Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4T6_LEIMU

TriTrypDb:

LmxM.33.1150

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4T6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	259	263	PF00082	0.721
CLV_PCSK_SKI1_1	47	51	PF00082	0.532
DEG_SPOP_SBC_1	120	124	PF00917	0.548
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.587
DOC_MAPK_HePTP_8	84	96	PF00069	0.552
DOC_MAPK_MEF2A_6	245	254	PF00069	0.474
DOC_MAPK_MEF2A_6	78	86	PF00069	0.560
DOC_MAPK_MEF2A_6	87	96	PF00069	0.525
DOC_PP2B_LxvP_1	178	181	PF13499	0.577
DOC_PP2B_PxIxI_1	91	97	PF00149	0.536
DOC_PP4_FxxP_1	23	26	PF00568	0.500
DOC_PP4_FxxP_1	68	71	PF00568	0.572
DOC_USP7_MATH_1	107	111	PF00917	0.534
DOC_USP7_MATH_1	120	124	PF00917	0.472
DOC_USP7_MATH_1	134	138	PF00917	0.520
DOC_USP7_MATH_1	170	174	PF00917	0.613
DOC_USP7_MATH_1	300	304	PF00917	0.586
DOC_USP7_MATH_1	42	46	PF00917	0.711
DOC_WW_Pin1_4	197	202	PF00397	0.587
DOC_WW_Pin1_4	203	208	PF00397	0.577
DOC_WW_Pin1_4	213	218	PF00397	0.564
DOC_WW_Pin1_4	38	43	PF00397	0.580
LIG_14-3-3_CanoR_1	118	127	PF00244	0.506
LIG_14-3-3_CanoR_1	168	178	PF00244	0.616
LIG_14-3-3_CanoR_1	195	199	PF00244	0.488
LIG_14-3-3_CanoR_1	263	272	PF00244	0.555
LIG_14-3-3_CanoR_1	281	290	PF00244	0.494
LIG_14-3-3_CanoR_1	291	297	PF00244	0.581
LIG_14-3-3_CanoR_1	47	52	PF00244	0.569
LIG_14-3-3_CanoR_1	7	13	PF00244	0.577
LIG_14-3-3_CterR_2	377	379	PF00244	0.583
LIG_Actin_WH2_2	181	197	PF00022	0.642
LIG_Actin_WH2_2	334	349	PF00022	0.475
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_BIR_III_2	39	43	PF00653	0.584
LIG_BRCT_BRCA1_1	123	127	PF00533	0.540
LIG_deltaCOP1_diTrp_1	274	277	PF00928	0.486
LIG_FHA_1	141	147	PF00498	0.551
LIG_FHA_1	173	179	PF00498	0.665
LIG_FHA_1	71	77	PF00498	0.685
LIG_FHA_1	91	97	PF00498	0.536
LIG_FHA_2	280	286	PF00498	0.509
LIG_FHA_2	351	357	PF00498	0.552
LIG_FHA_2	360	366	PF00498	0.569
LIG_FHA_2	48	54	PF00498	0.502
LIG_FHA_2	83	89	PF00498	0.549
LIG_LIR_Apic_2	20	26	PF02991	0.504
LIG_LIR_Apic_2	274	278	PF02991	0.491
LIG_LIR_Apic_2	65	71	PF02991	0.565
LIG_LIR_Gen_1	356	366	PF02991	0.524
LIG_LIR_Gen_1	95	105	PF02991	0.553
LIG_LIR_Nem_3	2	8	PF02991	0.633
LIG_LIR_Nem_3	274	280	PF02991	0.500
LIG_LIR_Nem_3	356	361	PF02991	0.532
LIG_LIR_Nem_3	95	101	PF02991	0.588
LIG_Pex14_2	34	38	PF04695	0.606
LIG_SH2_CRK	98	102	PF00017	0.549
LIG_SH3_2	204	209	PF14604	0.572
LIG_SH3_3	198	204	PF00018	0.571
LIG_SH3_3	211	217	PF00018	0.605
LIG_SH3_3	329	335	PF00018	0.594
LIG_SUMO_SIM_anti_2	328	334	PF11976	0.603
