DUF167-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised ACR, YggU family COG1872, putative

Species:

Leishmania mexicana

UniProt:

E9B4T7_LEIMU

TriTrypDb:

LmxM.33.1155

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4T7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	181	185	PF00082	0.510
CLV_PCSK_SKI1_1	76	80	PF00082	0.282
CLV_Separin_Metazoa	65	69	PF03568	0.422
DEG_APCC_DBOX_1	190	198	PF00400	0.500
DEG_APCC_DBOX_1	4	12	PF00400	0.448
DEG_SCF_FBW7_1	41	47	PF00400	0.422
DEG_SPOP_SBC_1	131	135	PF00917	0.569
DOC_CKS1_1	41	46	PF01111	0.422
DOC_MAPK_gen_1	179	187	PF00069	0.403
DOC_MAPK_MEF2A_6	179	187	PF00069	0.454
DOC_PP4_FxxP_1	38	41	PF00568	0.422
DOC_USP7_MATH_1	102	106	PF00917	0.612
DOC_USP7_MATH_1	108	112	PF00917	0.652
DOC_USP7_MATH_1	132	136	PF00917	0.671
DOC_USP7_MATH_1	137	141	PF00917	0.651
DOC_USP7_MATH_1	146	150	PF00917	0.750
DOC_USP7_MATH_1	152	156	PF00917	0.601
DOC_USP7_MATH_1	29	33	PF00917	0.357
DOC_USP7_UBL2_3	120	124	PF12436	0.641
DOC_WW_Pin1_4	154	159	PF00397	0.698
DOC_WW_Pin1_4	40	45	PF00397	0.440
LIG_14-3-3_CanoR_1	34	42	PF00244	0.317
LIG_FHA_1	180	186	PF00498	0.501
LIG_FHA_1	193	199	PF00498	0.448
LIG_FHA_1	41	47	PF00498	0.461
LIG_FHA_2	175	181	PF00498	0.504
LIG_FHA_2	188	194	PF00498	0.299
LIG_FHA_2	43	49	PF00498	0.423
LIG_LIR_Apic_2	36	41	PF02991	0.422
LIG_LIR_Gen_1	75	86	PF02991	0.286
LIG_LIR_Gen_1	91	102	PF02991	0.535
LIG_LIR_Nem_3	91	97	PF02991	0.516
LIG_PCNA_yPIPBox_3	63	76	PF02747	0.346
LIG_SH2_CRK	94	98	PF00017	0.530
LIG_SH2_STAP1	94	98	PF00017	0.518
LIG_SH2_STAT5	23	26	PF00017	0.438
LIG_SH2_STAT5	69	72	PF00017	0.438
LIG_SH2_STAT5	88	91	PF00017	0.544
LIG_SH3_3	38	44	PF00018	0.422
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.547
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.275
LIG_TYR_ITSM	90	97	PF00017	0.529
MOD_CK1_1	111	117	PF00069	0.499
MOD_CK1_1	135	141	PF00069	0.719
MOD_CK1_1	93	99	PF00069	0.565
MOD_CK2_1	174	180	PF00069	0.523
MOD_CK2_1	187	193	PF00069	0.322
MOD_CK2_1	42	48	PF00069	0.292
MOD_Cter_Amidation	118	121	PF01082	0.676
MOD_GlcNHglycan	104	107	PF01048	0.592
MOD_GlcNHglycan	110	113	PF01048	0.679
MOD_GlcNHglycan	115	118	PF01048	0.691
MOD_GlcNHglycan	121	124	PF01048	0.702
MOD_GlcNHglycan	135	138	PF01048	0.525
MOD_GlcNHglycan	159	162	PF01048	0.554
MOD_GlcNHglycan	31	34	PF01048	0.391
MOD_GlcNHglycan	35	38	PF01048	0.367
MOD_GSK3_1	104	111	PF00069	0.473
MOD_GSK3_1	131	138	PF00069	0.693
MOD_GSK3_1	153	160	PF00069	0.705
MOD_GSK3_1	175	182	PF00069	0.497
MOD_GSK3_1	29	36	PF00069	0.354
MOD_GSK3_1	40	47	PF00069	0.346
MOD_GSK3_1	89	96	PF00069	0.579
MOD_NEK2_1	1	6	PF00069	0.567
MOD_NEK2_2	23	28	PF00069	0.372
MOD_PIKK_1	146	152	PF00454	0.659
MOD_PKA_2	33	39	PF00069	0.312
MOD_Plk_1	168	174	PF00069	0.549
MOD_Plk_1	179	185	PF00069	0.450
MOD_Plk_1	192	198	PF00069	0.288
MOD_Plk_1	90	96	PF00069	0.419
MOD_Plk_4	168	174	PF00069	0.431
MOD_Plk_4	179	185	PF00069	0.407
MOD_Plk_4	93	99	PF00069	0.540
MOD_ProDKin_1	154	160	PF00069	0.696
MOD_ProDKin_1	40	46	PF00069	0.440
TRG_DiLeu_BaEn_1	180	185	PF01217	0.426
TRG_ENDOCYTIC_2	94	97	PF00928	0.527
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK74	Leptomonas seymouri	52%	100%
A0A1X0P9D1	Trypanosomatidae	31%	100%
A0A3Q8IKV6	Leishmania donovani	85%	100%
A0A422NGS4	Trypanosoma rangeli	32%	100%
A4I9S6	Leishmania infantum	85%	100%
C9ZMV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AI65	Leishmania braziliensis	70%	99%
Q4Q389	Leishmania major	86%	100%