Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4P2_LEIMU

TriTrypDb:

LmxM.33.0720

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4P2

PDB structure(s): 7ane_y

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004784	superoxide dismutase activity	2	4
GO:0005488	binding	1	4
GO:0016209	antioxidant activity	1	4
GO:0016491	oxidoreductase activity	2	4
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	3	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.565
CLV_C14_Caspase3-7	465	469	PF00656	0.412
CLV_C14_Caspase3-7	474	478	PF00656	0.433
CLV_NRD_NRD_1	11	13	PF00675	0.489
CLV_NRD_NRD_1	22	24	PF00675	0.630
CLV_NRD_NRD_1	300	302	PF00675	0.626
CLV_PCSK_KEX2_1	11	13	PF00082	0.415
CLV_PCSK_KEX2_1	201	203	PF00082	0.374
CLV_PCSK_KEX2_1	22	24	PF00082	0.495
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.374
CLV_PCSK_SKI1_1	11	15	PF00082	0.431
CLV_PCSK_SKI1_1	125	129	PF00082	0.369
CLV_PCSK_SKI1_1	46	50	PF00082	0.643
DEG_APCC_DBOX_1	10	18	PF00400	0.491
DEG_APCC_DBOX_1	75	83	PF00400	0.461
DEG_SCF_FBW7_1	160	167	PF00400	0.392
DEG_SPOP_SBC_1	353	357	PF00917	0.639
DOC_CKS1_1	161	166	PF01111	0.383
DOC_CYCLIN_RxL_1	122	132	PF00134	0.348
DOC_CYCLIN_RxL_1	57	65	PF00134	0.388
DOC_CYCLIN_RxL_1	9	20	PF00134	0.497
DOC_MAPK_DCC_7	11	19	PF00069	0.450
DOC_MAPK_FxFP_2	455	458	PF00069	0.526
DOC_MAPK_gen_1	11	19	PF00069	0.405
DOC_MAPK_gen_1	60	66	PF00069	0.563
DOC_MAPK_MEF2A_6	11	19	PF00069	0.464
DOC_PP4_FxxP_1	455	458	PF00568	0.526
DOC_USP7_MATH_1	146	150	PF00917	0.331
DOC_USP7_MATH_1	208	212	PF00917	0.487
DOC_USP7_MATH_1	27	31	PF00917	0.446
DOC_USP7_MATH_1	325	329	PF00917	0.552
DOC_USP7_MATH_1	377	381	PF00917	0.809
DOC_USP7_MATH_1	389	393	PF00917	0.602
DOC_USP7_MATH_1	432	436	PF00917	0.410
DOC_USP7_MATH_1	44	48	PF00917	0.546
DOC_WW_Pin1_4	151	156	PF00397	0.513
DOC_WW_Pin1_4	160	165	PF00397	0.473
DOC_WW_Pin1_4	229	234	PF00397	0.572
DOC_WW_Pin1_4	337	342	PF00397	0.667
DOC_WW_Pin1_4	345	350	PF00397	0.625
DOC_WW_Pin1_4	354	359	PF00397	0.530
DOC_WW_Pin1_4	392	397	PF00397	0.570
LIG_14-3-3_CanoR_1	109	118	PF00244	0.589
LIG_14-3-3_CanoR_1	231	237	PF00244	0.557
LIG_14-3-3_CanoR_1	471	476	PF00244	0.408
LIG_Actin_WH2_2	303	319	PF00022	0.575
LIG_AP2alpha_1	94	98	PF02296	0.272
LIG_BRCT_BRCA1_1	333	337	PF00533	0.609
LIG_BRCT_BRCA1_1	434	438	PF00533	0.504
