Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B4N3_LEIMU

TriTrypDb:

LmxM.33.0640

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0016020	membrane	2	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

E9B4N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4N3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.388
CLV_C14_Caspase3-7	221	225	PF00656	0.331
CLV_C14_Caspase3-7	324	328	PF00656	0.374
CLV_C14_Caspase3-7	335	339	PF00656	0.344
CLV_C14_Caspase3-7	56	60	PF00656	0.462
CLV_NRD_NRD_1	125	127	PF00675	0.607
CLV_NRD_NRD_1	143	145	PF00675	0.572
CLV_NRD_NRD_1	581	583	PF00675	0.718
CLV_PCSK_KEX2_1	143	145	PF00082	0.622
CLV_PCSK_SKI1_1	19	23	PF00082	0.335
CLV_PCSK_SKI1_1	25	29	PF00082	0.295
DEG_APCC_DBOX_1	125	133	PF00400	0.338
DEG_APCC_DBOX_1	143	151	PF00400	0.338
DEG_APCC_DBOX_1	373	381	PF00400	0.318
DEG_APCC_DBOX_1	487	495	PF00400	0.329
DEG_APCC_DBOX_1	83	91	PF00400	0.380
DEG_SCF_FBW7_1	110	116	PF00400	0.381
DOC_CDC14_PxL_1	506	514	PF14671	0.328
DOC_CKS1_1	110	115	PF01111	0.371
DOC_CKS1_1	481	486	PF01111	0.346
DOC_CYCLIN_RxL_1	255	264	PF00134	0.348
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.324
DOC_MAPK_DCC_7	63	71	PF00069	0.414
DOC_MAPK_gen_1	126	134	PF00069	0.318
DOC_MAPK_gen_1	531	541	PF00069	0.332
DOC_MAPK_gen_1	63	71	PF00069	0.386
DOC_MAPK_MEF2A_6	177	186	PF00069	0.271
DOC_MAPK_MEF2A_6	19	28	PF00069	0.285
DOC_MAPK_MEF2A_6	436	444	PF00069	0.335
DOC_MAPK_MEF2A_6	534	543	PF00069	0.325
DOC_MAPK_MEF2A_6	63	71	PF00069	0.414
DOC_MAPK_NFAT4_5	25	33	PF00069	0.238
DOC_PP2B_LxvP_1	283	286	PF13499	0.312
DOC_USP7_MATH_1	12	16	PF00917	0.614
DOC_USP7_MATH_1	195	199	PF00917	0.347
DOC_USP7_MATH_1	218	222	PF00917	0.337
DOC_USP7_MATH_1	329	333	PF00917	0.387
DOC_WW_Pin1_4	109	114	PF00397	0.350
DOC_WW_Pin1_4	249	254	PF00397	0.541
DOC_WW_Pin1_4	269	274	PF00397	0.274
DOC_WW_Pin1_4	434	439	PF00397	0.391
DOC_WW_Pin1_4	480	485	PF00397	0.355
DOC_WW_Pin1_4	520	525	PF00397	0.354
LIG_14-3-3_CanoR_1	13	17	PF00244	0.622
LIG_14-3-3_CanoR_1	193	202	PF00244	0.302
LIG_14-3-3_CanoR_1	531	537	PF00244	0.348
LIG_14-3-3_CanoR_1	542	550	PF00244	0.313
LIG_Actin_WH2_2	175	191	PF00022	0.355
LIG_Actin_WH2_2	32	49	PF00022	0.546
LIG_APCC_ABBA_1	28	33	PF00400	0.316
LIG_BRCT_BRCA1_1	539	543	PF00533	0.319
LIG_Clathr_ClatBox_1	343	347	PF01394	0.362
