EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania mexicana

UniProt:

E9B4S5_LEIMU

TriTrypDb:

LmxM.33.1030

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4S5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	208	214	PF00089	0.362
CLV_NRD_NRD_1	243	245	PF00675	0.324
CLV_PCSK_KEX2_1	243	245	PF00082	0.324
DEG_SPOP_SBC_1	63	67	PF00917	0.609
DOC_MAPK_JIP1_4	76	82	PF00069	0.602
DOC_PP1_RVXF_1	209	215	PF00149	0.362
DOC_USP7_MATH_1	103	107	PF00917	0.638
DOC_USP7_MATH_1	27	31	PF00917	0.617
DOC_USP7_MATH_1	36	40	PF00917	0.553
DOC_USP7_MATH_1	52	56	PF00917	0.526
DOC_USP7_MATH_1	63	67	PF00917	0.616
DOC_USP7_MATH_1	75	79	PF00917	0.522
DOC_USP7_UBL2_3	249	253	PF12436	0.542
DOC_WW_Pin1_4	70	75	PF00397	0.634
LIG_14-3-3_CanoR_1	236	240	PF00244	0.524
LIG_14-3-3_CanoR_1	243	249	PF00244	0.411
LIG_14-3-3_CanoR_1	7	15	PF00244	0.541
LIG_BIR_II_1	1	5	PF00653	0.429
LIG_BIR_III_4	183	187	PF00653	0.324
LIG_BRCT_BRCA1_1	176	180	PF00533	0.585
LIG_CaM_IQ_9	124	140	PF13499	0.591
LIG_deltaCOP1_diTrp_1	118	127	PF00928	0.541
LIG_FHA_1	195	201	PF00498	0.375
LIG_FHA_1	63	69	PF00498	0.614
LIG_FHA_1	85	91	PF00498	0.563
LIG_FHA_2	111	117	PF00498	0.493
LIG_FHA_2	14	20	PF00498	0.546
LIG_FHA_2	216	222	PF00498	0.324
LIG_LIR_Gen_1	118	127	PF02991	0.541
LIG_LIR_Gen_1	179	189	PF02991	0.467
LIG_LIR_Nem_3	118	124	PF02991	0.541
LIG_LIR_Nem_3	126	130	PF02991	0.460
LIG_LIR_Nem_3	161	165	PF02991	0.546
LIG_LIR_Nem_3	17	23	PF02991	0.494
LIG_LIR_Nem_3	179	185	PF02991	0.561
LIG_LIR_Nem_3	187	192	PF02991	0.354
LIG_LIR_Nem_3	240	245	PF02991	0.386
LIG_LIR_Nem_3	9	15	PF02991	0.544
LIG_LYPXL_S_1	11	15	PF13949	0.504
LIG_LYPXL_yS_3	12	15	PF13949	0.499
LIG_Pex14_2	158	162	PF04695	0.534
LIG_SH2_CRK	20	24	PF00017	0.555
LIG_SH2_SRC	192	195	PF00017	0.324
LIG_SH2_STAT5	165	168	PF00017	0.748
LIG_SH2_STAT5	199	202	PF00017	0.362
LIG_SH3_3	21	27	PF00018	0.583
LIG_SH3_3	71	77	PF00018	0.614
LIG_SUMO_SIM_anti_2	218	228	PF11976	0.358
LIG_TRAF2_1	218	221	PF00917	0.362
LIG_WRC_WIRS_1	124	129	PF05994	0.540
MOD_CDC14_SPxK_1	73	76	PF00782	0.506
MOD_CDK_SPxK_1	70	76	PF00069	0.510
MOD_CK1_1	106	112	PF00069	0.591
MOD_CK1_1	152	158	PF00069	0.475
MOD_CK1_1	28	34	PF00069	0.628
MOD_CK1_1	78	84	PF00069	0.636
MOD_CK2_1	13	19	PF00069	0.552
MOD_CK2_1	215	221	PF00069	0.449
MOD_GlcNHglycan	100	103	PF01048	0.746
MOD_GlcNHglycan	151	154	PF01048	0.638
MOD_GlcNHglycan	176	179	PF01048	0.625
MOD_GlcNHglycan	25	30	PF01048	0.469
MOD_GlcNHglycan	38	41	PF01048	0.601
MOD_GlcNHglycan	58	61	PF01048	0.567
MOD_GlcNHglycan	8	11	PF01048	0.542
MOD_GlcNHglycan	94	97	PF01048	0.790
MOD_GSK3_1	106	113	PF00069	0.569
MOD_GSK3_1	52	59	PF00069	0.649
MOD_N-GLC_1	158	163	PF02516	0.587
MOD_N-GLC_1	78	83	PF02516	0.633
MOD_NEK2_1	123	128	PF00069	0.666
MOD_NEK2_1	130	135	PF00069	0.571
MOD_PKA_2	103	109	PF00069	0.524
MOD_PKA_2	235	241	PF00069	0.524
MOD_PKA_2	6	12	PF00069	0.542
MOD_PKA_2	75	81	PF00069	0.602
MOD_Plk_1	158	164	PF00069	0.588
MOD_Plk_1	78	84	PF00069	0.603
MOD_ProDKin_1	70	76	PF00069	0.635
MOD_SUMO_rev_2	17	23	PF00179	0.521
TRG_DiLeu_BaEn_1	19	24	PF01217	0.554
TRG_DiLeu_BaEn_1	221	226	PF01217	0.362
TRG_ENDOCYTIC_2	12	15	PF00928	0.522
TRG_ENDOCYTIC_2	20	23	PF00928	0.507
TRG_ER_diArg_1	242	244	PF00400	0.324
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7M0	Leishmania donovani	87%	100%
A4HAL6	Leishmania braziliensis	67%	91%
A4I9Q9	Leishmania infantum	87%	100%
Q4Q3A2	Leishmania major	85%	98%