Uncharacterized protein (Inositol 5-phosphatase-like protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol 5-phosphatase-like protein

Species:

Leishmania mexicana

UniProt:

E9B4U5_LEIMU

TriTrypDb:

LmxM.33.1220

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B4U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4U5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	7
GO:0030258	lipid modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0046839	phospholipid dephosphorylation	5	7
GO:0046856	phosphatidylinositol dephosphorylation	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0005975	carbohydrate metabolic process	3	1
GO:0006066	alcohol metabolic process	3	1
GO:0009056	catabolic process	2	1
GO:0019751	polyol metabolic process	4	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	1
GO:0046855	obsolete inositol phosphate dephosphorylation	5	1
GO:0071545	inositol phosphate catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.355
CLV_C14_Caspase3-7	95	99	PF00656	0.474
CLV_NRD_NRD_1	117	119	PF00675	0.646
CLV_NRD_NRD_1	206	208	PF00675	0.740
CLV_NRD_NRD_1	374	376	PF00675	0.611
CLV_NRD_NRD_1	528	530	PF00675	0.611
CLV_NRD_NRD_1	531	533	PF00675	0.575
CLV_NRD_NRD_1	55	57	PF00675	0.736
CLV_NRD_NRD_1	689	691	PF00675	0.622
CLV_NRD_NRD_1	77	79	PF00675	0.668
CLV_PCSK_FUR_1	529	533	PF00082	0.594
CLV_PCSK_KEX2_1	116	118	PF00082	0.648
CLV_PCSK_KEX2_1	223	225	PF00082	0.762
CLV_PCSK_KEX2_1	356	358	PF00082	0.497
CLV_PCSK_KEX2_1	373	375	PF00082	0.552
CLV_PCSK_KEX2_1	40	42	PF00082	0.671
CLV_PCSK_KEX2_1	530	532	PF00082	0.599
CLV_PCSK_KEX2_1	57	59	PF00082	0.766
CLV_PCSK_KEX2_1	689	691	PF00082	0.606
CLV_PCSK_KEX2_1	77	79	PF00082	0.554
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.678
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.723
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.494
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.552
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.671
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.599
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.722
CLV_PCSK_PC7_1	112	118	PF00082	0.615
CLV_PCSK_SKI1_1	220	224	PF00082	0.585
CLV_PCSK_SKI1_1	356	360	PF00082	0.502
CLV_PCSK_SKI1_1	408	412	PF00082	0.684
CLV_PCSK_SKI1_1	539	543	PF00082	0.496
CLV_PCSK_SKI1_1	66	70	PF00082	0.670
CLV_PCSK_SKI1_1	692	696	PF00082	0.729
CLV_PCSK_SKI1_1	81	85	PF00082	0.641
CLV_Separin_Metazoa	174	178	PF03568	0.249
DEG_APCC_DBOX_1	125	133	PF00400	0.453
DEG_SPOP_SBC_1	616	620	PF00917	0.567
DOC_CYCLIN_RxL_1	77	88	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	137	143	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	610	616	PF00134	0.417
DOC_MAPK_gen_1	301	308	PF00069	0.311
DOC_MAPK_gen_1	384	392	PF00069	0.387
