Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

selenoprotein, putative

Species:

Leishmania mexicana

UniProt:

E9B4R6_LEIMU

TriTrypDb:

LmxM.33.0950

Length:

901

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4R6

Function

Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	1
GO:0006575	cellular modified amino acid metabolic process	3	1
GO:0006749	glutathione metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0070813	hydrogen sulfide metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4	1
GO:0050313	sulfur dioxygenase activity	5	1
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	604	608	PF00656	0.427
CLV_NRD_NRD_1	192	194	PF00675	0.541
CLV_NRD_NRD_1	33	35	PF00675	0.528
CLV_NRD_NRD_1	523	525	PF00675	0.650
CLV_NRD_NRD_1	590	592	PF00675	0.538
CLV_NRD_NRD_1	62	64	PF00675	0.484
CLV_NRD_NRD_1	634	636	PF00675	0.499
CLV_NRD_NRD_1	665	667	PF00675	0.409
CLV_PCSK_FUR_1	60	64	PF00082	0.603
CLV_PCSK_KEX2_1	192	194	PF00082	0.541
CLV_PCSK_KEX2_1	33	35	PF00082	0.444
CLV_PCSK_KEX2_1	523	525	PF00082	0.586
CLV_PCSK_KEX2_1	590	592	PF00082	0.538
CLV_PCSK_KEX2_1	62	64	PF00082	0.484
CLV_PCSK_KEX2_1	634	636	PF00082	0.497
CLV_PCSK_KEX2_1	665	667	PF00082	0.403
CLV_PCSK_SKI1_1	417	421	PF00082	0.336
CLV_PCSK_SKI1_1	440	444	PF00082	0.649
CLV_PCSK_SKI1_1	543	547	PF00082	0.463
CLV_PCSK_SKI1_1	55	59	PF00082	0.593
CLV_PCSK_SKI1_1	73	77	PF00082	0.539
CLV_PCSK_SKI1_1	756	760	PF00082	0.458
CLV_Separin_Metazoa	662	666	PF03568	0.279
DEG_APCC_DBOX_1	330	338	PF00400	0.343
DEG_APCC_DBOX_1	542	550	PF00400	0.467
DEG_APCC_DBOX_1	885	893	PF00400	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.590
DEG_ODPH_VHL_1	317	328	PF01847	0.349
DEG_SPOP_SBC_1	392	396	PF00917	0.482
DEG_SPOP_SBC_1	700	704	PF00917	0.425
DOC_CDC14_PxL_1	2	10	PF14671	0.433
DOC_CDC14_PxL_1	36	44	PF14671	0.573
DOC_CKS1_1	761	766	PF01111	0.491
DOC_CYCLIN_RxL_1	412	422	PF00134	0.382
DOC_MAPK_gen_1	331	339	PF00069	0.374
DOC_MAPK_gen_1	634	640	PF00069	0.330
DOC_MAPK_gen_1	893	900	PF00069	0.465
DOC_PP1_RVXF_1	703	709	PF00149	0.341
DOC_PP1_RVXF_1	725	732	PF00149	0.377
DOC_PP4_FxxP_1	112	115	PF00568	0.664
DOC_USP7_MATH_1	126	130	PF00917	0.591
DOC_USP7_MATH_1	157	161	PF00917	0.502
DOC_USP7_MATH_1	26	30	PF00917	0.555
DOC_USP7_MATH_1	392	396	PF00917	0.572
DOC_USP7_MATH_1	441	445	PF00917	0.688
DOC_USP7_MATH_1	692	696	PF00917	0.698
DOC_WW_Pin1_4	209	214	PF00397	0.573
