LeishMANIAdb
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Putative NLI-interacting factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative NLI-interacting factor
Gene product:
NLI-interacting factor, putative
Species:
Leishmania mexicana
UniProt:
E9B4U9_LEIMU
TriTrypDb:
LmxM.33.1250
Length:
358

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9B4U9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4U9

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016311 dephosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0004721 phosphoprotein phosphatase activity 3 2
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 2
GO:0016791 phosphatase activity 5 2
GO:0042578 phosphoric ester hydrolase activity 4 2
GO:0140096 catalytic activity, acting on a protein 2 2
GO:0004725 protein tyrosine phosphatase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 183 185 PF00675 0.389
CLV_NRD_NRD_1 227 229 PF00675 0.404
CLV_NRD_NRD_1 320 322 PF00675 0.325
CLV_NRD_NRD_1 47 49 PF00675 0.400
CLV_PCSK_KEX2_1 227 229 PF00082 0.404
CLV_PCSK_KEX2_1 320 322 PF00082 0.322
CLV_PCSK_KEX2_1 47 49 PF00082 0.400
CLV_PCSK_PC1ET2_1 47 49 PF00082 0.400
CLV_PCSK_SKI1_1 221 225 PF00082 0.330
CLV_PCSK_SKI1_1 259 263 PF00082 0.443
CLV_PCSK_SKI1_1 278 282 PF00082 0.244
CLV_PCSK_SKI1_1 4 8 PF00082 0.584
CLV_PCSK_SKI1_1 98 102 PF00082 0.280
DEG_APCC_DBOX_1 258 266 PF00400 0.429
DEG_Nend_UBRbox_1 1 4 PF02207 0.616
DOC_CDC14_PxL_1 176 184 PF14671 0.227
DOC_CDC14_PxL_1 262 270 PF14671 0.314
DOC_CKS1_1 200 205 PF01111 0.343
DOC_CYCLIN_yCln2_LP_2 39 45 PF00134 0.507
DOC_MAPK_gen_1 184 192 PF00069 0.370
DOC_MAPK_gen_1 254 264 PF00069 0.428
DOC_MAPK_gen_1 47 56 PF00069 0.284
DOC_MAPK_MEF2A_6 20 27 PF00069 0.430
DOC_MAPK_MEF2A_6 309 317 PF00069 0.482
DOC_MAPK_MEF2A_6 47 56 PF00069 0.245
DOC_MAPK_NFAT4_5 49 57 PF00069 0.273
DOC_PP1_RVXF_1 327 333 PF00149 0.595
DOC_PP2B_LxvP_1 37 40 PF13499 0.398
DOC_USP7_MATH_1 146 150 PF00917 0.414
DOC_USP7_MATH_1 18 22 PF00917 0.495
DOC_USP7_UBL2_3 147 151 PF12436 0.303
DOC_USP7_UBL2_3 278 282 PF12436 0.207
DOC_WW_Pin1_4 199 204 PF00397 0.309
DOC_WW_Pin1_4 320 325 PF00397 0.445
LIG_14-3-3_CanoR_1 137 145 PF00244 0.379
LIG_14-3-3_CanoR_1 166 171 PF00244 0.251
LIG_14-3-3_CanoR_1 184 190 PF00244 0.431
LIG_14-3-3_CanoR_1 2 7 PF00244 0.537
LIG_14-3-3_CanoR_1 320 324 PF00244 0.465
LIG_14-3-3_CanoR_1 48 53 PF00244 0.272
LIG_14-3-3_CanoR_1 8 18 PF00244 0.473
LIG_AP2alpha_2 210 212 PF02296 0.121
LIG_EVH1_1 37 41 PF00568 0.430
LIG_FHA_1 165 171 PF00498 0.325
LIG_FHA_1 279 285 PF00498 0.408
LIG_FHA_1 299 305 PF00498 0.186
LIG_FHA_1 320 326 PF00498 0.360
LIG_FHA_1 49 55 PF00498 0.233
LIG_FHA_2 314 320 PF00498 0.541
LIG_GBD_Chelix_1 52 60 PF00786 0.234
LIG_LIR_Apic_2 32 38 PF02991 0.422
LIG_LIR_Gen_1 138 146 PF02991 0.416
LIG_LIR_Gen_1 88 97 PF02991 0.296
LIG_LIR_Nem_3 138 143 PF02991 0.259
LIG_LIR_Nem_3 159 164 PF02991 0.354
LIG_LIR_Nem_3 285 290 PF02991 0.364
LIG_LIR_Nem_3 88 92 PF02991 0.263
LIG_PDZ_Class_1 353 358 PF00595 0.558
LIG_Pex14_2 108 112 PF04695 0.404
LIG_Pex14_2 31 35 PF04695 0.460
