Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4V6_LEIMU

TriTrypDb:

LmxM.33.1320

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.705
CLV_C14_Caspase3-7	439	443	PF00656	0.699
CLV_C14_Caspase3-7	579	583	PF00656	0.682
CLV_C14_Caspase3-7	595	599	PF00656	0.529
CLV_NRD_NRD_1	165	167	PF00675	0.620
CLV_NRD_NRD_1	195	197	PF00675	0.749
CLV_NRD_NRD_1	237	239	PF00675	0.625
CLV_NRD_NRD_1	464	466	PF00675	0.605
CLV_NRD_NRD_1	468	470	PF00675	0.615
CLV_NRD_NRD_1	513	515	PF00675	0.534
CLV_NRD_NRD_1	571	573	PF00675	0.629
CLV_NRD_NRD_1	60	62	PF00675	0.700
CLV_NRD_NRD_1	652	654	PF00675	0.549
CLV_NRD_NRD_1	717	719	PF00675	0.640
CLV_NRD_NRD_1	755	757	PF00675	0.697
CLV_NRD_NRD_1	92	94	PF00675	0.695
CLV_PCSK_FUR_1	163	167	PF00082	0.686
CLV_PCSK_FUR_1	235	239	PF00082	0.591
CLV_PCSK_FUR_1	462	466	PF00082	0.663
CLV_PCSK_KEX2_1	162	164	PF00082	0.692
CLV_PCSK_KEX2_1	165	167	PF00082	0.681
CLV_PCSK_KEX2_1	234	236	PF00082	0.663
CLV_PCSK_KEX2_1	237	239	PF00082	0.647
CLV_PCSK_KEX2_1	464	466	PF00082	0.611
CLV_PCSK_KEX2_1	467	469	PF00082	0.621
CLV_PCSK_KEX2_1	513	515	PF00082	0.544
CLV_PCSK_KEX2_1	571	573	PF00082	0.679
CLV_PCSK_KEX2_1	60	62	PF00082	0.676
CLV_PCSK_KEX2_1	652	654	PF00082	0.549
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.669
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.560
CLV_PCSK_PC7_1	464	470	PF00082	0.630
CLV_PCSK_SKI1_1	159	163	PF00082	0.736
CLV_PCSK_SKI1_1	213	217	PF00082	0.502
CLV_PCSK_SKI1_1	392	396	PF00082	0.549
CLV_PCSK_SKI1_1	640	644	PF00082	0.486
DEG_COP1_1	677	687	PF00400	0.521
DEG_Nend_UBRbox_1	1	4	PF02207	0.598
DEG_SCF_FBW7_2	292	299	PF00400	0.643
DEG_SCF_TRCP1_1	575	581	PF00400	0.576
DEG_SPOP_SBC_1	127	131	PF00917	0.713
DEG_SPOP_SBC_1	226	230	PF00917	0.633
DEG_SPOP_SBC_1	365	369	PF00917	0.580
DEG_SPOP_SBC_1	481	485	PF00917	0.658
DOC_CKS1_1	487	492	PF01111	0.649
DOC_CYCLIN_RxL_1	210	220	PF00134	0.496
DOC_CYCLIN_RxL_1	637	644	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	421	424	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.636
DOC_MAPK_MEF2A_6	689	698	PF00069	0.538
DOC_PP1_RVXF_1	531	537	PF00149	0.497
DOC_PP2B_LxvP_1	209	212	PF13499	0.692
DOC_PP2B_LxvP_1	421	424	PF13499	0.469
DOC_PP2B_LxvP_1	427	430	PF13499	0.513
DOC_PP2B_LxvP_1	478	481	PF13499	0.553
DOC_PP4_FxxP_1	279	282	PF00568	0.583
DOC_PP4_FxxP_1	536	539	PF00568	0.536
DOC_PP4_FxxP_1	604	607	PF00568	0.667
DOC_USP7_MATH_1	120	124	PF00917	0.755
DOC_USP7_MATH_1	127	131	PF00917	0.701
DOC_USP7_MATH_1	171	175	PF00917	0.737
DOC_USP7_MATH_1	226	230	PF00917	0.650
DOC_USP7_MATH_1	249	253	PF00917	0.759
DOC_USP7_MATH_1	29	33	PF00917	0.492
DOC_USP7_MATH_1	358	362	PF00917	0.660
DOC_USP7_MATH_1	365	369	PF00917	0.781
