Putative cysteine-leucine rich protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cysteine leucine rich protein

Species:

Leishmania mexicana

UniProt:

E9B4M4_LEIMU

TriTrypDb:

LmxM.33.0550

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9B4M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4M4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	542	546	PF00656	0.281
CLV_NRD_NRD_1	575	577	PF00675	0.489
CLV_PCSK_KEX2_1	504	506	PF00082	0.389
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.389
CLV_PCSK_SKI1_1	28	32	PF00082	0.588
CLV_PCSK_SKI1_1	289	293	PF00082	0.397
CLV_PCSK_SKI1_1	504	508	PF00082	0.387
CLV_PCSK_SKI1_1	555	559	PF00082	0.360
DEG_COP1_1	542	553	PF00400	0.282
DEG_ODPH_VHL_1	294	305	PF01847	0.256
DEG_SPOP_SBC_1	145	149	PF00917	0.565
DEG_SPOP_SBC_1	215	219	PF00917	0.564
DOC_CDC14_PxL_1	547	555	PF14671	0.388
DOC_CYCLIN_RxL_1	436	444	PF00134	0.383
DOC_CYCLIN_RxL_1	504	514	PF00134	0.266
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.518
DOC_MAPK_gen_1	504	511	PF00069	0.374
DOC_MAPK_gen_1	576	584	PF00069	0.411
DOC_MAPK_MEF2A_6	523	532	PF00069	0.344
DOC_PP1_RVXF_1	462	469	PF00149	0.445
DOC_PP2B_LxvP_1	470	473	PF13499	0.474
DOC_PP4_FxxP_1	102	105	PF00568	0.582
DOC_PP4_FxxP_1	233	236	PF00568	0.619
DOC_USP7_MATH_1	144	148	PF00917	0.625
DOC_USP7_MATH_1	215	219	PF00917	0.589
DOC_USP7_MATH_1	248	252	PF00917	0.669
DOC_USP7_MATH_1	263	267	PF00917	0.355
DOC_USP7_MATH_1	382	386	PF00917	0.338
DOC_USP7_MATH_1	478	482	PF00917	0.414
DOC_USP7_MATH_1	585	589	PF00917	0.567
DOC_USP7_MATH_1	81	85	PF00917	0.665
DOC_WW_Pin1_4	147	152	PF00397	0.614
DOC_WW_Pin1_4	167	172	PF00397	0.587
DOC_WW_Pin1_4	205	210	PF00397	0.557
DOC_WW_Pin1_4	309	314	PF00397	0.446
DOC_WW_Pin1_4	600	605	PF00397	0.592
DOC_WW_Pin1_4	613	618	PF00397	0.579
LIG_14-3-3_CanoR_1	321	330	PF00244	0.377
LIG_14-3-3_CanoR_1	340	347	PF00244	0.287
LIG_14-3-3_CanoR_1	407	414	PF00244	0.397
LIG_14-3-3_CanoR_1	505	510	PF00244	0.368
LIG_14-3-3_CanoR_1	523	530	PF00244	0.382
LIG_Actin_WH2_2	496	512	PF00022	0.271
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BIR_III_1	1	5	PF00653	0.667
LIG_BIR_III_3	1	5	PF00653	0.667
LIG_BRCT_BRCA1_1	350	354	PF00533	0.365
LIG_FHA_1	157	163	PF00498	0.671
LIG_FHA_1	170	176	PF00498	0.511
LIG_FHA_1	363	369	PF00498	0.473
LIG_FHA_1	428	434	PF00498	0.363
LIG_FHA_1	506	512	PF00498	0.361
LIG_FHA_1	552	558	PF00498	0.487
LIG_FHA_1	578	584	PF00498	0.363
LIG_FHA_1	81	87	PF00498	0.641
LIG_FHA_2	147	153	PF00498	0.676
LIG_FHA_2	515	521	PF00498	0.474
LIG_FHA_2	540	546	PF00498	0.382
LIG_FHA_2	576	582	PF00498	0.440
LIG_LIR_Apic_2	76	80	PF02991	0.486
LIG_LIR_Gen_1	476	487	PF02991	0.329
LIG_LIR_Gen_1	596	604	PF02991	0.563
LIG_LIR_Nem_3	176	181	PF02991	0.659
LIG_LIR_Nem_3	476	482	PF02991	0.345
LIG_LIR_Nem_3	67	72	PF02991	0.588
LIG_LYPXL_yS_3	72	75	PF13949	0.590
LIG_NRBOX	465	471	PF00104	0.446
LIG_Rb_pABgroove_1	348	356	PF01858	0.361
LIG_SH2_CRK	103	107	PF00017	0.625
LIG_SH2_CRK	77	81	PF00017	0.476
LIG_SH2_SRC	103	106	PF00017	0.624
LIG_SH2_STAP1	408	412	PF00017	0.366
LIG_SH2_STAT3	101	104	PF00017	0.676
LIG_SH2_STAT5	101	104	PF00017	0.627
LIG_SH2_STAT5	405	408	PF00017	0.353
LIG_SH3_1	103	109	PF00018	0.674
LIG_SH3_1	607	613	PF00018	0.660
LIG_SH3_3	103	109	PF00018	0.659
LIG_SH3_3	165	171	PF00018	0.612
LIG_SH3_3	190	196	PF00018	0.728
LIG_SH3_3	607	613	PF00018	0.660
LIG_SUMO_SIM_par_1	483	488	PF11976	0.346
LIG_UBA3_1	469	477	PF00899	0.341
MOD_CDK_SPxxK_3	600	607	PF00069	0.604
MOD_CK1_1	122	128	PF00069	0.522
MOD_CK1_1	147	153	PF00069	0.567
MOD_CK1_1	170	176	PF00069	0.581
MOD_CK1_1	205	211	PF00069	0.632
MOD_CK1_1	217	223	PF00069	0.570
MOD_CK1_1	376	382	PF00069	0.339
MOD_CK1_1	492	498	PF00069	0.392
MOD_CK1_1	522	528	PF00069	0.422
MOD_CK1_1	543	549	PF00069	0.276
MOD_CK1_1	611	617	PF00069	0.639
MOD_CK1_1	84	90	PF00069	0.651
MOD_CK2_1	146	152	PF00069	0.673
MOD_CK2_1	263	269	PF00069	0.440
MOD_CK2_1	514	520	PF00069	0.438
MOD_CK2_1	575	581	PF00069	0.436
MOD_GlcNHglycan	172	175	PF01048	0.660
MOD_GlcNHglycan	22	25	PF01048	0.535
MOD_GlcNHglycan	316	320	PF01048	0.313
MOD_GlcNHglycan	358	361	PF01048	0.350
MOD_GlcNHglycan	524	527	PF01048	0.370
MOD_GlcNHglycan	56	59	PF01048	0.527
MOD_GlcNHglycan	595	598	PF01048	0.776
MOD_GlcNHglycan	89	92	PF01048	0.562
MOD_GSK3_1	169	176	PF00069	0.614
MOD_GSK3_1	216	223	PF00069	0.578
MOD_GSK3_1	253	260	PF00069	0.460
MOD_GSK3_1	271	278	PF00069	0.287
MOD_GSK3_1	339	346	PF00069	0.379
MOD_GSK3_1	358	365	PF00069	0.369
MOD_GSK3_1	369	376	PF00069	0.380
MOD_GSK3_1	387	394	PF00069	0.358
MOD_GSK3_1	505	512	PF00069	0.365
MOD_GSK3_1	539	546	PF00069	0.407
MOD_GSK3_1	598	605	PF00069	0.589
MOD_GSK3_1	608	615	PF00069	0.662
MOD_GSK3_1	80	87	PF00069	0.547
MOD_N-GLC_1	185	190	PF02516	0.492
MOD_N-GLC_1	248	253	PF02516	0.619
MOD_N-GLC_1	356	361	PF02516	0.338
MOD_N-GLC_1	396	401	PF02516	0.487
MOD_N-GLC_1	473	478	PF02516	0.301
MOD_N-GLC_1	84	89	PF02516	0.689
MOD_N-GLC_2	334	336	PF02516	0.429
MOD_N-GLC_2	384	386	PF02516	0.343
MOD_NEK2_1	253	258	PF00069	0.482
MOD_NEK2_1	271	276	PF00069	0.402
MOD_NEK2_1	322	327	PF00069	0.369
MOD_NEK2_1	356	361	PF00069	0.338
MOD_NEK2_1	362	367	PF00069	0.358
MOD_NEK2_1	441	446	PF00069	0.473
MOD_NEK2_1	498	503	PF00069	0.502
MOD_NEK2_1	509	514	PF00069	0.366
MOD_NEK2_1	575	580	PF00069	0.436
MOD_PIKK_1	373	379	PF00454	0.319
MOD_PIKK_1	458	464	PF00454	0.370
MOD_PIKK_1	84	90	PF00454	0.612
MOD_PIKK_1	91	97	PF00454	0.575
MOD_PKA_2	328	334	PF00069	0.360
MOD_PKA_2	339	345	PF00069	0.366
MOD_PKA_2	406	412	PF00069	0.358
MOD_PKA_2	509	515	PF00069	0.363
MOD_PKA_2	522	528	PF00069	0.395
MOD_PKA_2	575	581	PF00069	0.436
MOD_Plk_1	202	208	PF00069	0.584
MOD_Plk_1	315	321	PF00069	0.312
MOD_Plk_1	390	396	PF00069	0.360
MOD_Plk_1	458	464	PF00069	0.352
MOD_Plk_1	519	525	PF00069	0.416
MOD_Plk_1	84	90	PF00069	0.579
MOD_Plk_4	158	164	PF00069	0.665
MOD_Plk_4	348	354	PF00069	0.368
MOD_Plk_4	358	364	PF00069	0.344
MOD_Plk_4	528	534	PF00069	0.325
MOD_ProDKin_1	147	153	PF00069	0.616
MOD_ProDKin_1	167	173	PF00069	0.585
MOD_ProDKin_1	205	211	PF00069	0.558
MOD_ProDKin_1	309	315	PF00069	0.440
MOD_ProDKin_1	600	606	PF00069	0.584
MOD_ProDKin_1	613	619	PF00069	0.581
MOD_SUMO_rev_2	120	125	PF00179	0.720
MOD_SUMO_rev_2	394	404	PF00179	0.356
MOD_SUMO_rev_2	565	569	PF00179	0.426
TRG_ENDOCYTIC_2	599	602	PF00928	0.564
TRG_ENDOCYTIC_2	72	75	PF00928	0.590
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N0	Leptomonas seymouri	63%	100%
A0A3S7X7J0	Leishmania donovani	92%	100%
A4H7D3	Leishmania braziliensis	81%	100%
A4I9M5	Leishmania infantum	92%	100%
Q4Q3F2	Leishmania major	91%	99%