Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4U4_LEIMU

TriTrypDb:

LmxM.33.1210

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	518	522	PF00656	0.621
CLV_C14_Caspase3-7	524	528	PF00656	0.601
CLV_MEL_PAP_1	153	159	PF00089	0.551
CLV_NRD_NRD_1	125	127	PF00675	0.666
CLV_NRD_NRD_1	180	182	PF00675	0.502
CLV_NRD_NRD_1	384	386	PF00675	0.464
CLV_NRD_NRD_1	417	419	PF00675	0.503
CLV_NRD_NRD_1	52	54	PF00675	0.520
CLV_NRD_NRD_1	552	554	PF00675	0.542
CLV_PCSK_KEX2_1	125	127	PF00082	0.570
CLV_PCSK_KEX2_1	179	181	PF00082	0.551
CLV_PCSK_KEX2_1	305	307	PF00082	0.538
CLV_PCSK_KEX2_1	384	386	PF00082	0.464
CLV_PCSK_KEX2_1	417	419	PF00082	0.503
CLV_PCSK_KEX2_1	434	436	PF00082	0.525
CLV_PCSK_KEX2_1	479	481	PF00082	0.463
CLV_PCSK_KEX2_1	552	554	PF00082	0.542
CLV_PCSK_KEX2_1	71	73	PF00082	0.540
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.538
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.492
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.441
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.540
CLV_PCSK_PC7_1	475	481	PF00082	0.559
CLV_PCSK_SKI1_1	388	392	PF00082	0.463
CLV_PCSK_SKI1_1	431	435	PF00082	0.527
CLV_PCSK_SKI1_1	437	441	PF00082	0.551
CLV_PCSK_SKI1_1	49	53	PF00082	0.461
CLV_PCSK_SKI1_1	498	502	PF00082	0.623
DEG_APCC_DBOX_1	48	56	PF00400	0.494
DEG_Nend_UBRbox_1	1	4	PF02207	0.581
DEG_SPOP_SBC_1	340	344	PF00917	0.545
DEG_SPOP_SBC_1	394	398	PF00917	0.611
DOC_CKS1_1	58	63	PF01111	0.473
DOC_CYCLIN_yClb5_NLxxxL_5	311	318	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	20	23	PF00134	0.476
DOC_MAPK_gen_1	384	391	PF00069	0.456
DOC_MAPK_gen_1	88	98	PF00069	0.533
DOC_MAPK_HePTP_8	153	165	PF00069	0.549
DOC_MAPK_HePTP_8	414	430	PF00069	0.546
DOC_MAPK_MEF2A_6	133	140	PF00069	0.636
DOC_MAPK_MEF2A_6	156	165	PF00069	0.550
DOC_PP2B_LxvP_1	20	23	PF13499	0.524
DOC_PP2B_LxvP_1	338	341	PF13499	0.564
DOC_PP4_FxxP_1	132	135	PF00568	0.427
DOC_USP7_MATH_1	13	17	PF00917	0.651
DOC_USP7_MATH_1	251	255	PF00917	0.515
DOC_USP7_MATH_1	341	345	PF00917	0.661
DOC_USP7_MATH_1	353	357	PF00917	0.725
DOC_USP7_MATH_1	366	370	PF00917	0.749
DOC_USP7_MATH_1	407	411	PF00917	0.529
DOC_USP7_MATH_1	466	470	PF00917	0.516
DOC_USP7_MATH_1	503	507	PF00917	0.659
DOC_WW_Pin1_4	23	28	PF00397	0.648
DOC_WW_Pin1_4	246	251	PF00397	0.621
DOC_WW_Pin1_4	367	372	PF00397	0.576
DOC_WW_Pin1_4	534	539	PF00397	0.645
DOC_WW_Pin1_4	57	62	PF00397	0.549
LIG_14-3-3_CanoR_1	15	23	PF00244	0.584
LIG_14-3-3_CanoR_1	156	160	PF00244	0.599
LIG_14-3-3_CanoR_1	222	230	PF00244	0.496
LIG_14-3-3_CanoR_1	261	267	PF00244	0.727
LIG_14-3-3_CanoR_1	269	275	PF00244	0.634
LIG_14-3-3_CanoR_1	327	333	PF00244	0.621
LIG_BRCT_BRCA1_1	254	258	PF00533	0.453
LIG_BRCT_BRCA1_1	330	334	PF00533	0.390
LIG_eIF4E_1	494	500	PF01652	0.568
LIG_EVH1_2	128	132	PF00568	0.446
LIG_FHA_1	108	114	PF00498	0.777
LIG_FHA_1	148	154	PF00498	0.588
LIG_FHA_1	15	21	PF00498	0.553
LIG_FHA_1	43	49	PF00498	0.463
LIG_FHA_1	78	84	PF00498	0.623
LIG_FHA_1	91	97	PF00498	0.735
LIG_FHA_2	241	247	PF00498	0.611
LIG_FHA_2	277	283	PF00498	0.481
LIG_FHA_2	294	300	PF00498	0.482
LIG_FHA_2	39	45	PF00498	0.467
LIG_FHA_2	438	444	PF00498	0.588
LIG_FHA_2	516	522	PF00498	0.593
LIG_FHA_2	58	64	PF00498	0.500
LIG_LIR_Nem_3	421	426	PF02991	0.559
LIG_SH2_CRK	34	38	PF00017	0.523
LIG_SH2_STAP1	212	216	PF00017	0.510
LIG_SH2_STAP1	231	235	PF00017	0.672
LIG_SH2_STAT5	34	37	PF00017	0.473
LIG_SH3_2	121	126	PF14604	0.617
LIG_SH3_2	67	72	PF14604	0.492
