DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial DNA polymerase I protein A, putative

Species:

Leishmania mexicana

UniProt:

E9B4V0_LEIMU

TriTrypDb:

LmxM.33.1260

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4V0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006259	DNA metabolic process	4	9
GO:0006260	DNA replication	5	9
GO:0006261	DNA-templated DNA replication	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003677	DNA binding	4	9
GO:0003824	catalytic activity	1	9
GO:0003887	DNA-directed DNA polymerase activity	5	9
GO:0005488	binding	1	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016779	nucleotidyltransferase activity	4	9
GO:0034061	DNA polymerase activity	4	9
GO:0097159	organic cyclic compound binding	2	9
GO:0140097	catalytic activity, acting on DNA	3	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.604
CLV_NRD_NRD_1	112	114	PF00675	0.500
CLV_NRD_NRD_1	164	166	PF00675	0.575
CLV_NRD_NRD_1	19	21	PF00675	0.739
CLV_NRD_NRD_1	35	37	PF00675	0.621
CLV_NRD_NRD_1	40	42	PF00675	0.701
CLV_NRD_NRD_1	422	424	PF00675	0.209
CLV_NRD_NRD_1	444	446	PF00675	0.347
CLV_NRD_NRD_1	503	505	PF00675	0.301
CLV_NRD_NRD_1	681	683	PF00675	0.301
CLV_NRD_NRD_1	792	794	PF00675	0.301
CLV_NRD_NRD_1	824	826	PF00675	0.344
CLV_NRD_NRD_1	879	881	PF00675	0.360
CLV_PCSK_KEX2_1	112	114	PF00082	0.500
CLV_PCSK_KEX2_1	163	165	PF00082	0.593
CLV_PCSK_KEX2_1	18	20	PF00082	0.731
CLV_PCSK_KEX2_1	35	37	PF00082	0.778
CLV_PCSK_KEX2_1	386	388	PF00082	0.396
CLV_PCSK_KEX2_1	42	44	PF00082	0.822
CLV_PCSK_KEX2_1	422	424	PF00082	0.209
CLV_PCSK_KEX2_1	681	683	PF00082	0.301
CLV_PCSK_KEX2_1	747	749	PF00082	0.321
CLV_PCSK_KEX2_1	792	794	PF00082	0.292
CLV_PCSK_KEX2_1	824	826	PF00082	0.317
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.593
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.832
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.396
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.822
CLV_PCSK_PC1ET2_1	747	749	PF00082	0.325
CLV_PCSK_PC7_1	743	749	PF00082	0.325
CLV_PCSK_SKI1_1	112	116	PF00082	0.562
CLV_PCSK_SKI1_1	160	164	PF00082	0.656
CLV_PCSK_SKI1_1	208	212	PF00082	0.436
CLV_PCSK_SKI1_1	325	329	PF00082	0.672
CLV_PCSK_SKI1_1	375	379	PF00082	0.456
CLV_PCSK_SKI1_1	387	391	PF00082	0.405
CLV_PCSK_SKI1_1	445	449	PF00082	0.325
CLV_PCSK_SKI1_1	456	460	PF00082	0.325
