HVA22-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

HVA22-like protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4R2_LEIMU

TriTrypDb:

LmxM.33.0910

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B4R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4R2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.611
CLV_NRD_NRD_1	49	51	PF00675	0.420
CLV_NRD_NRD_1	57	59	PF00675	0.422
CLV_NRD_NRD_1	81	83	PF00675	0.423
CLV_PCSK_KEX2_1	133	135	PF00082	0.616
CLV_PCSK_KEX2_1	140	142	PF00082	0.597
CLV_PCSK_KEX2_1	45	47	PF00082	0.416
CLV_PCSK_KEX2_1	49	51	PF00082	0.418
CLV_PCSK_KEX2_1	57	59	PF00082	0.420
CLV_PCSK_KEX2_1	81	83	PF00082	0.423
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.671
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.338
CLV_PCSK_SKI1_1	140	144	PF00082	0.640
DEG_APCC_DBOX_1	80	88	PF00400	0.618
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DOC_CDC14_PxL_1	104	112	PF14671	0.356
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.575
DOC_MAPK_gen_1	81	89	PF00069	0.691
DOC_PP2B_LxvP_1	3	6	PF13499	0.569
DOC_PP4_FxxP_1	105	108	PF00568	0.283
LIG_BRCT_BRCA1_1	101	105	PF00533	0.319
LIG_CSL_BTD_1	105	108	PF09270	0.283
LIG_CtBP_PxDLS_1	30	34	PF00389	0.556
LIG_DCNL_PONY_1	1	4	PF03556	0.579
LIG_FHA_1	158	164	PF00498	0.372
LIG_FHA_2	150	156	PF00498	0.409
LIG_FHA_2	32	38	PF00498	0.693
LIG_LIR_Apic_2	102	108	PF02991	0.342
LIG_LIR_Apic_2	16	22	PF02991	0.612
LIG_LIR_Gen_1	118	129	PF02991	0.395
LIG_LIR_Gen_1	15	25	PF02991	0.568
LIG_LIR_Gen_1	94	103	PF02991	0.283
LIG_LIR_Nem_3	102	107	PF02991	0.283
LIG_LIR_Nem_3	118	124	PF02991	0.337
LIG_LIR_Nem_3	15	20	PF02991	0.570
LIG_LIR_Nem_3	94	98	PF02991	0.283
LIG_MLH1_MIPbox_1	101	105	PF16413	0.342
LIG_Pex14_1	99	103	PF04695	0.307
LIG_SH2_CRK	121	125	PF00017	0.400
LIG_SH2_STAP1	101	105	PF00017	0.283
LIG_SH2_STAT5	11	14	PF00017	0.619
LIG_SH2_STAT5	91	94	PF00017	0.283
LIG_SH3_3	17	23	PF00018	0.564
LIG_SH3_3	69	75	PF00018	0.671
LIG_TRAF2_1	35	38	PF00917	0.601
LIG_WRC_WIRS_1	116	121	PF05994	0.421
MOD_CK1_1	157	163	PF00069	0.449
MOD_CK1_1	32	38	PF00069	0.592
MOD_CK2_1	149	155	PF00069	0.417
MOD_CK2_1	31	37	PF00069	0.655
MOD_CK2_1	73	79	PF00069	0.693
MOD_GSK3_1	145	152	PF00069	0.442
MOD_GSK3_1	25	32	PF00069	0.536
MOD_GSK3_1	73	80	PF00069	0.669
MOD_GSK3_1	9	16	PF00069	0.582
MOD_NEK2_1	143	148	PF00069	0.410
MOD_NEK2_1	154	159	PF00069	0.372
MOD_NEK2_1	25	30	PF00069	0.537
MOD_NEK2_1	66	71	PF00069	0.707
MOD_NEK2_1	77	82	PF00069	0.735
MOD_NEK2_1	9	14	PF00069	0.583
MOD_NEK2_2	52	57	PF00069	0.707
MOD_NEK2_2	99	104	PF00069	0.353
MOD_PIKK_1	145	151	PF00454	0.492
MOD_PK_1	36	42	PF00069	0.585
MOD_Plk_1	154	160	PF00069	0.397
MOD_Plk_1	36	42	PF00069	0.600
MOD_Plk_4	115	121	PF00069	0.408
MOD_Plk_4	13	19	PF00069	0.555
MOD_Plk_4	36	42	PF00069	0.572
MOD_Plk_4	73	79	PF00069	0.672
MOD_Plk_4	85	91	PF00069	0.403
MOD_Plk_4	99	105	PF00069	0.305
MOD_SUMO_rev_2	132	139	PF00179	0.400
MOD_SUMO_rev_2	62	72	PF00179	0.667
TRG_ENDOCYTIC_2	101	104	PF00928	0.285
TRG_ENDOCYTIC_2	121	124	PF00928	0.309
TRG_ER_diArg_1	139	141	PF00400	0.407
TRG_ER_diArg_1	48	50	PF00400	0.621
TRG_ER_diArg_1	56	58	PF00400	0.623
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JM59	Bodo saltans	56%	100%
A0A1X0PAL9	Trypanosomatidae	61%	100%
A0A3Q8IUG3	Leishmania donovani	93%	100%
A4HAK4	Leishmania braziliensis	94%	100%
A4I9P8	Leishmania infantum	93%	100%
C6K3V2	Leptomonas seymouri	91%	100%
C9ZMZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
Q4Q3B4	Leishmania major	92%	100%