LIG_SUMO_SIM_par_1	140	149	PF11976	0.585
LIG_TYR_ITIM	96	101	PF00017	0.517
LIG_WRC_WIRS_1	1	6	PF05994	0.563
LIG_WRC_WIRS_1	355	360	PF05994	0.539
MOD_CDC14_SPxK_1	206	209	PF00782	0.576
MOD_CDK_SPxK_1	203	209	PF00069	0.570
MOD_CK1_1	123	129	PF00069	0.550
MOD_CK1_1	137	143	PF00069	0.699
MOD_CK1_1	148	154	PF00069	0.760
MOD_CK1_1	172	178	PF00069	0.586
MOD_CK1_1	200	206	PF00069	0.586
MOD_CK1_1	216	222	PF00069	0.575
MOD_CK1_1	295	301	PF00069	0.587
MOD_CK1_1	349	355	PF00069	0.507
MOD_CK1_1	41	47	PF00069	0.603
MOD_CK2_1	107	113	PF00069	0.531
MOD_CK2_1	157	163	PF00069	0.630
MOD_CK2_1	279	285	PF00069	0.492
MOD_CK2_1	350	356	PF00069	0.523
MOD_CK2_1	359	365	PF00069	0.526
MOD_CK2_1	47	53	PF00069	0.545
MOD_CK2_1	82	88	PF00069	0.552
MOD_GlcNHglycan	140	143	PF01048	0.736
MOD_GlcNHglycan	211	214	PF01048	0.705
MOD_GlcNHglycan	228	231	PF01048	0.583
MOD_GlcNHglycan	302	305	PF01048	0.618
MOD_GlcNHglycan	362	365	PF01048	0.521
MOD_GlcNHglycan	43	47	PF01048	0.665
MOD_GSK3_1	119	126	PF00069	0.531
MOD_GSK3_1	134	141	PF00069	0.543
MOD_GSK3_1	148	155	PF00069	0.551
MOD_GSK3_1	157	164	PF00069	0.577
MOD_GSK3_1	209	216	PF00069	0.645
MOD_GSK3_1	222	229	PF00069	0.560
MOD_GSK3_1	255	262	PF00069	0.503
MOD_GSK3_1	34	41	PF00069	0.584
MOD_GSK3_1	345	352	PF00069	0.521
MOD_GSK3_1	356	363	PF00069	0.564
MOD_GSK3_1	82	89	PF00069	0.550
MOD_N-GLC_1	13	18	PF02516	0.613
MOD_NEK2_1	121	126	PF00069	0.598
MOD_NEK2_1	169	174	PF00069	0.547
MOD_NEK2_1	194	199	PF00069	0.488
MOD_NEK2_1	250	255	PF00069	0.461
MOD_NEK2_1	346	351	PF00069	0.540
MOD_PIKK_1	126	132	PF00454	0.528
MOD_PIKK_1	13	19	PF00454	0.567
MOD_PIKK_1	289	295	PF00454	0.654
MOD_PIKK_1	70	76	PF00454	0.661
MOD_PKA_2	170	176	PF00069	0.632
MOD_PKA_2	194	200	PF00069	0.487
MOD_PKA_2	264	270	PF00069	0.478
MOD_PKA_2	280	286	PF00069	0.509
MOD_PKA_2	86	92	PF00069	0.532
MOD_Plk_1	19	25	PF00069	0.625
MOD_Plk_1	259	265	PF00069	0.596
MOD_Plk_1	327	333	PF00069	0.617
MOD_Plk_4	140	146	PF00069	0.620
MOD_Plk_4	327	333	PF00069	0.617
MOD_ProDKin_1	197	203	PF00069	0.587
MOD_ProDKin_1	213	219	PF00069	0.564
MOD_ProDKin_1	38	44	PF00069	0.577
TRG_DiLeu_BaEn_1	104	109	PF01217	0.532
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.505
TRG_ENDOCYTIC_2	98	101	PF00928	0.554
TRG_ER_diArg_1	288	291	PF00400	0.588
TRG_NES_CRM1_1	74	88	PF08389	0.555
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWJ1	Leptomonas seymouri	52%	78%
A0A3Q8IH36	Leishmania donovani	91%	98%
A4HAN3	Leishmania braziliensis	78%	100%
A4I9S5	Leishmania infantum	92%	98%
Q4Q390	Leishmania major	92%	100%