Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4T1_LEIMU

TriTrypDb:

LmxM.33.1100

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4T1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.514
CLV_NRD_NRD_1	236	238	PF00675	0.636
CLV_NRD_NRD_1	298	300	PF00675	0.549
CLV_NRD_NRD_1	314	316	PF00675	0.662
CLV_NRD_NRD_1	39	41	PF00675	0.643
CLV_PCSK_KEX2_1	236	238	PF00082	0.636
CLV_PCSK_KEX2_1	298	300	PF00082	0.549
CLV_PCSK_KEX2_1	314	316	PF00082	0.662
CLV_PCSK_KEX2_1	39	41	PF00082	0.523
CLV_PCSK_SKI1_1	314	318	PF00082	0.634
CLV_PCSK_SKI1_1	319	323	PF00082	0.658
CLV_PCSK_SKI1_1	334	338	PF00082	0.332
CLV_PCSK_SKI1_1	366	370	PF00082	0.516
CLV_PCSK_SKI1_1	39	43	PF00082	0.529
DEG_APCC_DBOX_1	298	306	PF00400	0.614
DEG_APCC_DBOX_1	365	373	PF00400	0.631
DEG_APCC_DBOX_1	38	46	PF00400	0.654
DEG_SPOP_SBC_1	196	200	PF00917	0.551
DEG_SPOP_SBC_1	51	55	PF00917	0.485
DOC_ANK_TNKS_1	254	261	PF00023	0.496
DOC_CKS1_1	328	333	PF01111	0.567
DOC_CYCLIN_RxL_1	331	338	PF00134	0.642
DOC_CYCLIN_RxL_1	37	46	PF00134	0.659
DOC_MAPK_gen_1	298	304	PF00069	0.537
DOC_MAPK_gen_1	314	322	PF00069	0.632
DOC_MAPK_gen_1	39	45	PF00069	0.584
DOC_MAPK_HePTP_8	316	328	PF00069	0.700
DOC_MAPK_MEF2A_6	203	210	PF00069	0.511
DOC_MAPK_MEF2A_6	319	328	PF00069	0.695
DOC_MAPK_MEF2A_6	378	386	PF00069	0.598
DOC_MAPK_MEF2A_6	78	85	PF00069	0.705
DOC_PP2B_LxvP_1	74	77	PF13499	0.486
DOC_USP7_MATH_1	112	116	PF00917	0.563
DOC_USP7_MATH_1	124	128	PF00917	0.599
DOC_USP7_MATH_1	136	140	PF00917	0.553
DOC_USP7_MATH_1	243	247	PF00917	0.574
DOC_USP7_MATH_1	31	35	PF00917	0.604
DOC_USP7_MATH_1	49	53	PF00917	0.683
DOC_USP7_MATH_1	60	64	PF00917	0.730
DOC_WW_Pin1_4	102	107	PF00397	0.749
DOC_WW_Pin1_4	114	119	PF00397	0.534
DOC_WW_Pin1_4	248	253	PF00397	0.709
DOC_WW_Pin1_4	327	332	PF00397	0.583
DOC_WW_Pin1_4	52	57	PF00397	0.683
LIG_14-3-3_CanoR_1	140	146	PF00244	0.481
LIG_14-3-3_CanoR_1	203	209	PF00244	0.631
LIG_14-3-3_CanoR_1	314	322	PF00244	0.615
LIG_14-3-3_CanoR_1	40	46	PF00244	0.580
LIG_BRCT_BRCA1_1	206	210	PF00533	0.612
LIG_BRCT_BRCA1_1	382	386	PF00533	0.593
LIG_CaM_NSCaTE_8	289	296	PF13499	0.302
LIG_deltaCOP1_diTrp_1	5	11	PF00928	0.581
LIG_FHA_1	199	205	PF00498	0.705
LIG_FHA_1	315	321	PF00498	0.545
LIG_FHA_1	328	334	PF00498	0.475
LIG_FHA_2	209	215	PF00498	0.594
LIG_FHA_2	342	348	PF00498	0.604
LIG_GBD_Chelix_1	332	340	PF00786	0.645
LIG_Integrin_RGD_1	284	286	PF01839	0.398
LIG_LIR_Nem_3	335	340	PF02991	0.492
LIG_LIR_Nem_3	342	348	PF02991	0.449
LIG_LIR_Nem_3	35	41	PF02991	0.595
LIG_LIR_Nem_3	375	380	PF02991	0.538
LIG_LIR_Nem_3	5	10	PF02991	0.547
LIG_MAD2	40	48	PF02301	0.657
LIG_NRBOX	167	173	PF00104	0.597
LIG_PCNA_yPIPBox_3	366	380	PF02747	0.644
LIG_Pex14_2	337	341	PF04695	0.509
LIG_Pex14_2	355	359	PF04695	0.476
LIG_SH2_CRK	38	42	PF00017	0.659
LIG_SH2_STAP1	131	135	PF00017	0.644
LIG_SH2_STAP1	175	179	PF00017	0.501
LIG_SH3_1	307	313	PF00018	0.598
LIG_SH3_2	310	315	PF14604	0.609
