Putative importin beta-1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

importin beta-1 subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B4L7_LEIMU

TriTrypDb:

LmxM.33.0490

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	1
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B4L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4L7

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006913	nucleocytoplasmic transport	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0034504	protein localization to nucleus	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051169	nuclear transport	4	12
GO:0051170	import into nucleus	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0019899	enzyme binding	3	11
GO:0031267	small GTPase binding	5	11
GO:0051020	GTPase binding	4	11
GO:0005048	signal sequence binding	4	1
GO:0008139	nuclear localization sequence binding	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0061608	nuclear import signal receptor activity	3	1
GO:0140104	molecular carrier activity	1	1
GO:0140142	nucleocytoplasmic carrier activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	561	565	PF00656	0.645
CLV_C14_Caspase3-7	650	654	PF00656	0.584
CLV_C14_Caspase3-7	772	776	PF00656	0.595
CLV_NRD_NRD_1	376	378	PF00675	0.535
CLV_NRD_NRD_1	583	585	PF00675	0.501
CLV_PCSK_KEX2_1	378	380	PF00082	0.546
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.546
CLV_PCSK_SKI1_1	296	300	PF00082	0.534
CLV_PCSK_SKI1_1	323	327	PF00082	0.507
CLV_PCSK_SKI1_1	695	699	PF00082	0.411
CLV_PCSK_SKI1_1	76	80	PF00082	0.393
CLV_PCSK_SKI1_1	829	833	PF00082	0.498
CLV_PCSK_SKI1_1	855	859	PF00082	0.622
DEG_APCC_DBOX_1	860	868	PF00400	0.564
DEG_ODPH_VHL_1	777	789	PF01847	0.445
DOC_ANK_TNKS_1	741	748	PF00023	0.569
DOC_CKS1_1	443	448	PF01111	0.543
DOC_CYCLIN_RxL_1	320	330	PF00134	0.523
DOC_MAPK_gen_1	377	386	PF00069	0.407
DOC_MAPK_MEF2A_6	495	504	PF00069	0.555
DOC_MIT_MIM_1	664	674	PF04212	0.470
DOC_PP1_RVXF_1	853	860	PF00149	0.532
DOC_PP4_FxxP_1	649	652	PF00568	0.586
DOC_USP7_MATH_1	14	18	PF00917	0.553
DOC_USP7_MATH_1	140	144	PF00917	0.526
DOC_USP7_MATH_1	243	247	PF00917	0.461
DOC_USP7_MATH_1	424	428	PF00917	0.438
DOC_USP7_MATH_1	619	623	PF00917	0.470
DOC_USP7_MATH_1	675	679	PF00917	0.489
DOC_USP7_MATH_1	844	848	PF00917	0.552
DOC_USP7_UBL2_3	854	858	PF12436	0.603
DOC_WW_Pin1_4	101	106	PF00397	0.385
DOC_WW_Pin1_4	442	447	PF00397	0.493
LIG_14-3-3_CanoR_1	559	566	PF00244	0.603
LIG_14-3-3_CanoR_1	670	674	PF00244	0.491
LIG_14-3-3_CanoR_1	734	741	PF00244	0.551
LIG_Actin_WH2_2	402	419	PF00022	0.561