DOC_MAPK_gen_1	733	743	PF00069	0.350
DOC_MAPK_gen_1	77	86	PF00069	0.519
DOC_MAPK_HePTP_8	341	353	PF00069	0.389
DOC_MAPK_MEF2A_6	21	29	PF00069	0.368
DOC_MAPK_MEF2A_6	344	353	PF00069	0.373
DOC_MAPK_MEF2A_6	77	86	PF00069	0.479
DOC_MIT_MIM_1	461	469	PF04212	0.349
DOC_PP1_RVXF_1	382	389	PF00149	0.356
DOC_PP1_RVXF_1	537	543	PF00149	0.294
DOC_PP2B_LxvP_1	137	140	PF13499	0.412
DOC_PP2B_LxvP_1	703	706	PF13499	0.529
DOC_PP4_FxxP_1	388	391	PF00568	0.387
DOC_PP4_FxxP_1	569	572	PF00568	0.571
DOC_PP4_FxxP_1	659	662	PF00568	0.553
DOC_SPAK_OSR1_1	738	742	PF12202	0.355
DOC_USP7_MATH_1	198	202	PF00917	0.514
DOC_USP7_MATH_1	213	217	PF00917	0.544
DOC_USP7_MATH_1	291	295	PF00917	0.384
DOC_USP7_MATH_1	563	567	PF00917	0.558
DOC_USP7_MATH_1	61	65	PF00917	0.487
DOC_USP7_MATH_1	616	620	PF00917	0.600
DOC_USP7_MATH_1	645	649	PF00917	0.442
DOC_USP7_MATH_1	662	666	PF00917	0.579
DOC_USP7_MATH_1	722	726	PF00917	0.262
DOC_USP7_MATH_1	749	753	PF00917	0.400
DOC_USP7_UBL2_3	369	373	PF12436	0.429
DOC_WW_Pin1_4	101	106	PF00397	0.479
DOC_WW_Pin1_4	468	473	PF00397	0.429
DOC_WW_Pin1_4	49	54	PF00397	0.489
DOC_WW_Pin1_4	559	564	PF00397	0.608
DOC_WW_Pin1_4	575	580	PF00397	0.426
DOC_WW_Pin1_4	601	606	PF00397	0.495
LIG_14-3-3_CanoR_1	21	25	PF00244	0.282
LIG_14-3-3_CanoR_1	224	232	PF00244	0.419
LIG_14-3-3_CanoR_1	329	333	PF00244	0.334
LIG_14-3-3_CanoR_1	428	433	PF00244	0.456
LIG_14-3-3_CanoR_1	438	442	PF00244	0.409
LIG_14-3-3_CanoR_1	728	735	PF00244	0.312
LIG_AP2alpha_1	253	257	PF02296	0.321
LIG_BRCT_BRCA1_1	361	365	PF00533	0.325
LIG_BRCT_BRCA1_1	565	569	PF00533	0.567
LIG_Clathr_ClatBox_1	83	87	PF01394	0.469
LIG_deltaCOP1_diTrp_1	243	253	PF00928	0.370
LIG_deltaCOP1_diTrp_1	507	512	PF00928	0.367
LIG_deltaCOP1_diTrp_1	533	542	PF00928	0.293
LIG_deltaCOP1_diTrp_1	677	685	PF00928	0.360
LIG_eIF4E_1	354	360	PF01652	0.312
LIG_FHA_1	105	111	PF00498	0.386
LIG_FHA_1	145	151	PF00498	0.332
LIG_FHA_1	170	176	PF00498	0.362
LIG_FHA_1	21	27	PF00498	0.205
LIG_FHA_1	267	273	PF00498	0.490
LIG_FHA_1	333	339	PF00498	0.406
LIG_FHA_1	445	451	PF00498	0.356
LIG_FHA_1	586	592	PF00498	0.528
LIG_FHA_1	653	659	PF00498	0.417
LIG_FHA_1	670	676	PF00498	0.580
LIG_FHA_1	711	717	PF00498	0.426
LIG_FHA_2	223	229	PF00498	0.503
LIG_FHA_2	620	626	PF00498	0.569
LIG_HCF-1_HBM_1	452	455	PF13415	0.351
LIG_LIR_Apic_2	385	391	PF02991	0.378
LIG_LIR_Apic_2	566	572	PF02991	0.569
LIG_LIR_Apic_2	656	662	PF02991	0.540
LIG_LIR_Apic_2	677	683	PF02991	0.370
LIG_LIR_Gen_1	243	254	PF02991	0.393
LIG_LIR_Gen_1	424	432	PF02991	0.475
LIG_LIR_Gen_1	452	462	PF02991	0.293
LIG_LIR_Gen_1	482	487	PF02991	0.331
LIG_LIR_Gen_1	507	516	PF02991	0.358
LIG_LIR_Gen_1	589	598	PF02991	0.510
LIG_LIR_Nem_3	243	249	PF02991	0.347
LIG_LIR_Nem_3	250	256	PF02991	0.282
LIG_LIR_Nem_3	299	303	PF02991	0.378
LIG_LIR_Nem_3	424	429	PF02991	0.471
