Myosin_tail_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4N2_LEIMU

TriTrypDb:

LmxM.33.0630

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	630	634	PF00656	0.527
CLV_NRD_NRD_1	140	142	PF00675	0.339
CLV_NRD_NRD_1	273	275	PF00675	0.678
CLV_NRD_NRD_1	285	287	PF00675	0.611
CLV_NRD_NRD_1	392	394	PF00675	0.610
CLV_NRD_NRD_1	463	465	PF00675	0.699
CLV_NRD_NRD_1	531	533	PF00675	0.489
CLV_NRD_NRD_1	585	587	PF00675	0.691
CLV_NRD_NRD_1	759	761	PF00675	0.599
CLV_NRD_NRD_1	77	79	PF00675	0.474
CLV_NRD_NRD_1	83	85	PF00675	0.498
CLV_PCSK_FUR_1	364	368	PF00082	0.621
CLV_PCSK_FUR_1	461	465	PF00082	0.493
CLV_PCSK_FUR_1	529	533	PF00082	0.562
CLV_PCSK_KEX2_1	140	142	PF00082	0.339
CLV_PCSK_KEX2_1	273	275	PF00082	0.678
CLV_PCSK_KEX2_1	284	286	PF00082	0.619
CLV_PCSK_KEX2_1	366	368	PF00082	0.526
CLV_PCSK_KEX2_1	463	465	PF00082	0.764
CLV_PCSK_KEX2_1	531	533	PF00082	0.487
CLV_PCSK_KEX2_1	759	761	PF00082	0.667
CLV_PCSK_KEX2_1	77	79	PF00082	0.517
CLV_PCSK_KEX2_1	83	85	PF00082	0.508
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.612
CLV_PCSK_SKI1_1	131	135	PF00082	0.505
CLV_PCSK_SKI1_1	201	205	PF00082	0.554
CLV_PCSK_SKI1_1	366	370	PF00082	0.556
CLV_PCSK_SKI1_1	387	391	PF00082	0.632
CLV_PCSK_SKI1_1	464	468	PF00082	0.704
CLV_PCSK_SKI1_1	471	475	PF00082	0.685
CLV_PCSK_SKI1_1	60	64	PF00082	0.560
CLV_PCSK_SKI1_1	709	713	PF00082	0.633
CLV_PCSK_SKI1_1	760	764	PF00082	0.521
CLV_Separin_Metazoa	552	556	PF03568	0.540
CLV_Separin_Metazoa	563	567	PF03568	0.574
DEG_APCC_DBOX_1	366	374	PF00400	0.596
DEG_APCC_DBOX_1	613	621	PF00400	0.502
DEG_Nend_UBRbox_3	1	3	PF02207	0.668
DEG_SPOP_SBC_1	683	687	PF00917	0.603
DOC_CDC14_PxL_1	228	236	PF14671	0.553
DOC_CYCLIN_RxL_1	175	188	PF00134	0.544
DOC_CYCLIN_RxL_1	198	208	PF00134	0.562
DOC_CYCLIN_RxL_1	218	230	PF00134	0.330
DOC_CYCLIN_RxL_1	364	375	PF00134	0.603
DOC_CYCLIN_RxL_1	706	714	PF00134	0.471
DOC_MAPK_gen_1	364	373	PF00069	0.551
DOC_MAPK_gen_1	438	447	PF00069	0.590
DOC_MAPK_gen_1	529	538	PF00069	0.566
DOC_MAPK_gen_1	57	65	PF00069	0.509
DOC_MAPK_MEF2A_6	529	538	PF00069	0.579
DOC_MAPK_MEF2A_6	57	65	PF00069	0.550
DOC_MIT_MIM_1	703	711	PF04212	0.576
DOC_PP4_FxxP_1	298	301	PF00568	0.706
DOC_USP7_MATH_1	301	305	PF00917	0.689
DOC_USP7_MATH_1	421	425	PF00917	0.576
DOC_USP7_MATH_1	462	466	PF00917	0.708
DOC_USP7_MATH_1	504	508	PF00917	0.448
DOC_USP7_MATH_1	589	593	PF00917	0.597
DOC_USP7_MATH_1	601	605	PF00917	0.625
DOC_USP7_MATH_1	683	687	PF00917	0.603
DOC_USP7_MATH_1	738	742	PF00917	0.632
DOC_USP7_MATH_1	79	83	PF00917	0.646
DOC_USP7_MATH_2	506	512	PF00917	0.630
DOC_USP7_UBL2_3	159	163	PF12436	0.544
DOC_USP7_UBL2_3	411	415	PF12436	0.562
DOC_WW_Pin1_4	267	272	PF00397	0.733
DOC_WW_Pin1_4	278	283	PF00397	0.717
DOC_WW_Pin1_4	424	429	PF00397	0.550
DOC_WW_Pin1_4	500	505	PF00397	0.562
LIG_14-3-3_CanoR_1	119	125	PF00244	0.586
LIG_14-3-3_CanoR_1	152	158	PF00244	0.520
LIG_14-3-3_CanoR_1	190	198	PF00244	0.513
LIG_14-3-3_CanoR_1	218	222	PF00244	0.511
LIG_14-3-3_CanoR_1	226	234	PF00244	0.517
LIG_14-3-3_CanoR_1	264	270	PF00244	0.726
LIG_14-3-3_CanoR_1	461	467	PF00244	0.595
LIG_14-3-3_CanoR_1	535	544	PF00244	0.530
LIG_14-3-3_CanoR_1	638	643	PF00244	0.536
LIG_Actin_WH2_2	755	772	PF00022	0.579
LIG_APCC_ABBA_1	547	552	PF00400	0.538
LIG_BRCT_BRCA1_1	243	247	PF00533	0.602
LIG_BRCT_BRCA1_1	506	510	PF00533	0.420
LIG_CaM_IQ_9	147	162	PF13499	0.544
LIG_CaM_IQ_9	701	717	PF13499	0.594
LIG_Clathr_ClatBox_1	182	186	PF01394	0.510
LIG_Clathr_ClatBox_1	370	374	PF01394	0.585
LIG_Clathr_ClatBox_1	62	66	PF01394	0.535
LIG_FAT_LD_1	65	73	PF03623	0.542
LIG_FHA_1	264	270	PF00498	0.667
LIG_FHA_1	699	705	PF00498	0.733
LIG_FHA_1	764	770	PF00498	0.563
LIG_FHA_2	203	209	PF00498	0.506
LIG_FHA_2	231	237	PF00498	0.529
LIG_FHA_2	322	328	PF00498	0.592
LIG_FHA_2	558	564	PF00498	0.567
LIG_HCF-1_HBM_1	396	399	PF13415	0.593
LIG_Integrin_isoDGR_2	345	347	PF01839	0.614
LIG_LIR_Apic_2	295	301	PF02991	0.702
LIG_LIR_Apic_2	396	402	PF02991	0.489
LIG_LIR_Gen_1	244	253	PF02991	0.589
LIG_LIR_Gen_1	359	370	PF02991	0.611
LIG_LIR_Gen_1	641	650	PF02991	0.565
LIG_LIR_LC3C_4	24	28	PF02991	0.570
LIG_LIR_Nem_3	244	250	PF02991	0.545
LIG_LIR_Nem_3	328	334	PF02991	0.667
LIG_LIR_Nem_3	359	365	PF02991	0.613
LIG_LIR_Nem_3	424	429	PF02991	0.492
LIG_LIR_Nem_3	641	646	PF02991	0.565
LIG_LYPXL_yS_3	417	420	PF13949	0.569
LIG_NRBOX	707	713	PF00104	0.585
LIG_PCNA_yPIPBox_3	702	712	PF02747	0.430
LIG_PTB_Apo_2	411	418	PF02174	0.484
LIG_PTB_Phospho_1	411	417	PF10480	0.575
LIG_Rb_pABgroove_1	544	552	PF01858	0.542
LIG_SH2_CRK	331	335	PF00017	0.668
LIG_SH2_CRK	453	457	PF00017	0.614
LIG_SH2_GRB2like	572	575	PF00017	0.398
LIG_SH2_NCK_1	453	457	PF00017	0.614
LIG_SH2_NCK_1	572	576	PF00017	0.498
LIG_SH2_SRC	572	575	PF00017	0.398
LIG_SH2_SRC	783	786	PF00017	0.475
LIG_SH2_STAP1	143	147	PF00017	0.471
LIG_SH2_STAP1	403	407	PF00017	0.581