LIG_Actin_WH2_2	50	65	PF00022	0.393
LIG_Actin_WH2_2	544	561	PF00022	0.517
LIG_Actin_WH2_2	802	819	PF00022	0.388
LIG_AP2alpha_1	438	442	PF02296	0.391
LIG_APCC_ABBA_1	590	595	PF00400	0.526
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BRCT_BRCA1_1	714	718	PF00533	0.567
LIG_Clathr_ClatBox_1	673	677	PF01394	0.470
LIG_FHA_1	175	181	PF00498	0.466
LIG_FHA_1	198	204	PF00498	0.414
LIG_FHA_1	268	274	PF00498	0.409
LIG_FHA_1	3	9	PF00498	0.497
LIG_FHA_1	314	320	PF00498	0.467
LIG_FHA_1	37	43	PF00498	0.479
LIG_FHA_1	443	449	PF00498	0.536
LIG_FHA_1	488	494	PF00498	0.482
LIG_FHA_1	607	613	PF00498	0.477
LIG_FHA_1	681	687	PF00498	0.572
LIG_FHA_2	189	195	PF00498	0.551
LIG_FHA_2	255	261	PF00498	0.539
LIG_FHA_2	332	338	PF00498	0.559
LIG_FHA_2	687	693	PF00498	0.486
LIG_FHA_2	847	853	PF00498	0.583
LIG_GBD_Chelix_1	112	120	PF00786	0.442
LIG_GBD_Chelix_1	781	789	PF00786	0.512
LIG_Integrin_RGD_1	742	744	PF01839	0.652
LIG_LIR_Gen_1	252	263	PF02991	0.423
LIG_LIR_Gen_1	365	375	PF02991	0.583
LIG_LIR_Gen_1	436	446	PF02991	0.424
LIG_LIR_Gen_1	683	693	PF02991	0.502
LIG_LIR_Gen_1	703	713	PF02991	0.205
LIG_LIR_Gen_1	760	769	PF02991	0.422
LIG_LIR_LC3C_4	499	502	PF02991	0.559
LIG_LIR_Nem_3	127	133	PF02991	0.489
LIG_LIR_Nem_3	252	258	PF02991	0.412
LIG_LIR_Nem_3	365	371	PF02991	0.572
LIG_LIR_Nem_3	436	441	PF02991	0.399
LIG_LIR_Nem_3	494	500	PF02991	0.398
LIG_LIR_Nem_3	589	593	PF02991	0.518
LIG_LIR_Nem_3	653	659	PF02991	0.546
LIG_LIR_Nem_3	683	688	PF02991	0.473
LIG_LIR_Nem_3	703	708	PF02991	0.204
LIG_LIR_Nem_3	715	721	PF02991	0.374
LIG_LIR_Nem_3	760	765	PF02991	0.413
LIG_LIR_Nem_3	80	86	PF02991	0.316
LIG_PCNA_yPIPBox_3	517	528	PF02747	0.466
LIG_Pex14_2	438	442	PF04695	0.381
LIG_Pex14_2	701	705	PF04695	0.472
LIG_PTB_Apo_2	679	686	PF02174	0.534
LIG_PTB_Phospho_1	679	685	PF10480	0.527
LIG_SH2_CRK	255	259	PF00017	0.413
LIG_SH2_CRK	368	372	PF00017	0.532
LIG_SH2_CRK	656	660	PF00017	0.544
LIG_SH2_CRK	762	766	PF00017	0.373
LIG_SH2_GRB2like	368	371	PF00017	0.559
LIG_SH2_GRB2like	685	688	PF00017	0.571
LIG_SH2_NCK_1	368	372	PF00017	0.482
LIG_SH2_NCK_1	762	766	PF00017	0.507
LIG_SH2_PTP2	685	688	PF00017	0.571
LIG_SH2_SRC	368	371	PF00017	0.586
LIG_SH2_STAT3	310	313	PF00017	0.502
LIG_SH2_STAT3	539	542	PF00017	0.577
LIG_SH2_STAT3	611	614	PF00017	0.551
LIG_SH2_STAT5	158	161	PF00017	0.458
LIG_SH2_STAT5	209	212	PF00017	0.546
LIG_SH2_STAT5	222	225	PF00017	0.424
LIG_SH2_STAT5	261	264	PF00017	0.414
LIG_SH2_STAT5	415	418	PF00017	0.436
LIG_SH2_STAT5	539	542	PF00017	0.458
LIG_SH2_STAT5	611	614	PF00017	0.517
LIG_SH2_STAT5	625	628	PF00017	0.465
