Protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein phosphatase

Gene product:

Stage II sporulation protein E (SpoIIE), putative

Species:

Leishmania mexicana

UniProt:

E9B4P3_LEIMU

TriTrypDb:

LmxM.33.0730

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4P3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0004722	protein serine/threonine phosphatase activity	4	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0017018	myosin phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.421
CLV_NRD_NRD_1	155	157	PF00675	0.289
CLV_PCSK_FUR_1	14	18	PF00082	0.507
CLV_PCSK_KEX2_1	155	157	PF00082	0.260
CLV_PCSK_KEX2_1	16	18	PF00082	0.683
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.683
CLV_PCSK_SKI1_1	16	20	PF00082	0.479
CLV_PCSK_SKI1_1	2	6	PF00082	0.561
DEG_APCC_DBOX_1	1	9	PF00400	0.569
DEG_Nend_UBRbox_1	1	4	PF02207	0.543
DOC_MAPK_MEF2A_6	104	112	PF00069	0.455
DOC_PP4_FxxP_1	82	85	PF00568	0.408
DOC_USP7_MATH_1	12	16	PF00917	0.657
DOC_WW_Pin1_4	156	161	PF00397	0.433
DOC_WW_Pin1_4	195	200	PF00397	0.426
LIG_14-3-3_CanoR_1	17	24	PF00244	0.315
LIG_Clathr_ClatBox_1	205	209	PF01394	0.619
LIG_FAT_LD_1	122	130	PF03623	0.503
LIG_FHA_1	103	109	PF00498	0.350
LIG_FHA_1	179	185	PF00498	0.408
LIG_FHA_1	201	207	PF00498	0.529
LIG_FHA_2	44	50	PF00498	0.408
LIG_LIR_Apic_2	154	160	PF02991	0.421
LIG_LIR_Apic_2	81	85	PF02991	0.464
LIG_LIR_Gen_1	107	117	PF02991	0.455
LIG_LIR_Nem_3	107	112	PF02991	0.393
LIG_NRBOX	121	127	PF00104	0.503
LIG_SH2_STAT5	157	160	PF00017	0.472
LIG_SH2_STAT5	172	175	PF00017	0.363
LIG_SH2_STAT5	7	10	PF00017	0.602
LIG_SH3_1	86	92	PF00018	0.439
LIG_SH3_3	86	92	PF00018	0.421
LIG_TRAF2_2	85	90	PF00917	0.341
LIG_UBA3_1	201	210	PF00899	0.543
MOD_CDK_SPxxK_3	156	163	PF00069	0.408
MOD_CK2_1	91	97	PF00069	0.457
MOD_GlcNHglycan	93	96	PF01048	0.239
MOD_GSK3_1	12	19	PF00069	0.645
MOD_GSK3_1	188	195	PF00069	0.554
MOD_PKA_1	16	22	PF00069	0.524
MOD_PKA_2	16	22	PF00069	0.528
MOD_PKA_2	170	176	PF00069	0.439
MOD_Plk_1	178	184	PF00069	0.408
MOD_Plk_4	43	49	PF00069	0.419
MOD_Plk_4	51	57	PF00069	0.409
MOD_ProDKin_1	156	162	PF00069	0.433
MOD_ProDKin_1	195	201	PF00069	0.427
MOD_SUMO_for_1	99	102	PF00179	0.503
TRG_DiLeu_BaEn_1	121	126	PF01217	0.503
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.665
TRG_DiLeu_LyEn_5	121	126	PF01217	0.503
TRG_ER_diArg_1	155	157	PF00400	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH92	Leptomonas seymouri	73%	75%
A0A0S4IN49	Bodo saltans	30%	66%
A0A1X0P973	Trypanosomatidae	54%	76%
A0A3Q8IUF7	Leishmania donovani	97%	100%
A0A3R7RFR7	Trypanosoma rangeli	53%	75%
A4HAI2	Leishmania braziliensis	91%	100%
B3P5D3	Drosophila erecta	34%	66%
B4HZE7	Drosophila sechellia	32%	67%
B4JYN1	Drosophila grimshawi	35%	68%
B4K616	Drosophila mojavensis	35%	67%
B4M5T5	Drosophila virilis	33%	67%
B4NBL6	Drosophila willistoni	29%	67%
B4R089	Drosophila simulans	32%	67%
C9ZN10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	75%
E9AHS3	Leishmania infantum	97%	100%
O64730	Arabidopsis thaliana	34%	70%
Q09189	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	70%
Q4Q3D3	Leishmania major	96%	100%
Q5U3N5	Danio rerio	35%	71%
Q6GR25	Xenopus laevis	34%	71%
Q6H7J3	Oryza sativa subsp. japonica	30%	67%
Q6NVE9	Mus musculus	33%	68%
Q8NI37	Homo sapiens	33%	69%
Q9VAH4	Drosophila melanogaster	31%	67%
V5AUW7	Trypanosoma cruzi	54%	75%