D-isomer specific 2-hydroxyacid dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

d-isomer specific 2-hydroxyacid dehydrogenase- like protein

Species:

Leishmania mexicana

UniProt:

E9B4W5_LEIMU

TriTrypDb:

LmxM.33.1410

Length:

160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4W5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0005488	binding	1	8
GO:0036094	small molecule binding	2	8
GO:0051287	NAD binding	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.454
CLV_NRD_NRD_1	7	9	PF00675	0.276
CLV_PCSK_KEX2_1	130	132	PF00082	0.415
CLV_PCSK_KEX2_1	7	9	PF00082	0.276
CLV_PCSK_KEX2_1	84	86	PF00082	0.177
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.304
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.177
CLV_PCSK_SKI1_1	114	118	PF00082	0.220
CLV_PCSK_SKI1_1	131	135	PF00082	0.340
CLV_PCSK_SKI1_1	48	52	PF00082	0.265
CLV_PCSK_SKI1_1	53	57	PF00082	0.257
DEG_Nend_UBRbox_3	1	3	PF02207	0.359
DOC_MAPK_gen_1	12	21	PF00069	0.589
DOC_MAPK_gen_1	58	66	PF00069	0.520
DOC_MAPK_MEF2A_6	60	68	PF00069	0.435
DOC_USP7_UBL2_3	12	16	PF12436	0.532
DOC_USP7_UBL2_3	130	134	PF12436	0.275
DOC_WW_Pin1_4	102	107	PF00397	0.514
LIG_14-3-3_CanoR_1	70	75	PF00244	0.468
LIG_AP2alpha_1	136	140	PF02296	0.330
LIG_APCC_ABBA_1	133	138	PF00400	0.334
LIG_BRCT_BRCA1_1	61	65	PF00533	0.558
LIG_FHA_1	123	129	PF00498	0.411
LIG_FHA_1	130	136	PF00498	0.402
LIG_LIR_Apic_2	105	111	PF02991	0.454
LIG_LIR_Gen_1	137	145	PF02991	0.365
LIG_LIR_Gen_1	62	72	PF02991	0.455
LIG_LIR_Nem_3	137	143	PF02991	0.431
LIG_LIR_Nem_3	62	68	PF02991	0.458
LIG_Pex14_2	136	140	PF04695	0.550
LIG_REV1ctd_RIR_1	48	57	PF16727	0.476
LIG_UBA3_1	55	60	PF00899	0.377
LIG_UBA3_1	79	84	PF00899	0.532
MOD_CK1_1	150	156	PF00069	0.468
MOD_CK2_1	27	33	PF00069	0.558
MOD_CK2_1	70	76	PF00069	0.460
MOD_GlcNHglycan	120	123	PF01048	0.271
MOD_GlcNHglycan	141	146	PF01048	0.337
MOD_GlcNHglycan	149	152	PF01048	0.389
MOD_GlcNHglycan	61	64	PF01048	0.258
MOD_GlcNHglycan	8	11	PF01048	0.276
MOD_GSK3_1	118	125	PF00069	0.573
MOD_GSK3_1	141	148	PF00069	0.430
MOD_N-GLC_1	122	127	PF02516	0.406
MOD_NEK2_1	1	6	PF00069	0.476
MOD_NEK2_1	115	120	PF00069	0.568
MOD_NEK2_1	27	32	PF00069	0.536
MOD_NEK2_1	36	41	PF00069	0.467
MOD_PK_1	70	76	PF00069	0.532
MOD_PKA_1	84	90	PF00069	0.463
MOD_PKA_2	6	12	PF00069	0.476
MOD_PKA_2	84	90	PF00069	0.377
MOD_Plk_1	27	33	PF00069	0.558
MOD_Plk_4	36	42	PF00069	0.532
MOD_ProDKin_1	102	108	PF00069	0.514
MOD_SUMO_rev_2	109	116	PF00179	0.445
MOD_SUMO_rev_2	9	14	PF00179	0.558
TRG_ER_diArg_1	6	8	PF00400	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J7L8	Bodo saltans	47%	100%
A0A3R7MNZ9	Trypanosoma rangeli	49%	77%
A0A422MS17	Trypanosoma rangeli	49%	99%
A0A422MS45	Trypanosoma rangeli	57%	77%
A4HAQ6	Leishmania braziliensis	71%	83%
A4I9V3	Leishmania infantum	69%	78%