LIG_SH2_STAT5	634	637	PF00017	0.405
LIG_SH2_STAT5	645	648	PF00017	0.328
LIG_SH2_STAT5	685	688	PF00017	0.503
LIG_SH2_STAT5	750	753	PF00017	0.417
LIG_SH2_STAT5	780	783	PF00017	0.502
LIG_SH3_3	352	358	PF00018	0.526
LIG_SH3_3	816	822	PF00018	0.558
LIG_SUMO_SIM_anti_2	176	185	PF11976	0.499
LIG_SUMO_SIM_anti_2	499	505	PF11976	0.523
LIG_SUMO_SIM_par_1	603	610	PF11976	0.570
LIG_SUMO_SIM_par_1	615	622	PF11976	0.497
LIG_TRAF2_1	396	399	PF00917	0.555
LIG_TRAF2_1	481	484	PF00917	0.495
LIG_TRAF2_1	519	522	PF00917	0.498
LIG_TRAF2_1	78	81	PF00917	0.505
LIG_TYR_ITIM	253	258	PF00017	0.492
LIG_WRC_WIRS_1	34	39	PF05994	0.479
LIG_WRC_WIRS_1	784	789	PF05994	0.488
LIG_WRPW_2	718	721	PF00400	0.562
MOD_CDC14_SPxK_1	104	107	PF00782	0.501
MOD_CDK_SPxK_1	101	107	PF00069	0.393
MOD_CK1_1	233	239	PF00069	0.489
MOD_CK1_1	700	706	PF00069	0.523
MOD_CK1_1	760	766	PF00069	0.417
MOD_CK1_1	847	853	PF00069	0.608
MOD_CK2_1	140	146	PF00069	0.524
MOD_CK2_1	187	193	PF00069	0.450
MOD_CK2_1	287	293	PF00069	0.380
MOD_CK2_1	347	353	PF00069	0.500
MOD_CK2_1	66	72	PF00069	0.460
MOD_CK2_1	686	692	PF00069	0.494
MOD_CK2_1	750	756	PF00069	0.407
MOD_CK2_1	845	851	PF00069	0.645
MOD_GlcNHglycan	126	129	PF01048	0.572
MOD_GlcNHglycan	142	145	PF01048	0.447
MOD_GlcNHglycan	197	200	PF01048	0.525
MOD_GlcNHglycan	310	313	PF01048	0.498
MOD_GlcNHglycan	425	429	PF01048	0.442
MOD_GlcNHglycan	517	520	PF01048	0.525
MOD_GlcNHglycan	536	539	PF01048	0.587
MOD_GlcNHglycan	561	564	PF01048	0.612
MOD_GlcNHglycan	579	582	PF01048	0.482
MOD_GSK3_1	116	123	PF00069	0.243
MOD_GSK3_1	175	182	PF00069	0.524
MOD_GSK3_1	218	225	PF00069	0.477
MOD_GSK3_1	232	239	PF00069	0.382
MOD_GSK3_1	29	36	PF00069	0.479
MOD_GSK3_1	304	311	PF00069	0.537
MOD_GSK3_1	487	494	PF00069	0.460
MOD_GSK3_1	554	561	PF00069	0.481
MOD_GSK3_1	665	672	PF00069	0.491
MOD_GSK3_1	750	757	PF00069	0.413
MOD_GSK3_1	97	104	PF00069	0.414
MOD_N-GLC_1	2	7	PF02516	0.628
MOD_N-GLC_1	308	313	PF02516	0.547
MOD_N-GLC_1	338	343	PF02516	0.442
MOD_N-GLC_1	371	376	PF02516	0.588
MOD_N-GLC_1	686	691	PF02516	0.574
MOD_N-GLC_2	533	535	PF02516	0.460
MOD_NEK2_1	197	202	PF00069	0.526
MOD_NEK2_1	227	232	PF00069	0.415
MOD_NEK2_1	253	258	PF00069	0.423
MOD_NEK2_1	287	292	PF00069	0.371
MOD_NEK2_1	308	313	PF00069	0.509
MOD_NEK2_1	347	352	PF00069	0.370
MOD_NEK2_1	37	42	PF00069	0.443
MOD_NEK2_1	558	563	PF00069	0.588
MOD_NEK2_1	57	62	PF00069	0.378
MOD_NEK2_1	586	591	PF00069	0.494
MOD_NEK2_1	593	598	PF00069	0.483
MOD_NEK2_1	665	670	PF00069	0.442
MOD_NEK2_1	697	702	PF00069	0.410
MOD_NEK2_1	754	759	PF00069	0.392
MOD_NEK2_1	761	766	PF00069	0.384
MOD_NEK2_1	798	803	PF00069	0.481
MOD_NEK2_1	845	850	PF00069	0.608
MOD_OFUCOSY	228	234	PF10250	0.498
MOD_OFUCOSY	699	704	PF10250	0.507
MOD_PIKK_1	763	769	PF00454	0.481
MOD_PIKK_1	798	804	PF00454	0.533
MOD_PK_1	379	385	PF00069	0.532
MOD_PKA_2	416	422	PF00069	0.531
MOD_PKA_2	558	564	PF00069	0.607
MOD_PKA_2	669	675	PF00069	0.521
MOD_PKA_2	733	739	PF00069	0.561
MOD_PKB_1	377	385	PF00069	0.539
MOD_Plk_1	338	344	PF00069	0.423
MOD_Plk_1	379	385	PF00069	0.532
MOD_Plk_1	424	430	PF00069	0.504
MOD_Plk_1	491	497	PF00069	0.430
MOD_Plk_1	594	600	PF00069	0.553
MOD_Plk_1	663	669	PF00069	0.407
MOD_Plk_1	798	804	PF00069	0.505
MOD_Plk_2-3	331	337	PF00069	0.562
MOD_Plk_4	179	185	PF00069	0.572
MOD_Plk_4	243	249	PF00069	0.392
MOD_Plk_4	313	319	PF00069	0.418
MOD_Plk_4	33	39	PF00069	0.449
MOD_Plk_4	379	385	PF00069	0.532
MOD_Plk_4	57	63	PF00069	0.393
MOD_Plk_4	586	592	PF00069	0.541
MOD_Plk_4	651	657	PF00069	0.560
MOD_Plk_4	669	675	PF00069	0.365
MOD_Plk_4	680	686	PF00069	0.415
MOD_Plk_4	697	703	PF00069	0.272
MOD_Plk_4	750	756	PF00069	0.423
MOD_Plk_4	757	763	PF00069	0.407
MOD_Plk_4	811	817	PF00069	0.428
MOD_ProDKin_1	101	107	PF00069	0.385
MOD_ProDKin_1	442	448	PF00069	0.489
MOD_SUMO_for_1	94	97	PF00179	0.430
MOD_SUMO_rev_2	190	198	PF00179	0.548
MOD_SUMO_rev_2	44	52	PF00179	0.375
MOD_SUMO_rev_2	509	519	PF00179	0.561
MOD_SUMO_rev_2	692	700	PF00179	0.480
TRG_DiLeu_BaEn_1	129	134	PF01217	0.467
TRG_DiLeu_BaEn_4	277	283	PF01217	0.421
TRG_ENDOCYTIC_2	255	258	PF00928	0.391
TRG_ENDOCYTIC_2	368	371	PF00928	0.454
TRG_ENDOCYTIC_2	497	500	PF00928	0.460
TRG_ENDOCYTIC_2	656	659	PF00928	0.536
TRG_ENDOCYTIC_2	685	688	PF00928	0.509
TRG_ENDOCYTIC_2	762	765	PF00928	0.372
TRG_ER_diArg_1	376	379	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB22	Leptomonas seymouri	81%	100%
A0A0S4J2L0	Bodo saltans	48%	100%
A0A1X0P8K4	Trypanosomatidae	55%	100%
A0A3Q8IUD8	Leishmania donovani	98%	100%
A0A3R7LLX8	Trypanosoma rangeli	53%	100%
A4HAG4	Leishmania braziliensis	89%	100%
A4I9L9	Leishmania infantum	98%	100%
D0A1Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
O00410	Homo sapiens	21%	79%
O13864	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O18388	Drosophila melanogaster	28%	98%
P40069	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	20%	78%
P52296	Rattus norvegicus	28%	99%
P52297	Xenopus laevis	29%	99%
P70168	Mus musculus	29%	99%
Q06142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q14974	Homo sapiens	29%	99%
Q4Q3F9	Leishmania major	98%	100%
Q8BKC5	Mus musculus	21%	79%
Q9FJD4	Arabidopsis thaliana	30%	100%
V5BHR5	Trypanosoma cruzi	50%	100%