LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B4Q9_LEIMU
TriTrypDb:
LmxM.33.0880
Length:
931

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4Q9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Q9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 217 221 PF00656 0.577
CLV_C14_Caspase3-7 29 33 PF00656 0.754
CLV_C14_Caspase3-7 379 383 PF00656 0.699
CLV_C14_Caspase3-7 480 484 PF00656 0.720
CLV_C14_Caspase3-7 817 821 PF00656 0.624
CLV_C14_Caspase3-7 918 922 PF00656 0.698
CLV_NRD_NRD_1 296 298 PF00675 0.520
CLV_NRD_NRD_1 377 379 PF00675 0.681
CLV_NRD_NRD_1 434 436 PF00675 0.516
CLV_NRD_NRD_1 751 753 PF00675 0.511
CLV_NRD_NRD_1 771 773 PF00675 0.271
CLV_NRD_NRD_1 861 863 PF00675 0.748
CLV_NRD_NRD_1 875 877 PF00675 0.672
CLV_PCSK_KEX2_1 296 298 PF00082 0.520
CLV_PCSK_KEX2_1 377 379 PF00082 0.677
CLV_PCSK_KEX2_1 434 436 PF00082 0.516
CLV_PCSK_KEX2_1 750 752 PF00082 0.508
CLV_PCSK_KEX2_1 771 773 PF00082 0.602
CLV_PCSK_KEX2_1 861 863 PF00082 0.754
CLV_PCSK_KEX2_1 875 877 PF00082 0.634
CLV_PCSK_SKI1_1 434 438 PF00082 0.534
CLV_PCSK_SKI1_1 530 534 PF00082 0.673
CLV_PCSK_SKI1_1 708 712 PF00082 0.421
CLV_PCSK_SKI1_1 75 79 PF00082 0.525
CLV_PCSK_SKI1_1 752 756 PF00082 0.545
CLV_PCSK_SKI1_1 772 776 PF00082 0.278
DEG_APCC_DBOX_1 912 920 PF00400 0.621
DEG_APCC_KENBOX_2 553 557 PF00400 0.515
DEG_SCF_FBW7_1 700 707 PF00400 0.491
DEG_SPOP_SBC_1 495 499 PF00917 0.506
DOC_CDC14_PxL_1 436 444 PF14671 0.367
DOC_CKS1_1 133 138 PF01111 0.633
DOC_CKS1_1 234 239 PF01111 0.558
DOC_CKS1_1 701 706 PF01111 0.484
DOC_CYCLIN_RxL_1 248 258 PF00134 0.454
DOC_CYCLIN_RxL_1 45 56 PF00134 0.567
DOC_CYCLIN_yCln2_LP_2 205 211 PF00134 0.623
DOC_MAPK_gen_1 296 303 PF00069 0.602
DOC_MAPK_gen_1 708 716 PF00069 0.485
DOC_MAPK_MEF2A_6 591 599 PF00069 0.549
DOC_MAPK_MEF2A_6 708 716 PF00069 0.485
DOC_PP1_RVXF_1 524 530 PF00149 0.703
DOC_PP2B_LxvP_1 205 208 PF13499 0.579
DOC_PP2B_LxvP_1 509 512 PF13499 0.691
DOC_PP2B_LxvP_1 732 735 PF13499 0.593
DOC_PP4_FxxP_1 85 88 PF00568 0.581
DOC_PP4_FxxP_1 892 895 PF00568 0.473
DOC_PP4_MxPP_1 1 4 PF00568 0.659
DOC_USP7_MATH_1 13 17 PF00917 0.695
DOC_USP7_MATH_1 151 155 PF00917 0.681
DOC_USP7_MATH_1 162 166 PF00917 0.725
DOC_USP7_MATH_1 306 310 PF00917 0.425
DOC_USP7_MATH_1 383 387 PF00917 0.787
DOC_USP7_MATH_1 464 468 PF00917 0.672
DOC_USP7_MATH_1 491 495 PF00917 0.712
DOC_USP7_MATH_1 516 520 PF00917 0.541
DOC_USP7_MATH_1 610 614 PF00917 0.692