LIG_SH2_STAP1	550	554	PF00017	0.428
LIG_SH2_STAT5	237	240	PF00017	0.506
LIG_SH2_STAT5	256	259	PF00017	0.696
LIG_SH3_1	415	421	PF00018	0.597
LIG_SH3_3	415	421	PF00018	0.597
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.613
LIG_SUMO_SIM_par_1	181	186	PF11976	0.510
LIG_SUMO_SIM_par_1	351	357	PF11976	0.555
LIG_SUMO_SIM_par_1	369	375	PF11976	0.591
LIG_TRAF2_1	124	127	PF00917	0.500
LIG_TRAF2_1	514	517	PF00917	0.597
LIG_TRAF2_1	85	88	PF00917	0.560
LIG_UBA3_1	32	37	PF00899	0.549
LIG_UBA3_1	430	435	PF00899	0.548
MOD_CDC14_SPxK_1	270	273	PF00782	0.748
MOD_CDC14_SPxK_1	281	284	PF00782	0.717
MOD_CDK_SPK_2	500	505	PF00069	0.461
MOD_CDK_SPxK_1	267	273	PF00069	0.749
MOD_CDK_SPxK_1	278	284	PF00069	0.726
MOD_CDK_SPxxK_3	267	274	PF00069	0.717
MOD_CDK_SPxxK_3	278	285	PF00069	0.700
MOD_CK1_1	194	200	PF00069	0.528
MOD_CK1_1	267	273	PF00069	0.788
MOD_CK1_1	304	310	PF00069	0.713
MOD_CK1_1	317	323	PF00069	0.471
MOD_CK1_1	354	360	PF00069	0.689
MOD_CK1_1	424	430	PF00069	0.493
MOD_CK1_1	489	495	PF00069	0.692
MOD_CK1_1	496	502	PF00069	0.634
MOD_CK1_1	634	640	PF00069	0.500
MOD_CK1_1	641	647	PF00069	0.514
MOD_CK1_1	674	680	PF00069	0.725
MOD_CK1_1	681	687	PF00069	0.719
MOD_CK1_1	96	102	PF00069	0.355
MOD_CK2_1	163	169	PF00069	0.481
MOD_CK2_1	202	208	PF00069	0.507
MOD_CK2_1	321	327	PF00069	0.674
MOD_CK2_1	557	563	PF00069	0.562
MOD_CK2_1	578	584	PF00069	0.713
MOD_CK2_1	697	703	PF00069	0.753
MOD_GlcNHglycan	186	190	PF01048	0.549
MOD_GlcNHglycan	307	310	PF01048	0.698
MOD_GlcNHglycan	316	319	PF01048	0.661
MOD_GlcNHglycan	356	359	PF01048	0.551
MOD_GlcNHglycan	384	387	PF01048	0.589
MOD_GlcNHglycan	488	491	PF01048	0.727
MOD_GlcNHglycan	591	594	PF01048	0.580
MOD_GlcNHglycan	603	606	PF01048	0.492
MOD_GlcNHglycan	678	681	PF01048	0.728
MOD_GlcNHglycan	690	693	PF01048	0.735
MOD_GSK3_1	226	233	PF00069	0.470
MOD_GSK3_1	263	270	PF00069	0.679
MOD_GSK3_1	274	281	PF00069	0.733
MOD_GSK3_1	301	308	PF00069	0.770
MOD_GSK3_1	317	324	PF00069	0.625
MOD_GSK3_1	471	478	PF00069	0.702
MOD_GSK3_1	485	492	PF00069	0.619
MOD_GSK3_1	496	503	PF00069	0.603
MOD_GSK3_1	504	511	PF00069	0.535
MOD_GSK3_1	634	641	PF00069	0.530
MOD_GSK3_1	661	668	PF00069	0.702
MOD_GSK3_1	670	677	PF00069	0.763
MOD_GSK3_1	678	685	PF00069	0.807
MOD_GSK3_1	688	695	PF00069	0.781
MOD_N-GLC_1	314	319	PF02516	0.685
MOD_N-GLC_1	360	365	PF02516	0.601
MOD_N-GLC_1	573	578	PF02516	0.421
MOD_N-GLC_1	692	697	PF02516	0.492
