SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4S7_LEIMU

TriTrypDb:

LmxM.33.1050

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4S7

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.764
CLV_C14_Caspase3-7	188	192	PF00656	0.635
CLV_NRD_NRD_1	101	103	PF00675	0.601
CLV_NRD_NRD_1	164	166	PF00675	0.385
CLV_NRD_NRD_1	403	405	PF00675	0.337
CLV_NRD_NRD_1	555	557	PF00675	0.527
CLV_NRD_NRD_1	664	666	PF00675	0.479
CLV_NRD_NRD_1	78	80	PF00675	0.500
CLV_PCSK_KEX2_1	100	102	PF00082	0.590
CLV_PCSK_KEX2_1	164	166	PF00082	0.384
CLV_PCSK_KEX2_1	555	557	PF00082	0.494
CLV_PCSK_KEX2_1	652	654	PF00082	0.439
CLV_PCSK_KEX2_1	664	666	PF00082	0.477
CLV_PCSK_KEX2_1	78	80	PF00082	0.578
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.590
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.343
CLV_PCSK_SKI1_1	22	26	PF00082	0.734
CLV_PCSK_SKI1_1	290	294	PF00082	0.366
CLV_PCSK_SKI1_1	328	332	PF00082	0.521
CLV_PCSK_SKI1_1	408	412	PF00082	0.287
CLV_PCSK_SKI1_1	641	645	PF00082	0.411
CLV_Separin_Metazoa	661	665	PF03568	0.472
DEG_APCC_DBOX_1	508	516	PF00400	0.552
DOC_CDC14_PxL_1	333	341	PF14671	0.600
DOC_MAPK_gen_1	164	174	PF00069	0.528
DOC_MAPK_gen_1	218	227	PF00069	0.395
DOC_MAPK_gen_1	404	412	PF00069	0.539
DOC_MAPK_HePTP_8	162	174	PF00069	0.512
DOC_MAPK_MEF2A_6	165	174	PF00069	0.530
DOC_MAPK_NFAT4_5	167	175	PF00069	0.282
DOC_PP1_RVXF_1	639	645	PF00149	0.446
DOC_PP4_FxxP_1	293	296	PF00568	0.524
DOC_PP4_FxxP_1	666	669	PF00568	0.442
DOC_USP7_MATH_1	18	22	PF00917	0.517
DOC_USP7_MATH_1	425	429	PF00917	0.560
DOC_USP7_MATH_1	430	434	PF00917	0.564
DOC_USP7_MATH_1	472	476	PF00917	0.516
DOC_USP7_MATH_1	61	65	PF00917	0.431
DOC_USP7_MATH_2	427	433	PF00917	0.521
DOC_USP7_UBL2_3	90	94	PF12436	0.486
DOC_WW_Pin1_4	192	197	PF00397	0.599
DOC_WW_Pin1_4	248	253	PF00397	0.383
DOC_WW_Pin1_4	292	297	PF00397	0.526
DOC_WW_Pin1_4	342	347	PF00397	0.693
DOC_WW_Pin1_4	645	650	PF00397	0.598
DOC_WW_Pin1_4	687	692	PF00397	0.722
LIG_14-3-3_CanoR_1	131	135	PF00244	0.392
LIG_14-3-3_CanoR_1	164	170	PF00244	0.530
LIG_14-3-3_CanoR_1	241	248	PF00244	0.543
LIG_14-3-3_CanoR_1	511	516	PF00244	0.440
LIG_14-3-3_CanoR_1	561	571	PF00244	0.491
LIG_14-3-3_CanoR_1	78	87	PF00244	0.458
LIG_Actin_WH2_2	388	406	PF00022	0.433
LIG_APCC_ABBAyCdc20_2	131	137	PF00400	0.488
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_BRCT_BRCA1_1	131	135	PF00533	0.348
LIG_BRCT_BRCA1_1	288	292	PF00533	0.488
LIG_BRCT_BRCA1_1	63	67	PF00533	0.320
LIG_DLG_GKlike_1	165	172	PF00625	0.507
LIG_eIF4E_1	450	456	PF01652	0.537
LIG_FHA_1	110	116	PF00498	0.428
LIG_FHA_1	121	127	PF00498	0.439
LIG_FHA_1	257	263	PF00498	0.497
LIG_FHA_1	436	442	PF00498	0.507
LIG_FHA_1	566	572	PF00498	0.438
LIG_FHA_1	84	90	PF00498	0.538
LIG_FHA_2	350	356	PF00498	0.685
