ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4Q8_LEIMU

TriTrypDb:

LmxM.33.0870

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.571
CLV_C14_Caspase3-7	499	503	PF00656	0.687
CLV_NRD_NRD_1	125	127	PF00675	0.565
CLV_NRD_NRD_1	241	243	PF00675	0.692
CLV_NRD_NRD_1	349	351	PF00675	0.726
CLV_NRD_NRD_1	403	405	PF00675	0.481
CLV_NRD_NRD_1	432	434	PF00675	0.590
CLV_PCSK_KEX2_1	125	127	PF00082	0.498
CLV_PCSK_KEX2_1	241	243	PF00082	0.692
CLV_PCSK_KEX2_1	349	351	PF00082	0.726
CLV_PCSK_KEX2_1	402	404	PF00082	0.476
CLV_PCSK_KEX2_1	431	433	PF00082	0.581
CLV_PCSK_SKI1_1	103	107	PF00082	0.664
CLV_PCSK_SKI1_1	141	145	PF00082	0.495
CLV_PCSK_SKI1_1	552	556	PF00082	0.658
DEG_SPOP_SBC_1	47	51	PF00917	0.667
DOC_ANK_TNKS_1	298	305	PF00023	0.645
DOC_CKS1_1	480	485	PF01111	0.741
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.672
DOC_MAPK_FxFP_2	111	114	PF00069	0.501
DOC_MAPK_gen_1	437	446	PF00069	0.685
DOC_MAPK_JIP1_4	77	83	PF00069	0.545
DOC_PP1_RVXF_1	114	120	PF00149	0.502
DOC_PP2B_LxvP_1	144	147	PF13499	0.308
DOC_PP2B_LxvP_1	32	35	PF13499	0.698
DOC_PP4_FxxP_1	111	114	PF00568	0.501
DOC_USP7_MATH_1	165	169	PF00917	0.598
DOC_USP7_MATH_1	22	26	PF00917	0.689
DOC_USP7_MATH_1	252	256	PF00917	0.805
DOC_USP7_MATH_1	37	41	PF00917	0.729
DOC_USP7_MATH_1	374	378	PF00917	0.591
DOC_USP7_MATH_1	45	49	PF00917	0.654
DOC_USP7_MATH_1	450	454	PF00917	0.717
DOC_WW_Pin1_4	156	161	PF00397	0.651
DOC_WW_Pin1_4	255	260	PF00397	0.784
DOC_WW_Pin1_4	298	303	PF00397	0.576
DOC_WW_Pin1_4	403	408	PF00397	0.543
DOC_WW_Pin1_4	479	484	PF00397	0.744
LIG_14-3-3_CanoR_1	154	159	PF00244	0.637
LIG_14-3-3_CanoR_1	201	207	PF00244	0.544
LIG_14-3-3_CanoR_1	297	302	PF00244	0.580
LIG_14-3-3_CanoR_1	352	361	PF00244	0.752
LIG_Actin_WH2_2	538	554	PF00022	0.772
LIG_BIR_III_4	236	240	PF00653	0.746
LIG_BRCT_BRCA1_1	4	8	PF00533	0.471
LIG_deltaCOP1_diTrp_1	393	399	PF00928	0.507
LIG_deltaCOP1_diTrp_1	411	415	PF00928	0.578
LIG_FHA_1	148	154	PF00498	0.547
LIG_FHA_1	360	366	PF00498	0.558
LIG_FHA_1	479	485	PF00498	0.819
LIG_FHA_2	244	250	PF00498	0.692
LIG_FHA_2	473	479	PF00498	0.829
LIG_FHA_2	509	515	PF00498	0.756
LIG_LIR_Apic_2	108	114	PF02991	0.484
LIG_LIR_Apic_2	25	31	PF02991	0.780
LIG_LIR_Apic_2	33	39	PF02991	0.558
LIG_LIR_Apic_2	369	374	PF02991	0.579
LIG_LIR_Gen_1	5	15	PF02991	0.483
LIG_LIR_Nem_3	171	175	PF02991	0.572
LIG_LIR_Nem_3	421	427	PF02991	0.516
LIG_LIR_Nem_3	5	11	PF02991	0.478
LIG_PCNA_yPIPBox_3	417	431	PF02747	0.570
LIG_SH2_CRK	28	32	PF00017	0.692
LIG_SH2_CRK	36	40	PF00017	0.684
LIG_SH2_NCK_1	36	40	PF00017	0.778
