BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B4M2_LEIMU

TriTrypDb:

LmxM.33.0530

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4M2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.656
CLV_C14_Caspase3-7	399	403	PF00656	0.531
CLV_NRD_NRD_1	410	412	PF00675	0.622
CLV_NRD_NRD_1	456	458	PF00675	0.568
CLV_NRD_NRD_1	58	60	PF00675	0.705
CLV_PCSK_FUR_1	316	320	PF00082	0.484
CLV_PCSK_KEX2_1	318	320	PF00082	0.604
CLV_PCSK_KEX2_1	410	412	PF00082	0.597
CLV_PCSK_KEX2_1	456	458	PF00082	0.568
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.492
CLV_PCSK_PC7_1	406	412	PF00082	0.539
DEG_SCF_FBW7_2	21	28	PF00400	0.614
DEG_SPOP_SBC_1	160	164	PF00917	0.724
DEG_SPOP_SBC_1	204	208	PF00917	0.632
DOC_CKS1_1	22	27	PF01111	0.616
DOC_CKS1_1	241	246	PF01111	0.556
DOC_CYCLIN_RxL_1	303	313	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	419	425	PF00134	0.523
DOC_PP1_RVXF_1	359	366	PF00149	0.574
DOC_PP2B_LxvP_1	419	422	PF13499	0.516
DOC_PP2B_LxvP_1	485	488	PF13499	0.562
DOC_PP4_FxxP_1	238	241	PF00568	0.439
DOC_PP4_MxPP_1	458	461	PF00568	0.579
DOC_USP7_MATH_1	160	164	PF00917	0.678
DOC_USP7_MATH_1	204	208	PF00917	0.692
DOC_USP7_MATH_1	321	325	PF00917	0.574
DOC_USP7_MATH_1	444	448	PF00917	0.689
DOC_USP7_MATH_1	476	480	PF00917	0.522
DOC_USP7_MATH_1	50	54	PF00917	0.644
DOC_USP7_UBL2_3	157	161	PF12436	0.630
DOC_WW_Pin1_4	143	148	PF00397	0.758
DOC_WW_Pin1_4	161	166	PF00397	0.549
DOC_WW_Pin1_4	200	205	PF00397	0.636
DOC_WW_Pin1_4	21	26	PF00397	0.613
DOC_WW_Pin1_4	228	233	PF00397	0.633
DOC_WW_Pin1_4	240	245	PF00397	0.691
DOC_WW_Pin1_4	259	264	PF00397	0.526
DOC_WW_Pin1_4	285	290	PF00397	0.545
DOC_WW_Pin1_4	298	303	PF00397	0.587
DOC_WW_Pin1_4	483	488	PF00397	0.632
LIG_14-3-3_CanoR_1	11	21	PF00244	0.634
LIG_14-3-3_CanoR_1	394	399	PF00244	0.631
LIG_14-3-3_CanoR_1	410	414	PF00244	0.564
LIG_CtBP_PxDLS_1	136	140	PF00389	0.562
LIG_CtBP_PxDLS_1	167	171	PF00389	0.543
LIG_FHA_1	13	19	PF00498	0.614
LIG_FHA_1	222	228	PF00498	0.506
LIG_FHA_1	310	316	PF00498	0.588
LIG_FHA_1	366	372	PF00498	0.561
LIG_FHA_1	52	58	PF00498	0.744
LIG_FHA_2	1	7	PF00498	0.545
LIG_FHA_2	22	28	PF00498	0.704
LIG_FHA_2	342	348	PF00498	0.570
LIG_FHA_2	399	405	PF00498	0.639
LIG_FHA_2	448	454	PF00498	0.580
LIG_FHA_2	56	62	PF00498	0.730
LIG_LIR_Nem_3	210	216	PF02991	0.564
LIG_MAD2	39	47	PF02301	0.599
LIG_SH2_CRK	305	309	PF00017	0.515
LIG_SH2_GRB2like	320	323	PF00017	0.498
LIG_SH2_NCK_1	320	324	PF00017	0.496
LIG_SH2_SRC	320	323	PF00017	0.498
LIG_SH2_STAT5	396	399	PF00017	0.632
LIG_SH3_1	43	49	PF00018	0.585
LIG_SH3_1	456	462	PF00018	0.556
LIG_SH3_3	162	168	PF00018	0.731
LIG_SH3_3	19	25	PF00018	0.613
LIG_SH3_3	198	204	PF00018	0.705
LIG_SH3_3	238	244	PF00018	0.453
LIG_SH3_3	301	307	PF00018	0.394
LIG_SH3_3	356	362	PF00018	0.590
LIG_SH3_3	41	47	PF00018	0.597
LIG_SH3_3	456	462	PF00018	0.599
LIG_TRAF2_1	100	103	PF00917	0.569
LIG_TRAF2_1	115	118	PF00917	0.713
LIG_TRAF2_1	231	234	PF00917	0.571
LIG_TRAF2_1	267	270	PF00917	0.552
LIG_WW_1	461	464	PF00397	0.599
MOD_CDK_SPK_2	21	26	PF00069	0.677
MOD_CDK_SPK_2	298	303	PF00069	0.441
MOD_CK1_1	203	209	PF00069	0.602
MOD_CK1_1	280	286	PF00069	0.632
MOD_CK1_1	29	35	PF00069	0.627
MOD_CK1_1	341	347	PF00069	0.556
MOD_CK1_1	447	453	PF00069	0.638
MOD_CK1_1	483	489	PF00069	0.634
MOD_CK1_1	53	59	PF00069	0.687
MOD_CK2_1	112	118	PF00069	0.681
MOD_CK2_1	204	210	PF00069	0.508
MOD_CK2_1	228	234	PF00069	0.616
MOD_CK2_1	269	275	PF00069	0.598
MOD_CK2_1	280	286	PF00069	0.691
MOD_CK2_1	366	372	PF00069	0.554
MOD_CK2_1	378	384	PF00069	0.712
MOD_CK2_1	398	404	PF00069	0.634
MOD_CK2_1	447	453	PF00069	0.582
MOD_CK2_1	55	61	PF00069	0.735
MOD_GlcNHglycan	147	150	PF01048	0.696
MOD_GlcNHglycan	207	210	PF01048	0.586
MOD_GlcNHglycan	218	221	PF01048	0.521
MOD_GlcNHglycan	27	31	PF01048	0.634
MOD_GlcNHglycan	414	418	PF01048	0.530
MOD_GlcNHglycan	445	449	PF01048	0.689
MOD_GlcNHglycan	478	481	PF01048	0.619
MOD_GSK3_1	200	207	PF00069	0.554
MOD_GSK3_1	334	341	PF00069	0.622
MOD_GSK3_1	394	401	PF00069	0.661
MOD_GSK3_1	409	416	PF00069	0.689
MOD_GSK3_1	440	447	PF00069	0.625
MOD_GSK3_1	470	477	PF00069	0.665
MOD_GSK3_1	51	58	PF00069	0.689
MOD_N-GLC_1	221	226	PF02516	0.483
MOD_N-GLC_1	321	326	PF02516	0.517
MOD_NEK2_1	112	117	PF00069	0.466
MOD_NEK2_1	192	197	PF00069	0.705
MOD_PIKK_1	112	118	PF00454	0.530
MOD_PIKK_1	269	275	PF00454	0.719
MOD_PIKK_1	404	410	PF00454	0.644
MOD_PIKK_1	470	476	PF00454	0.578
MOD_PKA_2	409	415	PF00069	0.657
MOD_PKA_2	470	476	PF00069	0.578
MOD_PKA_2	63	69	PF00069	0.677
MOD_Plk_1	269	275	PF00069	0.611
MOD_Plk_1	444	450	PF00069	0.623
MOD_Plk_2-3	338	344	PF00069	0.620
MOD_Plk_2-3	98	104	PF00069	0.565
MOD_Plk_4	280	286	PF00069	0.620
MOD_Plk_4	480	486	PF00069	0.719
MOD_ProDKin_1	143	149	PF00069	0.759
MOD_ProDKin_1	161	167	PF00069	0.546
MOD_ProDKin_1	200	206	PF00069	0.631
MOD_ProDKin_1	21	27	PF00069	0.616
MOD_ProDKin_1	228	234	PF00069	0.630
MOD_ProDKin_1	240	246	PF00069	0.688
MOD_ProDKin_1	259	265	PF00069	0.521
MOD_ProDKin_1	285	291	PF00069	0.543
MOD_ProDKin_1	298	304	PF00069	0.580
MOD_ProDKin_1	483	489	PF00069	0.632
MOD_SUMO_for_1	25	28	PF00179	0.688
MOD_SUMO_rev_2	83	90	PF00179	0.815
MOD_SUMO_rev_2	96	106	PF00179	0.537
TRG_DiLeu_BaEn_3	233	239	PF01217	0.555
TRG_ENDOCYTIC_2	305	308	PF00928	0.507
TRG_ER_diArg_1	409	411	PF00400	0.593
TRG_ER_diArg_1	455	457	PF00400	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P589	Leptomonas seymouri	31%	68%
A0A3Q8IGZ7	Leishmania donovani	81%	100%
A4H7D5	Leishmania braziliensis	50%	100%
A4I9M3	Leishmania infantum	82%	100%
Q4Q3F4	Leishmania major	79%	100%