LIG_SH3_3	239	245	PF00018	0.453
LIG_SH3_3	307	313	PF00018	0.646
LIG_SH3_3	325	331	PF00018	0.594
LIG_SH3_3	42	48	PF00018	0.597
LIG_SH3_3	92	98	PF00018	0.720
LIG_SUMO_SIM_par_1	41	46	PF11976	0.649
LIG_TRAF2_1	271	274	PF00917	0.704
MOD_CDK_SPK_2	52	57	PF00069	0.490
MOD_CDK_SPxxK_3	248	255	PF00069	0.584
MOD_CDK_SPxxK_3	327	334	PF00069	0.645
MOD_CK1_1	102	108	PF00069	0.706
MOD_CK1_1	111	117	PF00069	0.675
MOD_CK1_1	125	131	PF00069	0.654
MOD_CK1_1	134	140	PF00069	0.569
MOD_CK1_1	142	148	PF00069	0.601
MOD_CK1_1	190	196	PF00069	0.695
MOD_CK1_1	198	204	PF00069	0.662
MOD_CK1_1	335	341	PF00069	0.640
MOD_CK1_1	52	58	PF00069	0.736
MOD_CK1_1	63	69	PF00069	0.660
MOD_CK2_1	208	214	PF00069	0.615
MOD_CK2_1	31	37	PF00069	0.511
MOD_CK2_1	341	347	PF00069	0.603
MOD_CK2_1	85	91	PF00069	0.664
MOD_GlcNHglycan	110	113	PF01048	0.602
MOD_GlcNHglycan	146	149	PF01048	0.721
MOD_GlcNHglycan	189	192	PF01048	0.720
MOD_GlcNHglycan	263	266	PF01048	0.503
MOD_GlcNHglycan	45	48	PF01048	0.606
MOD_GlcNHglycan	62	65	PF01048	0.587
MOD_GSK3_1	102	109	PF00069	0.740
MOD_GSK3_1	114	121	PF00069	0.527
MOD_GSK3_1	125	132	PF00069	0.662
MOD_GSK3_1	134	141	PF00069	0.508
MOD_GSK3_1	204	211	PF00069	0.429
MOD_GSK3_1	261	268	PF00069	0.675
MOD_GSK3_1	380	387	PF00069	0.663
MOD_GSK3_1	51	58	PF00069	0.709
MOD_GSK3_1	59	66	PF00069	0.741
MOD_GSK3_1	81	88	PF00069	0.787
MOD_LATS_1	120	126	PF00433	0.674
MOD_LATS_1	138	144	PF00433	0.486
MOD_NEK2_1	100	105	PF00069	0.712
MOD_NEK2_1	197	202	PF00069	0.661
MOD_NEK2_1	332	337	PF00069	0.613
MOD_NEK2_1	340	345	PF00069	0.597
MOD_NEK2_1	372	377	PF00069	0.504
MOD_NEK2_1	380	385	PF00069	0.501
MOD_NEK2_1	43	48	PF00069	0.662
MOD_NEK2_2	81	86	PF00069	0.501
MOD_PIKK_1	236	242	PF00454	0.679
MOD_PK_1	122	128	PF00069	0.669
MOD_PKA_1	236	242	PF00069	0.679
MOD_PKA_1	314	320	PF00069	0.699
MOD_PKA_2	139	145	PF00069	0.689
MOD_PKA_2	187	193	PF00069	0.734
MOD_PKA_2	23	29	PF00069	0.455
MOD_PKA_2	236	242	PF00069	0.679
MOD_PKA_2	314	320	PF00069	0.600
MOD_Plk_1	122	128	PF00069	0.793
MOD_Plk_1	341	347	PF00069	0.603
MOD_Plk_2-3	224	230	PF00069	0.593
MOD_Plk_4	159	165	PF00069	0.573
MOD_Plk_4	332	338	PF00069	0.641
MOD_Plk_4	341	347	PF00069	0.526
MOD_Plk_4	372	378	PF00069	0.599
MOD_Plk_4	380	386	PF00069	0.568
MOD_Plk_4	81	87	PF00069	0.734
MOD_ProDKin_1	102	108	PF00069	0.749
MOD_ProDKin_1	114	120	PF00069	0.535
MOD_ProDKin_1	248	254	PF00069	0.708
MOD_ProDKin_1	327	333	PF00069	0.574
MOD_ProDKin_1	52	58	PF00069	0.685
MOD_SUMO_rev_2	88	96	PF00179	0.784
TRG_ENDOCYTIC_2	38	41	PF00928	0.655
TRG_ER_diArg_1	235	237	PF00400	0.620
TRG_ER_diArg_1	313	315	PF00400	0.547
TRG_ER_diArg_1	38	40	PF00400	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P9L5	Trypanosomatidae	25%	94%
A0A3Q8II07	Leishmania donovani	86%	100%
A4HAM8	Leishmania braziliensis	67%	100%
A4I9S0	Leishmania infantum	86%	70%
C9ZMW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q395	Leishmania major	87%	99%