LIG_BRCT_BRCA1_1	90	94	PF00533	0.300
LIG_EH1_1	28	36	PF00400	0.504
LIG_FHA_1	118	124	PF00498	0.465
LIG_FHA_1	161	167	PF00498	0.442
LIG_FHA_1	26	32	PF00498	0.603
LIG_FHA_1	280	286	PF00498	0.372
LIG_FHA_1	324	330	PF00498	0.555
LIG_FHA_1	371	377	PF00498	0.704
LIG_FHA_1	426	432	PF00498	0.522
LIG_FHA_1	438	444	PF00498	0.497
LIG_FHA_1	459	465	PF00498	0.397
LIG_FHA_2	294	300	PF00498	0.492
LIG_FHA_2	451	457	PF00498	0.431
LIG_FHA_2	472	478	PF00498	0.408
LIG_LIR_Apic_2	452	458	PF02991	0.398
LIG_LIR_Nem_3	132	138	PF02991	0.405
LIG_LIR_Nem_3	91	97	PF02991	0.453
LIG_MYND_1	345	349	PF01753	0.472
LIG_PCNA_yPIPBox_3	424	436	PF02747	0.341
LIG_Pex14_1	418	422	PF04695	0.397
LIG_Pex14_2	94	98	PF04695	0.435
LIG_SH2_CRK	135	139	PF00017	0.424
LIG_SH2_CRK	162	166	PF00017	0.482
LIG_SH2_GRB2like	422	425	PF00017	0.359
LIG_SH2_SRC	475	478	PF00017	0.564
LIG_SH2_STAP1	40	44	PF00017	0.490
LIG_SH2_STAT5	162	165	PF00017	0.377
LIG_SH2_STAT5	88	91	PF00017	0.436
LIG_SH2_STAT5	97	100	PF00017	0.474
LIG_SH3_3	158	164	PF00018	0.493
LIG_SH3_3	174	180	PF00018	0.258
LIG_SH3_3	335	341	PF00018	0.605
LIG_SH3_3	373	379	PF00018	0.655
LIG_TRAF2_1	480	483	PF00917	0.337
LIG_WRC_WIRS_1	16	21	PF05994	0.480
MOD_CDC14_SPxK_1	154	157	PF00782	0.482
MOD_CDC14_SPxK_1	357	360	PF00782	0.626
MOD_CDK_SPK_2	229	234	PF00069	0.518
MOD_CDK_SPxK_1	151	157	PF00069	0.505
MOD_CDK_SPxK_1	354	360	PF00069	0.631
MOD_CDK_SPxxK_3	337	344	PF00069	0.466
MOD_CK1_1	113	119	PF00069	0.545
MOD_CK1_1	134	140	PF00069	0.468
MOD_CK1_1	259	265	PF00069	0.469
MOD_CK1_1	30	36	PF00069	0.483
MOD_CK1_1	333	339	PF00069	0.620
MOD_CK1_1	340	346	PF00069	0.607
MOD_CK1_1	370	376	PF00069	0.609
MOD_CK1_1	392	398	PF00069	0.580
MOD_CK1_1	442	448	PF00069	0.495
MOD_CK1_1	71	77	PF00069	0.426
MOD_CK1_1	90	96	PF00069	0.373
MOD_CK2_1	164	170	PF00069	0.624
MOD_CK2_1	286	292	PF00069	0.486
MOD_CK2_1	293	299	PF00069	0.497
MOD_CK2_1	450	456	PF00069	0.400
MOD_CK2_1	476	482	PF00069	0.436
MOD_Cter_Amidation	20	23	PF01082	0.574
MOD_GlcNHglycan	166	169	PF01048	0.645
MOD_GlcNHglycan	210	213	PF01048	0.504
MOD_GlcNHglycan	261	264	PF01048	0.562
MOD_GlcNHglycan	282	285	PF01048	0.447
MOD_GlcNHglycan	318	321	PF01048	0.504
MOD_GlcNHglycan	379	382	PF01048	0.737
MOD_GlcNHglycan	391	394	PF01048	0.700
MOD_GlcNHglycan	40	43	PF01048	0.576
MOD_GlcNHglycan	73	76	PF01048	0.302