DOC_USP7_MATH_1	435	439	PF00917	0.673
DOC_USP7_MATH_1	445	449	PF00917	0.783
DOC_USP7_MATH_1	482	486	PF00917	0.625
DOC_USP7_MATH_1	547	551	PF00917	0.610
DOC_USP7_MATH_1	607	611	PF00917	0.742
DOC_USP7_MATH_1	662	666	PF00917	0.656
DOC_USP7_MATH_1	667	671	PF00917	0.709
DOC_USP7_MATH_1	82	86	PF00917	0.754
DOC_USP7_UBL2_3	334	338	PF12436	0.578
DOC_WW_Pin1_4	178	183	PF00397	0.795
DOC_WW_Pin1_4	186	191	PF00397	0.671
DOC_WW_Pin1_4	19	24	PF00397	0.597
DOC_WW_Pin1_4	271	276	PF00397	0.678
DOC_WW_Pin1_4	278	283	PF00397	0.586
DOC_WW_Pin1_4	292	297	PF00397	0.507
DOC_WW_Pin1_4	483	488	PF00397	0.694
DOC_WW_Pin1_4	493	498	PF00397	0.513
DOC_WW_Pin1_4	632	637	PF00397	0.556
DOC_WW_Pin1_4	674	679	PF00397	0.600
DOC_WW_Pin1_4	748	753	PF00397	0.553
LIG_14-3-3_CanoR_1	177	182	PF00244	0.635
LIG_14-3-3_CanoR_1	28	34	PF00244	0.627
LIG_14-3-3_CanoR_1	689	697	PF00244	0.536
LIG_14-3-3_CanoR_1	718	728	PF00244	0.717
LIG_14-3-3_CanoR_1	756	760	PF00244	0.586
LIG_BRCT_BRCA1_1	275	279	PF00533	0.593
LIG_BRCT_BRCA1_1	317	321	PF00533	0.560
LIG_BRCT_BRCA1_1	49	53	PF00533	0.731
LIG_CaM_IQ_9	452	467	PF13499	0.645
LIG_CaM_IQ_9	501	516	PF13499	0.530
LIG_deltaCOP1_diTrp_1	673	679	PF00928	0.476
LIG_eIF4E_1	637	643	PF01652	0.560
LIG_FHA_1	201	207	PF00498	0.521
LIG_FHA_1	258	264	PF00498	0.671
LIG_FHA_1	268	274	PF00498	0.678
LIG_FHA_1	308	314	PF00498	0.533
LIG_FHA_1	381	387	PF00498	0.642
LIG_FHA_1	406	412	PF00498	0.592
LIG_FHA_1	450	456	PF00498	0.534
LIG_FHA_1	487	493	PF00498	0.667
LIG_FHA_1	63	69	PF00498	0.674
LIG_FHA_1	693	699	PF00498	0.551
LIG_FHA_1	744	750	PF00498	0.557
LIG_FHA_2	367	373	PF00498	0.692
LIG_FHA_2	429	435	PF00498	0.717
LIG_LIR_Apic_2	276	282	PF02991	0.589
LIG_LIR_Gen_1	288	296	PF02991	0.488
LIG_LIR_Gen_1	31	41	PF02991	0.642
LIG_LIR_Gen_1	391	401	PF02991	0.531
LIG_LIR_Gen_1	410	418	PF02991	0.580
LIG_LIR_Nem_3	31	36	PF02991	0.634
LIG_LIR_Nem_3	391	397	PF02991	0.529
LIG_LIR_Nem_3	410	415	PF02991	0.589
LIG_LIR_Nem_3	673	679	PF02991	0.664
LIG_MYND_1	207	211	PF01753	0.621
LIG_MYND_1	493	497	PF01753	0.562
LIG_MYND_3	206	210	PF01753	0.559
LIG_SH2_CRK	528	532	PF00017	0.546
LIG_SH2_CRK	776	780	PF00017	0.590
LIG_SH2_STAP1	287	291	PF00017	0.661
LIG_SH2_STAP1	612	616	PF00017	0.700
LIG_SH2_STAP1	690	694	PF00017	0.557
LIG_SH2_STAT5	287	290	PF00017	0.699
LIG_SH2_STAT5	336	339	PF00017	0.511
LIG_SH2_STAT5	522	525	PF00017	0.643
LIG_SH2_STAT5	637	640	PF00017	0.589
LIG_SH2_STAT5	776	779	PF00017	0.628
LIG_SH3_1	682	688	PF00018	0.538
LIG_SH3_2	208	213	PF14604	0.503
LIG_SH3_3	107	113	PF00018	0.731
LIG_SH3_3	205	211	PF00018	0.642
LIG_SH3_3	438	444	PF00018	0.811
LIG_SH3_3	484	490	PF00018	0.719
LIG_SH3_3	599	605	PF00018	0.645
LIG_SH3_3	624	630	PF00018	0.688
