LeishMANIAdb
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Mitochondrial ATPase inhibitor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial ATPase inhibitor
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B4M7_LEIMU
TriTrypDb:
LmxM.33.0580
Length:
122

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4M7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4M7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 86 90 PF00656 0.496
CLV_NRD_NRD_1 11 13 PF00675 0.637
CLV_PCSK_KEX2_1 11 13 PF00082 0.605
CLV_PCSK_KEX2_1 77 79 PF00082 0.495
CLV_PCSK_KEX2_1 95 97 PF00082 0.595
CLV_PCSK_PC1ET2_1 77 79 PF00082 0.489
CLV_PCSK_PC1ET2_1 95 97 PF00082 0.595
CLV_PCSK_SKI1_1 37 41 PF00082 0.587
DEG_Nend_UBRbox_3 1 3 PF02207 0.598
DOC_CKS1_1 60 65 PF01111 0.542
DOC_USP7_MATH_1 14 18 PF00917 0.652
DOC_USP7_MATH_1 5 9 PF00917 0.603
DOC_USP7_UBL2_3 37 41 PF12436 0.587
DOC_USP7_UBL2_3 84 88 PF12436 0.489
DOC_WW_Pin1_4 59 64 PF00397 0.504
LIG_14-3-3_CanoR_1 29 35 PF00244 0.544
LIG_FHA_2 60 66 PF00498 0.530
LIG_SH2_GRB2like 34 37 PF00017 0.615
LIG_SH2_SRC 67 70 PF00017 0.504
LIG_SH2_STAT5 34 37 PF00017 0.615
LIG_TRAF2_1 62 65 PF00917 0.491
MOD_CDK_SPxxK_3 59 66 PF00069 0.496
MOD_CK1_1 17 23 PF00069 0.654
MOD_CK2_1 58 64 PF00069 0.487
MOD_GlcNHglycan 19 22 PF01048 0.644
MOD_N-GLC_1 117 122 PF02516 0.355
MOD_N-GLC_1 58 63 PF02516 0.620
MOD_PIKK_1 78 84 PF00454 0.495
MOD_PKA_2 28 34 PF00069 0.627
MOD_Plk_4 14 20 PF00069 0.547
MOD_Plk_4 5 11 PF00069 0.552
MOD_ProDKin_1 59 65 PF00069 0.500
MOD_SUMO_for_1 105 108 PF00179 0.501
MOD_SUMO_for_1 83 86 PF00179 0.502
TRG_DiLeu_BaEn_4 107 113 PF01217 0.313
TRG_ER_diArg_1 10 12 PF00400 0.640
TRG_Pf-PMV_PEXEL_1 50 55 PF00026 0.487

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HXR7 Leptomonas seymouri 60% 97%
A0A1X0P8N6 Trypanosomatidae 39% 100%
A0A3Q8IUE6 Leishmania donovani 89% 100%
A0A3R7KP65 Trypanosoma rangeli 34% 100%
A4HAG8 Leishmania braziliensis 82% 100%
A4I9M8 Leishmania infantum 89% 100%
D0A1Z3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
Q4Q3E9 Leishmania major 90% 100%
V5DIQ6 Trypanosoma cruzi 33% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS