Translation factor GUF1 homolog, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translation factor GUF1, mitochondrial, putative

Species:

Leishmania mexicana

UniProt:

E9B4M6_LEIMU

TriTrypDb:

LmxM.33.0570

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005743	mitochondrial inner membrane	5	11
GO:0005759	mitochondrial matrix	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1

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Expansion

Sequence features

E9B4M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4M6

Function

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Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006417	regulation of translation	6	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0009891	positive regulation of biosynthetic process	5	11
GO:0009893	positive regulation of metabolic process	4	11

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.462
CLV_C14_Caspase3-7	259	263	PF00656	0.476
CLV_C14_Caspase3-7	73	77	PF00656	0.524
CLV_NRD_NRD_1	334	336	PF00675	0.615
CLV_NRD_NRD_1	607	609	PF00675	0.604
CLV_NRD_NRD_1	64	66	PF00675	0.654
CLV_NRD_NRD_1	7	9	PF00675	0.562
CLV_NRD_NRD_1	738	740	PF00675	0.354
CLV_NRD_NRD_1	774	776	PF00675	0.313
CLV_NRD_NRD_1	788	790	PF00675	0.297

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ1	Leptomonas seymouri	75%	99%
A0A1X0P8W8	Trypanosomatidae	60%	100%
A0A3Q8IH98	Leishmania donovani	93%	99%
A0A3R7K0R2	Trypanosoma rangeli	60%	100%
A0AIS8	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	34%	100%
A0JX50	Arthrobacter sp. (strain FB24)	34%	100%
A0K5V7	Burkholderia cenocepacia (strain HI2424)	34%	100%
A0KZN4	Shewanella sp. (strain ANA-3)	34%	100%
A0L631	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	36%	100%
A0LI00	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	33%	100%

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