Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4W1_LEIMU

TriTrypDb:

LmxM.33.1370

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4W1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.560
CLV_C14_Caspase3-7	200	204	PF00656	0.454
CLV_C14_Caspase3-7	271	275	PF00656	0.450
CLV_NRD_NRD_1	26	28	PF00675	0.669
CLV_NRD_NRD_1	260	262	PF00675	0.451
CLV_NRD_NRD_1	287	289	PF00675	0.560
CLV_NRD_NRD_1	300	302	PF00675	0.482
CLV_NRD_NRD_1	314	316	PF00675	0.351
CLV_NRD_NRD_1	320	322	PF00675	0.534
CLV_NRD_NRD_1	53	55	PF00675	0.471
CLV_PCSK_FUR_1	34	38	PF00082	0.549
CLV_PCSK_KEX2_1	26	28	PF00082	0.682
CLV_PCSK_KEX2_1	287	289	PF00082	0.566
CLV_PCSK_KEX2_1	299	301	PF00082	0.397
CLV_PCSK_KEX2_1	313	315	PF00082	0.493
CLV_PCSK_KEX2_1	319	321	PF00082	0.517
CLV_PCSK_KEX2_1	36	38	PF00082	0.585
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.608
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.621
CLV_PCSK_PC7_1	295	301	PF00082	0.413
CLV_PCSK_PC7_1	315	321	PF00082	0.603
CLV_PCSK_SKI1_1	262	266	PF00082	0.502
CLV_PCSK_SKI1_1	27	31	PF00082	0.678
CLV_PCSK_SKI1_1	315	319	PF00082	0.463
DEG_Nend_Nbox_1	1	3	PF02207	0.632
DEG_SPOP_SBC_1	18	22	PF00917	0.524
DOC_CYCLIN_yClb1_LxF_4	74	80	PF00134	0.460
DOC_MAPK_gen_1	61	68	PF00069	0.481
DOC_USP7_MATH_1	138	142	PF00917	0.572
DOC_USP7_MATH_1	145	149	PF00917	0.552
DOC_USP7_MATH_1	18	22	PF00917	0.595
DOC_USP7_MATH_1	8	12	PF00917	0.704
DOC_USP7_UBL2_3	249	253	PF12436	0.392
DOC_USP7_UBL2_3	319	323	PF12436	0.640
DOC_WW_Pin1_4	37	42	PF00397	0.590
DOC_WW_Pin1_4	95	100	PF00397	0.749
LIG_14-3-3_CanoR_1	189	197	PF00244	0.501
LIG_14-3-3_CanoR_1	261	265	PF00244	0.535
LIG_APCC_ABBA_1	166	171	PF00400	0.458
LIG_eIF4E_1	160	166	PF01652	0.469
LIG_FHA_1	125	131	PF00498	0.744
LIG_FHA_1	80	86	PF00498	0.502
LIG_FHA_1	92	98	PF00498	0.536
LIG_FHA_2	127	133	PF00498	0.664
LIG_FHA_2	210	216	PF00498	0.455
LIG_FHA_2	261	267	PF00498	0.565
LIG_LIR_Gen_1	116	124	PF02991	0.591
LIG_LIR_Gen_1	78	89	PF02991	0.677
LIG_LIR_Nem_3	116	120	PF02991	0.584
LIG_LIR_Nem_3	45	51	PF02991	0.497
LIG_Pex14_2	117	121	PF04695	0.610
LIG_SH2_STAP1	161	165	PF00017	0.443
LIG_SH2_STAP1	81	85	PF00017	0.498
LIG_SH2_STAT5	81	84	PF00017	0.491
LIG_SH3_3	4	10	PF00018	0.693
LIG_TRAF2_1	243	246	PF00917	0.340
LIG_UBA3_1	120	125	PF00899	0.559
MOD_CK1_1	126	132	PF00069	0.786
MOD_CK1_1	148	154	PF00069	0.473
MOD_CK1_1	16	22	PF00069	0.730
MOD_CK1_1	95	101	PF00069	0.692
MOD_CK2_1	130	136	PF00069	0.674
MOD_CK2_1	138	144	PF00069	0.640
MOD_CK2_1	202	208	PF00069	0.566
MOD_CK2_1	209	215	PF00069	0.525
MOD_CK2_1	223	229	PF00069	0.502
MOD_CK2_1	260	266	PF00069	0.562
MOD_CK2_1	37	43	PF00069	0.553
MOD_CK2_1	67	73	PF00069	0.573
MOD_Cter_Amidation	311	314	PF01082	0.506
MOD_GlcNHglycan	106	109	PF01048	0.595
MOD_GlcNHglycan	135	139	PF01048	0.626
MOD_GlcNHglycan	162	165	PF01048	0.435
MOD_GlcNHglycan	21	24	PF01048	0.539
MOD_GlcNHglycan	223	226	PF01048	0.474
MOD_GlcNHglycan	233	236	PF01048	0.414
MOD_GlcNHglycan	69	72	PF01048	0.618
MOD_GlcNHglycan	99	102	PF01048	0.679
MOD_GSK3_1	100	107	PF00069	0.563
MOD_GSK3_1	126	133	PF00069	0.695
MOD_GSK3_1	13	20	PF00069	0.677
MOD_GSK3_1	134	141	PF00069	0.587
MOD_GSK3_1	67	74	PF00069	0.603
MOD_GSK3_1	91	98	PF00069	0.562
MOD_N-GLC_1	303	308	PF02516	0.448
MOD_NEK2_1	124	129	PF00069	0.701
MOD_NEK2_1	223	228	PF00069	0.510
MOD_NEK2_1	79	84	PF00069	0.484
MOD_PIKK_1	145	151	PF00454	0.503
MOD_PIKK_1	92	98	PF00454	0.673
MOD_PKA_2	260	266	PF00069	0.562
MOD_Plk_1	193	199	PF00069	0.563
MOD_Plk_1	303	309	PF00069	0.448
MOD_Plk_4	260	266	PF00069	0.501
MOD_ProDKin_1	37	43	PF00069	0.586
MOD_ProDKin_1	95	101	PF00069	0.750
MOD_SUMO_for_1	279	282	PF00179	0.462
MOD_SUMO_for_1	29	32	PF00179	0.676
MOD_SUMO_rev_2	119	127	PF00179	0.572
TRG_DiLeu_BaEn_1	298	303	PF01217	0.486
TRG_DiLeu_BaEn_4	215	221	PF01217	0.579
TRG_DiLeu_LyEn_5	298	303	PF01217	0.425
TRG_ENDOCYTIC_2	81	84	PF00928	0.659
TRG_ER_diArg_1	286	288	PF00400	0.563
TRG_ER_diArg_1	299	301	PF00400	0.356
TRG_ER_diArg_1	313	315	PF00400	0.390
TRG_NLS_Bipartite_1	26	40	PF00514	0.655
TRG_NLS_MonoCore_2	318	323	PF00514	0.632
TRG_NLS_MonoExtC_3	318	323	PF00514	0.632
TRG_NLS_MonoExtN_4	34	40	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R6	Leptomonas seymouri	51%	100%
A0A3Q8IIE4	Leishmania donovani	88%	100%
A4HAQ3	Leishmania braziliensis	72%	100%
A4I9V0	Leishmania infantum	89%	100%
Q4Q365	Leishmania major	85%	100%