Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania mexicana

UniProt:

E9B4R9_LEIMU

TriTrypDb:

LmxM.33.0970

Length:

203

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 183
NetGPI	no	yes: 0, no: 193

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	171
GO:0110165	cellular anatomical entity	1	171

Expansion

Sequence features

E9B4R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4R9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	75	79	PF00082	0.411
CLV_PCSK_KEX2_1	77	79	PF00082	0.496
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.409
DEG_Nend_UBRbox_2	1	3	PF02207	0.565
DOC_MAPK_gen_1	108	117	PF00069	0.464
DOC_MAPK_MEF2A_6	111	119	PF00069	0.548
DOC_PP1_RVXF_1	106	113	PF00149	0.456
DOC_PP1_RVXF_1	5	11	PF00149	0.419
DOC_PP2B_LxvP_1	199	202	PF13499	0.578
DOC_USP7_MATH_1	94	98	PF00917	0.203
DOC_USP7_UBL2_3	66	70	PF12436	0.335
LIG_14-3-3_CanoR_1	7	13	PF00244	0.402
LIG_FHA_2	26	32	PF00498	0.404
LIG_GBD_Chelix_1	87	95	PF00786	0.347
LIG_LIR_Gen_1	11	21	PF02991	0.221
LIG_LIR_Nem_3	11	16	PF02991	0.241
LIG_Pex14_1	189	193	PF04695	0.239
LIG_PTB_Apo_2	146	153	PF02174	0.205
LIG_PTB_Apo_2	192	199	PF02174	0.415
LIG_PTB_Phospho_1	146	152	PF10480	0.201
LIG_SH2_CRK	13	17	PF00017	0.356
LIG_SH2_STAT5	106	109	PF00017	0.588
LIG_SH2_STAT5	13	16	PF00017	0.452
LIG_SH2_STAT5	185	188	PF00017	0.348
LIG_SH3_3	157	163	PF00018	0.403
MOD_CK1_1	39	45	PF00069	0.321
MOD_CK1_1	62	68	PF00069	0.313
MOD_GlcNHglycan	92	95	PF01048	0.451
MOD_GSK3_1	55	62	PF00069	0.324
MOD_GSK3_1	90	97	PF00069	0.290
MOD_N-GLC_1	147	152	PF02516	0.484
MOD_N-GLC_1	36	41	PF02516	0.432
MOD_N-GLC_2	149	151	PF02516	0.528
MOD_NEK2_1	25	30	PF00069	0.360
MOD_NEK2_1	59	64	PF00069	0.317
MOD_NEK2_2	147	152	PF00069	0.209
MOD_Plk_1	147	153	PF00069	0.301
MOD_Plk_1	36	42	PF00069	0.319
MOD_Plk_4	156	162	PF00069	0.209
MOD_Plk_4	25	31	PF00069	0.325
MOD_Plk_4	36	42	PF00069	0.335
MOD_Plk_4	45	51	PF00069	0.301
MOD_Plk_4	94	100	PF00069	0.351
TRG_ENDOCYTIC_2	13	16	PF00928	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	26%	100%
A0A0N0P547	Leptomonas seymouri	36%	100%
A0A0N1HWY5	Leptomonas seymouri	26%	100%
A0A0N1PDH0	Leptomonas seymouri	53%	100%
A0A1X0NUH1	Trypanosomatidae	26%	89%
A0A1X0P988	Trypanosomatidae	35%	100%
A0A381MTA7	Leishmania infantum	35%	100%
A0A381MTB8	Leishmania infantum	29%	100%
A0A381MTC7	Leishmania infantum	34%	99%
A0A381MTN2	Leishmania infantum	32%	100%
A0A381MVY0	Leishmania infantum	35%	100%
A0A3Q8ID16	Leishmania donovani	23%	100%
A0A3Q8IE85	Leishmania donovani	37%	100%
A0A3Q8IEC2	Leishmania donovani	31%	100%
A0A3Q8IEI1	Leishmania donovani	32%	100%
A0A3Q8IF65	Leishmania donovani	29%	100%
A0A3Q8IFB9	Leishmania donovani	84%	100%
A0A3Q8IFH7	Leishmania donovani	34%	99%
A0A3Q8IFI8	Leishmania donovani	23%	96%
