C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-5' exonuclease, putative

Species:

Leishmania mexicana

UniProt:

E9B4U7_LEIMU

TriTrypDb:

LmxM.33.1240

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4U7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004527	exonuclease activity	5	7
GO:0005488	binding	1	7
GO:0008408	3'-5' exonuclease activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.510
CLV_NRD_NRD_1	268	270	PF00675	0.533
CLV_NRD_NRD_1	344	346	PF00675	0.374
CLV_NRD_NRD_1	422	424	PF00675	0.427
CLV_PCSK_KEX2_1	265	267	PF00082	0.380
CLV_PCSK_KEX2_1	380	382	PF00082	0.444
CLV_PCSK_KEX2_1	422	424	PF00082	0.461
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.380
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.395
CLV_PCSK_SKI1_1	125	129	PF00082	0.273
CLV_PCSK_SKI1_1	195	199	PF00082	0.427
CLV_PCSK_SKI1_1	262	266	PF00082	0.517
CLV_PCSK_SKI1_1	269	273	PF00082	0.508
CLV_PCSK_SKI1_1	332	336	PF00082	0.391
CLV_PCSK_SKI1_1	407	411	PF00082	0.348
CLV_PCSK_SKI1_1	56	60	PF00082	0.253
DEG_SCF_SKP2-CKS1_1	531	538	PF00560	0.577
DOC_CYCLIN_RxL_1	401	413	PF00134	0.416
DOC_MAPK_gen_1	265	276	PF00069	0.544
DOC_MAPK_gen_1	77	86	PF00069	0.593
DOC_MAPK_MEF2A_6	269	278	PF00069	0.414
DOC_MAPK_MEF2A_6	6	14	PF00069	0.275
DOC_PP1_SILK_1	368	373	PF00149	0.259
DOC_PP4_FxxP_1	347	350	PF00568	0.488
DOC_PP4_MxPP_1	348	351	PF00568	0.416
DOC_USP7_MATH_1	148	152	PF00917	0.443
DOC_USP7_MATH_1	33	37	PF00917	0.453
DOC_USP7_UBL2_3	110	114	PF12436	0.472
DOC_USP7_UBL2_3	397	401	PF12436	0.372
DOC_USP7_UBL2_3	431	435	PF12436	0.359
DOC_USP7_UBL2_3	538	542	PF12436	0.574
DOC_WW_Pin1_4	241	246	PF00397	0.416
DOC_WW_Pin1_4	337	342	PF00397	0.345
DOC_WW_Pin1_4	532	537	PF00397	0.637
LIG_14-3-3_CanoR_1	181	188	PF00244	0.487
LIG_14-3-3_CanoR_1	381	389	PF00244	0.269
LIG_APCC_ABBA_1	371	376	PF00400	0.392
LIG_APCC_ABBAyCdc20_2	435	441	PF00400	0.394
LIG_BRCT_BRCA1_1	18	22	PF00533	0.464
LIG_BRCT_BRCA1_1	35	39	PF00533	0.453
LIG_BRCT_BRCA1_1	435	439	PF00533	0.433
LIG_FHA_1	259	265	PF00498	0.364
LIG_FHA_1	329	335	PF00498	0.345
LIG_FHA_1	410	416	PF00498	0.397
LIG_FHA_2	382	388	PF00498	0.515
LIG_FHA_2	435	441	PF00498	0.443
LIG_IRF3_LxIS_1	39	44	PF10401	0.507
LIG_LIR_Apic_2	130	135	PF02991	0.453
LIG_LIR_Gen_1	436	446	PF02991	0.450
LIG_LIR_Nem_3	19	25	PF02991	0.429
LIG_LIR_Nem_3	343	347	PF02991	0.371
LIG_LIR_Nem_3	357	363	PF02991	0.388
LIG_LIR_Nem_3	436	442	PF02991	0.366
LIG_LIR_Nem_3	492	497	PF02991	0.255
LIG_LIR_Nem_3	516	520	PF02991	0.436
LIG_PALB2_WD40_1	17	25	PF16756	0.429
LIG_PCNA_yPIPBox_3	77	90	PF02747	0.472
LIG_Pex14_2	442	446	PF04695	0.386
LIG_Pex14_2	490	494	PF04695	0.353
LIG_REV1ctd_RIR_1	43	51	PF16727	0.507
LIG_SH2_CRK	289	293	PF00017	0.328
LIG_SH2_CRK	405	409	PF00017	0.400
LIG_SH2_CRK	95	99	PF00017	0.472
LIG_SH2_NCK_1	383	387	PF00017	0.442