DOC_WW_Pin1_4	27	32	PF00397	0.672
DOC_WW_Pin1_4	326	331	PF00397	0.545
DOC_WW_Pin1_4	340	345	PF00397	0.234
DOC_WW_Pin1_4	422	427	PF00397	0.421
DOC_WW_Pin1_4	459	464	PF00397	0.606
DOC_WW_Pin1_4	668	673	PF00397	0.350
DOC_WW_Pin1_4	760	765	PF00397	0.430
DOC_WW_Pin1_4	803	808	PF00397	0.377
DOC_WW_Pin1_4	861	866	PF00397	0.410
LIG_14-3-3_CanoR_1	102	111	PF00244	0.583
LIG_14-3-3_CanoR_1	235	240	PF00244	0.305
LIG_14-3-3_CanoR_1	278	284	PF00244	0.385
LIG_14-3-3_CanoR_1	33	39	PF00244	0.482
LIG_14-3-3_CanoR_1	333	338	PF00244	0.469
LIG_14-3-3_CanoR_1	570	574	PF00244	0.449
LIG_14-3-3_CanoR_1	591	597	PF00244	0.585
LIG_14-3-3_CanoR_1	665	672	PF00244	0.510
LIG_14-3-3_CanoR_1	73	79	PF00244	0.496
LIG_Actin_WH2_2	554	572	PF00022	0.272
LIG_Actin_WH2_2	716	732	PF00022	0.311
LIG_AP2alpha_2	243	245	PF02296	0.418
LIG_BIR_III_2	369	373	PF00653	0.333
LIG_EVH1_1	525	529	PF00568	0.565
LIG_FHA_1	122	128	PF00498	0.605
LIG_FHA_1	146	152	PF00498	0.732
LIG_FHA_1	172	178	PF00498	0.673
LIG_FHA_1	221	227	PF00498	0.359
LIG_FHA_1	321	327	PF00498	0.431
LIG_FHA_1	334	340	PF00498	0.185
LIG_FHA_1	360	366	PF00498	0.293
LIG_FHA_1	482	488	PF00498	0.388
LIG_FHA_1	535	541	PF00498	0.384
LIG_FHA_1	56	62	PF00498	0.452
LIG_FHA_1	701	707	PF00498	0.594
LIG_FHA_1	718	724	PF00498	0.347
LIG_FHA_1	753	759	PF00498	0.384
LIG_FHA_1	817	823	PF00498	0.428
LIG_FHA_1	867	873	PF00498	0.298
LIG_FHA_2	147	153	PF00498	0.539
LIG_FHA_2	180	186	PF00498	0.616
LIG_FHA_2	320	326	PF00498	0.495
LIG_FHA_2	459	465	PF00498	0.396
LIG_FHA_2	511	517	PF00498	0.420
LIG_FHA_2	678	684	PF00498	0.368
LIG_FHA_2	740	746	PF00498	0.522
LIG_FHA_2	761	767	PF00498	0.358
LIG_FHA_2	80	86	PF00498	0.539
LIG_HP1_1	649	653	PF01393	0.357
LIG_LIR_Apic_2	421	426	PF02991	0.415
LIG_LIR_Gen_1	350	360	PF02991	0.371
LIG_LIR_Gen_1	597	605	PF02991	0.454
LIG_LIR_Gen_1	610	619	PF02991	0.449
LIG_LIR_Gen_1	742	752	PF02991	0.409
LIG_LIR_Nem_3	195	200	PF02991	0.475
LIG_LIR_Nem_3	350	356	PF02991	0.375
LIG_LIR_Nem_3	37	42	PF02991	0.456
LIG_LIR_Nem_3	421	427	PF02991	0.336
LIG_LIR_Nem_3	488	494	PF02991	0.412
LIG_LIR_Nem_3	516	521	PF02991	0.403
LIG_LIR_Nem_3	595	599	PF02991	0.532
LIG_LIR_Nem_3	610	614	PF02991	0.437
LIG_LIR_Nem_3	625	629	PF02991	0.598
LIG_LIR_Nem_3	687	693	PF02991	0.490
LIG_LIR_Nem_3	707	711	PF02991	0.395
LIG_LIR_Nem_3	742	747	PF02991	0.414
LIG_LIR_Nem_3	864	870	PF02991	0.404
LIG_LYPXL_S_1	38	42	PF13949	0.557