A0A3Q8IH65	Leishmania donovani	28%	100%
A0A3Q8IHN2	Leishmania donovani	32%	100%
A0A3Q8IHW7	Leishmania donovani	32%	100%
A0A3Q8IHZ6	Leishmania donovani	31%	96%
A0A3Q8IIH1	Leishmania donovani	30%	100%
A0A3Q8IL03	Leishmania donovani	30%	100%
A0A3Q8IUK8	Leishmania donovani	30%	100%
A0A3Q8IUR5	Leishmania donovani	32%	100%
A0A3S5H662	Leishmania donovani	30%	100%
A0A3S5H663	Leishmania donovani	30%	100%
A0A3S5H665	Leishmania donovani	30%	100%
A0A3S5H666	Leishmania donovani	38%	100%
A0A3S5H667	Leishmania donovani	30%	100%
A0A3S5H7D2	Leishmania donovani	27%	100%
A0A3S5H7L2	Leishmania donovani	29%	99%
A0A3S5H7V9	Leishmania donovani	31%	100%
A0A3S5H7W2	Leishmania donovani	31%	100%
A0A3S5H7W6	Leishmania donovani	30%	100%
A0A3S7WQA0	Leishmania donovani	30%	100%
A0A3S7WQA8	Leishmania donovani	32%	100%
A0A3S7WQC1	Leishmania donovani	34%	100%
A0A3S7X2E6	Leishmania donovani	29%	100%
A0A3S7X381	Leishmania donovani	23%	97%
A0A3S7X453	Leishmania donovani	28%	100%
A0A3S7X472	Leishmania donovani	31%	100%
A0A3S7X7E5	Leishmania donovani	36%	81%
A0A3S7X7M4	Leishmania donovani	31%	96%
A0A3S7X7U1	Leishmania donovani	28%	97%
A0A3S7X7U4	Leishmania donovani	31%	78%
A0A3S7X7W2	Leishmania donovani	31%	97%
A0A3S7X7Y0	Leishmania donovani	30%	100%
A4H595	Leishmania braziliensis	27%	100%
A4H596	Leishmania braziliensis	27%	100%
A4H597	Leishmania braziliensis	27%	100%
A4H5D1	Leishmania braziliensis	32%	100%
A4H5D2	Leishmania braziliensis	32%	95%
A4H5G0	Leishmania braziliensis	34%	98%
A4H5G4	Leishmania braziliensis	32%	100%
A4H5G6	Leishmania braziliensis	29%	100%
A4H5G7	Leishmania braziliensis	29%	100%
A4H5G9	Leishmania braziliensis	33%	95%
A4H5H0	Leishmania braziliensis	33%	95%
A4H5H1	Leishmania braziliensis	32%	97%
A4H5H2	Leishmania braziliensis	34%	95%
A4H5H3	Leishmania braziliensis	32%	100%
A4H6C8	Leishmania braziliensis	33%	100%
A4H7D7	Leishmania braziliensis	32%	100%
A4H9E8	Leishmania braziliensis	29%	100%
A4H9E9	Leishmania braziliensis	33%	100%
A4HAJ4	Leishmania braziliensis	29%	100%
A4HAJ5	Leishmania braziliensis	33%	100%
A4HAJ6	Leishmania braziliensis	27%	100%
A4HAL1	Leishmania braziliensis	24%	95%
A4HAL2	Leishmania braziliensis	28%	97%
A4HAM2	Leishmania braziliensis	35%	100%
A4HAM4	Leishmania braziliensis	35%	100%
A4HAR1	Leishmania braziliensis	34%	97%
A4HAZ8	Leishmania braziliensis	34%	98%
A4HB00	Leishmania braziliensis	32%	97%
A4HB02	Leishmania braziliensis	37%	100%
A4HB47	Leishmania braziliensis	69%	100%
A4HBJ0	Leishmania braziliensis	31%	98%
A4HBJ1	Leishmania braziliensis	35%	100%
A4HBJ2	Leishmania braziliensis	34%	100%
A4HTM3	Leishmania infantum	34%	100%
A4HTM4	Leishmania infantum	31%	100%
A4HTM5	Leishmania infantum	37%	100%
A4I0W4	Leishmania infantum	27%	100%
A4I0W5	Leishmania infantum	23%	100%