LIG_LIR_Nem_3	452	458	PF02991	0.299
LIG_LIR_Nem_3	482	486	PF02991	0.336
LIG_LIR_Nem_3	500	505	PF02991	0.342
LIG_LIR_Nem_3	507	512	PF02991	0.324
LIG_LIR_Nem_3	589	595	PF02991	0.510
LIG_LIR_Nem_3	707	712	PF02991	0.454
LIG_PCNA_yPIPBox_3	116	129	PF02747	0.326
LIG_Pex14_1	426	430	PF04695	0.471
LIG_Pex14_2	253	257	PF04695	0.321
LIG_Pex14_2	437	441	PF04695	0.518
LIG_Pex14_2	505	509	PF04695	0.367
LIG_SH2_CRK	300	304	PF00017	0.319
LIG_SH2_CRK	483	487	PF00017	0.371
LIG_SH2_GRB2like	483	486	PF00017	0.410
LIG_SH2_NCK_1	158	162	PF00017	0.349
LIG_SH2_NCK_1	721	725	PF00017	0.334
LIG_SH2_SRC	158	161	PF00017	0.361
LIG_SH2_SRC	178	181	PF00017	0.302
LIG_SH2_STAP1	158	162	PF00017	0.402
LIG_SH2_STAP1	483	487	PF00017	0.371
LIG_SH2_STAT5	128	131	PF00017	0.305
LIG_SH2_STAT5	324	327	PF00017	0.334
LIG_SH2_STAT5	455	458	PF00017	0.284
LIG_SH3_3	192	198	PF00018	0.545
LIG_SUMO_SIM_anti_2	23	28	PF11976	0.205
LIG_SUMO_SIM_anti_2	701	707	PF11976	0.379
LIG_SUMO_SIM_par_1	22	28	PF11976	0.369
LIG_SUMO_SIM_par_1	257	263	PF11976	0.286
LIG_SUMO_SIM_par_1	32	38	PF11976	0.389
LIG_SUMO_SIM_par_1	701	707	PF11976	0.379
LIG_SUMO_SIM_par_1	742	747	PF11976	0.378
LIG_TRAF2_1	260	263	PF00917	0.287
LIG_TRAF2_1	594	597	PF00917	0.535
LIG_TYR_ITIM	298	303	PF00017	0.317
LIG_UBA3_1	313	320	PF00899	0.333
LIG_WRC_WIRS_1	401	406	PF05994	0.362
LIG_WRC_WIRS_1	429	434	PF05994	0.513
LIG_WW_1	155	158	PF00397	0.421
LIG_WW_1	513	516	PF00397	0.302
MOD_CDK_SPxxK_3	468	475	PF00069	0.421
MOD_CDK_SPxxK_3	49	56	PF00069	0.522
MOD_CK1_1	440	446	PF00069	0.409
MOD_CK1_1	565	571	PF00069	0.547
MOD_CK1_1	604	610	PF00069	0.481
MOD_CK1_1	615	621	PF00069	0.519
MOD_CK1_1	629	635	PF00069	0.458
MOD_CK1_1	96	102	PF00069	0.462
MOD_CK2_1	222	228	PF00069	0.500
MOD_CK2_1	257	263	PF00069	0.283
MOD_CK2_1	440	446	PF00069	0.409
MOD_CK2_1	551	557	PF00069	0.529
MOD_CK2_1	591	597	PF00069	0.562
MOD_CK2_1	619	625	PF00069	0.498
MOD_CK2_1	695	701	PF00069	0.526
MOD_Cter_Amidation	354	357	PF01082	0.507
MOD_GlcNHglycan	209	212	PF01048	0.768
MOD_GlcNHglycan	361	364	PF01048	0.523
MOD_GlcNHglycan	423	426	PF01048	0.648
MOD_GlcNHglycan	434	437	PF01048	0.697
MOD_GlcNHglycan	442	445	PF01048	0.510
MOD_GlcNHglycan	497	500	PF01048	0.556
MOD_GlcNHglycan	564	568	PF01048	0.705
MOD_GlcNHglycan	588	591	PF01048	0.788
MOD_GlcNHglycan	606	609	PF01048	0.768
MOD_GlcNHglycan	614	617	PF01048	0.730
MOD_GlcNHglycan	698	701	PF01048	0.726
MOD_GlcNHglycan	95	98	PF01048	0.670
MOD_GlcNHglycan	99	102	PF01048	0.719
MOD_GSK3_1	196	203	PF00069	0.593
MOD_GSK3_1	218	225	PF00069	0.513
MOD_GSK3_1	272	279	PF00069	0.496
MOD_GSK3_1	328	335	PF00069	0.350
MOD_GSK3_1	411	418	PF00069	0.374
MOD_GSK3_1	428	435	PF00069	0.503
MOD_GSK3_1	440	447	PF00069	0.391
MOD_GSK3_1	508	515	PF00069	0.360
MOD_GSK3_1	559	566	PF00069	0.460
