Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4S3_LEIMU

TriTrypDb:

LmxM.33.1010

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4S3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	474	478	PF00656	0.607
CLV_C14_Caspase3-7	71	75	PF00656	0.583
CLV_NRD_NRD_1	223	225	PF00675	0.481
CLV_NRD_NRD_1	356	358	PF00675	0.454
CLV_PCSK_KEX2_1	223	225	PF00082	0.481
CLV_PCSK_KEX2_1	358	360	PF00082	0.543
CLV_PCSK_KEX2_1	370	372	PF00082	0.636
CLV_PCSK_KEX2_1	375	377	PF00082	0.624
CLV_PCSK_KEX2_1	419	421	PF00082	0.600
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.543
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.636
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.624
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.600
CLV_PCSK_PC7_1	371	377	PF00082	0.529
CLV_PCSK_SKI1_1	298	302	PF00082	0.419
CLV_PCSK_SKI1_1	428	432	PF00082	0.564
CLV_PCSK_SKI1_1	555	559	PF00082	0.493
DEG_APCC_DBOX_1	554	562	PF00400	0.389
DEG_SPOP_SBC_1	401	405	PF00917	0.541
DEG_SPOP_SBC_1	422	426	PF00917	0.612
DOC_CKS1_1	175	180	PF01111	0.579
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.429
DOC_MAPK_MEF2A_6	325	332	PF00069	0.413
DOC_MAPK_MEF2A_6	56	63	PF00069	0.443
DOC_USP7_MATH_1	138	142	PF00917	0.586
DOC_USP7_MATH_1	176	180	PF00917	0.640
DOC_USP7_MATH_1	183	187	PF00917	0.578
DOC_USP7_MATH_1	35	39	PF00917	0.667
DOC_USP7_MATH_1	423	427	PF00917	0.677
DOC_USP7_MATH_1	508	512	PF00917	0.444
DOC_USP7_MATH_1	94	98	PF00917	0.654
DOC_USP7_UBL2_3	317	321	PF12436	0.466
DOC_WW_Pin1_4	174	179	PF00397	0.580
DOC_WW_Pin1_4	201	206	PF00397	0.576
DOC_WW_Pin1_4	247	252	PF00397	0.574
DOC_WW_Pin1_4	406	411	PF00397	0.662
DOC_WW_Pin1_4	414	419	PF00397	0.594
LIG_14-3-3_CanoR_1	113	121	PF00244	0.597
LIG_14-3-3_CanoR_1	157	163	PF00244	0.604
LIG_14-3-3_CanoR_1	164	172	PF00244	0.653
LIG_14-3-3_CanoR_1	247	251	PF00244	0.552
LIG_14-3-3_CanoR_1	518	527	PF00244	0.424
LIG_14-3-3_CanoR_1	555	565	PF00244	0.453
LIG_14-3-3_CanoR_1	56	60	PF00244	0.476
LIG_14-3-3_CanoR_1	569	573	PF00244	0.360
LIG_BIR_III_4	65	69	PF00653	0.466
LIG_BRCT_BRCA1_1	426	430	PF00533	0.579
LIG_Clathr_ClatBox_1	307	311	PF01394	0.405
LIG_FHA_1	125	131	PF00498	0.515
LIG_FHA_1	153	159	PF00498	0.668
LIG_FHA_1	175	181	PF00498	0.601
LIG_FHA_1	191	197	PF00498	0.702
LIG_FHA_1	42	48	PF00498	0.454
LIG_FHA_1	471	477	PF00498	0.703
LIG_FHA_1	56	62	PF00498	0.478
LIG_FHA_1	8	14	PF00498	0.615
LIG_FHA_2	135	141	PF00498	0.682