LIG_SH2_NCK_1	371	375	PF00017	0.633
LIG_SH2_SRC	427	430	PF00017	0.581
LIG_SH2_STAT5	158	161	PF00017	0.646
LIG_SH2_STAT5	291	294	PF00017	0.535
LIG_SH2_STAT5	427	430	PF00017	0.683
LIG_SH3_1	433	439	PF00018	0.595
LIG_SH3_2	436	441	PF14604	0.644
LIG_SH3_3	16	22	PF00018	0.788
LIG_SH3_3	161	167	PF00018	0.615
LIG_SH3_3	373	379	PF00018	0.640
LIG_SH3_3	433	439	PF00018	0.595
LIG_TRAF2_1	485	488	PF00917	0.723
LIG_UBA3_1	169	176	PF00899	0.575
LIG_UBA3_1	544	552	PF00899	0.643
LIG_WRC_WIRS_1	86	91	PF05994	0.508
LIG_WW_3	379	383	PF00397	0.693
MOD_CDK_SPxK_1	156	162	PF00069	0.654
MOD_CK1_1	168	174	PF00069	0.568
MOD_CK1_1	255	261	PF00069	0.698
MOD_CK1_1	406	412	PF00069	0.561
MOD_CK1_1	48	54	PF00069	0.788
MOD_CK2_1	243	249	PF00069	0.798
MOD_CK2_1	508	514	PF00069	0.756
MOD_CMANNOS	396	399	PF00535	0.507
MOD_CMANNOS	412	415	PF00535	0.587
MOD_Cter_Amidation	239	242	PF01082	0.697
MOD_GlcNHglycan	197	200	PF01048	0.685
MOD_GlcNHglycan	254	257	PF01048	0.683
MOD_GlcNHglycan	32	35	PF01048	0.702
MOD_GlcNHglycan	39	42	PF01048	0.661
MOD_GlcNHglycan	408	411	PF01048	0.523
MOD_GlcNHglycan	451	455	PF01048	0.696
MOD_GlcNHglycan	548	551	PF01048	0.593
MOD_GSK3_1	154	161	PF00069	0.686
MOD_GSK3_1	243	250	PF00069	0.640
MOD_GSK3_1	255	262	PF00069	0.732
MOD_GSK3_1	335	342	PF00069	0.635
MOD_GSK3_1	39	46	PF00069	0.744
MOD_GSK3_1	47	54	PF00069	0.761
MOD_N-GLC_1	84	89	PF02516	0.534
MOD_NEK2_1	202	207	PF00069	0.509
MOD_NEK2_1	423	428	PF00069	0.466
MOD_NEK2_2	359	364	PF00069	0.682
MOD_OFUCOSY	272	278	PF10250	0.522
MOD_PIKK_1	105	111	PF00454	0.511
MOD_PIKK_1	339	345	PF00454	0.747
MOD_PKA_2	2	8	PF00069	0.470
MOD_PKA_2	211	217	PF00069	0.668
MOD_PKA_2	79	85	PF00069	0.535
MOD_Plk_1	247	253	PF00069	0.503
MOD_Plk_1	84	90	PF00069	0.539
MOD_Plk_4	165	171	PF00069	0.533
MOD_Plk_4	202	208	PF00069	0.509
MOD_Plk_4	39	45	PF00069	0.780
MOD_ProDKin_1	156	162	PF00069	0.654
MOD_ProDKin_1	255	261	PF00069	0.776
MOD_ProDKin_1	298	304	PF00069	0.588
MOD_ProDKin_1	403	409	PF00069	0.548
MOD_ProDKin_1	479	485	PF00069	0.742
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.529
TRG_ER_diArg_1	153	156	PF00400	0.566
TRG_ER_diArg_1	402	404	PF00400	0.476
TRG_ER_diArg_1	431	433	PF00400	0.581
TRG_ER_diArg_1	89	92	PF00400	0.509
TRG_NLS_MonoCore_2	439	444	PF00514	0.472
TRG_NLS_MonoExtC_3	439	445	PF00514	0.669
TRG_NLS_MonoExtN_4	437	444	PF00514	0.660
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A7	Leptomonas seymouri	52%	100%
A0A3S7X7L7	Leishmania donovani	88%	100%
A4HAK0	Leishmania braziliensis	74%	99%
A4I9P4	Leishmania infantum	88%	100%
Q4Q3B8	Leishmania major	91%	99%