CLV_PCSK_SKI1_1	65	69	PF00082	0.669
CLV_PCSK_SKI1_1	748	752	PF00082	0.293
CLV_PCSK_SKI1_1	830	834	PF00082	0.295
CLV_PCSK_SKI1_1	854	858	PF00082	0.301
CLV_PCSK_SKI1_1	881	885	PF00082	0.337
DEG_APCC_DBOX_1	400	408	PF00400	0.471
DEG_APCC_DBOX_1	444	452	PF00400	0.525
DEG_APCC_DBOX_1	879	887	PF00400	0.538
DEG_Nend_UBRbox_3	1	3	PF02207	0.603
DEG_SPOP_SBC_1	717	721	PF00917	0.597
DOC_CYCLIN_RxL_1	453	461	PF00134	0.538
DOC_CYCLIN_RxL_1	62	72	PF00134	0.730
DOC_CYCLIN_yCln2_LP_2	901	907	PF00134	0.501
DOC_MAPK_DCC_7	208	218	PF00069	0.405
DOC_MAPK_gen_1	383	392	PF00069	0.469
DOC_MAPK_gen_1	859	867	PF00069	0.594
DOC_MAPK_gen_1	880	888	PF00069	0.538
DOC_MAPK_MEF2A_6	120	128	PF00069	0.463
DOC_MAPK_MEF2A_6	177	186	PF00069	0.551
DOC_MAPK_MEF2A_6	305	312	PF00069	0.547
DOC_MAPK_MEF2A_6	383	392	PF00069	0.469
DOC_MAPK_MEF2A_6	396	404	PF00069	0.482
DOC_MAPK_MEF2A_6	881	890	PF00069	0.538
DOC_MAPK_NFAT4_5	387	395	PF00069	0.445
DOC_PP1_RVXF_1	745	752	PF00149	0.525
DOC_PP2B_LxvP_1	901	904	PF13499	0.501
DOC_USP7_MATH_1	175	179	PF00917	0.500
DOC_USP7_MATH_1	286	290	PF00917	0.612
DOC_USP7_MATH_1	29	33	PF00917	0.796
DOC_USP7_MATH_1	346	350	PF00917	0.584
DOC_USP7_MATH_1	542	546	PF00917	0.711
DOC_USP7_MATH_1	6	10	PF00917	0.808
DOC_USP7_MATH_1	832	836	PF00917	0.560
DOC_USP7_MATH_1	889	893	PF00917	0.538
DOC_USP7_MATH_1	91	95	PF00917	0.555
DOC_USP7_UBL2_3	35	39	PF12436	0.788
DOC_USP7_UBL2_3	456	460	PF12436	0.538
DOC_WW_Pin1_4	527	532	PF00397	0.785
DOC_WW_Pin1_4	562	567	PF00397	0.791
DOC_WW_Pin1_4	576	581	PF00397	0.708
DOC_WW_Pin1_4	613	618	PF00397	0.822
LIG_14-3-3_CanoR_1	164	173	PF00244	0.604
LIG_14-3-3_CanoR_1	208	216	PF00244	0.443
LIG_14-3-3_CanoR_1	479	487	PF00244	0.530
LIG_14-3-3_CanoR_1	584	593	PF00244	0.714
LIG_14-3-3_CanoR_1	626	632	PF00244	0.582
LIG_14-3-3_CanoR_1	644	652	PF00244	0.434
LIG_14-3-3_CanoR_1	65	71	PF00244	0.733
LIG_14-3-3_CanoR_1	818	822	PF00244	0.570
LIG_14-3-3_CanoR_1	824	828	PF00244	0.548
LIG_Actin_WH2_2	444	462	PF00022	0.538
LIG_BRCT_BRCA1_1	166	170	PF00533	0.619
LIG_Clathr_ClatBox_1	692	696	PF01394	0.501
LIG_EH1_1	896	904	PF00400	0.501
LIG_eIF4E_1	292	298	PF01652	0.508
LIG_FHA_1	198	204	PF00498	0.436
LIG_FHA_1	286	292	PF00498	0.583
LIG_FHA_1	307	313	PF00498	0.569
LIG_FHA_1	640	646	PF00498	0.485
LIG_FHA_1	659	665	PF00498	0.467
LIG_FHA_1	775	781	PF00498	0.599