LIG_SH3_3	118	124	PF00018	0.667
LIG_SH3_3	506	512	PF00018	0.653
LIG_SH3_3	55	61	PF00018	0.644
LIG_SH3_3	64	70	PF00018	0.639
LIG_SUMO_SIM_anti_2	425	430	PF11976	0.529
LIG_SUMO_SIM_par_1	109	114	PF11976	0.666
LIG_SUMO_SIM_par_1	369	375	PF11976	0.550
LIG_SxIP_EBH_1	115	125	PF03271	0.541
LIG_TRAF2_1	190	193	PF00917	0.616
LIG_TRAF2_1	300	303	PF00917	0.506
LIG_TRAF2_1	62	65	PF00917	0.656
LIG_TRFH_1	132	136	PF08558	0.425
LIG_WW_3	119	123	PF00397	0.581
LIG_WW_3	21	25	PF00397	0.450
MOD_CDK_SPK_2	534	539	PF00069	0.626
MOD_CK1_1	104	110	PF00069	0.772
MOD_CK1_1	26	32	PF00069	0.597
MOD_CK1_1	276	282	PF00069	0.652
MOD_CK1_1	339	345	PF00069	0.625
MOD_CK1_1	356	362	PF00069	0.583
MOD_CK1_1	396	402	PF00069	0.665
MOD_CK1_1	460	466	PF00069	0.453
MOD_CK1_1	537	543	PF00069	0.471
MOD_CK1_1	86	92	PF00069	0.624
MOD_CK2_1	240	246	PF00069	0.420
MOD_CK2_1	276	282	PF00069	0.488
MOD_CK2_1	293	299	PF00069	0.485
MOD_GlcNHglycan	103	106	PF01048	0.762
MOD_GlcNHglycan	186	189	PF01048	0.454
MOD_GlcNHglycan	223	226	PF01048	0.489
MOD_GlcNHglycan	286	289	PF01048	0.506
MOD_GlcNHglycan	338	341	PF01048	0.637
MOD_GlcNHglycan	348	351	PF01048	0.688
MOD_GlcNHglycan	362	365	PF01048	0.496
MOD_GlcNHglycan	374	377	PF01048	0.687
MOD_GlcNHglycan	398	401	PF01048	0.621
MOD_GlcNHglycan	459	462	PF01048	0.519
MOD_GlcNHglycan	547	550	PF01048	0.568
MOD_GlcNHglycan	7	10	PF01048	0.564
MOD_GSK3_1	1	8	PF00069	0.615
MOD_GSK3_1	103	110	PF00069	0.761
MOD_GSK3_1	22	29	PF00069	0.608
MOD_GSK3_1	240	247	PF00069	0.641
MOD_GSK3_1	270	277	PF00069	0.666
MOD_GSK3_1	336	343	PF00069	0.624
MOD_GSK3_1	356	363	PF00069	0.452
MOD_GSK3_1	38	45	PF00069	0.404
MOD_GSK3_1	394	401	PF00069	0.676
MOD_GSK3_1	517	524	PF00069	0.761
MOD_GSK3_1	77	84	PF00069	0.805
MOD_GSK3_1	86	93	PF00069	0.756
MOD_N-GLC_1	360	365	PF02516	0.656
MOD_N-GLC_1	81	86	PF02516	0.528
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	14	19	PF00069	0.579
MOD_NEK2_1	545	550	PF00069	0.581
MOD_NEK2_2	155	160	PF00069	0.541
MOD_NEK2_2	33	38	PF00069	0.525
MOD_PIKK_1	356	362	PF00454	0.478
MOD_PKA_2	107	113	PF00069	0.710
MOD_PKA_2	14	20	PF00069	0.583
MOD_PKA_2	155	161	PF00069	0.541
MOD_PKA_2	221	227	PF00069	0.486
MOD_PKA_2	522	528	PF00069	0.637
MOD_PKA_2	545	551	PF00069	0.578
MOD_Plk_1	237	243	PF00069	0.597
MOD_Plk_4	107	113	PF00069	0.714
MOD_Plk_4	15	21	PF00069	0.490
MOD_Plk_4	167	173	PF00069	0.346
MOD_Plk_4	328	334	PF00069	0.565
MOD_Plk_4	446	452	PF00069	0.502
MOD_ProDKin_1	23	29	PF00069	0.646
MOD_ProDKin_1	246	252	PF00069	0.622
MOD_ProDKin_1	367	373	PF00069	0.574
MOD_ProDKin_1	534	540	PF00069	0.642
MOD_ProDKin_1	57	63	PF00069	0.554
MOD_SUMO_for_1	217	220	PF00179	0.298
MOD_SUMO_rev_2	297	307	PF00179	0.539
TRG_ENDOCYTIC_2	34	37	PF00928	0.521
TRG_ER_diArg_1	124	126	PF00400	0.576
TRG_ER_diArg_1	179	181	PF00400	0.522
TRG_ER_diArg_1	200	203	PF00400	0.424
TRG_ER_diArg_1	384	386	PF00400	0.464
TRG_ER_diArg_1	416	418	PF00400	0.498
TRG_ER_diArg_1	551	553	PF00400	0.530
TRG_NLS_Bipartite_1	417	438	PF00514	0.375
TRG_NLS_MonoExtC_3	433	438	PF00514	0.420
TRG_NLS_MonoExtN_4	431	438	PF00514	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY58	Leptomonas seymouri	43%	100%
A0A3Q8II15	Leishmania donovani	86%	100%
A0A422MPI6	Trypanosoma rangeli	24%	100%
A4HBJ3	Leishmania braziliensis	63%	99%
A4I9T3	Leishmania infantum	87%	100%
C9ZMU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
Q4Q382	Leishmania major	86%	100%
V5BIT8	Trypanosoma cruzi	22%	100%