DOC_USP7_MATH_1 677 681 PF00917 0.455
DOC_USP7_MATH_1 704 708 PF00917 0.497
DOC_USP7_MATH_1 735 739 PF00917 0.558
DOC_USP7_MATH_1 841 845 PF00917 0.683
DOC_USP7_MATH_1 901 905 PF00917 0.724
DOC_USP7_MATH_1 92 96 PF00917 0.567
DOC_WW_Pin1_4 132 137 PF00397 0.581
DOC_WW_Pin1_4 219 224 PF00397 0.670
DOC_WW_Pin1_4 233 238 PF00397 0.548
DOC_WW_Pin1_4 315 320 PF00397 0.715
DOC_WW_Pin1_4 321 326 PF00397 0.722
DOC_WW_Pin1_4 365 370 PF00397 0.488
DOC_WW_Pin1_4 40 45 PF00397 0.620
DOC_WW_Pin1_4 475 480 PF00397 0.623
DOC_WW_Pin1_4 507 512 PF00397 0.814
DOC_WW_Pin1_4 606 611 PF00397 0.658
DOC_WW_Pin1_4 700 705 PF00397 0.561
DOC_WW_Pin1_4 715 720 PF00397 0.377
DOC_WW_Pin1_4 885 890 PF00397 0.728
LIG_14-3-3_CanoR_1 190 197 PF00244 0.521
LIG_14-3-3_CanoR_1 290 296 PF00244 0.565
LIG_14-3-3_CanoR_1 330 336 PF00244 0.612
LIG_14-3-3_CanoR_1 344 349 PF00244 0.411
LIG_14-3-3_CanoR_1 465 470 PF00244 0.720
LIG_14-3-3_CanoR_1 530 538 PF00244 0.680
LIG_14-3-3_CanoR_1 545 550 PF00244 0.470
LIG_14-3-3_CanoR_1 619 629 PF00244 0.596
LIG_14-3-3_CanoR_1 663 670 PF00244 0.289
LIG_14-3-3_CanoR_1 752 762 PF00244 0.574
LIG_14-3-3_CanoR_1 771 777 PF00244 0.538
LIG_14-3-3_CanoR_1 829 834 PF00244 0.684
LIG_14-3-3_CanoR_1 840 846 PF00244 0.651
LIG_14-3-3_CanoR_1 875 879 PF00244 0.762
LIG_BIR_III_2 10 14 PF00653 0.638
LIG_BIR_III_2 220 224 PF00653 0.654
LIG_BIR_III_2 483 487 PF00653 0.724
LIG_BIR_III_4 152 156 PF00653 0.738
LIG_BRCT_BRCA1_1 717 721 PF00533 0.276
LIG_CaM_NSCaTE_8 580 587 PF13499 0.391
LIG_CSL_BTD_1 366 369 PF09270 0.582
LIG_EH1_1 199 207 PF00400 0.571
LIG_EH1_1 761 769 PF00400 0.474
LIG_eIF4E_1 200 206 PF01652 0.490
LIG_eIF4E_1 762 768 PF01652 0.556
LIG_FHA_1 126 132 PF00498 0.413
LIG_FHA_1 177 183 PF00498 0.501
LIG_FHA_1 189 195 PF00498 0.499
LIG_FHA_1 201 207 PF00498 0.496
LIG_FHA_1 266 272 PF00498 0.634
LIG_FHA_1 322 328 PF00498 0.683
LIG_FHA_1 450 456 PF00498 0.679
LIG_FHA_1 537 543 PF00498 0.522
LIG_FHA_1 579 585 PF00498 0.472
LIG_FHA_1 621 627 PF00498 0.609
LIG_FHA_1 657 663 PF00498 0.453
LIG_FHA_1 700 706 PF00498 0.499
LIG_FHA_1 826 832 PF00498 0.581
LIG_FHA_1 841 847 PF00498 0.749
LIG_FHA_1 886 892 PF00498 0.674
LIG_FHA_1 94 100 PF00498 0.608
LIG_FHA_2 112 118 PF00498 0.371
LIG_FHA_2 215 221 PF00498 0.758
LIG_FHA_2 234 240 PF00498 0.546
LIG_FHA_2 24 30 PF00498 0.656
LIG_FHA_2 475 481 PF00498 0.792
LIG_FHA_2 497 503 PF00498 0.505
