Stc1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized conserved protein (DUF2039), putative

Species:

Leishmania mexicana

UniProt:

E9B4N9_LEIMU

TriTrypDb:

LmxM.33.0700

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4N9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.576
CLV_NRD_NRD_1	169	171	PF00675	0.563
CLV_NRD_NRD_1	172	174	PF00675	0.536
CLV_NRD_NRD_1	189	191	PF00675	0.292
CLV_NRD_NRD_1	193	195	PF00675	0.479
CLV_NRD_NRD_1	48	50	PF00675	0.326
CLV_NRD_NRD_1	70	72	PF00675	0.313
CLV_PCSK_FUR_1	170	174	PF00082	0.579
CLV_PCSK_FUR_1	187	191	PF00082	0.342
CLV_PCSK_KEX2_1	171	173	PF00082	0.624
CLV_PCSK_KEX2_1	189	191	PF00082	0.331
CLV_PCSK_KEX2_1	2	4	PF00082	0.581
CLV_PCSK_KEX2_1	48	50	PF00082	0.309
CLV_PCSK_KEX2_1	70	72	PF00082	0.347
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.580
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.600
CLV_PCSK_PC7_1	185	191	PF00082	0.427
CLV_PCSK_SKI1_1	141	145	PF00082	0.560
CLV_PCSK_SKI1_1	190	194	PF00082	0.477
CLV_PCSK_SKI1_1	3	7	PF00082	0.606
DEG_APCC_DBOX_1	177	185	PF00400	0.584
DEG_Nend_UBRbox_1	1	4	PF02207	0.650
DOC_USP7_MATH_1	105	109	PF00917	0.645
DOC_USP7_MATH_1	177	181	PF00917	0.349
DOC_USP7_MATH_1	202	206	PF00917	0.676
DOC_USP7_UBL2_3	2	6	PF12436	0.645
DOC_WW_Pin1_4	6	11	PF00397	0.595
LIG_14-3-3_CanoR_1	178	182	PF00244	0.494
LIG_14-3-3_CanoR_1	189	193	PF00244	0.441
LIG_14-3-3_CanoR_1	36	42	PF00244	0.479
LIG_FHA_1	160	166	PF00498	0.624
LIG_FHA_1	36	42	PF00498	0.398
LIG_FHA_2	110	116	PF00498	0.642
LIG_FHA_2	117	123	PF00498	0.659
LIG_FHA_2	62	68	PF00498	0.414
LIG_LIR_Gen_1	140	149	PF02991	0.537
LIG_LIR_Gen_1	81	92	PF02991	0.187
LIG_LIR_Nem_3	140	145	PF02991	0.512
LIG_LIR_Nem_3	59	63	PF02991	0.309
LIG_LIR_Nem_3	81	87	PF02991	0.197
LIG_PDZ_Class_3	204	209	PF00595	0.701
LIG_Pex14_1	56	60	PF04695	0.309
LIG_SH2_CRK	84	88	PF00017	0.440
LIG_SH2_GRB2like	16	19	PF00017	0.369
LIG_SH2_STAT3	63	66	PF00017	0.440
LIG_SH2_STAT5	132	135	PF00017	0.630
LIG_SH2_STAT5	63	66	PF00017	0.304
LIG_TRAF2_1	121	124	PF00917	0.737
LIG_TRAF2_1	149	152	PF00917	0.551
LIG_TRAF2_1	64	67	PF00917	0.440
MOD_CDK_SPxxK_3	6	13	PF00069	0.596
MOD_CK1_1	126	132	PF00069	0.665
MOD_CK1_1	180	186	PF00069	0.612
MOD_CK1_1	35	41	PF00069	0.409
MOD_CK2_1	118	124	PF00069	0.665
MOD_CK2_1	180	186	PF00069	0.624
MOD_CK2_1	61	67	PF00069	0.414
MOD_GlcNHglycan	107	110	PF01048	0.692
MOD_GSK3_1	105	112	PF00069	0.589
MOD_GSK3_1	118	125	PF00069	0.647
MOD_GSK3_1	155	162	PF00069	0.655
MOD_GSK3_1	62	69	PF00069	0.465
MOD_N-GLC_1	17	22	PF02516	0.414
MOD_N-GLC_2	73	75	PF02516	0.309
MOD_NEK2_1	17	22	PF00069	0.414
MOD_PIKK_1	62	68	PF00454	0.412
MOD_PKA_1	194	200	PF00069	0.574
MOD_PKA_2	155	161	PF00069	0.657
MOD_PKA_2	177	183	PF00069	0.539
MOD_PKA_2	188	194	PF00069	0.399
MOD_PKA_2	32	38	PF00069	0.399
MOD_ProDKin_1	6	12	PF00069	0.596
TRG_DiLeu_BaEn_4	152	158	PF01217	0.594
TRG_ENDOCYTIC_2	142	145	PF00928	0.540
TRG_ENDOCYTIC_2	84	87	PF00928	0.309
TRG_ER_diArg_1	169	172	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAJ2	Leptomonas seymouri	62%	100%
A0A0S4KI64	Bodo saltans	42%	92%
A0A1X0PAK0	Trypanosomatidae	41%	87%
A0A3S7X7J4	Leishmania donovani	93%	74%
A0A422MR74	Trypanosoma rangeli	42%	91%
A4HAH9	Leishmania braziliensis	79%	100%
A4IAN9	Leishmania infantum	93%	74%
C9ZN14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	73%
Q4Q3D7	Leishmania major	93%	100%
V5BJE2	Trypanosoma cruzi	39%	71%