LIG_FHA_1	174	180	PF00498	0.349
LIG_FHA_1	261	267	PF00498	0.344
LIG_FHA_1	313	319	PF00498	0.373
LIG_FHA_1	381	387	PF00498	0.324
LIG_FHA_1	435	441	PF00498	0.363
LIG_FHA_1	512	518	PF00498	0.326
LIG_FHA_1	536	542	PF00498	0.353
LIG_FHA_1	98	104	PF00498	0.324
LIG_FHA_2	225	231	PF00498	0.263
LIG_FHA_2	286	292	PF00498	0.300
LIG_FHA_2	46	52	PF00498	0.457
LIG_FHA_2	521	527	PF00498	0.353
LIG_GBD_Chelix_1	103	111	PF00786	0.532
LIG_LIR_Gen_1	545	554	PF02991	0.335
LIG_LIR_Gen_1	563	572	PF02991	0.337
LIG_LIR_Gen_1	73	82	PF02991	0.361
LIG_LIR_Nem_3	545	550	PF02991	0.333
LIG_LIR_Nem_3	563	567	PF02991	0.336
LIG_MYND_3	509	513	PF01753	0.327
LIG_NRBOX	279	285	PF00104	0.324
LIG_PCNA_PIPBox_1	24	33	PF02747	0.238
LIG_Pex14_2	543	547	PF04695	0.336
LIG_SH2_CRK	234	238	PF00017	0.327
LIG_SH2_STAP1	234	238	PF00017	0.452
LIG_SH2_STAP1	303	307	PF00017	0.339
LIG_SH2_STAP1	572	576	PF00017	0.364
LIG_SH2_STAT3	276	279	PF00017	0.326
LIG_SH2_STAT5	276	279	PF00017	0.326
LIG_SH2_STAT5	289	292	PF00017	0.278
LIG_SH2_STAT5	384	387	PF00017	0.334
LIG_SH2_STAT5	496	499	PF00017	0.350
LIG_SH2_STAT5	570	573	PF00017	0.335
LIG_SH3_1	320	326	PF00018	0.401
LIG_SH3_3	107	113	PF00018	0.356
LIG_SH3_3	244	250	PF00018	0.556
LIG_SH3_3	320	326	PF00018	0.401
LIG_SH3_3	39	45	PF00018	0.465
LIG_SH3_3	61	67	PF00018	0.450
LIG_SUMO_SIM_par_1	181	187	PF11976	0.424
LIG_SUMO_SIM_par_1	308	315	PF11976	0.356
LIG_SUMO_SIM_par_1	342	349	PF11976	0.383
LIG_SUMO_SIM_par_1	513	521	PF11976	0.337
LIG_SUMO_SIM_par_1	67	73	PF11976	0.408
LIG_WRC_WIRS_1	561	566	PF05994	0.389
MOD_CDK_SPxxK_3	434	441	PF00069	0.445
MOD_CK1_1	109	115	PF00069	0.428
MOD_CK1_1	332	338	PF00069	0.597
MOD_CK1_1	424	430	PF00069	0.600
MOD_CK1_1	452	458	PF00069	0.377
MOD_CK1_1	532	538	PF00069	0.559
MOD_CK1_1	8	14	PF00069	0.572
MOD_CK2_1	114	120	PF00069	0.574
MOD_CK2_1	166	172	PF00069	0.502
MOD_CK2_1	224	230	PF00069	0.331
MOD_CK2_1	45	51	PF00069	0.558
MOD_CK2_1	458	464	PF00069	0.411
MOD_CK2_1	520	526	PF00069	0.414
MOD_GlcNHglycan	172	176	PF01048	0.455
MOD_GlcNHglycan	197	200	PF01048	0.528
MOD_GlcNHglycan	224	227	PF01048	0.384
MOD_GlcNHglycan	241	244	PF01048	0.324
MOD_GlcNHglycan	263	266	PF01048	0.403
MOD_GlcNHglycan	306	310	PF01048	0.496
MOD_GlcNHglycan	424	427	PF01048	0.700
MOD_GlcNHglycan	429	432	PF01048	0.650
