Ran gtpase-activating protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4V3_LEIMU

TriTrypDb:

LmxM.33.1290

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

E9B4V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4V3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.573
CLV_NRD_NRD_1	30	32	PF00675	0.520
CLV_NRD_NRD_1	410	412	PF00675	0.615
CLV_NRD_NRD_1	578	580	PF00675	0.765
CLV_NRD_NRD_1	604	606	PF00675	0.824
CLV_NRD_NRD_1	696	698	PF00675	0.704
CLV_NRD_NRD_1	7	9	PF00675	0.531
CLV_PCSK_FUR_1	4	8	PF00082	0.550
CLV_PCSK_KEX2_1	121	123	PF00082	0.531
CLV_PCSK_KEX2_1	156	158	PF00082	0.408
CLV_PCSK_KEX2_1	30	32	PF00082	0.520
CLV_PCSK_KEX2_1	409	411	PF00082	0.617
CLV_PCSK_KEX2_1	6	8	PF00082	0.510
CLV_PCSK_KEX2_1	604	606	PF00082	0.824
CLV_PCSK_KEX2_1	71	73	PF00082	0.628
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.305
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.617
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.655
CLV_PCSK_PC7_1	2	8	PF00082	0.613
CLV_PCSK_PC7_1	405	411	PF00082	0.622
CLV_PCSK_SKI1_1	230	234	PF00082	0.540
CLV_PCSK_SKI1_1	619	623	PF00082	0.775
CLV_PCSK_SKI1_1	7	11	PF00082	0.500
DEG_APCC_DBOX_1	6	14	PF00400	0.518
DEG_Nend_UBRbox_1	1	4	PF02207	0.567
DOC_CKS1_1	226	231	PF01111	0.515
DOC_CKS1_1	34	39	PF01111	0.619
DOC_CKS1_1	61	66	PF01111	0.434
DOC_CYCLIN_RxL_1	157	169	PF00134	0.441
DOC_CYCLIN_RxL_1	264	273	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.435
DOC_MAPK_DCC_7	278	287	PF00069	0.653
DOC_MAPK_gen_1	156	164	PF00069	0.370
DOC_MAPK_gen_1	379	388	PF00069	0.253
DOC_MAPK_gen_1	440	450	PF00069	0.447
DOC_MAPK_MEF2A_6	443	450	PF00069	0.524
DOC_PP1_RVXF_1	228	235	PF00149	0.545
DOC_PP1_RVXF_1	408	415	PF00149	0.496
DOC_PP2B_LxvP_1	541	544	PF13499	0.693
DOC_USP7_MATH_1	149	153	PF00917	0.683
DOC_USP7_MATH_1	19	23	PF00917	0.615
DOC_USP7_MATH_1	323	327	PF00917	0.490
DOC_USP7_MATH_1	42	46	PF00917	0.491
DOC_USP7_MATH_1	519	523	PF00917	0.681
DOC_USP7_MATH_1	524	528	PF00917	0.677
DOC_USP7_MATH_1	565	569	PF00917	0.735
DOC_USP7_MATH_1	637	641	PF00917	0.742
DOC_WW_Pin1_4	130	135	PF00397	0.526
DOC_WW_Pin1_4	225	230	PF00397	0.515
DOC_WW_Pin1_4	246	251	PF00397	0.501
DOC_WW_Pin1_4	33	38	PF00397	0.623
DOC_WW_Pin1_4	349	354	PF00397	0.486
DOC_WW_Pin1_4	561	566	PF00397	0.735
DOC_WW_Pin1_4	595	600	PF00397	0.661
DOC_WW_Pin1_4	60	65	PF00397	0.422
DOC_WW_Pin1_4	635	640	PF00397	0.655
LIG_14-3-3_CanoR_1	121	130	PF00244	0.552
LIG_14-3-3_CanoR_1	197	206	PF00244	0.624
LIG_14-3-3_CanoR_1	334	342	PF00244	0.480
LIG_14-3-3_CanoR_1	405	412	PF00244	0.662
LIG_14-3-3_CanoR_1	458	466	PF00244	0.446
LIG_14-3-3_CanoR_1	657	664	PF00244	0.741
LIG_BRCT_BRCA1_1	526	530	PF00533	0.437
LIG_FHA_1	131	137	PF00498	0.593
LIG_FHA_1	226	232	PF00498	0.508
LIG_FHA_1	252	258	PF00498	0.469
LIG_FHA_1	323	329	PF00498	0.423
LIG_FHA_1	34	40	PF00498	0.556
LIG_FHA_1	342	348	PF00498	0.405
