MT domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellar attachment zone protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9B4N7_LEIMU

TriTrypDb:

LmxM.33.0680

Length:

1124

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B4N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4N7

Function

Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.541
CLV_C14_Caspase3-7	193	197	PF00656	0.504
CLV_C14_Caspase3-7	338	342	PF00656	0.716
CLV_C14_Caspase3-7	560	564	PF00656	0.664
CLV_C14_Caspase3-7	782	786	PF00656	0.680
CLV_C14_Caspase3-7	912	916	PF00656	0.466
CLV_C14_Caspase3-7	947	951	PF00656	0.411
CLV_NRD_NRD_1	19	21	PF00675	0.583
CLV_NRD_NRD_1	48	50	PF00675	0.467
CLV_NRD_NRD_1	91	93	PF00675	0.544
CLV_PCSK_FUR_1	323	327	PF00082	0.742
CLV_PCSK_FUR_1	459	463	PF00082	0.653
CLV_PCSK_FUR_1	545	549	PF00082	0.658
CLV_PCSK_FUR_1	681	685	PF00082	0.655
CLV_PCSK_FUR_1	767	771	PF00082	0.650
CLV_PCSK_KEX2_1	162	164	PF00082	0.578
CLV_PCSK_KEX2_1	19	21	PF00082	0.593
CLV_PCSK_KEX2_1	232	234	PF00082	0.624
CLV_PCSK_KEX2_1	325	327	PF00082	0.750
CLV_PCSK_KEX2_1	461	463	PF00082	0.554
CLV_PCSK_KEX2_1	547	549	PF00082	0.666
CLV_PCSK_KEX2_1	683	685	PF00082	0.649
CLV_PCSK_KEX2_1	769	771	PF00082	0.597
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.554
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.582
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.650
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.558
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.666
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.659
CLV_PCSK_PC1ET2_1	769	771	PF00082	0.657
CLV_PCSK_SKI1_1	1043	1047	PF00082	0.596
CLV_PCSK_SKI1_1	1098	1102	PF00082	0.583
CLV_PCSK_SKI1_1	184	188	PF00082	0.568
CLV_PCSK_SKI1_1	233	237	PF00082	0.616
CLV_PCSK_SKI1_1	286	290	PF00082	0.554
CLV_PCSK_SKI1_1	49	53	PF00082	0.547
CLV_PCSK_SKI1_1	930	934	PF00082	0.443
DEG_APCC_DBOX_1	11	19	PF00400	0.551
DEG_APCC_KENBOX_2	1036	1040	PF00400	0.586
DEG_MDM2_SWIB_1	1082	1089	PF02201	0.612
DEG_Nend_UBRbox_1	1	4	PF02207	0.427
DEG_SPOP_SBC_1	272	276	PF00917	0.576
DOC_MAPK_gen_1	35	42	PF00069	0.459
DOC_MAPK_gen_1	953	961	PF00069	0.575
DOC_MAPK_MEF2A_6	209	218	PF00069	0.671
DOC_MAPK_MEF2A_6	953	961	PF00069	0.425
DOC_PP1_RVXF_1	284	290	PF00149	0.555
DOC_USP7_MATH_1	109	113	PF00917	0.454
DOC_USP7_MATH_1	272	276	PF00917	0.526
DOC_USP7_MATH_1	351	355	PF00917	0.775