LIG_FHA_1	90	96	PF00498	0.510
LIG_FHA_2	480	486	PF00498	0.501
LIG_FHA_2	510	516	PF00498	0.560
LIG_FHA_2	69	75	PF00498	0.596
LIG_FHA_2	718	724	PF00498	0.608
LIG_LIR_Apic_2	191	197	PF02991	0.482
LIG_LIR_Gen_1	105	115	PF02991	0.468
LIG_LIR_Gen_1	167	176	PF02991	0.534
LIG_LIR_Gen_1	293	301	PF02991	0.440
LIG_LIR_Gen_1	694	705	PF02991	0.508
LIG_LIR_Gen_1	94	104	PF02991	0.577
LIG_LIR_Nem_3	105	111	PF02991	0.476
LIG_LIR_Nem_3	150	155	PF02991	0.596
LIG_LIR_Nem_3	167	173	PF02991	0.425
LIG_LIR_Nem_3	293	297	PF02991	0.535
LIG_LIR_Nem_3	363	368	PF02991	0.388
LIG_LIR_Nem_3	694	700	PF02991	0.508
LIG_LIR_Nem_3	781	787	PF02991	0.505
LIG_LIR_Nem_3	94	100	PF02991	0.485
LIG_NRBOX	226	232	PF00104	0.375
LIG_NRBOX	367	373	PF00104	0.492
LIG_NRBOX	390	396	PF00104	0.430
LIG_PCNA_APIM_2	454	460	PF02747	0.538
LIG_PCNA_yPIPBox_3	224	235	PF02747	0.470
LIG_Pex14_2	581	585	PF04695	0.504
LIG_Pex14_2	680	684	PF04695	0.525
LIG_Rb_LxCxE_1	640	661	PF01857	0.542
LIG_SH2_CRK	194	198	PF00017	0.459
LIG_SH2_CRK	294	298	PF00017	0.405
LIG_SH2_CRK	365	369	PF00017	0.420
LIG_SH2_CRK	503	507	PF00017	0.554
LIG_SH2_CRK	520	524	PF00017	0.530
LIG_SH2_CRK	628	632	PF00017	0.438
LIG_SH2_NCK_1	194	198	PF00017	0.444
LIG_SH2_NCK_1	697	701	PF00017	0.520
LIG_SH2_PTP2	97	100	PF00017	0.570
LIG_SH2_SRC	292	295	PF00017	0.468
LIG_SH2_SRC	513	516	PF00017	0.560
LIG_SH2_STAP1	294	298	PF00017	0.349
LIG_SH2_STAT5	233	236	PF00017	0.445
LIG_SH2_STAT5	360	363	PF00017	0.476
LIG_SH2_STAT5	457	460	PF00017	0.560
LIG_SH2_STAT5	513	516	PF00017	0.501
LIG_SH2_STAT5	813	816	PF00017	0.560
LIG_SH2_STAT5	97	100	PF00017	0.495
LIG_SH3_3	340	346	PF00018	0.640
LIG_SH3_3	618	624	PF00018	0.733
LIG_SH3_3	90	96	PF00018	0.571
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.501
LIG_SUMO_SIM_anti_2	863	869	PF11976	0.597
LIG_SUMO_SIM_par_1	565	571	PF11976	0.506
LIG_SUMO_SIM_par_1	691	696	PF11976	0.502
LIG_SUMO_SIM_par_1	848	853	PF11976	0.525
LIG_SUMO_SIM_par_1	903	908	PF11976	0.525
LIG_TRAF2_1	103	106	PF00917	0.604
LIG_TRAF2_1	739	742	PF00917	0.525
LIG_TYR_ITIM	501	506	PF00017	0.560
LIG_TYR_ITIM	695	700	PF00017	0.501
LIG_TYR_ITIM	95	100	PF00017	0.579
LIG_UBA3_1	226	235	PF00899	0.470
LIG_UBA3_1	390	396	PF00899	0.508
LIG_UBA3_1	901	910	PF00899	0.501
LIG_WRC_WIRS_1	218	223	PF05994	0.373
MOD_CK1_1	13	19	PF00069	0.764
MOD_CK1_1	131	137	PF00069	0.569