LIG_FHA_2	157	163	PF00498	0.693
LIG_FHA_2	189	195	PF00498	0.665
LIG_FHA_2	274	280	PF00498	0.427
LIG_FHA_2	489	495	PF00498	0.529
LIG_FHA_2	521	527	PF00498	0.389
LIG_FHA_2	548	554	PF00498	0.459
LIG_GBD_Chelix_1	221	229	PF00786	0.457
LIG_LIR_Apic_2	74	80	PF02991	0.739
LIG_LIR_Gen_1	302	313	PF02991	0.417
LIG_LIR_Gen_1	44	51	PF02991	0.370
LIG_LIR_Gen_1	559	570	PF02991	0.472
LIG_LIR_Gen_1	577	587	PF02991	0.307
LIG_LIR_Nem_3	44	48	PF02991	0.364
LIG_LIR_Nem_3	559	565	PF02991	0.548
LIG_LIR_Nem_3	577	582	PF02991	0.367
LIG_LYPXL_yS_3	327	330	PF13949	0.406
LIG_PCNA_PIPBox_1	573	582	PF02747	0.451
LIG_PCNA_yPIPBox_3	569	580	PF02747	0.444
LIG_PTAP_UEV_1	95	100	PF05743	0.535
LIG_SH2_CRK	503	507	PF00017	0.382
LIG_SH2_PTP2	562	565	PF00017	0.322
LIG_SH2_STAP1	503	507	PF00017	0.362
LIG_SH2_STAP1	520	524	PF00017	0.450
LIG_SH2_STAT3	570	573	PF00017	0.446
LIG_SH2_STAT5	12	15	PF00017	0.548
LIG_SH2_STAT5	275	278	PF00017	0.431
LIG_SH2_STAT5	305	308	PF00017	0.400
LIG_SH2_STAT5	347	350	PF00017	0.448
LIG_SH2_STAT5	562	565	PF00017	0.472
LIG_SH2_STAT5	579	582	PF00017	0.365
LIG_SH3_3	225	231	PF00018	0.381
LIG_SH3_3	289	295	PF00018	0.489
LIG_SH3_3	404	410	PF00018	0.694
LIG_SH3_3	93	99	PF00018	0.682
LIG_SUMO_SIM_anti_2	493	500	PF11976	0.467
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.426
LIG_TRAF2_1	192	195	PF00917	0.668
LIG_TRAF2_1	491	494	PF00917	0.525
LIG_TRAF2_1	523	526	PF00917	0.500
LIG_TRAF2_1	550	553	PF00917	0.458
MOD_CDC14_SPxK_1	417	420	PF00782	0.606
MOD_CDK_SPK_2	414	419	PF00069	0.657
MOD_CDK_SPxK_1	414	420	PF00069	0.613
MOD_CK1_1	112	118	PF00069	0.636
MOD_CK1_1	152	158	PF00069	0.703
MOD_CK1_1	179	185	PF00069	0.608
MOD_CK1_1	186	192	PF00069	0.641
MOD_CK1_1	197	203	PF00069	0.748
MOD_CK1_1	250	256	PF00069	0.696
MOD_CK1_1	379	385	PF00069	0.654
MOD_CK1_1	472	478	PF00069	0.586
MOD_CK2_1	134	140	PF00069	0.678
MOD_CK2_1	188	194	PF00069	0.686
MOD_CK2_1	265	271	PF00069	0.586
MOD_CK2_1	430	436	PF00069	0.494
MOD_CK2_1	488	494	PF00069	0.629
MOD_CK2_1	508	514	PF00069	0.276
MOD_CK2_1	520	526	PF00069	0.336
MOD_CK2_1	547	553	PF00069	0.478
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.526
MOD_GlcNHglycan	149	152	PF01048	0.837
MOD_GlcNHglycan	181	184	PF01048	0.714
MOD_GlcNHglycan	199	202	PF01048	0.536
MOD_GlcNHglycan	218	221	PF01048	0.441
MOD_GlcNHglycan	252	255	PF01048	0.514
MOD_GlcNHglycan	35	38	PF01048	0.605
MOD_GlcNHglycan	362	366	PF01048	0.614