LIG_LYPXL_yS_3	39	42	PF13949	0.554
LIG_MAD2	756	764	PF02301	0.401
LIG_NRBOX	541	547	PF00104	0.456
LIG_PCNA_yPIPBox_3	62	76	PF02747	0.542
LIG_Pex14_2	420	424	PF04695	0.375
LIG_SH2_CRK	200	204	PF00017	0.470
LIG_SH2_CRK	480	484	PF00017	0.350
LIG_SH2_CRK	599	603	PF00017	0.489
LIG_SH2_CRK	611	615	PF00017	0.438
LIG_SH2_CRK	68	72	PF00017	0.518
LIG_SH2_CRK	846	850	PF00017	0.291
LIG_SH2_GRB2like	229	232	PF00017	0.480
LIG_SH2_GRB2like	599	602	PF00017	0.372
LIG_SH2_NCK_1	246	250	PF00017	0.468
LIG_SH2_NCK_1	480	484	PF00017	0.350
LIG_SH2_SRC	292	295	PF00017	0.426
LIG_SH2_STAP1	147	151	PF00017	0.454
LIG_SH2_STAP1	272	276	PF00017	0.350
LIG_SH2_STAP1	599	603	PF00017	0.216
LIG_SH2_STAP1	9	13	PF00017	0.505
LIG_SH2_STAT3	132	135	PF00017	0.588
LIG_SH2_STAT3	9	12	PF00017	0.598
LIG_SH2_STAT5	147	150	PF00017	0.542
LIG_SH2_STAT5	229	232	PF00017	0.347
LIG_SH2_STAT5	246	249	PF00017	0.399
LIG_SH2_STAT5	292	295	PF00017	0.426
LIG_SH2_STAT5	352	355	PF00017	0.388
LIG_SH2_STAT5	418	421	PF00017	0.332
LIG_SH2_STAT5	423	426	PF00017	0.291
LIG_SH2_STAT5	494	497	PF00017	0.424
LIG_SH2_STAT5	841	844	PF00017	0.309
LIG_SH3_1	523	529	PF00018	0.515
LIG_SH3_3	313	319	PF00018	0.427
LIG_SH3_3	334	340	PF00018	0.417
LIG_SH3_3	428	434	PF00018	0.507
LIG_SH3_3	469	475	PF00018	0.379
LIG_SH3_3	523	529	PF00018	0.409
LIG_SH3_3	617	623	PF00018	0.294
LIG_SH3_3	640	646	PF00018	0.330
LIG_SH3_3	720	726	PF00018	0.473
LIG_SH3_3	758	764	PF00018	0.439
LIG_SH3_4	550	557	PF00018	0.270
LIG_SUMO_SIM_anti_2	469	476	PF11976	0.360
LIG_SUMO_SIM_par_1	39	44	PF11976	0.487
LIG_SUMO_SIM_par_1	469	476	PF11976	0.452
LIG_SUMO_SIM_par_1	601	607	PF11976	0.313
LIG_SUMO_SIM_par_1	757	763	PF11976	0.357
LIG_SxIP_EBH_1	310	321	PF03271	0.349
LIG_TRAF2_1	655	658	PF00917	0.452
LIG_UBA3_1	545	550	PF00899	0.248
LIG_WRC_WIRS_1	593	598	PF05994	0.566
LIG_WW_2	526	529	PF00397	0.447
MOD_CDC14_SPxK_1	212	215	PF00782	0.439
MOD_CDK_SPK_2	326	331	PF00069	0.434
MOD_CDK_SPK_2	803	808	PF00069	0.416
MOD_CDK_SPxK_1	209	215	PF00069	0.429
MOD_CDK_SPxK_1	27	33	PF00069	0.616
MOD_CDK_SPxxK_3	27	34	PF00069	0.461
MOD_CDK_SPxxK_3	326	333	PF00069	0.409
MOD_CDK_SPxxK_3	668	675	PF00069	0.417
MOD_CDK_SPxxK_3	861	868	PF00069	0.404
MOD_CK1_1	101	107	PF00069	0.601
MOD_CK1_1	145	151	PF00069	0.687
MOD_CK1_1	16	22	PF00069	0.477
MOD_CK1_1	178	184	PF00069	0.691
MOD_CK1_1	220	226	PF00069	0.442
MOD_CK1_1	234	240	PF00069	0.413
MOD_CK1_1	297	303	PF00069	0.291