DOC_USP7_MATH_1	468	472	PF00917	0.568
DOC_USP7_MATH_1	573	577	PF00917	0.786
DOC_USP7_MATH_1	690	694	PF00917	0.571
DOC_USP7_MATH_1	795	799	PF00917	0.679
DOC_USP7_UBL2_3	125	129	PF12436	0.590
DOC_USP7_UBL2_3	35	39	PF12436	0.554
DOC_WW_Pin1_4	132	137	PF00397	0.453
DOC_WW_Pin1_4	220	225	PF00397	0.612
DOC_WW_Pin1_4	353	358	PF00397	0.761
DOC_WW_Pin1_4	55	60	PF00397	0.569
DOC_WW_Pin1_4	575	580	PF00397	0.790
DOC_WW_Pin1_4	797	802	PF00397	0.682
LIG_14-3-3_CanoR_1	209	213	PF00244	0.679
LIG_14-3-3_CanoR_1	25	33	PF00244	0.567
LIG_14-3-3_CanoR_1	252	259	PF00244	0.447
LIG_14-3-3_CanoR_1	277	287	PF00244	0.404
LIG_14-3-3_CanoR_1	311	317	PF00244	0.585
LIG_14-3-3_CanoR_1	371	381	PF00244	0.760
LIG_14-3-3_CanoR_1	469	473	PF00244	0.675
LIG_14-3-3_CanoR_1	49	57	PF00244	0.572
LIG_14-3-3_CanoR_1	593	603	PF00244	0.766
LIG_14-3-3_CanoR_1	691	695	PF00244	0.679
LIG_14-3-3_CanoR_1	815	825	PF00244	0.758
LIG_14-3-3_CanoR_1	92	100	PF00244	0.627
LIG_Actin_WH2_2	36	51	PF00022	0.558
LIG_BIR_III_4	341	345	PF00653	0.661
LIG_BIR_III_4	410	414	PF00653	0.657
LIG_BIR_III_4	563	567	PF00653	0.679
LIG_BIR_III_4	632	636	PF00653	0.635
LIG_BIR_III_4	785	789	PF00653	0.685
LIG_BIR_III_4	854	858	PF00653	0.697
LIG_FHA_1	101	107	PF00498	0.472
LIG_FHA_1	1062	1068	PF00498	0.676
LIG_FHA_1	1073	1079	PF00498	0.680
LIG_FHA_1	144	150	PF00498	0.435
LIG_FHA_1	208	214	PF00498	0.583
LIG_FHA_1	504	510	PF00498	0.739
LIG_FHA_1	726	732	PF00498	0.738
LIG_FHA_1	92	98	PF00498	0.536
LIG_FHA_1	956	962	PF00498	0.407
LIG_FHA_2	1008	1014	PF00498	0.585
LIG_FHA_2	235	241	PF00498	0.633
LIG_FHA_2	279	285	PF00498	0.550
LIG_FHA_2	400	406	PF00498	0.780
LIG_FHA_2	521	527	PF00498	0.699
LIG_FHA_2	622	628	PF00498	0.680
LIG_FHA_2	743	749	PF00498	0.626
LIG_FHA_2	75	81	PF00498	0.598
LIG_FHA_2	844	850	PF00498	0.714
LIG_LIR_Apic_2	1061	1066	PF02991	0.525
LIG_LIR_Gen_1	1058	1067	PF02991	0.664
LIG_LIR_Gen_1	1083	1094	PF02991	0.612
LIG_LIR_Gen_1	83	91	PF02991	0.446
LIG_LIR_Gen_1	985	994	PF02991	0.651
LIG_LIR_Nem_3	1058	1062	PF02991	0.658
LIG_LIR_Nem_3	1083	1089	PF02991	0.618
LIG_LIR_Nem_3	382	388	PF02991	0.695
LIG_LIR_Nem_3	604	610	PF02991	0.709
LIG_LIR_Nem_3	826	832	PF02991	0.710
LIG_LIR_Nem_3	83	87	PF02991	0.457
LIG_LIR_Nem_3	950	955	PF02991	0.565
LIG_LIR_Nem_3	985	990	PF02991	0.655
LIG_LYPXL_SIV_4	150	158	PF13949	0.524
LIG_LYPXL_SIV_4	951	959	PF13949	0.426
LIG_NRBOX	1041	1047	PF00104	0.596
LIG_PCNA_yPIPBox_3	1037	1046	PF02747	0.579