LIG_FHA_2 620 626 PF00498 0.618
LIG_FHA_2 773 779 PF00498 0.614
LIG_FHA_2 815 821 PF00498 0.633
LIG_FHA_2 96 102 PF00498 0.596
LIG_GBD_Chelix_1 246 254 PF00786 0.451
LIG_IRF3_LxIS_1 579 586 PF10401 0.386
LIG_LIR_Apic_2 649 655 PF02991 0.466
LIG_LIR_Apic_2 84 88 PF02991 0.511
LIG_LIR_Gen_1 667 677 PF02991 0.468
LIG_LIR_Gen_1 718 729 PF02991 0.483
LIG_LIR_Gen_1 788 795 PF02991 0.514
LIG_LIR_Nem_3 258 263 PF02991 0.340
LIG_LIR_Nem_3 351 357 PF02991 0.438
LIG_LIR_Nem_3 667 673 PF02991 0.416
LIG_LIR_Nem_3 718 724 PF02991 0.488
LIG_LIR_Nem_3 788 793 PF02991 0.513
LIG_LYPXL_yS_3 439 442 PF13949 0.369
LIG_MYND_1 889 893 PF01753 0.666
LIG_NRBOX 537 543 PF00104 0.593
LIG_NRBOX 628 634 PF00104 0.569
LIG_SH2_CRK 410 414 PF00017 0.425
LIG_SH2_CRK 670 674 PF00017 0.457
LIG_SH2_NCK_1 621 625 PF00017 0.578
LIG_SH2_STAP1 410 414 PF00017 0.479
LIG_SH2_STAP1 600 604 PF00017 0.458
LIG_SH2_STAP1 648 652 PF00017 0.512
LIG_SH2_STAP1 670 674 PF00017 0.529
LIG_SH2_STAP1 79 83 PF00017 0.283
LIG_SH2_STAT3 186 189 PF00017 0.585
LIG_SH2_STAT3 631 634 PF00017 0.436
LIG_SH2_STAT3 762 765 PF00017 0.558
LIG_SH2_STAT5 200 203 PF00017 0.493
LIG_SH2_STAT5 429 432 PF00017 0.446
LIG_SH2_STAT5 621 624 PF00017 0.572
LIG_SH2_STAT5 631 634 PF00017 0.387
LIG_SH2_STAT5 652 655 PF00017 0.461
LIG_SH2_STAT5 713 716 PF00017 0.443
LIG_SH2_STAT5 753 756 PF00017 0.496
LIG_SH2_STAT5 762 765 PF00017 0.403
LIG_SH2_STAT5 915 918 PF00017 0.643
LIG_SH3_3 133 139 PF00018 0.674
LIG_SH3_3 231 237 PF00018 0.544
LIG_SH3_3 505 511 PF00018 0.711
LIG_SH3_3 713 719 PF00018 0.572
LIG_SH3_3 810 816 PF00018 0.633
LIG_Sin3_3 300 307 PF02671 0.541
LIG_SUMO_SIM_anti_2 242 248 PF11976 0.538
LIG_SUMO_SIM_anti_2 281 287 PF11976 0.533
LIG_SUMO_SIM_anti_2 451 457 PF11976 0.685
LIG_SUMO_SIM_anti_2 49 54 PF11976 0.622
LIG_SUMO_SIM_anti_2 581 586 PF11976 0.396
LIG_SUMO_SIM_par_1 580 586 PF11976 0.469
LIG_SUMO_SIM_par_1 594 601 PF11976 0.479
LIG_TYR_ITIM 343 348 PF00017 0.631
LIG_TYR_ITIM 408 413 PF00017 0.483
LIG_TYR_ITIM 437 442 PF00017 0.360
LIG_TYR_ITIM 77 82 PF00017 0.575
LIG_UBA3_1 546 554 PF00899 0.513
LIG_UBA3_1 82 87 PF00899 0.278
LIG_WRC_WIRS_1 177 182 PF05994 0.270
MOD_CDK_SPK_2 233 238 PF00069 0.571
MOD_CK1_1 15 21 PF00069 0.780
MOD_CK1_1 160 166 PF00069 0.760
MOD_CK1_1 192 198 PF00069 0.510
MOD_CK1_1 23 29 PF00069 0.681
MOD_CK1_1 309 315 PF00069 0.664
MOD_CK1_1 318 324 PF00069 0.705
MOD_CK1_1 385 391 PF00069 0.697
