MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4P5_LEIMU

TriTrypDb:

LmxM.33.0750

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.429
CLV_NRD_NRD_1	34	36	PF00675	0.417
CLV_PCSK_FUR_1	34	38	PF00082	0.427
CLV_PCSK_KEX2_1	184	186	PF00082	0.432
CLV_PCSK_KEX2_1	34	36	PF00082	0.443
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.518
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.464
CLV_PCSK_SKI1_1	129	133	PF00082	0.385
CLV_PCSK_SKI1_1	252	256	PF00082	0.337
CLV_PCSK_SKI1_1	338	342	PF00082	0.390
CLV_PCSK_SKI1_1	345	349	PF00082	0.389
CLV_PCSK_SKI1_1	36	40	PF00082	0.443
CLV_PCSK_SKI1_1	438	442	PF00082	0.447
DEG_APCC_DBOX_1	337	345	PF00400	0.448
DEG_COP1_1	348	357	PF00400	0.302
DEG_Nend_UBRbox_3	1	3	PF02207	0.461
DOC_CYCLIN_RxL_1	247	259	PF00134	0.352
DOC_CYCLIN_yCln2_LP_2	318	324	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.422
DOC_MAPK_FxFP_2	74	77	PF00069	0.399
DOC_MAPK_gen_1	183	192	PF00069	0.423
DOC_PP1_RVXF_1	396	402	PF00149	0.399
DOC_PP1_SILK_1	51	56	PF00149	0.486
DOC_PP2B_LxvP_1	282	285	PF13499	0.403
DOC_PP2B_LxvP_1	318	321	PF13499	0.436
DOC_PP4_FxxP_1	223	226	PF00568	0.299
DOC_PP4_FxxP_1	74	77	PF00568	0.399
DOC_PP4_MxPP_1	1	4	PF00568	0.454
DOC_USP7_UBL2_3	15	19	PF12436	0.545
DOC_USP7_UBL2_3	398	402	PF12436	0.369
DOC_WW_Pin1_4	167	172	PF00397	0.517
DOC_WW_Pin1_4	202	207	PF00397	0.441
DOC_WW_Pin1_4	236	241	PF00397	0.437
DOC_WW_Pin1_4	79	84	PF00397	0.459
LIG_14-3-3_CanoR_1	209	216	PF00244	0.409
LIG_14-3-3_CanoR_1	35	41	PF00244	0.412
LIG_14-3-3_CanoR_1	362	368	PF00244	0.518
LIG_14-3-3_CanoR_1	436	441	PF00244	0.507
LIG_14-3-3_CanoR_1	90	95	PF00244	0.511
LIG_Actin_WH2_2	114	131	PF00022	0.366
LIG_APCC_ABBA_1	25	30	PF00400	0.406
LIG_BRCT_BRCA1_1	109	113	PF00533	0.390
LIG_deltaCOP1_diTrp_1	29	40	PF00928	0.413
LIG_EH_1	218	222	PF12763	0.358
LIG_eIF4E_1	250	256	PF01652	0.318
LIG_FHA_1	100	106	PF00498	0.496
LIG_FHA_1	442	448	PF00498	0.552
LIG_FHA_2	157	163	PF00498	0.597
LIG_FHA_2	257	263	PF00498	0.383
LIG_LIR_Apic_2	72	77	PF02991	0.404
LIG_LIR_Gen_1	133	143	PF02991	0.338
LIG_LIR_Gen_1	380	390	PF02991	0.344
LIG_LIR_Gen_1	64	75	PF02991	0.388
LIG_LIR_Nem_3	110	116	PF02991	0.356
LIG_LIR_Nem_3	124	128	PF02991	0.329
LIG_LIR_Nem_3	133	138	PF02991	0.336
LIG_LIR_Nem_3	199	204	PF02991	0.387
LIG_LIR_Nem_3	380	386	PF02991	0.331
LIG_LIR_Nem_3	394	400	PF02991	0.372
LIG_LIR_Nem_3	64	70	PF02991	0.382
LIG_LYPXL_SIV_4	378	386	PF13949	0.422
LIG_PCNA_PIPBox_1	106	115	PF02747	0.487
LIG_PCNA_yPIPBox_3	421	429	PF02747	0.524
LIG_Pex14_2	221	225	PF04695	0.329
LIG_Pex14_2	397	401	PF04695	0.497
LIG_SH2_CRK	379	383	PF00017	0.336
LIG_SH2_CRK	67	71	PF00017	0.355
LIG_SH2_NCK_1	150	154	PF00017	0.455
LIG_SH2_NCK_1	379	383	PF00017	0.320
LIG_SH2_NCK_1	67	71	PF00017	0.354
LIG_SH2_SRC	150	153	PF00017	0.444
LIG_SH2_STAP1	23	27	PF00017	0.415
LIG_SH2_STAP1	250	254	PF00017	0.315
LIG_SH2_STAP1	379	383	PF00017	0.336
LIG_SH2_STAT5	146	149	PF00017	0.438
LIG_SH2_STAT5	235	238	PF00017	0.522
LIG_SH2_STAT5	379	382	PF00017	0.342
LIG_SH2_STAT5	383	386	PF00017	0.339