LIG_Pex14_2	1059	1063	PF04695	0.504
LIG_Pex14_2	1082	1086	PF04695	0.511
LIG_SH2_CRK	155	159	PF00017	0.557
LIG_SH2_CRK	952	956	PF00017	0.579
LIG_SH2_NCK_1	270	274	PF00017	0.621
LIG_SH2_SRC	385	388	PF00017	0.595
LIG_SH2_SRC	607	610	PF00017	0.608
LIG_SH2_SRC	829	832	PF00017	0.608
LIG_SH2_STAP1	279	283	PF00017	0.498
LIG_SH2_STAP1	399	403	PF00017	0.796
LIG_SH2_STAP1	621	625	PF00017	0.700
LIG_SH2_STAP1	843	847	PF00017	0.721
LIG_SH2_STAP1	987	991	PF00017	0.581
LIG_SH2_STAT5	253	256	PF00017	0.523
LIG_SH2_STAT5	520	523	PF00017	0.735
LIG_SH2_STAT5	742	745	PF00017	0.670
LIG_SH3_3	211	217	PF00018	0.560
LIG_SH3_3	218	224	PF00018	0.556
LIG_SH3_3	384	390	PF00018	0.687
LIG_SH3_3	505	511	PF00018	0.738
LIG_SH3_3	606	612	PF00018	0.603
LIG_SH3_3	727	733	PF00018	0.737
LIG_SH3_3	828	834	PF00018	0.600
LIG_SUMO_SIM_anti_2	38	45	PF11976	0.562
LIG_SUMO_SIM_par_1	957	965	PF11976	0.425
LIG_TRAF2_1	402	405	PF00917	0.674
LIG_TRAF2_1	523	526	PF00917	0.737
LIG_TRAF2_1	624	627	PF00917	0.715
LIG_TRAF2_1	745	748	PF00917	0.729
LIG_TRAF2_1	846	849	PF00917	0.705
LIG_WRC_WIRS_1	1059	1064	PF05994	0.658
LIG_WRC_WIRS_1	204	209	PF05994	0.682
MOD_CDK_SPxxK_3	353	360	PF00069	0.781
MOD_CDK_SPxxK_3	575	582	PF00069	0.792
MOD_CDK_SPxxK_3	797	804	PF00069	0.788
MOD_CK1_1	1061	1067	PF00069	0.612
MOD_CK1_1	112	118	PF00069	0.631
MOD_CK1_1	349	355	PF00069	0.802
MOD_CK1_1	571	577	PF00069	0.785
MOD_CK1_1	793	799	PF00069	0.821
MOD_CK2_1	1007	1013	PF00069	0.583
MOD_CK2_1	234	240	PF00069	0.698
MOD_CK2_1	278	284	PF00069	0.553
MOD_CK2_1	312	318	PF00069	0.611
MOD_CK2_1	399	405	PF00069	0.789
MOD_CK2_1	520	526	PF00069	0.723
MOD_CK2_1	621	627	PF00069	0.688
MOD_CK2_1	74	80	PF00069	0.585
MOD_CK2_1	742	748	PF00069	0.654
MOD_CK2_1	843	849	PF00069	0.718
MOD_GlcNHglycan	111	114	PF01048	0.607
MOD_GlcNHglycan	218	221	PF01048	0.663
MOD_GlcNHglycan	295	298	PF01048	0.574
MOD_GlcNHglycan	348	351	PF01048	0.658
MOD_GlcNHglycan	366	369	PF01048	0.808
MOD_GlcNHglycan	484	487	PF01048	0.744
MOD_GlcNHglycan	570	573	PF01048	0.776
MOD_GlcNHglycan	588	591	PF01048	0.714
MOD_GlcNHglycan	706	709	PF01048	0.741
MOD_GlcNHglycan	792	795	PF01048	0.771
MOD_GlcNHglycan	810	813	PF01048	0.748
MOD_GSK3_1	1072	1079	PF00069	0.638
MOD_GSK3_1	112	119	PF00069	0.594
MOD_GSK3_1	14	21	PF00069	0.561
MOD_GSK3_1	203	210	PF00069	0.541
MOD_GSK3_1	212	219	PF00069	0.613
MOD_GSK3_1	345	352	PF00069	0.668