MOD_CK1_1	259	265	PF00069	0.724
MOD_CK1_1	331	337	PF00069	0.730
MOD_CK1_1	545	551	PF00069	0.829
MOD_CK1_1	69	75	PF00069	0.737
MOD_CK1_1	778	784	PF00069	0.542
MOD_CK1_1	823	829	PF00069	0.560
MOD_CK1_1	863	869	PF00069	0.597
MOD_CK1_1	893	899	PF00069	0.560
MOD_CK2_1	100	106	PF00069	0.529
MOD_CK2_1	478	484	PF00069	0.501
MOD_CK2_1	509	515	PF00069	0.548
MOD_CK2_1	593	599	PF00069	0.797
MOD_CK2_1	605	611	PF00069	0.626
MOD_CK2_1	643	649	PF00069	0.501
MOD_CK2_1	68	74	PF00069	0.681
MOD_CK2_1	736	742	PF00069	0.505
MOD_CK2_1	823	829	PF00069	0.525
MOD_GlcNHglycan	102	105	PF01048	0.510
MOD_GlcNHglycan	130	133	PF01048	0.553
MOD_GlcNHglycan	156	159	PF01048	0.617
MOD_GlcNHglycan	275	278	PF01048	0.733
MOD_GlcNHglycan	302	305	PF01048	0.597
MOD_GlcNHglycan	348	351	PF01048	0.500
MOD_GlcNHglycan	43	46	PF01048	0.720
MOD_GlcNHglycan	460	463	PF01048	0.386
MOD_GlcNHglycan	596	599	PF01048	0.774
MOD_GlcNHglycan	6	9	PF01048	0.825
MOD_GlcNHglycan	720	723	PF01048	0.368
MOD_GlcNHglycan	807	810	PF01048	0.298
MOD_GlcNHglycan	839	842	PF01048	0.299
MOD_GlcNHglycan	892	895	PF01048	0.360
MOD_GSK3_1	131	138	PF00069	0.638
MOD_GSK3_1	150	157	PF00069	0.539
MOD_GSK3_1	164	171	PF00069	0.492
MOD_GSK3_1	237	244	PF00069	0.380
MOD_GSK3_1	281	288	PF00069	0.738
MOD_GSK3_1	319	326	PF00069	0.598
MOD_GSK3_1	360	367	PF00069	0.470
MOD_GSK3_1	37	44	PF00069	0.622
MOD_GSK3_1	479	486	PF00069	0.506
MOD_GSK3_1	541	548	PF00069	0.787
MOD_GSK3_1	6	13	PF00069	0.791
MOD_GSK3_1	639	646	PF00069	0.487
MOD_GSK3_1	66	73	PF00069	0.647
MOD_GSK3_1	737	744	PF00069	0.542
MOD_GSK3_1	774	781	PF00069	0.505
MOD_GSK3_1	816	823	PF00069	0.560
MOD_GSK3_1	85	92	PF00069	0.640
MOD_GSK3_1	889	896	PF00069	0.560
MOD_N-GLC_1	135	140	PF02516	0.539
MOD_N-GLC_1	150	155	PF02516	0.541
MOD_N-GLC_1	313	318	PF02516	0.463
MOD_N-GLC_1	613	618	PF02516	0.526
MOD_NEK2_1	321	326	PF00069	0.738
MOD_NEK2_1	328	333	PF00069	0.590
MOD_NEK2_1	371	376	PF00069	0.470
MOD_NEK2_1	458	463	PF00069	0.538
MOD_NEK2_1	472	477	PF00069	0.504
MOD_NEK2_1	509	514	PF00069	0.499
MOD_NEK2_1	586	591	PF00069	0.806
MOD_NEK2_1	68	73	PF00069	0.631
MOD_NEK2_1	774	779	PF00069	0.520
MOD_NEK2_1	803	808	PF00069	0.548
MOD_NEK2_1	890	895	PF00069	0.554
MOD_NEK2_1	905	910	PF00069	0.436
MOD_NEK2_1	911	916	PF00069	0.501
MOD_NEK2_2	360	365	PF00069	0.471
MOD_NEK2_2	483	488	PF00069	0.560
