
MOD_GSK3_1	475	482	PF00069	0.331
MOD_GSK3_1	525	532	PF00069	0.274
MOD_GSK3_1	8	15	PF00069	0.393
MOD_N-GLC_1	422	427	PF02516	0.424
MOD_NEK2_1	114	119	PF00069	0.347
MOD_NEK2_1	151	156	PF00069	0.263
MOD_NEK2_1	282	287	PF00069	0.375
MOD_NEK2_1	340	345	PF00069	0.375
MOD_NEK2_1	404	409	PF00069	0.371
MOD_NEK2_1	479	484	PF00069	0.427
MOD_NEK2_1	61	66	PF00069	0.686
MOD_PIKK_1	344	350	PF00454	0.292
MOD_PIKK_1	354	360	PF00454	0.260
MOD_PIKK_1	439	445	PF00454	0.608
MOD_PKA_1	243	249	PF00069	0.259
MOD_PKA_2	178	184	PF00069	0.321
MOD_PKA_2	223	229	PF00069	0.404
MOD_PKA_2	246	252	PF00069	0.421
MOD_PKA_2	258	264	PF00069	0.419
MOD_PKA_2	265	271	PF00069	0.444
MOD_PKA_2	479	485	PF00069	0.306
MOD_PKB_1	342	350	PF00069	0.153
MOD_Plk_1	25	31	PF00069	0.492
MOD_Plk_1	422	428	PF00069	0.511
MOD_Plk_1	475	481	PF00069	0.350
MOD_Plk_1	67	73	PF00069	0.573
MOD_Plk_4	115	121	PF00069	0.310
MOD_Plk_4	123	129	PF00069	0.334
MOD_Plk_4	313	319	PF00069	0.287
MOD_Plk_4	404	410	PF00069	0.456
MOD_Plk_4	92	98	PF00069	0.392
MOD_ProDKin_1	106	112	PF00069	0.496
MOD_ProDKin_1	157	163	PF00069	0.386
MOD_ProDKin_1	352	358	PF00069	0.279
MOD_ProDKin_1	6	12	PF00069	0.614
TRG_DiLeu_BaEn_1	143	148	PF01217	0.471
TRG_DiLeu_BaEn_2	235	241	PF01217	0.329
TRG_ENDOCYTIC_2	116	119	PF00928	0.331
TRG_ENDOCYTIC_2	245	248	PF00928	0.415
TRG_ENDOCYTIC_2	30	33	PF00928	0.540
TRG_ENDOCYTIC_2	52	55	PF00928	0.569
TRG_ENDOCYTIC_2	79	82	PF00928	0.504
TRG_ER_diArg_1	241	243	PF00400	0.407
TRG_ER_diArg_1	27	30	PF00400	0.480
TRG_ER_diArg_1	341	344	PF00400	0.347
TRG_ER_diArg_1	380	383	PF00400	0.368
TRG_ER_diArg_1	384	386	PF00400	0.370
TRG_ER_diArg_1	397	399	PF00400	0.396
TRG_ER_diArg_1	416	418	PF00400	0.323
TRG_NES_CRM1_1	36	49	PF08389	0.368
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N6	Leptomonas seymouri	69%	95%
A0A0S4J8D3	Bodo saltans	27%	100%
A0A0S4JNQ3	Bodo saltans	27%	66%
A0A1X0PAB6	Trypanosomatidae	39%	92%
A0A3S7X7V0	Leishmania donovani	93%	100%
A4H7T1	Leishmania braziliensis	82%	100%
A4I9V5	Leishmania infantum	93%	100%
Q4Q359	Leishmania major	91%	100%
Q6XPS3	Homo sapiens	30%	100%
V5BT25	Trypanosoma cruzi	40%	92%