LIG_SH3_3	682	688	PF00018	0.538
LIG_SH3_3	766	772	PF00018	0.774
LIG_SUMO_SIM_anti_2	691	699	PF11976	0.541
LIG_SUMO_SIM_par_1	310	316	PF11976	0.538
LIG_SUMO_SIM_par_1	694	699	PF11976	0.545
LIG_SUMO_SIM_par_1	706	713	PF11976	0.553
LIG_UBA3_1	501	509	PF00899	0.523
LIG_WRC_WIRS_1	30	35	PF05994	0.653
LIG_WW_2	490	493	PF00397	0.602
MOD_CDK_SPK_2	292	297	PF00069	0.656
MOD_CDK_SPxxK_3	493	500	PF00069	0.559
MOD_CK1_1	141	147	PF00069	0.539
MOD_CK1_1	150	156	PF00069	0.565
MOD_CK1_1	180	186	PF00069	0.718
MOD_CK1_1	188	194	PF00069	0.749
MOD_CK1_1	240	246	PF00069	0.772
MOD_CK1_1	259	265	PF00069	0.526
MOD_CK1_1	320	326	PF00069	0.559
MOD_CK1_1	448	454	PF00069	0.740
MOD_CK1_1	47	53	PF00069	0.736
MOD_CK1_1	483	489	PF00069	0.713
MOD_CK1_1	555	561	PF00069	0.525
MOD_CK1_1	576	582	PF00069	0.637
MOD_CK1_1	583	589	PF00069	0.626
MOD_CK1_1	610	616	PF00069	0.695
MOD_CK1_1	631	637	PF00069	0.616
MOD_CK1_1	665	671	PF00069	0.718
MOD_CK1_1	674	680	PF00069	0.620
MOD_CK1_1	720	726	PF00069	0.707
MOD_CK1_1	751	757	PF00069	0.727
MOD_CK1_1	758	764	PF00069	0.584
MOD_CK1_1	81	87	PF00069	0.710
MOD_CK2_1	126	132	PF00069	0.672
MOD_CK2_1	366	372	PF00069	0.804
MOD_CK2_1	493	499	PF00069	0.510
MOD_CK2_1	667	673	PF00069	0.733
MOD_CK2_1	707	713	PF00069	0.553
MOD_CK2_1	721	727	PF00069	0.739
MOD_Cter_Amidation	163	166	PF01082	0.630
MOD_Cter_Amidation	231	234	PF01082	0.731
MOD_Cter_Amidation	235	238	PF01082	0.643
MOD_Cter_Amidation	462	465	PF01082	0.667
MOD_Cter_Amidation	58	61	PF01082	0.750
MOD_GlcNHglycan	140	143	PF01048	0.714
MOD_GlcNHglycan	149	152	PF01048	0.678
MOD_GlcNHglycan	173	176	PF01048	0.688
MOD_GlcNHglycan	182	185	PF01048	0.613
MOD_GlcNHglycan	239	242	PF01048	0.760
MOD_GlcNHglycan	251	254	PF01048	0.561
MOD_GlcNHglycan	315	318	PF01048	0.557
MOD_GlcNHglycan	447	450	PF01048	0.825
MOD_GlcNHglycan	549	552	PF01048	0.650
MOD_GlcNHglycan	575	578	PF01048	0.662
MOD_GlcNHglycan	664	667	PF01048	0.629
MOD_GlcNHglycan	669	672	PF01048	0.625
MOD_GlcNHglycan	723	726	PF01048	0.710
MOD_GlcNHglycan	80	83	PF01048	0.698
MOD_GlcNHglycan	87	90	PF01048	0.718
MOD_GSK3_1	116	123	PF00069	0.652
MOD_GSK3_1	136	143	PF00069	0.559
MOD_GSK3_1	173	180	PF00069	0.694
MOD_GSK3_1	185	192	PF00069	0.592
MOD_GSK3_1	24	31	PF00069	0.476
MOD_GSK3_1	240	247	PF00069	0.709
MOD_GSK3_1	267	274	PF00069	0.690
MOD_GSK3_1	291	298	PF00069	0.630
MOD_GSK3_1	313	320	PF00069	0.545
MOD_GSK3_1	322	329	PF00069	0.566
MOD_GSK3_1	356	363	PF00069	0.628
MOD_GSK3_1	43	50	PF00069	0.555
MOD_GSK3_1	445	452	PF00069	0.684
MOD_GSK3_1	476	483	PF00069	0.779
MOD_GSK3_1	576	583	PF00069	0.629
MOD_GSK3_1	607	614	PF00069	0.653
MOD_GSK3_1	628	635	PF00069	0.660
MOD_GSK3_1	641	648	PF00069	0.427
MOD_GSK3_1	667	674	PF00069	0.655
