NmrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4P6_LEIMU

TriTrypDb:

LmxM.33.0760

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B4P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4P6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0016043	cellular component organization	3	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022607	cellular component assembly	4	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.707
CLV_NRD_NRD_1	112	114	PF00675	0.502
CLV_NRD_NRD_1	171	173	PF00675	0.606
CLV_NRD_NRD_1	267	269	PF00675	0.555
CLV_NRD_NRD_1	280	282	PF00675	0.475
CLV_NRD_NRD_1	306	308	PF00675	0.518
CLV_PCSK_KEX2_1	112	114	PF00082	0.504
CLV_PCSK_KEX2_1	142	144	PF00082	0.513
CLV_PCSK_KEX2_1	158	160	PF00082	0.635
CLV_PCSK_KEX2_1	171	173	PF00082	0.545
CLV_PCSK_KEX2_1	267	269	PF00082	0.557
CLV_PCSK_KEX2_1	280	282	PF00082	0.475
CLV_PCSK_KEX2_1	306	308	PF00082	0.519
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.620
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.570
CLV_PCSK_SKI1_1	128	132	PF00082	0.462
CLV_PCSK_SKI1_1	175	179	PF00082	0.466
CLV_PCSK_SKI1_1	203	207	PF00082	0.493
CLV_PCSK_SKI1_1	306	310	PF00082	0.534
DEG_APCC_DBOX_1	202	210	PF00400	0.570
DEG_APCC_DBOX_1	377	385	PF00400	0.489
DOC_CKS1_1	7	12	PF01111	0.659
DOC_CYCLIN_RxL_1	122	136	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.542
DOC_MAPK_gen_1	112	119	PF00069	0.440
DOC_MAPK_gen_1	126	134	PF00069	0.441
DOC_MAPK_gen_1	400	410	PF00069	0.613
DOC_MAPK_MEF2A_6	112	119	PF00069	0.440
DOC_MAPK_MEF2A_6	126	134	PF00069	0.441
DOC_PP1_RVXF_1	64	71	PF00149	0.656
DOC_PP2B_LxvP_1	130	133	PF13499	0.538
DOC_USP7_MATH_1	191	195	PF00917	0.644
DOC_USP7_MATH_1	196	200	PF00917	0.709
DOC_USP7_MATH_1	335	339	PF00917	0.564
DOC_WW_Pin1_4	255	260	PF00397	0.638
DOC_WW_Pin1_4	287	292	PF00397	0.517
DOC_WW_Pin1_4	297	302	PF00397	0.539
DOC_WW_Pin1_4	329	334	PF00397	0.533
DOC_WW_Pin1_4	372	377	PF00397	0.573
DOC_WW_Pin1_4	6	11	PF00397	0.747
LIG_14-3-3_CanoR_1	112	118	PF00244	0.546
LIG_14-3-3_CanoR_1	143	148	PF00244	0.640
LIG_14-3-3_CanoR_1	183	189	PF00244	0.627
LIG_14-3-3_CanoR_1	224	229	PF00244	0.478
LIG_14-3-3_CanoR_1	306	312	PF00244	0.558
LIG_14-3-3_CanoR_1	336	340	PF00244	0.550
LIG_14-3-3_CanoR_1	358	366	PF00244	0.637
LIG_14-3-3_CanoR_1	378	382	PF00244	0.454
LIG_14-3-3_CanoR_1	383	390	PF00244	0.433
LIG_Actin_WH2_2	229	247	PF00022	0.371
LIG_Actin_WH2_2	435	451	PF00022	0.692
LIG_Actin_WH2_2	99	114	PF00022	0.494
LIG_APCC_ABBA_1	30	35	PF00400	0.709
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	226	230	PF00533	0.495
LIG_CSL_BTD_1	256	259	PF09270	0.597
LIG_deltaCOP1_diTrp_1	352	357	PF00928	0.592
LIG_eIF4E_1	303	309	PF01652	0.592
LIG_FHA_1	214	220	PF00498	0.571
LIG_FHA_1	361	367	PF00498	0.696
LIG_FHA_1	90	96	PF00498	0.457
LIG_FHA_2	7	13	PF00498	0.660
LIG_FHA_2	79	85	PF00498	0.668
LIG_GBD_Chelix_1	228	236	PF00786	0.529
LIG_LIR_Apic_2	253	259	PF02991	0.592
LIG_LIR_Gen_1	283	294	PF02991	0.544
LIG_LIR_Gen_1	462	470	PF02991	0.654
LIG_LIR_Nem_3	129	134	PF02991	0.543
LIG_LIR_Nem_3	146	152	PF02991	0.668
LIG_LIR_Nem_3	181	185	PF02991	0.456
LIG_LIR_Nem_3	283	289	PF02991	0.539
LIG_LIR_Nem_3	386	392	PF02991	0.610
LIG_LIR_Nem_3	462	467	PF02991	0.641
LIG_LYPXL_yS_3	57	60	PF13949	0.643
LIG_Pex14_1	357	361	PF04695	0.500
LIG_SH2_CRK	149	153	PF00017	0.719
LIG_SH2_CRK	305	309	PF00017	0.554
LIG_SH2_STAP1	11	15	PF00017	0.513
LIG_SH2_STAT5	110	113	PF00017	0.576
LIG_SH2_STAT5	231	234	PF00017	0.465