LIG_FHA_1	350	356	PF00498	0.393
LIG_FHA_1	470	476	PF00498	0.504
LIG_FHA_1	612	618	PF00498	0.599
LIG_FHA_1	659	665	PF00498	0.761
LIG_FHA_2	101	107	PF00498	0.473
LIG_FHA_2	419	425	PF00498	0.680
LIG_FHA_2	487	493	PF00498	0.572
LIG_LIR_Gen_1	179	188	PF02991	0.542
LIG_LIR_Gen_1	89	100	PF02991	0.484
LIG_LIR_Nem_3	179	183	PF02991	0.537
LIG_LIR_Nem_3	536	541	PF02991	0.729
LIG_MYND_1	589	593	PF01753	0.499
LIG_PCNA_yPIPBox_3	452	464	PF02747	0.424
LIG_PCNA_yPIPBox_3	484	494	PF02747	0.566
LIG_Pex14_1	29	33	PF04695	0.498
LIG_PTB_Apo_2	104	111	PF02174	0.481
LIG_SH2_CRK	538	542	PF00017	0.736
LIG_SH2_NCK_1	420	424	PF00017	0.603
LIG_SH2_NCK_1	495	499	PF00017	0.563
LIG_SH2_STAT3	688	691	PF00017	0.733
LIG_SH2_STAT5	224	227	PF00017	0.502
LIG_SH2_STAT5	270	273	PF00017	0.417
LIG_SH2_STAT5	33	36	PF00017	0.560
LIG_SH2_STAT5	420	423	PF00017	0.685
LIG_SH2_STAT5	495	498	PF00017	0.471
LIG_SH3_1	443	449	PF00018	0.524
LIG_SH3_3	278	284	PF00018	0.634
LIG_SH3_3	443	449	PF00018	0.497
LIG_SH3_3	55	61	PF00018	0.509
LIG_SUMO_SIM_par_1	163	169	PF11976	0.532
LIG_SUMO_SIM_par_1	354	359	PF11976	0.488
LIG_SUMO_SIM_par_1	384	389	PF11976	0.442
LIG_SUMO_SIM_par_1	54	59	PF11976	0.563
LIG_TRAF2_1	439	442	PF00917	0.587
LIG_UBA3_1	447	456	PF00899	0.497
LIG_WRC_WIRS_1	127	132	PF05994	0.312
LIG_WRC_WIRS_1	177	182	PF05994	0.536
LIG_WRC_WIRS_1	231	236	PF05994	0.391
MOD_CDC14_SPxK_1	564	567	PF00782	0.731
MOD_CDK_SPK_2	225	230	PF00069	0.569
MOD_CDK_SPxK_1	561	567	PF00069	0.729
MOD_CK1_1	138	144	PF00069	0.641
MOD_CK1_1	246	252	PF00069	0.470
MOD_CK1_1	326	332	PF00069	0.434
MOD_CK1_1	389	395	PF00069	0.470
MOD_CK1_1	413	419	PF00069	0.612
MOD_CK1_1	533	539	PF00069	0.611
MOD_CK1_1	546	552	PF00069	0.655
MOD_CK1_1	559	565	PF00069	0.630
MOD_CK1_1	610	616	PF00069	0.758
MOD_CK1_1	670	676	PF00069	0.787
MOD_CK2_1	100	106	PF00069	0.471
MOD_CK2_1	418	424	PF00069	0.616
MOD_CK2_1	430	436	PF00069	0.657
MOD_CK2_1	486	492	PF00069	0.540
MOD_CK2_1	565	571	PF00069	0.759
MOD_CK2_1	606	612	PF00069	0.808
MOD_CK2_1	635	641	PF00069	0.599
MOD_Cter_Amidation	695	698	PF01082	0.494
MOD_GlcNHglycan	137	140	PF01048	0.739
MOD_GlcNHglycan	199	202	PF01048	0.608
MOD_GlcNHglycan	213	216	PF01048	0.374
MOD_GlcNHglycan	245	248	PF01048	0.296
MOD_GlcNHglycan	263	266	PF01048	0.492
MOD_GlcNHglycan	432	435	PF01048	0.653
MOD_GlcNHglycan	483	487	PF01048	0.396
MOD_GlcNHglycan	521	524	PF01048	0.620
MOD_GlcNHglycan	526	529	PF01048	0.619
MOD_GlcNHglycan	548	551	PF01048	0.695
MOD_GlcNHglycan	573	576	PF01048	0.626
MOD_GlcNHglycan	58	61	PF01048	0.598
MOD_GlcNHglycan	675	678	PF01048	0.785
MOD_GlcNHglycan	96	99	PF01048	0.522
MOD_GSK3_1	122	129	PF00069	0.363
MOD_GSK3_1	145	152	PF00069	0.753
MOD_GSK3_1	19	26	PF00069	0.542
MOD_GSK3_1	322	329	PF00069	0.439
MOD_GSK3_1	410	417	PF00069	0.606
MOD_GSK3_1	482	489	PF00069	0.472
MOD_GSK3_1	493	500	PF00069	0.417