MOD_GSK3_1	688	695	PF00069	0.555
MOD_GSK3_1	703	710	PF00069	0.623
MOD_GSK3_1	713	720	PF00069	0.564
MOD_GSK3_1	751	758	PF00069	0.599
MOD_GSK3_1	78	85	PF00069	0.712
MOD_N-GLC_1	583	588	PF02516	0.554
MOD_NEK2_1	126	131	PF00069	0.672
MOD_NEK2_1	257	262	PF00069	0.557
MOD_NEK2_1	291	296	PF00069	0.730
MOD_NEK2_1	321	326	PF00069	0.576
MOD_NEK2_2	29	34	PF00069	0.638
MOD_NEK2_2	407	412	PF00069	0.552
MOD_PIKK_1	358	364	PF00454	0.707
MOD_PIKK_1	515	521	PF00454	0.512
MOD_PIKK_1	615	621	PF00454	0.657
MOD_PK_1	437	443	PF00069	0.640
MOD_PKA_1	237	243	PF00069	0.689
MOD_PKA_1	718	724	PF00069	0.651
MOD_PKA_2	237	243	PF00069	0.683
MOD_PKA_2	305	311	PF00069	0.486
MOD_PKA_2	688	694	PF00069	0.540
MOD_PKA_2	717	723	PF00069	0.689
MOD_PKA_2	755	761	PF00069	0.587
MOD_PKA_2	85	91	PF00069	0.718
MOD_PKB_1	235	243	PF00069	0.501
MOD_Plk_1	257	263	PF00069	0.584
MOD_Plk_1	542	548	PF00069	0.526
MOD_Plk_1	583	589	PF00069	0.559
MOD_Plk_1	597	603	PF00069	0.639
MOD_Plk_1	736	742	PF00069	0.684
MOD_Plk_2-3	707	713	PF00069	0.553
MOD_Plk_4	211	217	PF00069	0.544
MOD_Plk_4	240	246	PF00069	0.643
MOD_Plk_4	274	280	PF00069	0.670
MOD_Plk_4	317	323	PF00069	0.586
MOD_Plk_4	407	413	PF00069	0.573
MOD_Plk_4	555	561	PF00069	0.504
MOD_Plk_4	583	589	PF00069	0.656
MOD_Plk_4	607	613	PF00069	0.684
MOD_Plk_4	628	634	PF00069	0.566
MOD_ProDKin_1	178	184	PF00069	0.793
MOD_ProDKin_1	186	192	PF00069	0.674
MOD_ProDKin_1	19	25	PF00069	0.597
MOD_ProDKin_1	271	277	PF00069	0.679
MOD_ProDKin_1	278	284	PF00069	0.585
MOD_ProDKin_1	292	298	PF00069	0.499
MOD_ProDKin_1	483	489	PF00069	0.693
MOD_ProDKin_1	493	499	PF00069	0.508
MOD_ProDKin_1	632	638	PF00069	0.546
MOD_ProDKin_1	674	680	PF00069	0.599
MOD_ProDKin_1	748	754	PF00069	0.555
MOD_SUMO_rev_2	454	461	PF00179	0.645
TRG_DiLeu_BaEn_1	417	422	PF01217	0.562
TRG_DiLeu_BaEn_2	627	633	PF01217	0.651
TRG_DiLeu_BaLyEn_6	638	643	PF01217	0.494
TRG_ENDOCYTIC_2	289	292	PF00928	0.552
TRG_ENDOCYTIC_2	528	531	PF00928	0.550
TRG_ENDOCYTIC_2	776	779	PF00928	0.592
TRG_ER_diArg_1	163	166	PF00400	0.688
TRG_ER_diArg_1	235	238	PF00400	0.573
TRG_ER_diArg_1	397	400	PF00400	0.449
TRG_ER_diArg_1	462	465	PF00400	0.609
TRG_ER_diArg_1	467	469	PF00400	0.608
TRG_ER_diArg_1	533	536	PF00400	0.490
TRG_ER_diArg_1	651	653	PF00400	0.550
TRG_NLS_MonoExtC_3	161	166	PF00514	0.615
TRG_NLS_MonoExtC_3	232	237	PF00514	0.550
TRG_NLS_MonoExtN_4	159	166	PF00514	0.667
TRG_NLS_MonoExtN_4	231	238	PF00514	0.547
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL05	Leptomonas seymouri	45%	100%
A0A1X0P9E8	Trypanosomatidae	29%	100%
A0A3S7X7P6	Leishmania donovani	90%	100%
A4HAP9	Leishmania braziliensis	75%	100%
A4I9U5	Leishmania infantum	90%	100%
Q4Q370	Leishmania major	89%	100%