Putative translation elongation factor 1-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation elongation factor 1-beta, putative

Species:

Leishmania mexicana

UniProt:

E9B4Q5_LEIMU

TriTrypDb:

LmxM.33.0840

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005853	eukaryotic translation elongation factor 1 complex	2	13
GO:0032991	protein-containing complex	1	13
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Q5

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003746	translation elongation factor activity	4	13
GO:0005488	binding	1	13
GO:0008135	translation factor activity, RNA binding	3	13
GO:0045182	translation regulator activity	1	13
GO:0090079	translation regulator activity, nucleic acid binding	2	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.540
CLV_PCSK_SKI1_1	126	130	PF00082	0.513
CLV_PCSK_SKI1_1	212	216	PF00082	0.649
CLV_PCSK_SKI1_1	226	230	PF00082	0.561
CLV_PCSK_SKI1_1	97	101	PF00082	0.523
DOC_CDC14_PxL_1	33	41	PF14671	0.468
DOC_CKS1_1	48	53	PF01111	0.463
DOC_CKS1_1	68	73	PF01111	0.501
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.782
DOC_MAPK_DCC_7	25	33	PF00069	0.442
DOC_MAPK_gen_1	281	289	PF00069	0.361
DOC_MAPK_MEF2A_6	147	155	PF00069	0.778
DOC_MAPK_MEF2A_6	25	33	PF00069	0.583
DOC_MAPK_MEF2A_6	42	49	PF00069	0.565
DOC_PP2B_LxvP_1	153	156	PF13499	0.779
DOC_USP7_MATH_1	165	169	PF00917	0.707
DOC_USP7_MATH_1	2	6	PF00917	0.515
DOC_USP7_MATH_1	234	238	PF00917	0.440
DOC_USP7_MATH_1	76	80	PF00917	0.595
DOC_USP7_UBL2_3	175	179	PF12436	0.539
DOC_USP7_UBL2_3	225	229	PF12436	0.576
DOC_WW_Pin1_4	31	36	PF00397	0.479
DOC_WW_Pin1_4	47	52	PF00397	0.639
DOC_WW_Pin1_4	57	62	PF00397	0.530
DOC_WW_Pin1_4	67	72	PF00397	0.500
LIG_14-3-3_CanoR_1	59	65	PF00244	0.474
LIG_APCC_ABBA_1	201	206	PF00400	0.614
LIG_BRCT_BRCA1_1	236	240	PF00533	0.380
LIG_Clathr_ClatBox_1	286	290	PF01394	0.361
LIG_CtBP_PxDLS_1	75	79	PF00389	0.444
LIG_FHA_1	246	252	PF00498	0.380
LIG_FHA_1	4	10	PF00498	0.373
LIG_FHA_2	104	110	PF00498	0.584
LIG_FHA_2	131	137	PF00498	0.513
LIG_FHA_2	205	211	PF00498	0.614
LIG_LIR_Gen_1	5	15	PF02991	0.369
LIG_LIR_Nem_3	5	10	PF02991	0.379
LIG_LIR_Nem_3	62	67	PF02991	0.701
LIG_NRBOX	11	17	PF00104	0.352
LIG_SH2_STAT5	134	137	PF00017	0.625
LIG_SH3_2	54	59	PF14604	0.456
LIG_SH3_3	145	151	PF00018	0.611
LIG_SH3_3	180	186	PF00018	0.703
LIG_SH3_3	26	32	PF00018	0.440
LIG_SH3_3	48	54	PF00018	0.459
LIG_SH3_3	65	71	PF00018	0.711
LIG_SUMO_SIM_par_1	13	18	PF11976	0.354
LIG_SUMO_SIM_par_1	246	252	PF11976	0.404
LIG_SUMO_SIM_par_1	285	292	PF11976	0.361
LIG_TRAF2_1	194	197	PF00917	0.709
LIG_TRAF2_1	207	210	PF00917	0.537
LIG_UBA3_1	286	293	PF00899	0.357
MOD_CK1_1	3	9	PF00069	0.401
MOD_CK1_1	52	58	PF00069	0.475
MOD_CK1_1	60	66	PF00069	0.469
MOD_CK1_1	92	98	PF00069	0.533
MOD_CK2_1	130	136	PF00069	0.500
MOD_CK2_1	204	210	PF00069	0.639
MOD_GlcNHglycan	2	5	PF01048	0.536
MOD_GlcNHglycan	294	297	PF01048	0.380
MOD_GlcNHglycan	94	97	PF01048	0.494
MOD_GSK3_1	27	34	PF00069	0.472
MOD_GSK3_1	62	69	PF00069	0.496
MOD_NEK2_1	15	20	PF00069	0.364
MOD_PKA_2	92	98	PF00069	0.396
MOD_Plk_1	245	251	PF00069	0.380
MOD_Plk_1	76	82	PF00069	0.517
MOD_Plk_2-3	309	315	PF00069	0.404
MOD_Plk_4	120	126	PF00069	0.458
MOD_Plk_4	234	240	PF00069	0.361
MOD_ProDKin_1	31	37	PF00069	0.479
MOD_ProDKin_1	47	53	PF00069	0.636
MOD_ProDKin_1	57	63	PF00069	0.530
MOD_ProDKin_1	67	73	PF00069	0.497
MOD_SUMO_rev_2	108	113	PF00179	0.391
MOD_SUMO_rev_2	136	141	PF00179	0.554
MOD_SUMO_rev_2	168	177	PF00179	0.678
MOD_SUMO_rev_2	206	214	PF00179	0.661
MOD_SUMO_rev_2	222	228	PF00179	0.518
MOD_SUMO_rev_2	236	244	PF00179	0.327
MOD_SUMO_rev_2	264	274	PF00179	0.378
MOD_SUMO_rev_2	290	295	PF00179	0.361
TRG_DiLeu_BaEn_1	262	267	PF01217	0.281
TRG_DiLeu_BaEn_4	210	216	PF01217	0.620
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.463
TRG_NLS_MonoExtC_3	225	230	PF00514	0.633
TRG_NLS_MonoExtN_4	225	230	PF00514	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZF7	Leptomonas seymouri	78%	100%
A0A0S4JK70	Bodo saltans	70%	100%
A0A1X0PA37	Trypanosomatidae	68%	100%
A0A3S5H7W1	Leishmania donovani	89%	100%
A0A422N8N9	Trypanosoma rangeli	70%	100%
A4HAJ3	Leishmania braziliensis	79%	100%
A4HAJ7	Leishmania braziliensis	79%	98%
A4I9P1	Leishmania infantum	89%	100%
C9ZN03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	96%
E9B4Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O74173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O96827	Drosophila melanogaster	39%	100%
P29546	Triticum aestivum	32%	100%
P30151	Xenopus laevis	38%	100%
P34827	Trypanosoma cruzi	65%	100%
Q40682	Oryza sativa subsp. japonica	34%	100%
Q4Q3C1	Leishmania major	82%	97%
Q6DET9	Xenopus tropicalis	35%	100%
Q84WM9	Arabidopsis thaliana	33%	100%
Q9GRF8	Dictyostelium discoideum	38%	100%
Q9SI20	Arabidopsis thaliana	36%	100%