MOD_CK1_1 494 500 PF00069 0.784
MOD_CK1_1 51 57 PF00069 0.601
MOD_CK1_1 510 516 PF00069 0.550
MOD_CK1_1 613 619 PF00069 0.671
MOD_CK1_1 95 101 PF00069 0.609
MOD_CK2_1 111 117 PF00069 0.490
MOD_CK2_1 233 239 PF00069 0.545
MOD_CK2_1 310 316 PF00069 0.669
MOD_CK2_1 386 392 PF00069 0.679
MOD_CK2_1 399 405 PF00069 0.598
MOD_CK2_1 474 480 PF00069 0.713
MOD_CK2_1 619 625 PF00069 0.590
MOD_DYRK1A_RPxSP_1 715 719 PF00069 0.293
MOD_GlcNHglycan 15 18 PF01048 0.615
MOD_GlcNHglycan 152 156 PF01048 0.646
MOD_GlcNHglycan 162 165 PF01048 0.693
MOD_GlcNHglycan 183 186 PF01048 0.436
MOD_GlcNHglycan 308 311 PF01048 0.493
MOD_GlcNHglycan 320 323 PF01048 0.670
MOD_GlcNHglycan 38 41 PF01048 0.659
MOD_GlcNHglycan 388 391 PF01048 0.683
MOD_GlcNHglycan 493 496 PF01048 0.751
MOD_GlcNHglycan 505 508 PF01048 0.594
MOD_GlcNHglycan 519 522 PF01048 0.704
MOD_GlcNHglycan 585 588 PF01048 0.472
MOD_GlcNHglycan 616 619 PF01048 0.710
MOD_GlcNHglycan 884 888 PF01048 0.607
MOD_GSK3_1 11 18 PF00069 0.717
MOD_GSK3_1 158 165 PF00069 0.716
MOD_GSK3_1 181 188 PF00069 0.492
MOD_GSK3_1 192 199 PF00069 0.430
MOD_GSK3_1 215 222 PF00069 0.778
MOD_GSK3_1 306 313 PF00069 0.604
MOD_GSK3_1 317 324 PF00069 0.786
MOD_GSK3_1 325 332 PF00069 0.510
MOD_GSK3_1 36 43 PF00069 0.644
MOD_GSK3_1 378 385 PF00069 0.681
MOD_GSK3_1 395 402 PF00069 0.604
MOD_GSK3_1 470 477 PF00069 0.725
MOD_GSK3_1 490 497 PF00069 0.520
MOD_GSK3_1 503 510 PF00069 0.809
MOD_GSK3_1 606 613 PF00069 0.658
MOD_GSK3_1 700 707 PF00069 0.534
MOD_GSK3_1 814 821 PF00069 0.647
MOD_GSK3_1 825 832 PF00069 0.614
MOD_GSK3_1 836 843 PF00069 0.566
MOD_N-GLC_1 141 146 PF02516 0.724
MOD_NEK2_1 111 116 PF00069 0.464
MOD_NEK2_1 176 181 PF00069 0.473
MOD_NEK2_1 372 377 PF00069 0.665
MOD_NEK2_1 413 418 PF00069 0.462
MOD_NEK2_1 583 588 PF00069 0.430
MOD_NEK2_1 632 637 PF00069 0.414
MOD_NEK2_1 65 70 PF00069 0.561
MOD_NEK2_1 668 673 PF00069 0.497
MOD_NEK2_1 767 772 PF00069 0.517
MOD_NEK2_1 825 830 PF00069 0.694
MOD_NEK2_1 923 928 PF00069 0.596
MOD_NEK2_2 310 315 PF00069 0.470
MOD_NEK2_2 471 476 PF00069 0.723
MOD_NEK2_2 874 879 PF00069 0.758
MOD_PIKK_1 185 191 PF00454 0.571
MOD_PIKK_1 200 206 PF00454 0.376
MOD_PIKK_1 265 271 PF00454 0.588
MOD_PIKK_1 570 576 PF00454 0.589
MOD_PIKK_1 656 662 PF00454 0.440
MOD_PK_1 465 471 PF00069 0.722
MOD_PK_1 807 813 PF00069 0.646
MOD_PK_1 829 835 PF00069 0.736
MOD_PKA_1 377 383 PF00069 0.701
MOD_PKA_2 189 195 PF00069 0.537