MOD_GSK3_1	567	574	PF00069	0.819
MOD_GSK3_1	789	796	PF00069	0.773
MOD_N-GLC_2	1107	1109	PF02516	0.610
MOD_NEK2_1	207	212	PF00069	0.625
MOD_NEK2_1	259	264	PF00069	0.582
MOD_NEK2_1	312	317	PF00069	0.617
MOD_PIKK_1	251	257	PF00454	0.440
MOD_PIKK_1	372	378	PF00454	0.755
MOD_PIKK_1	594	600	PF00454	0.761
MOD_PIKK_1	816	822	PF00454	0.693
MOD_PK_1	14	20	PF00069	0.559
MOD_PKA_1	49	55	PF00069	0.572
MOD_PKA_2	1076	1082	PF00069	0.648
MOD_PKA_2	18	24	PF00069	0.569
MOD_PKA_2	208	214	PF00069	0.677
MOD_PKA_2	251	257	PF00069	0.498
MOD_PKA_2	370	376	PF00069	0.761
MOD_PKA_2	468	474	PF00069	0.675
MOD_PKA_2	592	598	PF00069	0.765
MOD_PKA_2	690	696	PF00069	0.613
MOD_PKA_2	814	820	PF00069	0.756
MOD_PKA_2	91	97	PF00069	0.620
MOD_Plk_1	1084	1090	PF00069	0.609
MOD_Plk_4	1058	1064	PF00069	0.569
MOD_Plk_4	208	214	PF00069	0.767
MOD_ProDKin_1	132	138	PF00069	0.444
MOD_ProDKin_1	220	226	PF00069	0.615
MOD_ProDKin_1	353	359	PF00069	0.763
MOD_ProDKin_1	55	61	PF00069	0.559
MOD_ProDKin_1	575	581	PF00069	0.790
MOD_ProDKin_1	797	803	PF00069	0.681
MOD_SUMO_for_1	188	191	PF00179	0.585
MOD_SUMO_for_1	437	440	PF00179	0.584
MOD_SUMO_for_1	450	453	PF00179	0.505
MOD_SUMO_for_1	659	662	PF00179	0.574
MOD_SUMO_for_1	672	675	PF00179	0.500
MOD_SUMO_for_1	881	884	PF00179	0.591
MOD_SUMO_for_1	932	935	PF00179	0.491
MOD_SUMO_rev_2	119	126	PF00179	0.599
MOD_SUMO_rev_2	242	251	PF00179	0.609
MOD_SUMO_rev_2	404	408	PF00179	0.666
MOD_SUMO_rev_2	626	630	PF00179	0.657
MOD_SUMO_rev_2	848	852	PF00179	0.708
TRG_DiLeu_BaEn_1	38	43	PF01217	0.555
TRG_DiLeu_BaEn_1	986	991	PF01217	0.511
TRG_DiLeu_BaEn_1	996	1001	PF01217	0.433
TRG_ENDOCYTIC_2	155	158	PF00928	0.552
TRG_ENDOCYTIC_2	385	388	PF00928	0.745
TRG_ENDOCYTIC_2	4	7	PF00928	0.560
TRG_ENDOCYTIC_2	607	610	PF00928	0.758
TRG_ENDOCYTIC_2	829	832	PF00928	0.758
TRG_ENDOCYTIC_2	952	955	PF00928	0.478
TRG_ENDOCYTIC_2	987	990	PF00928	0.582
TRG_ER_diArg_1	1090	1093	PF00400	0.686
TRG_ER_diArg_1	18	20	PF00400	0.608
TRG_NES_CRM1_1	421	435	PF08389	0.632
TRG_NES_CRM1_1	643	657	PF08389	0.621
TRG_NES_CRM1_1	865	879	PF08389	0.643
TRG_NES_CRM1_1	971	986	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	1043	1047	PF00026	0.596
TRG_PTS2	1	33	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HBI8	Leishmania braziliensis	27%	100%
A4I9N8	Leishmania infantum	85%	88%
Q4Q3D9	Leishmania major	92%	100%
Q585H6	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	29%	66%