MOD_NEK2_1	136	141	PF00069	0.573
MOD_NEK2_1	150	155	PF00069	0.587
MOD_NEK2_1	185	190	PF00069	0.536
MOD_NEK2_1	257	262	PF00069	0.718
MOD_NEK2_1	536	541	PF00069	0.571
MOD_NEK2_1	747	752	PF00069	0.577
MOD_OFUCOSY	619	625	PF10250	0.523
MOD_PIKK_1	161	167	PF00454	0.560
MOD_PIKK_1	537	543	PF00454	0.560
MOD_PKA_2	118	124	PF00069	0.585
MOD_PKA_2	191	197	PF00069	0.480
MOD_PKA_2	217	223	PF00069	0.570
MOD_PKA_2	263	269	PF00069	0.683
MOD_PKA_2	272	278	PF00069	0.638
MOD_PKA_2	462	468	PF00069	0.697
MOD_PKA_2	496	502	PF00069	0.693
MOD_PKA_2	578	584	PF00069	0.684
MOD_PKA_2	93	99	PF00069	0.559
MOD_PKB_1	190	198	PF00069	0.552
MOD_PKB_1	262	270	PF00069	0.722
MOD_Plk_1	294	300	PF00069	0.704
MOD_Plk_1	360	366	PF00069	0.614
MOD_Plk_2-3	202	208	PF00069	0.463
MOD_Plk_2-3	230	236	PF00069	0.474
MOD_Plk_2-3	294	300	PF00069	0.704
MOD_Plk_4	638	644	PF00069	0.565
MOD_Plk_4	694	700	PF00069	0.685
MOD_Plk_4	747	753	PF00069	0.558
MOD_ProDKin_1	267	273	PF00069	0.735
MOD_ProDKin_1	278	284	PF00069	0.717
MOD_ProDKin_1	424	430	PF00069	0.544
MOD_ProDKin_1	500	506	PF00069	0.556
MOD_SUMO_for_1	36	39	PF00179	0.554
MOD_SUMO_rev_2	138	147	PF00179	0.533
MOD_SUMO_rev_2	5	12	PF00179	0.557
MOD_SUMO_rev_2	53	62	PF00179	0.553
MOD_SUMO_rev_2	581	589	PF00179	0.682
TRG_DiLeu_BaEn_1	58	63	PF01217	0.551
TRG_DiLeu_BaEn_4	374	380	PF01217	0.583
TRG_DiLeu_BaEn_4	38	44	PF01217	0.560
TRG_DiLeu_BaEn_4	58	64	PF01217	0.552
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.334
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.478
TRG_DiLeu_BaLyEn_6	613	618	PF01217	0.530
TRG_ENDOCYTIC_2	331	334	PF00928	0.672
TRG_ENDOCYTIC_2	403	406	PF00928	0.493
TRG_ENDOCYTIC_2	417	420	PF00928	0.510
TRG_ENDOCYTIC_2	550	553	PF00928	0.435
TRG_ENDOCYTIC_2	643	646	PF00928	0.569
TRG_ER_diArg_1	190	193	PF00400	0.513
TRG_ER_diArg_1	284	286	PF00400	0.619
TRG_ER_diArg_1	444	447	PF00400	0.568
TRG_ER_diArg_1	461	464	PF00400	0.616
TRG_ER_diArg_1	529	532	PF00400	0.486
TRG_ER_diArg_1	758	760	PF00400	0.666
TRG_NLS_MonoExtN_4	364	370	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	709	714	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M8	Leptomonas seymouri	56%	76%
A0A3Q8IHX7	Leishmania donovani	94%	100%
A0A422N4B9	Trypanosoma rangeli	28%	89%
A4HAH3	Leishmania braziliensis	83%	99%
A4I9N3	Leishmania infantum	94%	100%
D0A1Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q3E4	Leishmania major	92%	99%