MOD_NEK2_2	627	632	PF00069	0.529
MOD_PIKK_1	292	298	PF00454	0.375
MOD_PIKK_1	866	872	PF00454	0.560
MOD_PKA_1	164	170	PF00069	0.552
MOD_PKA_1	41	47	PF00069	0.655
MOD_PKA_1	504	510	PF00069	0.560
MOD_PKA_2	164	170	PF00069	0.582
MOD_PKA_2	478	484	PF00069	0.560
MOD_PKA_2	606	612	PF00069	0.756
MOD_PKA_2	643	649	PF00069	0.501
MOD_PKA_2	817	823	PF00069	0.570
MOD_PKB_1	502	510	PF00069	0.597
MOD_Plk_1	150	156	PF00069	0.529
MOD_Plk_1	286	292	PF00069	0.665
MOD_Plk_1	29	35	PF00069	0.636
MOD_Plk_1	483	489	PF00069	0.501
MOD_Plk_1	741	747	PF00069	0.503
MOD_Plk_1	863	869	PF00069	0.597
MOD_Plk_1	919	925	PF00069	0.463
MOD_Plk_2-3	281	287	PF00069	0.701
MOD_Plk_4	234	240	PF00069	0.454
MOD_Plk_4	286	292	PF00069	0.665
MOD_Plk_4	360	366	PF00069	0.482
MOD_Plk_4	509	515	PF00069	0.525
MOD_Plk_4	775	781	PF00069	0.525
MOD_Plk_4	817	823	PF00069	0.541
MOD_Plk_4	832	838	PF00069	0.436
MOD_Plk_4	863	869	PF00069	0.597
MOD_ProDKin_1	527	533	PF00069	0.788
MOD_ProDKin_1	562	568	PF00069	0.789
MOD_ProDKin_1	576	582	PF00069	0.707
MOD_ProDKin_1	613	619	PF00069	0.819
TRG_ENDOCYTIC_2	294	297	PF00928	0.411
TRG_ENDOCYTIC_2	365	368	PF00928	0.423
TRG_ENDOCYTIC_2	369	372	PF00928	0.420
TRG_ENDOCYTIC_2	397	400	PF00928	0.427
TRG_ENDOCYTIC_2	449	452	PF00928	0.501
TRG_ENDOCYTIC_2	503	506	PF00928	0.554
TRG_ENDOCYTIC_2	520	523	PF00928	0.527
TRG_ENDOCYTIC_2	628	631	PF00928	0.484
TRG_ENDOCYTIC_2	697	700	PF00928	0.509
TRG_ENDOCYTIC_2	97	100	PF00928	0.570
TRG_ER_diArg_1	111	113	PF00400	0.493
TRG_ER_diArg_1	164	166	PF00400	0.575
TRG_ER_diArg_1	18	20	PF00400	0.815
TRG_ER_diArg_1	422	424	PF00400	0.406
TRG_ER_diArg_1	523	526	PF00400	0.476
TRG_ER_diArg_1	680	682	PF00400	0.501
TRG_ER_diArg_1	792	794	PF00400	0.501
TRG_ER_diArg_1	810	813	PF00400	0.501
TRG_NLS_Bipartite_1	18	40	PF00514	0.807
TRG_NLS_MonoCore_2	35	40	PF00514	0.815
TRG_NLS_MonoExtC_3	34	39	PF00514	0.824
TRG_NLS_MonoExtN_4	160	167	PF00514	0.601
TRG_NLS_MonoExtN_4	35	40	PF00514	0.765
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	812	816	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I668	Leptomonas seymouri	63%	73%
A0A1X0P9E5	Trypanosomatidae	42%	94%
A0A3Q8IH45	Leishmania donovani	92%	100%
A4HAP3	Leishmania braziliensis	79%	100%
A4I9T9	Leishmania infantum	92%	74%
C9ZMU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	97%
Q8IS90	Leishmania major	91%	100%