LIG_FHA_2	394	400	PF00498	0.523
LIG_FHA_2	512	518	PF00498	0.511
LIG_HCF-1_HBM_1	138	141	PF13415	0.566
LIG_LIR_Gen_1	171	182	PF02991	0.532
LIG_LIR_Gen_1	504	512	PF02991	0.486
LIG_LIR_Gen_1	573	581	PF02991	0.463
LIG_LIR_Gen_1	64	74	PF02991	0.528
LIG_LIR_Nem_3	157	162	PF02991	0.432
LIG_LIR_Nem_3	171	177	PF02991	0.420
LIG_LIR_Nem_3	31	36	PF02991	0.558
LIG_LIR_Nem_3	494	500	PF02991	0.500
LIG_LIR_Nem_3	517	522	PF02991	0.512
LIG_LIR_Nem_3	573	577	PF02991	0.442
LIG_LIR_Nem_3	64	70	PF02991	0.524
LIG_LYPXL_yS_3	336	339	PF13949	0.594
LIG_MYND_1	346	350	PF01753	0.719
LIG_NRBOX	123	129	PF00104	0.403
LIG_NRBOX	54	60	PF00104	0.551
LIG_Rb_LxCxE_1	110	133	PF01857	0.497
LIG_SH2_CRK	327	331	PF00017	0.479
LIG_SH2_CRK	497	501	PF00017	0.560
LIG_SH2_GRB2like	111	114	PF00017	0.491
LIG_SH2_NCK_1	253	257	PF00017	0.503
LIG_SH2_PTP2	580	583	PF00017	0.541
LIG_SH2_SRC	141	144	PF00017	0.523
LIG_SH2_SRC	253	256	PF00017	0.462
LIG_SH2_SRC	574	577	PF00017	0.448
LIG_SH2_SRC	667	670	PF00017	0.418
LIG_SH2_SRC	679	682	PF00017	0.413
LIG_SH2_STAP1	253	257	PF00017	0.433
LIG_SH2_STAP1	563	567	PF00017	0.404
LIG_SH2_STAP1	574	578	PF00017	0.366
LIG_SH2_STAT3	268	271	PF00017	0.483
LIG_SH2_STAT5	111	114	PF00017	0.386
LIG_SH2_STAT5	268	271	PF00017	0.397
LIG_SH2_STAT5	391	394	PF00017	0.510
LIG_SH2_STAT5	465	468	PF00017	0.523
LIG_SH2_STAT5	544	547	PF00017	0.428
LIG_SH2_STAT5	580	583	PF00017	0.510
LIG_SH2_STAT5	603	606	PF00017	0.481
LIG_SH2_STAT5	679	682	PF00017	0.495
LIG_SH3_3	529	535	PF00018	0.600
LIG_SH3_3	581	587	PF00018	0.482
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.467
LIG_SUMO_SIM_anti_2	54	60	PF11976	0.548
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.444
LIG_SUMO_SIM_par_1	54	60	PF11976	0.563
LIG_SUMO_SIM_par_1	567	573	PF11976	0.456
LIG_TRAF2_1	185	188	PF00917	0.553
LIG_TYR_ITIM	325	330	PF00017	0.473
LIG_TYR_ITIM	495	500	PF00017	0.413
LIG_UBA3_1	55	63	PF00899	0.516
LIG_WRC_WIRS_1	465	470	PF05994	0.344
LIG_WW_3	215	219	PF00397	0.556
MOD_CDK_SPxxK_3	645	652	PF00069	0.535
MOD_CK1_1	195	201	PF00069	0.544
MOD_CK1_1	2	8	PF00069	0.686
MOD_CK1_1	240	246	PF00069	0.499
MOD_CK1_1	264	270	PF00069	0.482
MOD_CK1_1	501	507	PF00069	0.507
MOD_CK2_1	165	171	PF00069	0.473
MOD_CK2_1	182	188	PF00069	0.481
MOD_CK2_1	393	399	PF00069	0.496
MOD_CK2_1	645	651	PF00069	0.481
MOD_Cter_Amidation	553	556	PF01082	0.498
MOD_GlcNHglycan	12	15	PF01048	0.718
MOD_GlcNHglycan	207	210	PF01048	0.574
MOD_GlcNHglycan	228	232	PF01048	0.552
MOD_GlcNHglycan	263	266	PF01048	0.464
MOD_GlcNHglycan	272	275	PF01048	0.441
MOD_GlcNHglycan	28	31	PF01048	0.617
MOD_GlcNHglycan	341	345	PF01048	0.699
MOD_GlcNHglycan	4	7	PF01048	0.694
MOD_GlcNHglycan	432	435	PF01048	0.378
MOD_GlcNHglycan	59	62	PF01048	0.484
MOD_GSK3_1	1	8	PF00069	0.746
MOD_GSK3_1	18	25	PF00069	0.771
MOD_GSK3_1	182	189	PF00069	0.605
MOD_GSK3_1	360	367	PF00069	0.623
MOD_GSK3_1	380	387	PF00069	0.181
MOD_GSK3_1	421	428	PF00069	0.418
MOD_GSK3_1	57	64	PF00069	0.442
MOD_N-GLC_1	129	134	PF02516	0.420
MOD_N-GLC_1	430	435	PF02516	0.474
MOD_NEK2_1	1	6	PF00069	0.746
MOD_NEK2_1	109	114	PF00069	0.405
MOD_NEK2_1	270	275	PF00069	0.402
MOD_NEK2_1	364	369	PF00069	0.659
MOD_NEK2_1	420	425	PF00069	0.489
MOD_NEK2_1	435	440	PF00069	0.368
MOD_NEK2_1	493	498	PF00069	0.449
MOD_NEK2_1	57	62	PF00069	0.536
MOD_NEK2_1	73	78	PF00069	0.456
MOD_NEK2_1	83	88	PF00069	0.521
MOD_NEK2_2	498	503	PF00069	0.519
MOD_NEK2_2	524	529	PF00069	0.469
MOD_OFUCOSY	523	528	PF10250	0.516
MOD_PKA_1	78	84	PF00069	0.563
MOD_PKA_2	130	136	PF00069	0.386
MOD_PKA_2	240	246	PF00069	0.491
MOD_PKA_2	421	427	PF00069	0.392
MOD_PKA_2	78	84	PF00069	0.484
MOD_PKB_1	509	517	PF00069	0.495
MOD_Plk_1	129	135	PF00069	0.414
MOD_Plk_1	415	421	PF00069	0.410
MOD_Plk_1	430	436	PF00069	0.467
MOD_Plk_1	491	497	PF00069	0.342
MOD_Plk_1	637	643	PF00069	0.459
MOD_Plk_1	680	686	PF00069	0.558
MOD_Plk_1	83	89	PF00069	0.487
MOD_Plk_2-3	349	355	PF00069	0.630
MOD_Plk_4	130	136	PF00069	0.391
MOD_Plk_4	154	160	PF00069	0.483
MOD_Plk_4	380	386	PF00069	0.405
MOD_Plk_4	437	443	PF00069	0.414
MOD_Plk_4	565	571	PF00069	0.392
MOD_Plk_4	668	674	PF00069	0.470
MOD_ProDKin_1	192	198	PF00069	0.598
MOD_ProDKin_1	248	254	PF00069	0.380
MOD_ProDKin_1	292	298	PF00069	0.522
MOD_ProDKin_1	342	348	PF00069	0.694
MOD_ProDKin_1	645	651	PF00069	0.598
MOD_ProDKin_1	687	693	PF00069	0.725
MOD_SUMO_for_1	684	687	PF00179	0.570
TRG_DiLeu_BaEn_1	54	59	PF01217	0.550
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.457
TRG_ENDOCYTIC_2	327	330	PF00928	0.477
TRG_ENDOCYTIC_2	336	339	PF00928	0.594
TRG_ENDOCYTIC_2	465	468	PF00928	0.435
TRG_ENDOCYTIC_2	497	500	PF00928	0.430
TRG_ENDOCYTIC_2	519	522	PF00928	0.501
TRG_ENDOCYTIC_2	574	577	PF00928	0.448
TRG_ENDOCYTIC_2	603	606	PF00928	0.516
TRG_ER_diArg_1	101	103	PF00400	0.518
TRG_ER_diArg_1	164	167	PF00400	0.469
TRG_ER_diArg_1	217	220	PF00400	0.389
TRG_ER_diArg_1	508	511	PF00400	0.438
TRG_ER_diArg_1	555	557	PF00400	0.494
TRG_ER_diArg_1	663	665	PF00400	0.459
TRG_ER_diArg_1	78	80	PF00400	0.578
TRG_NES_CRM1_1	614	630	PF08389	0.403
TRG_NES_CRM1_1	676	689	PF08389	0.437
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	555	560	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKN8	Leptomonas seymouri	76%	99%
A0A0S4JQY2	Bodo saltans	42%	100%
A0A1X0P998	Trypanosomatidae	37%	100%
A0A3Q8IKU3	Leishmania donovani	94%	100%
A0A422N693	Trypanosoma rangeli	37%	100%
A4HAL8	Leishmania braziliensis	87%	100%
A4I9Q7	Leishmania infantum	94%	100%
C9ZMX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4Q3A0	Leishmania major	94%	100%
V5BJB7	Trypanosoma cruzi	35%	100%