LIG_SH2_SRC	360	363	PF00017	0.400
LIG_SH2_STAP1	375	379	PF00017	0.395
LIG_SH2_STAP1	405	409	PF00017	0.324
LIG_SH2_STAP1	95	99	PF00017	0.507
LIG_SH2_STAT5	152	155	PF00017	0.398
LIG_SH2_STAT5	251	254	PF00017	0.446
LIG_SH2_STAT5	360	363	PF00017	0.484
LIG_SH2_STAT5	383	386	PF00017	0.435
LIG_SH2_STAT5	497	500	PF00017	0.358
LIG_UBA3_1	220	229	PF00899	0.409
MOD_CDC14_SPxK_1	244	247	PF00782	0.314
MOD_CDK_SPxK_1	241	247	PF00069	0.300
MOD_CDK_SPxK_1	532	538	PF00069	0.578
MOD_CK1_1	163	169	PF00069	0.501
MOD_CK1_1	212	218	PF00069	0.617
MOD_CK2_1	127	133	PF00069	0.453
MOD_CK2_1	197	203	PF00069	0.631
MOD_CK2_1	381	387	PF00069	0.439
MOD_CK2_1	434	440	PF00069	0.434
MOD_CK2_1	538	544	PF00069	0.593
MOD_GlcNHglycan	168	171	PF01048	0.560
MOD_GlcNHglycan	213	217	PF01048	0.585
MOD_GlcNHglycan	225	228	PF01048	0.441
MOD_GlcNHglycan	71	74	PF01048	0.272
MOD_GlcNHglycan	95	98	PF01048	0.279
MOD_GSK3_1	317	324	PF00069	0.360
MOD_GSK3_1	409	416	PF00069	0.280
MOD_GSK3_1	506	513	PF00069	0.407
MOD_GSK3_1	69	76	PF00069	0.472
MOD_N-GLC_1	117	122	PF02516	0.307
MOD_N-GLC_1	166	171	PF02516	0.434
MOD_N-GLC_1	82	87	PF02516	0.272
MOD_NEK2_1	1	6	PF00069	0.418
MOD_NEK2_1	112	117	PF00069	0.453
MOD_NEK2_1	136	141	PF00069	0.472
MOD_NEK2_1	179	184	PF00069	0.396
MOD_NEK2_1	317	322	PF00069	0.463
MOD_NEK2_1	32	37	PF00069	0.563
MOD_NEK2_1	41	46	PF00069	0.458
MOD_NEK2_2	434	439	PF00069	0.352
MOD_PIKK_1	381	387	PF00454	0.391
MOD_PKA_2	180	186	PF00069	0.410
MOD_Plk_1	117	123	PF00069	0.507
MOD_Plk_1	73	79	PF00069	0.541
MOD_Plk_1	82	88	PF00069	0.467
MOD_Plk_4	148	154	PF00069	0.468
MOD_Plk_4	366	372	PF00069	0.367
MOD_Plk_4	388	394	PF00069	0.582
MOD_Plk_4	434	440	PF00069	0.476
MOD_Plk_4	475	481	PF00069	0.277
MOD_Plk_4	60	66	PF00069	0.438
MOD_Plk_4	85	91	PF00069	0.453
MOD_ProDKin_1	241	247	PF00069	0.420
MOD_ProDKin_1	337	343	PF00069	0.351
MOD_ProDKin_1	532	538	PF00069	0.578
MOD_SUMO_rev_2	183	193	PF00179	0.431
MOD_SUMO_rev_2	200	208	PF00179	0.433
MOD_SUMO_rev_2	273	282	PF00179	0.479
MOD_SUMO_rev_2	313	323	PF00179	0.268
MOD_SUMO_rev_2	500	509	PF00179	0.411
MOD_SUMO_rev_2	513	519	PF00179	0.412
TRG_DiLeu_BaEn_1	273	278	PF01217	0.289
TRG_DiLeu_BaEn_3	387	393	PF01217	0.457
TRG_DiLeu_BaEn_3	424	430	PF01217	0.387
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.399
TRG_ENDOCYTIC_2	289	292	PF00928	0.365
TRG_ENDOCYTIC_2	360	363	PF00928	0.521
TRG_ENDOCYTIC_2	405	408	PF00928	0.304
TRG_ENDOCYTIC_2	95	98	PF00928	0.507
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV0	Leptomonas seymouri	55%	98%
A0A1X0NK05	Trypanosomatidae	24%	73%
A0A3S7X7Q1	Leishmania donovani	88%	100%
A0A422NPF9	Trypanosoma rangeli	24%	69%
A4HAP1	Leishmania braziliensis	71%	100%
A4I9T6	Leishmania infantum	87%	100%
Q4Q379	Leishmania major	88%	100%
Q8VEG4	Mus musculus	25%	84%
Q9NVH0	Homo sapiens	23%	88%