MOD_GlcNHglycan	404	407	PF01048	0.633
MOD_GlcNHglycan	96	99	PF01048	0.582
MOD_GSK3_1	105	112	PF00069	0.765
MOD_GSK3_1	122	129	PF00069	0.392
MOD_GSK3_1	134	141	PF00069	0.573
MOD_GSK3_1	147	154	PF00069	0.677
MOD_GSK3_1	179	186	PF00069	0.619
MOD_GSK3_1	190	197	PF00069	0.668
MOD_GSK3_1	242	249	PF00069	0.607
MOD_GSK3_1	250	257	PF00069	0.553
MOD_GSK3_1	261	268	PF00069	0.382
MOD_GSK3_1	361	368	PF00069	0.729
MOD_GSK3_1	376	383	PF00069	0.579
MOD_GSK3_1	402	409	PF00069	0.639
MOD_GSK3_1	414	421	PF00069	0.620
MOD_GSK3_1	466	473	PF00069	0.493
MOD_GSK3_1	477	484	PF00069	0.559
MOD_GSK3_1	547	554	PF00069	0.594
MOD_LATS_1	19	25	PF00433	0.491
MOD_N-GLC_1	33	38	PF02516	0.510
MOD_N-GLC_1	385	390	PF02516	0.621
MOD_NEK2_1	243	248	PF00069	0.471
MOD_NEK2_1	287	292	PF00069	0.519
MOD_NEK2_1	380	385	PF00069	0.527
MOD_NEK2_1	430	435	PF00069	0.617
MOD_NEK2_1	86	91	PF00069	0.505
MOD_PIKK_1	124	130	PF00454	0.647
MOD_PIKK_1	466	472	PF00454	0.553
MOD_PIKK_1	534	540	PF00454	0.482
MOD_PIKK_1	547	553	PF00454	0.595
MOD_PKA_2	112	118	PF00069	0.666
MOD_PKA_2	138	144	PF00069	0.659
MOD_PKA_2	156	162	PF00069	0.594
MOD_PKA_2	20	26	PF00069	0.549
MOD_PKA_2	232	238	PF00069	0.480
MOD_PKA_2	246	252	PF00069	0.524
MOD_PKA_2	450	456	PF00069	0.515
MOD_PKA_2	55	61	PF00069	0.476
MOD_PKA_2	568	574	PF00069	0.399
MOD_PKB_1	376	384	PF00069	0.640
MOD_Plk_1	194	200	PF00069	0.630
MOD_Plk_1	376	382	PF00069	0.573
MOD_Plk_4	126	132	PF00069	0.567
MOD_Plk_4	176	182	PF00069	0.668
MOD_Plk_4	183	189	PF00069	0.681
MOD_Plk_4	508	514	PF00069	0.445
MOD_ProDKin_1	174	180	PF00069	0.580
MOD_ProDKin_1	201	207	PF00069	0.574
MOD_ProDKin_1	247	253	PF00069	0.573
MOD_ProDKin_1	406	412	PF00069	0.664
MOD_ProDKin_1	414	420	PF00069	0.592
MOD_SUMO_rev_2	311	318	PF00179	0.478
TRG_DiLeu_BaEn_4	194	200	PF01217	0.659
TRG_ENDOCYTIC_2	305	308	PF00928	0.400
TRG_ENDOCYTIC_2	327	330	PF00928	0.406
TRG_ENDOCYTIC_2	45	48	PF00928	0.418
TRG_ENDOCYTIC_2	503	506	PF00928	0.383
TRG_ENDOCYTIC_2	562	565	PF00928	0.378
TRG_ENDOCYTIC_2	579	582	PF00928	0.391
TRG_ER_diArg_1	222	224	PF00400	0.480
TRG_ER_diArg_1	295	298	PF00400	0.535
TRG_NES_CRM1_1	342	355	PF08389	0.448
TRG_NLS_MonoExtC_3	356	361	PF00514	0.478
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P311	Leptomonas seymouri	41%	93%
A0A3S7X7P4	Leishmania donovani	89%	100%
A4HAL4	Leishmania braziliensis	69%	100%
A4I9R1	Leishmania infantum	89%	95%
Q4Q3A4	Leishmania major	91%	100%