MOD_GSK3_1	109	116	PF00069	0.744
MOD_GSK3_1	147	154	PF00069	0.484
MOD_GSK3_1	160	167	PF00069	0.312
MOD_GSK3_1	17	24	PF00069	0.672
MOD_GSK3_1	255	262	PF00069	0.564
MOD_GSK3_1	287	294	PF00069	0.439
MOD_GSK3_1	30	37	PF00069	0.335
MOD_GSK3_1	323	330	PF00069	0.530
MOD_GSK3_1	333	340	PF00069	0.568
MOD_GSK3_1	377	384	PF00069	0.728
MOD_GSK3_1	385	392	PF00069	0.707
MOD_GSK3_1	40	47	PF00069	0.454
MOD_GSK3_1	437	444	PF00069	0.514
MOD_LATS_1	107	113	PF00433	0.477
MOD_N-GLC_1	109	114	PF02516	0.433
MOD_N-GLC_1	196	201	PF02516	0.353
MOD_N-GLC_1	345	350	PF02516	0.577
MOD_N-GLC_1	425	430	PF02516	0.578
MOD_N-GLC_1	458	463	PF02516	0.411
MOD_N-GLC_1	49	54	PF02516	0.552
MOD_NEK2_1	141	146	PF00069	0.467
MOD_NEK2_1	147	152	PF00069	0.464
MOD_NEK2_1	17	22	PF00069	0.674
MOD_NEK2_1	316	321	PF00069	0.499
MOD_NEK2_1	34	39	PF00069	0.491
MOD_NEK2_1	443	448	PF00069	0.390
MOD_PIKK_1	291	297	PF00454	0.418
MOD_PIKK_1	368	374	PF00454	0.726
MOD_PK_1	256	262	PF00069	0.370
MOD_PKA_2	108	114	PF00069	0.453
MOD_PKA_2	21	27	PF00069	0.602
MOD_PKA_2	470	476	PF00069	0.365
MOD_Plk_1	131	137	PF00069	0.498
MOD_Plk_1	458	464	PF00069	0.408
MOD_Plk_1	69	75	PF00069	0.453
MOD_Plk_4	113	119	PF00069	0.640
MOD_Plk_4	172	178	PF00069	0.351
MOD_Plk_4	30	36	PF00069	0.487
MOD_Plk_4	333	339	PF00069	0.652
MOD_Plk_4	443	449	PF00069	0.483
MOD_Plk_4	450	456	PF00069	0.362
MOD_Plk_4	459	465	PF00069	0.337
MOD_Plk_4	62	68	PF00069	0.367
MOD_ProDKin_1	151	157	PF00069	0.505
MOD_ProDKin_1	160	166	PF00069	0.486
MOD_ProDKin_1	229	235	PF00069	0.578
MOD_ProDKin_1	337	343	PF00069	0.669
MOD_ProDKin_1	345	351	PF00069	0.627
MOD_ProDKin_1	354	360	PF00069	0.531
MOD_ProDKin_1	392	398	PF00069	0.571
MOD_SUMO_rev_2	93	103	PF00179	0.464
TRG_DiLeu_BaEn_1	9	14	PF01217	0.354
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.375
TRG_DiLeu_LyEn_5	9	14	PF01217	0.467
TRG_ENDOCYTIC_2	135	138	PF00928	0.418
TRG_ER_diArg_1	10	12	PF00400	0.399
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P312	Leptomonas seymouri	50%	95%
A0A1X0PA30	Trypanosomatidae	38%	100%
A0A3Q8IHA9	Leishmania donovani	88%	100%
A0A3R7K8T3	Trypanosoma rangeli	36%	100%
A4HAI1	Leishmania braziliensis	81%	100%
A4IAP2	Leishmania infantum	88%	100%
C9ZN11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q3D4	Leishmania major	90%	100%
V5DAY1	Trypanosoma cruzi	37%	100%