MOD_GlcNHglycan	453	457	PF01048	0.448
MOD_GlcNHglycan	469	472	PF01048	0.288
MOD_GlcNHglycan	53	56	PF01048	0.669
MOD_GlcNHglycan	72	75	PF01048	0.494
MOD_GSK3_1	109	116	PF00069	0.442
MOD_GSK3_1	156	163	PF00069	0.417
MOD_GSK3_1	189	196	PF00069	0.502
MOD_GSK3_1	218	225	PF00069	0.389
MOD_GSK3_1	249	256	PF00069	0.527
MOD_GSK3_1	305	312	PF00069	0.366
MOD_GSK3_1	329	336	PF00069	0.469
MOD_GSK3_1	421	428	PF00069	0.581
MOD_GSK3_1	516	523	PF00069	0.511
MOD_GSK3_1	8	15	PF00069	0.560
MOD_LATS_1	370	376	PF00433	0.387
MOD_N-GLC_1	403	408	PF02516	0.338
MOD_NEK2_1	182	187	PF00069	0.400
MOD_NEK2_1	260	265	PF00069	0.385
MOD_NEK2_1	31	36	PF00069	0.353
MOD_NEK2_1	380	385	PF00069	0.479
MOD_NEK2_1	386	391	PF00069	0.513
MOD_NEK2_1	403	408	PF00069	0.434
MOD_NEK2_1	421	426	PF00069	0.578
MOD_NEK2_1	492	497	PF00069	0.366
MOD_NEK2_1	530	535	PF00069	0.415
MOD_NEK2_1	90	95	PF00069	0.426
MOD_NEK2_2	166	171	PF00069	0.501
MOD_NEK2_2	253	258	PF00069	0.458
MOD_NEK2_2	309	314	PF00069	0.316
MOD_NEK2_2	387	392	PF00069	0.380
MOD_PIKK_1	135	141	PF00454	0.407
MOD_PIKK_1	241	247	PF00454	0.437
MOD_PIKK_1	403	409	PF00454	0.379
MOD_PIKK_1	58	64	PF00454	0.550
MOD_PKA_2	12	18	PF00069	0.560
MOD_PKA_2	46	52	PF00069	0.714
MOD_PKA_2	5	11	PF00069	0.718
MOD_PKA_2	530	536	PF00069	0.406
MOD_PKA_2	97	103	PF00069	0.375
MOD_Plk_1	166	172	PF00069	0.502
MOD_Plk_1	305	311	PF00069	0.404
MOD_Plk_1	380	386	PF00069	0.364
MOD_Plk_1	492	498	PF00069	0.376
MOD_Plk_2-3	224	230	PF00069	0.331
MOD_Plk_4	106	112	PF00069	0.398
MOD_Plk_4	12	18	PF00069	0.445
MOD_Plk_4	211	217	PF00069	0.394
MOD_Plk_4	309	315	PF00069	0.322
MOD_Plk_4	31	37	PF00069	0.299
MOD_Plk_4	511	517	PF00069	0.384
MOD_ProDKin_1	109	115	PF00069	0.428
MOD_ProDKin_1	249	255	PF00069	0.661
MOD_ProDKin_1	269	275	PF00069	0.302
MOD_ProDKin_1	434	440	PF00069	0.452
MOD_ProDKin_1	480	486	PF00069	0.409
MOD_ProDKin_1	520	526	PF00069	0.414
MOD_SUMO_rev_2	521	530	PF00179	0.419
TRG_ENDOCYTIC_2	234	237	PF00928	0.550
TRG_ENDOCYTIC_2	572	575	PF00928	0.412
TRG_ER_diArg_1	63	66	PF00400	0.595
TRG_ER_diLys_1	583	586	PF00400	0.551
TRG_NES_CRM1_1	485	498	PF08389	0.389
TRG_NES_CRM1_1	508	521	PF08389	0.389
TRG_NLS_MonoCore_2	581	586	PF00514	0.425
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7I2	Leishmania donovani	90%	100%
Q4Q3E3	Leishmania major	90%	100%