A4I4J2	Leishmania infantum	27%	99%
A4I4J3	Leishmania infantum	33%	79%
A4I5B8	Leishmania infantum	23%	99%
A4I6E5	Leishmania infantum	31%	100%
A4I9Q4	Leishmania infantum	32%	100%
A4I9R4	Leishmania infantum	31%	100%
A4I9R5	Leishmania infantum	84%	100%
A4I9R7	Leishmania infantum	32%	100%
A4I9W8	Leishmania infantum	31%	78%
A4I9X0	Leishmania infantum	31%	97%
A4IA59	Leishmania infantum	31%	78%
A4IAL7	Leishmania infantum	32%	100%
A4IAM1	Leishmania infantum	33%	100%
A4IAM2	Leishmania infantum	33%	100%
C6K3X5	Leptomonas seymouri	24%	100%
C6K3X9	Leptomonas seymouri	26%	100%
E8NHC3	Leishmania infantum	32%	100%
E8NHD3	Leishmania infantum	29%	99%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	96%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	97%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	97%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	99%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	96%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	99%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AG81	Leishmania infantum	31%	100%
E9AG82	Leishmania infantum	31%	100%
E9AG83	Leishmania infantum	38%	100%
E9AG85	Leishmania infantum	31%	100%
E9AHI9	Leishmania infantum	29%	100%
E9AHT2	Leishmania infantum	31%	96%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	89%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	99%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	99%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	98%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	96%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	85%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
Q4Q1U9	Leishmania major	31%	98%
Q4Q305	Leishmania major	31%	97%
Q4Q309	Leishmania major	33%	100%
Q4Q313	Leishmania major	31%	97%
Q4Q317	Leishmania major	31%	100%
Q4Q325	Leishmania major	31%	100%
Q4Q327	Leishmania major	29%	100%
Q4Q329	Leishmania major	30%	97%
Q4Q333	Leishmania major	31%	97%
Q4Q335	Leishmania major	32%	97%
Q4Q337	Leishmania major	30%	100%
Q4Q339	Leishmania major	31%	97%
Q4Q341	Leishmania major	34%	92%
Q4Q397	Leishmania major	32%	100%
Q4Q3A7	Leishmania major	32%	100%
Q4Q3A8	Leishmania major	83%	100%
Q4Q3A9	Leishmania major	32%	100%
Q4Q3F7	Leishmania major	33%	100%
Q4Q6L8	Leishmania major	26%	100%
Q4Q7L7	Leishmania major	25%	97%
Q4Q7L8	Leishmania major	25%	97%
Q4QAK5	Leishmania major	23%	90%
Q4QAK6	Leishmania major	27%	88%
Q4QI84	Leishmania major	37%	90%
Q4QI85	Leishmania major	36%	98%
Q4QI86	Leishmania major	35%	90%
Q4QI87	Leishmania major	36%	98%
Q4QI88	Leishmania major	38%	95%
Q4QI92	Leishmania major	31%	100%
Q4QI93	Leishmania major	31%	100%
Q4QI95	Leishmania major	32%	100%
Q4QI97	Leishmania major	32%	100%
Q4QIA0	Leishmania major	31%	100%
Q4QIA1	Leishmania major	31%	100%