LIG_PTB_Apo_2 331 338 PF02174 0.422
LIG_SH2_CRK 89 93 PF00017 0.393
LIG_SH2_NCK_1 140 144 PF00017 0.194
LIG_SH2_STAP1 64 68 PF00017 0.121
LIG_SH2_STAT5 120 123 PF00017 0.262
LIG_SH2_STAT5 178 181 PF00017 0.286
LIG_SH2_STAT5 292 295 PF00017 0.280
LIG_SH3_1 197 203 PF00018 0.234
LIG_SH3_1 208 214 PF00018 0.234
LIG_SH3_3 197 203 PF00018 0.234
LIG_SH3_3 208 214 PF00018 0.234
LIG_SH3_3 30 36 PF00018 0.331
LIG_SH3_3 38 44 PF00018 0.344
LIG_SUMO_SIM_par_1 187 194 PF11976 0.229
LIG_SUMO_SIM_par_1 50 55 PF11976 0.227
LIG_SxIP_EBH_1 320 331 PF03271 0.530
LIG_TRFH_1 199 203 PF08558 0.227
LIG_TYR_ITIM 87 92 PF00017 0.303
LIG_WW_2 41 44 PF00397 0.541
MOD_CDK_SPK_2 199 204 PF00069 0.320
MOD_CK1_1 12 18 PF00069 0.488
MOD_CK1_1 138 144 PF00069 0.395
MOD_CK1_1 154 160 PF00069 0.404
MOD_CK2_1 138 144 PF00069 0.381
MOD_CK2_1 313 319 PF00069 0.531
MOD_Cter_Amidation 182 185 PF01082 0.404
MOD_GlcNHglycan 11 14 PF01048 0.617
MOD_GlcNHglycan 305 308 PF01048 0.458
MOD_GlcNHglycan 334 337 PF01048 0.417
MOD_GlcNHglycan 339 342 PF01048 0.435
MOD_GSK3_1 152 159 PF00069 0.286
MOD_GSK3_1 162 169 PF00069 0.185
MOD_GSK3_1 195 202 PF00069 0.305
MOD_GSK3_1 349 356 PF00069 0.482
MOD_GSK3_1 56 63 PF00069 0.273
MOD_GSK3_1 64 71 PF00069 0.273
MOD_LATS_1 46 52 PF00433 0.210
MOD_NEK2_1 152 157 PF00069 0.317
MOD_NEK2_1 164 169 PF00069 0.176
MOD_NEK2_1 298 303 PF00069 0.356
MOD_NEK2_1 313 318 PF00069 0.361
MOD_NEK2_1 332 337 PF00069 0.266
MOD_NEK2_1 60 65 PF00069 0.274
MOD_NEK2_1 68 73 PF00069 0.270
MOD_NEK2_2 343 348 PF00069 0.417
MOD_NEK2_2 64 69 PF00069 0.121
MOD_PIKK_1 164 170 PF00454 0.252
MOD_PK_1 185 191 PF00069 0.303
MOD_PKA_1 184 190 PF00069 0.404
MOD_PKA_1 48 54 PF00069 0.140
MOD_PKA_2 319 325 PF00069 0.407
MOD_Plk_1 343 349 PF00069 0.540
MOD_Plk_1 56 62 PF00069 0.227
MOD_Plk_4 185 191 PF00069 0.285
MOD_Plk_4 48 54 PF00069 0.227
MOD_Plk_4 56 62 PF00069 0.227
MOD_Plk_4 82 88 PF00069 0.432
MOD_ProDKin_1 199 205 PF00069 0.309
MOD_ProDKin_1 320 326 PF00069 0.448
TRG_ENDOCYTIC_2 140 143 PF00928 0.303
TRG_ENDOCYTIC_2 178 181 PF00928 0.261
TRG_ENDOCYTIC_2 89 92 PF00928 0.362
TRG_ER_diArg_1 1 4 PF00400 0.585
TRG_ER_diArg_1 226 228 PF00400 0.404
TRG_NES_CRM1_1 134 148 PF08389 0.303
TRG_NLS_MonoExtN_4 44 51 PF00514 0.234
TRG_Pf-PMV_PEXEL_1 259 263 PF00026 0.435
TRG_Pf-PMV_PEXEL_1 4 9 PF00026 0.473
TRG_PTS1 355 358 PF00515 0.544

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6D2 Leptomonas seymouri 75% 100%
A0A0S4IXS3 Bodo saltans 34% 92%
A0A0S4J698 Bodo saltans 33% 76%
A0A0S4J952 Bodo saltans 36% 100%
A0A0S4JFL1 Bodo saltans 35% 100%
A0A0S4JIG1 Bodo saltans 28% 98%
A0A0S4JJI6 Bodo saltans 42% 95%
A0A0S4JU68 Bodo saltans 35% 100%
A0A1X0NUJ8 Trypanosomatidae 53% 98%
A0A3S7X7S3 Leishmania donovani 95% 100%
A0A422N4T2 Trypanosoma rangeli 54% 100%
A4HAP2 Leishmania braziliensis 86% 100%
A4I9T8 Leishmania infantum 94% 100%
C9ZXU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
C9ZXU8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
Q4Q377 Leishmania major 94% 100%
Q8JIL9 Xenopus laevis 31% 100%
V5B4L5 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS