Gamma-soluble NSF attachment protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein, gamma), putative

Species:

Leishmania mexicana

UniProt:

E9B4M3_LEIMU

TriTrypDb:

LmxM.33.0540

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9B4M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4M3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005483	soluble NSF attachment protein activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	381	385	PF00656	0.707
CLV_NRD_NRD_1	159	161	PF00675	0.621
CLV_PCSK_KEX2_1	159	161	PF00082	0.621
CLV_PCSK_KEX2_1	179	181	PF00082	0.387
CLV_PCSK_KEX2_1	228	230	PF00082	0.426
CLV_PCSK_KEX2_1	24	26	PF00082	0.403
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.387
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.426
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.403
CLV_PCSK_SKI1_1	24	28	PF00082	0.281
CLV_PCSK_SKI1_1	247	251	PF00082	0.376
CLV_PCSK_SKI1_1	338	342	PF00082	0.381
CLV_Separin_Fungi	283	289	PF03568	0.232
DEG_SPOP_SBC_1	233	237	PF00917	0.522
DEG_SPOP_SBC_1	370	374	PF00917	0.561
DOC_CYCLIN_RxL_1	338	346	PF00134	0.464
DOC_CYCLIN_yClb5_NLxxxL_5	247	253	PF00134	0.488
DOC_MAPK_MEF2A_6	261	268	PF00069	0.309
DOC_PP4_FxxP_1	201	204	PF00568	0.484
DOC_USP7_MATH_1	161	165	PF00917	0.643
DOC_USP7_MATH_1	195	199	PF00917	0.555
DOC_USP7_MATH_1	334	338	PF00917	0.490
DOC_USP7_MATH_1	364	368	PF00917	0.713
DOC_USP7_MATH_1	371	375	PF00917	0.735
DOC_USP7_MATH_1	76	80	PF00917	0.375
DOC_USP7_UBL2_3	20	24	PF12436	0.424
DOC_WW_Pin1_4	234	239	PF00397	0.612
LIG_14-3-3_CanoR_1	151	161	PF00244	0.601
LIG_BRCT_BRCA1_1	197	201	PF00533	0.532
LIG_eIF4E_1	207	213	PF01652	0.382
LIG_FHA_1	105	111	PF00498	0.444
LIG_FHA_1	169	175	PF00498	0.494
LIG_FHA_2	235	241	PF00498	0.611
LIG_FHA_2	271	277	PF00498	0.484
LIG_FHA_2	381	387	PF00498	0.716
LIG_FHA_2	7	13	PF00498	0.411
LIG_LIR_Apic_2	155	161	PF02991	0.533
LIG_LIR_Apic_2	198	204	PF02991	0.529
LIG_LIR_Gen_1	209	215	PF02991	0.386
LIG_LIR_Gen_1	280	289	PF02991	0.487
LIG_LIR_Gen_1	327	336	PF02991	0.438
LIG_LIR_Nem_3	177	181	PF02991	0.485
LIG_LIR_Nem_3	205	210	PF02991	0.370
LIG_LIR_Nem_3	280	284	PF02991	0.478
LIG_LIR_Nem_3	327	332	PF02991	0.446
LIG_SH2_CRK	158	162	PF00017	0.564
LIG_SH2_CRK	178	182	PF00017	0.451
LIG_SH2_CRK	47	51	PF00017	0.426
LIG_SH2_GRB2like	47	50	PF00017	0.426
LIG_SH2_NCK_1	122	126	PF00017	0.426
LIG_SH2_SRC	122	125	PF00017	0.426
LIG_SH2_SRC	243	246	PF00017	0.538
LIG_SH2_STAT5	173	176	PF00017	0.468
LIG_SH2_STAT5	279	282	PF00017	0.494
LIG_SH2_STAT5	47	50	PF00017	0.300
LIG_SH2_STAT5	90	93	PF00017	0.392
LIG_SUMO_SIM_anti_2	184	190	PF11976	0.478
LIG_SUMO_SIM_anti_2	265	270	PF11976	0.304
LIG_SUMO_SIM_par_1	184	190	PF11976	0.437
LIG_TRAF2_1	121	124	PF00917	0.432
LIG_TRAF2_1	298	301	PF00917	0.406
LIG_TRAF2_1	318	321	PF00917	0.446
MOD_CK1_1	152	158	PF00069	0.578
MOD_CK1_1	94	100	PF00069	0.425
MOD_CK2_1	2	8	PF00069	0.376
MOD_CK2_1	295	301	PF00069	0.370
MOD_CK2_1	380	386	PF00069	0.670
MOD_Cter_Amidation	17	20	PF01082	0.519
MOD_GlcNHglycan	16	19	PF01048	0.491
MOD_GlcNHglycan	163	166	PF01048	0.658
MOD_GlcNHglycan	216	219	PF01048	0.438
MOD_GlcNHglycan	365	369	PF01048	0.725
MOD_GlcNHglycan	4	7	PF01048	0.434
MOD_GlcNHglycan	99	102	PF01048	0.392
MOD_GSK3_1	104	111	PF00069	0.324
MOD_GSK3_1	161	168	PF00069	0.600
MOD_GSK3_1	2	9	PF00069	0.526
MOD_GSK3_1	378	385	PF00069	0.790
MOD_GSK3_1	61	68	PF00069	0.218
MOD_GSK3_1	93	100	PF00069	0.429
MOD_N-GLC_1	133	138	PF02516	0.383
MOD_N-GLC_1	296	301	PF02516	0.376
MOD_N-GLC_2	326	328	PF02516	0.449
MOD_NEK2_1	1	6	PF00069	0.487
MOD_NEK2_1	269	274	PF00069	0.348
MOD_PIKK_1	105	111	PF00454	0.153
MOD_PIKK_1	371	377	PF00454	0.646
MOD_PIKK_1	58	64	PF00454	0.383
MOD_PIKK_1	85	91	PF00454	0.426
MOD_PKA_1	341	347	PF00069	0.513
MOD_Plk_1	334	340	PF00069	0.389
MOD_Plk_1	364	370	PF00069	0.477
MOD_Plk_2-3	382	388	PF00069	0.715
MOD_ProDKin_1	234	240	PF00069	0.610
MOD_SUMO_rev_2	194	201	PF00179	0.400
MOD_SUMO_rev_2	240	249	PF00179	0.524
TRG_DiLeu_BaEn_1	184	189	PF01217	0.395
TRG_DiLeu_BaEn_4	123	129	PF01217	0.426
TRG_ENDOCYTIC_2	178	181	PF00928	0.484
TRG_ENDOCYTIC_2	210	213	PF00928	0.387
TRG_ENDOCYTIC_2	47	50	PF00928	0.347
TRG_ER_diArg_1	158	160	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I337	Leptomonas seymouri	67%	99%
A0A0S4J5L6	Bodo saltans	31%	100%
A0A1X0P9K4	Trypanosomatidae	38%	100%
A0A3Q8IKP9	Leishmania donovani	91%	100%
A0A422MZB1	Trypanosoma rangeli	37%	100%
A4H7D4	Leishmania braziliensis	76%	100%
A4I9M4	Leishmania infantum	91%	100%
D0A1Z0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q3F3	Leishmania major	89%	100%
V5BRU6	Trypanosoma cruzi	37%	100%