RIBOSOMAL_L9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4T8_LEIMU

TriTrypDb:

LmxM.33.1160

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4T8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.493
CLV_NRD_NRD_1	182	184	PF00675	0.571
CLV_NRD_NRD_1	2	4	PF00675	0.461
CLV_NRD_NRD_1	304	306	PF00675	0.450
CLV_NRD_NRD_1	344	346	PF00675	0.376
CLV_NRD_NRD_1	437	439	PF00675	0.701
CLV_NRD_NRD_1	69	71	PF00675	0.432
CLV_PCSK_KEX2_1	135	137	PF00082	0.480
CLV_PCSK_KEX2_1	182	184	PF00082	0.571
CLV_PCSK_KEX2_1	2	4	PF00082	0.480
CLV_PCSK_KEX2_1	344	346	PF00082	0.376
CLV_PCSK_KEX2_1	69	71	PF00082	0.432
CLV_PCSK_SKI1_1	137	141	PF00082	0.482
CLV_PCSK_SKI1_1	154	158	PF00082	0.294
CLV_PCSK_SKI1_1	183	187	PF00082	0.504
CLV_PCSK_SKI1_1	26	30	PF00082	0.669
CLV_PCSK_SKI1_1	3	7	PF00082	0.544
CLV_PCSK_SKI1_1	318	322	PF00082	0.480
CLV_PCSK_SKI1_1	357	361	PF00082	0.421
CLV_PCSK_SKI1_1	363	367	PF00082	0.448
CLV_PCSK_SKI1_1	378	382	PF00082	0.534
CLV_PCSK_SKI1_1	70	74	PF00082	0.404
DEG_APCC_DBOX_1	1	9	PF00400	0.567
DEG_APCC_DBOX_1	25	33	PF00400	0.646
DEG_Nend_UBRbox_1	1	4	PF02207	0.601
DEG_SCF_FBW7_2	219	225	PF00400	0.384
DOC_CKS1_1	219	224	PF01111	0.381
DOC_CKS1_1	274	279	PF01111	0.379
DOC_CKS1_1	45	50	PF01111	0.525
DOC_CYCLIN_RxL_1	148	160	PF00134	0.452
DOC_CYCLIN_RxL_1	2	13	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.439
DOC_MAPK_gen_1	193	201	PF00069	0.487
DOC_MAPK_gen_1	2	10	PF00069	0.538
DOC_MAPK_gen_1	69	77	PF00069	0.383
DOC_MAPK_MEF2A_6	2	10	PF00069	0.591
DOC_MAPK_NFAT4_5	3	11	PF00069	0.547
DOC_PP1_RVXF_1	252	258	PF00149	0.404
DOC_PP2B_LxvP_1	163	166	PF13499	0.344
DOC_PP2B_LxvP_1	202	205	PF13499	0.412
DOC_PP4_FxxP_1	114	117	PF00568	0.362
DOC_USP7_MATH_1	205	209	PF00917	0.455
DOC_USP7_UBL2_3	38	42	PF12436	0.543
DOC_WW_Pin1_4	13	18	PF00397	0.559
DOC_WW_Pin1_4	218	223	PF00397	0.377
DOC_WW_Pin1_4	256	261	PF00397	0.350
DOC_WW_Pin1_4	273	278	PF00397	0.390
DOC_WW_Pin1_4	32	37	PF00397	0.549
DOC_WW_Pin1_4	331	336	PF00397	0.572
DOC_WW_Pin1_4	44	49	PF00397	0.521
LIG_14-3-3_CanoR_1	136	146	PF00244	0.472
LIG_14-3-3_CanoR_1	2	6	PF00244	0.493
LIG_14-3-3_CanoR_1	69	77	PF00244	0.383
LIG_APCC_ABBA_1	99	104	PF00400	0.414
LIG_BRCT_BRCA1_1	15	19	PF00533	0.562
LIG_Clathr_ClatBox_1	235	239	PF01394	0.235
LIG_deltaCOP1_diTrp_1	43	51	PF00928	0.528
LIG_FHA_1	158	164	PF00498	0.462
LIG_FHA_1	274	280	PF00498	0.397
LIG_FHA_1	319	325	PF00498	0.414
LIG_FHA_1	71	77	PF00498	0.364
LIG_FHA_2	124	130	PF00498	0.534
LIG_FHA_2	248	254	PF00498	0.480
LIG_FHA_2	297	303	PF00498	0.422
LIG_FHA_2	331	337	PF00498	0.449
LIG_FHA_2	364	370	PF00498	0.481
LIG_LIR_Apic_2	112	117	PF02991	0.378
LIG_LIR_Apic_2	409	414	PF02991	0.577
LIG_LIR_Apic_2	43	48	PF02991	0.518
LIG_LIR_Gen_1	127	134	PF02991	0.448
LIG_LIR_Gen_1	140	151	PF02991	0.351
LIG_LIR_Gen_1	226	236	PF02991	0.386
LIG_LIR_Gen_1	389	398	PF02991	0.606
LIG_LIR_Gen_1	442	449	PF02991	0.513
LIG_LIR_Nem_3	127	133	PF02991	0.424
LIG_LIR_Nem_3	140	146	PF02991	0.424
LIG_LIR_Nem_3	226	232	PF02991	0.413
LIG_LIR_Nem_3	288	292	PF02991	0.382
LIG_LIR_Nem_3	389	395	PF02991	0.599
LIG_LIR_Nem_3	39	44	PF02991	0.536
LIG_LIR_Nem_3	442	447	PF02991	0.572
LIG_LIR_Nem_3	93	99	PF02991	0.363
LIG_NRBOX	4	10	PF00104	0.644
LIG_Pex14_2	41	45	PF04695	0.537
LIG_PTB_Apo_2	228	235	PF02174	0.353
LIG_PTB_Phospho_1	228	234	PF10480	0.377
LIG_SH2_CRK	392	396	PF00017	0.694
LIG_SH2_CRK	444	448	PF00017	0.683
LIG_SH2_CRK	96	100	PF00017	0.356
LIG_SH2_NCK_1	392	396	PF00017	0.646
LIG_SH2_STAP1	348	352	PF00017	0.457
LIG_SH2_STAT3	37	40	PF00017	0.533
LIG_SH2_STAT3	416	419	PF00017	0.617
LIG_SH2_STAT5	109	112	PF00017	0.585
LIG_SH2_STAT5	234	237	PF00017	0.336
LIG_SH2_STAT5	246	249	PF00017	0.429
LIG_SH2_STAT5	342	345	PF00017	0.389
LIG_SH3_2	178	183	PF14604	0.489
LIG_SH3_3	114	120	PF00018	0.383
LIG_SH3_3	172	178	PF00018	0.456
LIG_SH3_3	319	325	PF00018	0.460
LIG_SH3_3	370	376	PF00018	0.596
LIG_SUMO_SIM_anti_2	160	166	PF11976	0.461
LIG_SUMO_SIM_par_1	118	129	PF11976	0.429
LIG_SUMO_SIM_par_1	233	239	PF11976	0.380
LIG_SUMO_SIM_par_1	278	284	PF11976	0.381
LIG_TRAF2_1	366	369	PF00917	0.515
LIG_UBA3_1	162	167	PF00899	0.348
LIG_WRC_WIRS_1	289	294	PF05994	0.266
MOD_CDC14_SPxK_1	35	38	PF00782	0.545
MOD_CDK_SPxK_1	32	38	PF00069	0.551
MOD_CDK_SPxxK_3	13	20	PF00069	0.566
MOD_CDK_SPxxK_3	331	338	PF00069	0.568
MOD_CK1_1	13	19	PF00069	0.563
MOD_CK1_1	208	214	PF00069	0.489
MOD_CK2_1	247	253	PF00069	0.451
MOD_CK2_1	256	262	PF00069	0.330
MOD_CK2_1	330	336	PF00069	0.446
MOD_CK2_1	363	369	PF00069	0.454
MOD_CK2_1	443	449	PF00069	0.722
MOD_Cter_Amidation	436	439	PF01082	0.685
MOD_GlcNHglycan	12	15	PF01048	0.561
MOD_GSK3_1	115	122	PF00069	0.397
MOD_GSK3_1	230	237	PF00069	0.433
MOD_N-GLC_1	10	15	PF02516	0.560
MOD_N-GLC_1	230	235	PF02516	0.464
MOD_NEK2_1	1	6	PF00069	0.547
MOD_NEK2_1	157	162	PF00069	0.464
MOD_NEK2_1	206	211	PF00069	0.484
MOD_NEK2_1	390	395	PF00069	0.736
MOD_NEK2_1	443	448	PF00069	0.653
MOD_PIKK_1	138	144	PF00454	0.589
MOD_PIKK_1	208	214	PF00454	0.386
MOD_PKA_2	1	7	PF00069	0.507
MOD_PKA_2	102	108	PF00069	0.585
MOD_PKA_2	337	343	PF00069	0.565
MOD_PKA_2	421	427	PF00069	0.536
MOD_PKA_2	437	443	PF00069	0.433
MOD_PKB_1	135	143	PF00069	0.594
MOD_Plk_1	206	212	PF00069	0.484
MOD_Plk_1	230	236	PF00069	0.445
MOD_Plk_2-3	124	130	PF00069	0.428
MOD_Plk_4	230	236	PF00069	0.461
MOD_Plk_4	318	324	PF00069	0.426
MOD_Plk_4	71	77	PF00069	0.441
MOD_ProDKin_1	13	19	PF00069	0.563
MOD_ProDKin_1	218	224	PF00069	0.381
MOD_ProDKin_1	256	262	PF00069	0.354
MOD_ProDKin_1	273	279	PF00069	0.386
MOD_ProDKin_1	32	38	PF00069	0.551
MOD_ProDKin_1	331	337	PF00069	0.567
MOD_ProDKin_1	44	50	PF00069	0.526
MOD_SUMO_rev_2	92	99	PF00179	0.385
TRG_DiLeu_BaEn_1	377	382	PF01217	0.522
TRG_DiLeu_BaEn_4	369	375	PF01217	0.622
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.564
TRG_ENDOCYTIC_2	392	395	PF00928	0.610
TRG_ENDOCYTIC_2	444	447	PF00928	0.629
TRG_ENDOCYTIC_2	96	99	PF00928	0.356
TRG_ER_diArg_1	1	3	PF00400	0.502
TRG_ER_diArg_1	134	137	PF00400	0.478
TRG_ER_diArg_1	181	183	PF00400	0.606
TRG_ER_diArg_1	343	345	PF00400	0.378
TRG_NES_CRM1_1	197	207	PF08389	0.515
TRG_Pf-PMV_PEXEL_1	154	159	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC51	Leptomonas seymouri	80%	100%
A0A0S4ITQ6	Bodo saltans	59%	92%
A0A1X0PA81	Trypanosomatidae	68%	100%
A0A3Q8IHD9	Leishmania donovani	96%	100%
A4HAN4	Leishmania braziliensis	93%	100%
A4I9S7	Leishmania infantum	96%	100%
C9ZMV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
Q4Q388	Leishmania major	96%	100%
V5BIT5	Trypanosoma cruzi	68%	100%