MOD_CK1_1	435	441	PF00069	0.725
MOD_CK1_1	444	450	PF00069	0.771
MOD_CK1_1	586	592	PF00069	0.558
MOD_CK1_1	595	601	PF00069	0.414
MOD_CK1_1	668	674	PF00069	0.488
MOD_CK1_1	718	724	PF00069	0.355
MOD_CK2_1	146	152	PF00069	0.545
MOD_CK2_1	16	22	PF00069	0.477
MOD_CK2_1	458	464	PF00069	0.500
MOD_CK2_1	510	516	PF00069	0.422
MOD_CK2_1	704	710	PF00069	0.503
MOD_CK2_1	739	745	PF00069	0.520
MOD_CK2_1	760	766	PF00069	0.353
MOD_CK2_1	79	85	PF00069	0.655
MOD_GlcNHglycan	15	18	PF01048	0.740
MOD_GlcNHglycan	160	163	PF01048	0.693
MOD_GlcNHglycan	177	180	PF01048	0.578
MOD_GlcNHglycan	217	220	PF01048	0.635
MOD_GlcNHglycan	247	250	PF01048	0.518
MOD_GlcNHglycan	296	299	PF01048	0.422
MOD_GlcNHglycan	312	315	PF01048	0.256
MOD_GlcNHglycan	379	382	PF01048	0.502
MOD_GlcNHglycan	437	440	PF01048	0.693
MOD_GlcNHglycan	443	446	PF01048	0.733
MOD_GlcNHglycan	574	578	PF01048	0.567
MOD_GlcNHglycan	667	670	PF01048	0.449
MOD_GlcNHglycan	689	693	PF01048	0.441
MOD_GlcNHglycan	860	864	PF01048	0.480
MOD_GlcNHglycan	875	878	PF01048	0.293
MOD_GlcNHglycan	91	95	PF01048	0.689
MOD_GSK3_1	117	124	PF00069	0.602
MOD_GSK3_1	142	149	PF00069	0.666
MOD_GSK3_1	171	178	PF00069	0.714
MOD_GSK3_1	205	212	PF00069	0.592
MOD_GSK3_1	231	238	PF00069	0.342
MOD_GSK3_1	458	465	PF00069	0.517
MOD_GSK3_1	530	537	PF00069	0.422
MOD_GSK3_1	569	576	PF00069	0.488
MOD_GSK3_1	684	691	PF00069	0.373
MOD_GSK3_1	700	707	PF00069	0.373
MOD_GSK3_1	717	724	PF00069	0.324
MOD_GSK3_1	74	81	PF00069	0.655
MOD_GSK3_1	768	775	PF00069	0.355
MOD_GSK3_1	792	799	PF00069	0.523
MOD_GSK3_1	845	852	PF00069	0.353
MOD_GSK3_1	98	105	PF00069	0.629
MOD_N-GLC_1	121	126	PF02516	0.598
MOD_N-GLC_1	209	214	PF02516	0.649
MOD_N-GLC_1	481	486	PF02516	0.341
MOD_N-GLC_1	586	591	PF02516	0.539
MOD_N-GLC_1	739	744	PF02516	0.441
MOD_N-GLC_1	768	773	PF02516	0.358
MOD_N-GLC_1	873	878	PF02516	0.380
MOD_NEK2_1	1	6	PF00069	0.544
MOD_NEK2_1	205	210	PF00069	0.519
MOD_NEK2_1	245	250	PF00069	0.527
MOD_NEK2_1	302	307	PF00069	0.497
MOD_NEK2_1	377	382	PF00069	0.530
MOD_NEK2_1	419	424	PF00069	0.466
MOD_NEK2_1	427	432	PF00069	0.620
MOD_NEK2_1	458	463	PF00069	0.432
MOD_NEK2_1	501	506	PF00069	0.375
MOD_NEK2_1	534	539	PF00069	0.403
MOD_NEK2_1	688	693	PF00069	0.477
MOD_NEK2_1	78	83	PF00069	0.567
MOD_NEK2_1	8	13	PF00069	0.625
MOD_NEK2_1	849	854	PF00069	0.437
MOD_NEK2_1	873	878	PF00069	0.507
MOD_NEK2_2	813	818	PF00069	0.292