LIG_SH2_STAT5	67	70	PF00017	0.356
LIG_SH3_3	384	390	PF00018	0.470
LIG_SH3_3	82	88	PF00018	0.433
LIG_TYR_ITIM	377	382	PF00017	0.334
LIG_TYR_ITSM	63	70	PF00017	0.355
LIG_UBA3_1	340	345	PF00899	0.404
MOD_CDK_SPxK_1	236	242	PF00069	0.425
MOD_CDK_SPxxK_3	202	209	PF00069	0.439
MOD_CK2_1	97	103	PF00069	0.426
MOD_GlcNHglycan	452	455	PF01048	0.449
MOD_GSK3_1	117	124	PF00069	0.463
MOD_GSK3_1	13	20	PF00069	0.501
MOD_GSK3_1	165	172	PF00069	0.606
MOD_GSK3_1	441	448	PF00069	0.597
MOD_N-GLC_1	98	103	PF02516	0.462
MOD_NEK2_1	117	122	PF00069	0.454
MOD_NEK2_1	165	170	PF00069	0.536
MOD_NEK2_1	256	261	PF00069	0.379
MOD_NEK2_1	312	317	PF00069	0.373
MOD_NEK2_1	377	382	PF00069	0.343
MOD_NEK2_1	441	446	PF00069	0.461
MOD_NEK2_1	48	53	PF00069	0.545
MOD_NEK2_2	245	250	PF00069	0.350
MOD_PIKK_1	156	162	PF00454	0.565
MOD_PIKK_1	348	354	PF00454	0.518
MOD_PK_1	49	55	PF00069	0.416
MOD_PKA_1	36	42	PF00069	0.450
MOD_PKA_2	208	214	PF00069	0.414
MOD_PKA_2	267	273	PF00069	0.580
MOD_PKA_2	36	42	PF00069	0.426
MOD_PKA_2	361	367	PF00069	0.533
MOD_PKA_2	48	54	PF00069	0.425
MOD_Plk_1	17	23	PF00069	0.552
MOD_Plk_1	196	202	PF00069	0.438
MOD_Plk_1	29	35	PF00069	0.436
MOD_Plk_1	330	336	PF00069	0.479
MOD_Plk_1	65	71	PF00069	0.362
MOD_Plk_2-3	186	192	PF00069	0.452
MOD_Plk_4	196	202	PF00069	0.482
MOD_Plk_4	250	256	PF00069	0.344
MOD_Plk_4	377	383	PF00069	0.335
MOD_Plk_4	436	442	PF00069	0.522
MOD_Plk_4	49	55	PF00069	0.389
MOD_Plk_4	65	71	PF00069	0.337
MOD_Plk_4	90	96	PF00069	0.503
MOD_ProDKin_1	167	173	PF00069	0.509
MOD_ProDKin_1	202	208	PF00069	0.435
MOD_ProDKin_1	236	242	PF00069	0.431
MOD_ProDKin_1	79	85	PF00069	0.460
MOD_SUMO_for_1	334	337	PF00179	0.432
MOD_SUMO_rev_2	158	166	PF00179	0.644
MOD_SUMO_rev_2	18	27	PF00179	0.425
MOD_SUMO_rev_2	337	347	PF00179	0.410
MOD_SUMO_rev_2	8	17	PF00179	0.455
TRG_DiLeu_BaEn_1	420	425	PF01217	0.435
TRG_DiLeu_BaEn_2	196	202	PF01217	0.368
TRG_DiLeu_BaEn_2	341	347	PF01217	0.412
TRG_DiLeu_BaEn_4	342	348	PF01217	0.413
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.342
TRG_ENDOCYTIC_2	150	153	PF00928	0.473
TRG_ENDOCYTIC_2	28	31	PF00928	0.412
TRG_ENDOCYTIC_2	379	382	PF00928	0.334
TRG_ENDOCYTIC_2	383	386	PF00928	0.332
TRG_ENDOCYTIC_2	389	392	PF00928	0.364
TRG_ENDOCYTIC_2	67	70	PF00928	0.365
TRG_ER_diArg_1	182	185	PF00400	0.418
TRG_ER_diArg_1	33	35	PF00400	0.432
TRG_ER_diArg_1	54	57	PF00400	0.406
TRG_NLS_MonoExtN_4	34	39	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA50	Leptomonas seymouri	89%	93%
A0A0N1PBN6	Leptomonas seymouri	26%	66%
A0A0S4JJ07	Bodo saltans	69%	99%
A0A1X0P990	Trypanosomatidae	73%	95%
A0A3Q8IE69	Leishmania donovani	96%	99%
A0A3R7MZ34	Trypanosoma rangeli	28%	68%
A0A3R7N7Y7	Trypanosoma rangeli	72%	95%
A4HAI4	Leishmania braziliensis	92%	100%
C9ZN08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	96%
C9ZVC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	67%
E9AHS5	Leishmania infantum	96%	99%
E9AWF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	68%
Q4Q3D1	Leishmania major	96%	100%
Q4QB18	Leishmania major	27%	67%
V5BJD7	Trypanosoma cruzi	72%	95%