MOD_GSK3_1	597	604	PF00069	0.504
MOD_GSK3_1	612	619	PF00069	0.491
MOD_GSK3_1	723	730	PF00069	0.377
MOD_GSK3_1	85	92	PF00069	0.450
MOD_GSK3_1	93	100	PF00069	0.441
MOD_N-GLC_2	144	146	PF02516	0.574
MOD_NEK2_1	106	111	PF00069	0.508
MOD_NEK2_1	222	227	PF00069	0.383
MOD_NEK2_1	257	262	PF00069	0.322
MOD_NEK2_1	266	271	PF00069	0.420
MOD_NEK2_1	330	335	PF00069	0.334
MOD_NEK2_1	349	354	PF00069	0.195
MOD_NEK2_1	359	364	PF00069	0.280
MOD_NEK2_1	432	437	PF00069	0.497
MOD_NEK2_1	525	530	PF00069	0.400
MOD_NEK2_1	586	591	PF00069	0.538
MOD_NEK2_2	111	116	PF00069	0.456
MOD_NEK2_2	200	205	PF00069	0.489
MOD_NEK2_2	61	66	PF00069	0.488
MOD_NEK2_2	723	728	PF00069	0.412
MOD_PIKK_1	273	279	PF00454	0.402
MOD_PIKK_1	645	651	PF00454	0.487
MOD_PKA_1	207	213	PF00069	0.535
MOD_PKA_1	223	229	PF00069	0.470
MOD_PKA_1	373	379	PF00069	0.383
MOD_PKA_2	111	117	PF00069	0.446
MOD_PKA_2	20	26	PF00069	0.282
MOD_PKA_2	223	229	PF00069	0.503
MOD_PKA_2	328	334	PF00069	0.336
MOD_PKA_2	349	355	PF00069	0.302
MOD_PKA_2	373	379	PF00069	0.416
MOD_PKA_2	437	443	PF00069	0.443
MOD_PKA_2	519	525	PF00069	0.390
MOD_PKA_2	727	733	PF00069	0.315
MOD_PKB_1	205	213	PF00069	0.567
MOD_Plk_1	415	421	PF00069	0.515
MOD_Plk_1	61	67	PF00069	0.487
MOD_Plk_1	629	635	PF00069	0.548
MOD_Plk_4	106	112	PF00069	0.342
MOD_Plk_4	161	167	PF00069	0.409
MOD_Plk_4	20	26	PF00069	0.246
MOD_Plk_4	336	342	PF00069	0.416
MOD_Plk_4	349	355	PF00069	0.260
MOD_Plk_4	400	406	PF00069	0.401
MOD_Plk_4	577	583	PF00069	0.538
MOD_ProDKin_1	101	107	PF00069	0.477
MOD_ProDKin_1	468	474	PF00069	0.423
MOD_ProDKin_1	49	55	PF00069	0.487
MOD_ProDKin_1	559	565	PF00069	0.607
MOD_ProDKin_1	575	581	PF00069	0.426
MOD_ProDKin_1	601	607	PF00069	0.496
MOD_SUMO_rev_2	174	184	PF00179	0.414
MOD_SUMO_rev_2	245	254	PF00179	0.386
MOD_SUMO_rev_2	294	303	PF00179	0.364
MOD_SUMO_rev_2	594	603	PF00179	0.544
TRG_DiLeu_BaEn_1	482	487	PF01217	0.330
TRG_DiLeu_BaEn_1	491	496	PF01217	0.314
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.419
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.477
TRG_ENDOCYTIC_2	300	303	PF00928	0.317
TRG_ENDOCYTIC_2	455	458	PF00928	0.287
TRG_ENDOCYTIC_2	483	486	PF00928	0.344
TRG_ER_diArg_1	204	207	PF00400	0.542
TRG_ER_diArg_1	529	532	PF00400	0.438
TRG_ER_diArg_1	55	58	PF00400	0.562
TRG_ER_diArg_1	689	692	PF00400	0.487
TRG_ER_diArg_1	735	738	PF00400	0.348
TRG_ER_diArg_1	77	79	PF00400	0.485
TRG_ER_FFAT_2	435	447	PF00635	0.496
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	543	548	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	631	636	PF00026	0.779

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ6	Leptomonas seymouri	57%	100%
A0A3Q8IFD8	Leishmania donovani	90%	100%
A0A422NU02	Trypanosoma rangeli	36%	99%
A4I9T4	Leishmania infantum	90%	100%
Q4Q381	Leishmania major	89%	100%