LIG_SH2_STAT5	29	32	PF00017	0.711
LIG_SH2_STAT5	315	318	PF00017	0.461
LIG_SH2_STAT5	69	72	PF00017	0.584
LIG_SH3_3	1	7	PF00018	0.720
LIG_SH3_3	185	191	PF00018	0.641
LIG_SH3_3	384	390	PF00018	0.603
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.423
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.499
LIG_TRAF2_1	235	238	PF00917	0.598
LIG_WRC_WIRS_1	389	394	PF05994	0.603
MOD_CDC14_SPxK_1	375	378	PF00782	0.577
MOD_CDK_SPxK_1	372	378	PF00069	0.569
MOD_CDK_SPxxK_3	329	336	PF00069	0.579
MOD_CK1_1	192	198	PF00069	0.718
MOD_CK1_1	258	264	PF00069	0.691
MOD_CK1_1	297	303	PF00069	0.529
MOD_CK1_1	359	365	PF00069	0.619
MOD_CK2_1	167	173	PF00069	0.520
MOD_CK2_1	388	394	PF00069	0.587
MOD_CK2_1	433	439	PF00069	0.645
MOD_CK2_1	78	84	PF00069	0.666
MOD_CMANNOS	353	356	PF00535	0.605
MOD_Cter_Amidation	265	268	PF01082	0.645
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.673
MOD_GlcNHglycan	12	16	PF01048	0.573
MOD_GlcNHglycan	191	194	PF01048	0.749
MOD_GlcNHglycan	237	242	PF01048	0.645
MOD_GlcNHglycan	252	255	PF01048	0.623
MOD_GlcNHglycan	264	267	PF01048	0.548
MOD_GlcNHglycan	329	332	PF01048	0.596
MOD_GSK3_1	192	199	PF00069	0.731
MOD_GSK3_1	219	226	PF00069	0.382
MOD_GSK3_1	258	265	PF00069	0.582
MOD_GSK3_1	325	332	PF00069	0.645
MOD_GSK3_1	356	363	PF00069	0.482
MOD_GSK3_1	433	440	PF00069	0.594
MOD_GSK3_1	87	94	PF00069	0.406
MOD_N-GLC_1	196	201	PF02516	0.642
MOD_NEK2_1	161	166	PF00069	0.642
MOD_NEK2_1	219	224	PF00069	0.519
MOD_NEK2_1	250	255	PF00069	0.700
MOD_NEK2_1	327	332	PF00069	0.579
MOD_NEK2_1	427	432	PF00069	0.598
MOD_NEK2_1	433	438	PF00069	0.521
MOD_NEK2_2	28	33	PF00069	0.667
MOD_PIKK_1	213	219	PF00454	0.506
MOD_PIKK_1	325	331	PF00454	0.601
MOD_PK_1	113	119	PF00069	0.488
MOD_PK_1	224	230	PF00069	0.500
MOD_PKA_2	167	173	PF00069	0.574
MOD_PKA_2	223	229	PF00069	0.291
MOD_PKA_2	335	341	PF00069	0.589
MOD_PKA_2	359	365	PF00069	0.646
MOD_PKA_2	377	383	PF00069	0.458
MOD_PKB_1	358	366	PF00069	0.499
MOD_PKB_1	447	455	PF00069	0.448
MOD_Plk_1	219	225	PF00069	0.527
MOD_Plk_1	322	328	PF00069	0.558
MOD_Plk_4	115	121	PF00069	0.430
MOD_Plk_4	126	132	PF00069	0.428
MOD_Plk_4	224	230	PF00069	0.444
MOD_Plk_4	258	264	PF00069	0.651
MOD_Plk_4	322	328	PF00069	0.558
MOD_Plk_4	433	439	PF00069	0.679
MOD_Plk_4	91	97	PF00069	0.460
MOD_ProDKin_1	255	261	PF00069	0.632
MOD_ProDKin_1	287	293	PF00069	0.519
MOD_ProDKin_1	297	303	PF00069	0.529
MOD_ProDKin_1	329	335	PF00069	0.530
MOD_ProDKin_1	372	378	PF00069	0.569
MOD_ProDKin_1	6	12	PF00069	0.742
MOD_SUMO_rev_2	136	144	PF00179	0.349
TRG_DiLeu_BaEn_1	91	96	PF01217	0.549
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.564
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.611
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.665
TRG_ENDOCYTIC_2	149	152	PF00928	0.678
TRG_ENDOCYTIC_2	29	32	PF00928	0.597
TRG_ENDOCYTIC_2	305	308	PF00928	0.538
TRG_ENDOCYTIC_2	57	60	PF00928	0.643
TRG_ER_diArg_1	111	113	PF00400	0.502
TRG_ER_diArg_1	17	20	PF00400	0.652
TRG_ER_diArg_1	267	269	PF00400	0.557
TRG_ER_diArg_1	280	282	PF00400	0.471
TRG_ER_diArg_1	305	307	PF00400	0.518
TRG_ER_diArg_1	357	360	PF00400	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN2	Leptomonas seymouri	66%	98%
A0A0S4IVY0	Bodo saltans	24%	100%
A0A1X0P965	Trypanosomatidae	33%	100%
A0A3Q8IIA0	Leishmania donovani	92%	100%
A4HAI5	Leishmania braziliensis	80%	100%
E9AHS6	Leishmania infantum	92%	100%
Q4Q3D0	Leishmania major	89%	100%
V5BEX5	Trypanosoma cruzi	34%	100%