MOD_GSK3_1	530	537	PF00069	0.642
MOD_GSK3_1	559	566	PF00069	0.733
MOD_GSK3_1	56	63	PF00069	0.395
MOD_GSK3_1	606	613	PF00069	0.715
MOD_GSK3_1	622	629	PF00069	0.509
MOD_GSK3_1	663	670	PF00069	0.738
MOD_GSK3_1	687	694	PF00069	0.673
MOD_N-GLC_1	113	118	PF02516	0.545
MOD_N-GLC_1	130	135	PF02516	0.511
MOD_N-GLC_1	326	331	PF02516	0.422
MOD_N-GLC_1	456	461	PF02516	0.411
MOD_N-GLC_1	468	473	PF02516	0.435
MOD_N-GLC_1	486	491	PF02516	0.551
MOD_NEK2_1	100	105	PF00069	0.442
MOD_NEK2_1	13	18	PF00069	0.517
MOD_NEK2_1	301	306	PF00069	0.436
MOD_NEK2_1	356	361	PF00069	0.460
MOD_NEK2_1	386	391	PF00069	0.397
MOD_NEK2_1	404	409	PF00069	0.533
MOD_NEK2_1	414	419	PF00069	0.595
MOD_NEK2_1	430	435	PF00069	0.432
MOD_NEK2_1	510	515	PF00069	0.579
MOD_NEK2_1	530	535	PF00069	0.701
MOD_NEK2_1	56	61	PF00069	0.372
MOD_NEK2_1	611	616	PF00069	0.716
MOD_PIKK_1	458	464	PF00454	0.461
MOD_PIKK_1	611	617	PF00454	0.799
MOD_PIKK_1	658	664	PF00454	0.610
MOD_PIKK_1	687	693	PF00454	0.727
MOD_PKA_1	410	416	PF00069	0.624
MOD_PKA_2	209	215	PF00069	0.527
MOD_PKA_2	404	410	PF00069	0.520
MOD_PKA_2	546	552	PF00069	0.695
MOD_PKA_2	656	662	PF00069	0.735
MOD_Plk_1	100	106	PF00069	0.424
MOD_Plk_1	301	307	PF00069	0.574
MOD_Plk_1	326	332	PF00069	0.452
MOD_Plk_1	356	362	PF00069	0.364
MOD_Plk_1	386	392	PF00069	0.430
MOD_Plk_1	456	462	PF00069	0.390
MOD_Plk_1	486	492	PF00069	0.508
MOD_Plk_1	651	657	PF00069	0.783
MOD_Plk_1	667	673	PF00069	0.668
MOD_Plk_4	100	106	PF00069	0.459
MOD_Plk_4	230	236	PF00069	0.393
MOD_Plk_4	327	333	PF00069	0.459
MOD_Plk_4	410	416	PF00069	0.619
MOD_Plk_4	42	48	PF00069	0.436
MOD_Plk_4	548	554	PF00069	0.735
MOD_Plk_4	587	593	PF00069	0.760
MOD_Plk_4	613	619	PF00069	0.605
MOD_Plk_4	642	648	PF00069	0.709
MOD_Plk_4	651	657	PF00069	0.505
MOD_ProDKin_1	130	136	PF00069	0.537
MOD_ProDKin_1	225	231	PF00069	0.507
MOD_ProDKin_1	246	252	PF00069	0.497
MOD_ProDKin_1	33	39	PF00069	0.615
MOD_ProDKin_1	349	355	PF00069	0.480
MOD_ProDKin_1	561	567	PF00069	0.736
MOD_ProDKin_1	595	601	PF00069	0.662
MOD_ProDKin_1	60	66	PF00069	0.425
MOD_ProDKin_1	635	641	PF00069	0.655
MOD_SUMO_for_1	505	508	PF00179	0.463
MOD_SUMO_rev_2	15	25	PF00179	0.409
MOD_SUMO_rev_2	500	507	PF00179	0.495
MOD_SUMO_rev_2	666	670	PF00179	0.497
TRG_DiLeu_BaLyEn_6	443	448	PF01217	0.442
TRG_ENDOCYTIC_2	538	541	PF00928	0.736
TRG_ENDOCYTIC_2	689	692	PF00928	0.583
TRG_ER_diArg_1	1	4	PF00400	0.600
TRG_ER_diArg_1	120	122	PF00400	0.569
TRG_ER_diArg_1	29	31	PF00400	0.495
TRG_ER_diArg_1	410	412	PF00400	0.637
TRG_ER_diArg_1	5	8	PF00400	0.536
TRG_ER_diArg_1	576	579	PF00400	0.766
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T2	Leptomonas seymouri	53%	92%
A0A3Q8IHF2	Leishmania donovani	87%	97%
A0A3R7MW53	Trypanosoma rangeli	28%	100%
A4HAP6	Leishmania braziliensis	68%	100%
A4I9U2	Leishmania infantum	87%	97%
Q4Q373	Leishmania major	84%	99%
V5B3D0	Trypanosoma cruzi	27%	100%