MOD_NEK2_2	866	871	PF00069	0.414
MOD_OFUCOSY	138	144	PF10250	0.493
MOD_PIKK_1	55	61	PF00454	0.583
MOD_PIKK_1	796	802	PF00454	0.516
MOD_PIKK_1	8	14	PF00454	0.732
MOD_PIKK_1	881	887	PF00454	0.487
MOD_PK_1	893	899	PF00069	0.456
MOD_PKA_1	665	671	PF00069	0.484
MOD_PKA_2	101	107	PF00069	0.476
MOD_PKA_2	234	240	PF00069	0.352
MOD_PKA_2	383	389	PF00069	0.683
MOD_PKA_2	435	441	PF00069	0.566
MOD_PKA_2	569	575	PF00069	0.441
MOD_PKA_2	665	671	PF00069	0.511
MOD_PKB_1	331	339	PF00069	0.374
MOD_Plk_1	187	193	PF00069	0.465
MOD_Plk_1	274	280	PF00069	0.406
MOD_Plk_1	534	540	PF00069	0.467
MOD_Plk_1	688	694	PF00069	0.397
MOD_Plk_1	721	727	PF00069	0.412
MOD_Plk_1	739	745	PF00069	0.538
MOD_Plk_1	831	837	PF00069	0.493
MOD_Plk_1	893	899	PF00069	0.456
MOD_Plk_4	220	226	PF00069	0.360
MOD_Plk_4	235	241	PF00069	0.322
MOD_Plk_4	34	40	PF00069	0.428
MOD_Plk_4	419	425	PF00069	0.223
MOD_Plk_4	850	856	PF00069	0.286
MOD_ProDKin_1	209	215	PF00069	0.576
MOD_ProDKin_1	27	33	PF00069	0.671
MOD_ProDKin_1	326	332	PF00069	0.540
MOD_ProDKin_1	340	346	PF00069	0.230
MOD_ProDKin_1	422	428	PF00069	0.423
MOD_ProDKin_1	459	465	PF00069	0.588
MOD_ProDKin_1	668	674	PF00069	0.349
MOD_ProDKin_1	760	766	PF00069	0.432
MOD_ProDKin_1	803	809	PF00069	0.369
MOD_ProDKin_1	861	867	PF00069	0.403
MOD_SUMO_for_1	549	552	PF00179	0.271
MOD_SUMO_rev_2	449	458	PF00179	0.488
TRG_DiLeu_BaEn_1	469	474	PF01217	0.413
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.612
TRG_ENDOCYTIC_2	200	203	PF00928	0.470
TRG_ENDOCYTIC_2	39	42	PF00928	0.554
TRG_ENDOCYTIC_2	480	483	PF00928	0.364
TRG_ENDOCYTIC_2	599	602	PF00928	0.526
TRG_ENDOCYTIC_2	611	614	PF00928	0.273
TRG_ENDOCYTIC_2	68	71	PF00928	0.522
TRG_ENDOCYTIC_2	744	747	PF00928	0.400
TRG_ENDOCYTIC_2	846	849	PF00928	0.294
TRG_ER_diArg_1	191	193	PF00400	0.533
TRG_ER_diArg_1	330	333	PF00400	0.418
TRG_ER_diArg_1	523	525	PF00400	0.592
TRG_ER_diArg_1	60	63	PF00400	0.473
TRG_ER_diArg_1	64	67	PF00400	0.500
TRG_ER_diArg_1	664	666	PF00400	0.395
TRG_ER_FFAT_2	143	152	PF00635	0.447
TRG_NES_CRM1_1	779	790	PF08389	0.260
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P997	Trypanosomatidae	34%	100%
A0A3Q8IIB2	Leishmania donovani	87%	100%
A0A422N289	Trypanosoma rangeli	36%	100%
A4I9Q2	Leishmania infantum	88%	100%
C6K3V6	Leptomonas seymouri	55%	93%
C9ZMY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q3B0	Leishmania major	88%	100%
V5AUV4	Trypanosoma cruzi	35%	100%