MOD_PKA_2 329 335 PF00069 0.640
MOD_PKA_2 377 383 PF00069 0.701
MOD_PKA_2 464 470 PF00069 0.718
MOD_PKA_2 63 69 PF00069 0.553
MOD_PKA_2 656 662 PF00069 0.440
MOD_PKA_2 874 880 PF00069 0.755
MOD_PKA_2 924 930 PF00069 0.732
MOD_Plk_1 192 198 PF00069 0.492
MOD_Plk_1 242 248 PF00069 0.466
MOD_Plk_1 48 54 PF00069 0.487
MOD_Plk_2-3 625 631 PF00069 0.528
MOD_Plk_2-3 814 820 PF00069 0.665
MOD_Plk_4 176 182 PF00069 0.326
MOD_Plk_4 242 248 PF00069 0.484
MOD_Plk_4 33 39 PF00069 0.584
MOD_Plk_4 449 455 PF00069 0.664
MOD_Plk_4 48 54 PF00069 0.548
MOD_Plk_4 545 551 PF00069 0.499
MOD_Plk_4 841 847 PF00069 0.689
MOD_ProDKin_1 132 138 PF00069 0.592
MOD_ProDKin_1 219 225 PF00069 0.657
MOD_ProDKin_1 233 239 PF00069 0.539
MOD_ProDKin_1 315 321 PF00069 0.714
MOD_ProDKin_1 365 371 PF00069 0.502
MOD_ProDKin_1 40 46 PF00069 0.609
MOD_ProDKin_1 475 481 PF00069 0.622
MOD_ProDKin_1 507 513 PF00069 0.812
MOD_ProDKin_1 606 612 PF00069 0.671
MOD_ProDKin_1 700 706 PF00069 0.554
MOD_ProDKin_1 715 721 PF00069 0.368
MOD_ProDKin_1 885 891 PF00069 0.731
MOD_SUMO_rev_2 695 700 PF00179 0.623
TRG_DiLeu_BaEn_1 432 437 PF01217 0.512
TRG_DiLeu_BaEn_1 451 456 PF01217 0.689
TRG_DiLeu_BaEn_2 337 343 PF01217 0.500
TRG_DiLeu_BaEn_2 716 722 PF01217 0.495
TRG_DiLeu_BaLyEn_6 542 547 PF01217 0.490
TRG_DiLeu_BaLyEn_6 705 710 PF01217 0.479
TRG_DiLeu_BaLyEn_6 73 78 PF01217 0.541
TRG_DiLeu_BaLyEn_6 778 783 PF01217 0.562
TRG_DiLeu_BaLyEn_6 886 891 PF01217 0.651
TRG_DiLeu_LyEn_5 432 437 PF01217 0.512
TRG_ENDOCYTIC_2 260 263 PF00928 0.278
TRG_ENDOCYTIC_2 345 348 PF00928 0.644
TRG_ENDOCYTIC_2 410 413 PF00928 0.427
TRG_ENDOCYTIC_2 439 442 PF00928 0.369
TRG_ENDOCYTIC_2 670 673 PF00928 0.459
TRG_ENDOCYTIC_2 713 716 PF00928 0.496
TRG_ENDOCYTIC_2 79 82 PF00928 0.570
TRG_ER_diArg_1 295 297 PF00400 0.571
TRG_ER_diArg_1 376 378 PF00400 0.681
TRG_ER_diArg_1 434 436 PF00400 0.516
TRG_ER_diArg_1 750 752 PF00400 0.511
TRG_ER_diArg_1 771 773 PF00400 0.534
TRG_ER_diArg_1 874 876 PF00400 0.691
TRG_NES_CRM1_1 780 796 PF08389 0.541
TRG_Pf-PMV_PEXEL_1 868 872 PF00026 0.716

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCK2 Leptomonas seymouri 50% 91%
A0A3Q8IH15 Leishmania donovani 93% 100%
A4HAK1 Leishmania braziliensis 80% 99%
A4I9P5 Leishmania infantum 93% 100%
C9ZMZ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
Q4Q3B7 Leishmania major 92% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS