Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B4L5_LEIMU

TriTrypDb:

LmxM.33.0470

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0005730	nucleolus	5	5

Expansion

Sequence features

E9B4L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4L5

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	3
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	3
GO:0000398	mRNA splicing, via spliceosome	8	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0008380	RNA splicing	7	3
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0000027	ribosomal large subunit assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.507
CLV_NRD_NRD_1	294	296	PF00675	0.543
CLV_NRD_NRD_1	440	442	PF00675	0.496
CLV_NRD_NRD_1	514	516	PF00675	0.645
CLV_NRD_NRD_1	701	703	PF00675	0.444
CLV_PCSK_KEX2_1	107	109	PF00082	0.507
CLV_PCSK_KEX2_1	294	296	PF00082	0.543
CLV_PCSK_KEX2_1	440	442	PF00082	0.496
CLV_PCSK_KEX2_1	701	703	PF00082	0.492
CLV_PCSK_PC7_1	436	442	PF00082	0.490
CLV_PCSK_SKI1_1	155	159	PF00082	0.341
CLV_PCSK_SKI1_1	373	377	PF00082	0.294
CLV_PCSK_SKI1_1	385	389	PF00082	0.478
CLV_PCSK_SKI1_1	615	619	PF00082	0.422
DEG_APCC_DBOX_1	444	452	PF00400	0.476
DEG_SCF_FBW7_1	455	462	PF00400	0.523
DEG_SPOP_SBC_1	185	189	PF00917	0.518
DEG_SPOP_SBC_1	208	212	PF00917	0.463
DOC_CYCLIN_yClb5_NLxxxL_5	648	656	PF00134	0.438
DOC_MAPK_gen_1	233	242	PF00069	0.325
DOC_PP1_RVXF_1	134	141	PF00149	0.348
DOC_PP1_RVXF_1	413	419	PF00149	0.560
DOC_PP2B_LxvP_1	101	104	PF13499	0.507
DOC_PP4_FxxP_1	427	430	PF00568	0.543
DOC_USP7_MATH_1	165	169	PF00917	0.522
DOC_USP7_MATH_1	185	189	PF00917	0.429
DOC_USP7_MATH_1	204	208	PF00917	0.495
DOC_USP7_MATH_1	283	287	PF00917	0.555
DOC_USP7_MATH_1	414	418	PF00917	0.579
DOC_USP7_MATH_1	432	436	PF00917	0.475
DOC_USP7_MATH_1	459	463	PF00917	0.641
DOC_USP7_MATH_1	482	486	PF00917	0.545
DOC_USP7_MATH_1	493	497	PF00917	0.587
DOC_USP7_MATH_1	501	505	PF00917	0.541
DOC_USP7_MATH_1	522	526	PF00917	0.635
DOC_USP7_MATH_1	571	575	PF00917	0.528
DOC_USP7_MATH_1	655	659	PF00917	0.441
DOC_USP7_MATH_2	522	528	PF00917	0.520
DOC_USP7_UBL2_3	456	460	PF12436	0.519
DOC_WW_Pin1_4	37	42	PF00397	0.541
DOC_WW_Pin1_4	408	413	PF00397	0.620
DOC_WW_Pin1_4	426	431	PF00397	0.517
DOC_WW_Pin1_4	455	460	PF00397	0.576
DOC_WW_Pin1_4	509	514	PF00397	0.628
DOC_WW_Pin1_4	518	523	PF00397	0.586
DOC_WW_Pin1_4	602	607	PF00397	0.577
DOC_WW_Pin1_4	706	711	PF00397	0.500
DOC_WW_Pin1_4	81	86	PF00397	0.483
LIG_14-3-3_CanoR_1	107	115	PF00244	0.556
LIG_14-3-3_CanoR_1	294	300	PF00244	0.482
LIG_14-3-3_CanoR_1	426	430	PF00244	0.667
LIG_14-3-3_CanoR_1	507	513	PF00244	0.595
LIG_14-3-3_CanoR_1	643	649	PF00244	0.424
LIG_14-3-3_CanoR_1	701	705	PF00244	0.452
LIG_AP2alpha_2	13	15	PF02296	0.443
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BIR_III_4	264	268	PF00653	0.463
LIG_BRCT_BRCA1_1	210	214	PF00533	0.463
LIG_BRCT_BRCA1_1	249	253	PF00533	0.447
LIG_BRCT_BRCA1_1	31	35	PF00533	0.463
LIG_BRCT_BRCA1_1	354	358	PF00533	0.463
LIG_BRCT_BRCA1_1	522	526	PF00533	0.524
LIG_CSL_BTD_1	101	104	PF09270	0.664
LIG_FHA_1	110	116	PF00498	0.687
LIG_FHA_1	200	206	PF00498	0.447
LIG_FHA_1	329	335	PF00498	0.472
LIG_FHA_1	372	378	PF00498	0.534
LIG_FHA_1	663	669	PF00498	0.443
LIG_FHA_2	512	518	PF00498	0.634
LIG_FHA_2	519	525	PF00498	0.579
LIG_FHA_2	597	603	PF00498	0.606
LIG_HCF-1_HBM_1	146	149	PF13415	0.277
LIG_LIR_Apic_2	286	290	PF02991	0.469
LIG_LIR_Gen_1	212	219	PF02991	0.463
LIG_LIR_Gen_1	633	644	PF02991	0.456
LIG_LIR_Gen_1	96	104	PF02991	0.474
LIG_LIR_Nem_3	182	186	PF02991	0.381
LIG_LIR_Nem_3	2	6	PF02991	0.613
LIG_LIR_Nem_3	211	217	PF02991	0.479
LIG_LIR_Nem_3	32	38	PF02991	0.402
LIG_LIR_Nem_3	633	639	PF02991	0.463
LIG_LIR_Nem_3	96	101	PF02991	0.481
LIG_MLH1_MIPbox_1	211	215	PF16413	0.463
LIG_MYND_1	37	41	PF01753	0.463
LIG_Pex14_1	160	164	PF04695	0.376
LIG_Pex14_2	179	183	PF04695	0.366
LIG_Rb_pABgroove_1	236	244	PF01858	0.372
LIG_SH2_CRK	343	347	PF00017	0.269
LIG_SH2_CRK	636	640	PF00017	0.457
LIG_SH2_PTP2	98	101	PF00017	0.463
LIG_SH2_STAP1	688	692	PF00017	0.435
LIG_SH2_STAT5	149	152	PF00017	0.304
LIG_SH2_STAT5	209	212	PF00017	0.476
LIG_SH2_STAT5	217	220	PF00017	0.438
LIG_SH2_STAT5	258	261	PF00017	0.488
LIG_SH2_STAT5	303	306	PF00017	0.436
LIG_SH2_STAT5	341	344	PF00017	0.347
LIG_SH2_STAT5	532	535	PF00017	0.531
LIG_SH2_STAT5	565	568	PF00017	0.597
LIG_SH2_STAT5	98	101	PF00017	0.493
LIG_SH3_3	11	17	PF00018	0.433
LIG_SH3_3	40	46	PF00018	0.481
LIG_SUMO_SIM_par_1	201	207	PF11976	0.447
LIG_TRAF2_1	620	623	PF00917	0.474
LIG_WRC_WIRS_1	180	185	PF05994	0.402
MOD_CDC14_SPxK_1	512	515	PF00782	0.606
MOD_CDK_SPK_2	410	415	PF00069	0.506
MOD_CDK_SPK_2	455	460	PF00069	0.576
MOD_CDK_SPK_2	81	86	PF00069	0.463
MOD_CDK_SPxK_1	509	515	PF00069	0.603
MOD_CDK_SPxxK_3	408	415	PF00069	0.558
MOD_CDK_SPxxK_3	509	516	PF00069	0.606
MOD_CK1_1	207	213	PF00069	0.502
MOD_CK1_1	247	253	PF00069	0.486
MOD_CK1_1	278	284	PF00069	0.744
MOD_CK1_1	466	472	PF00069	0.565
MOD_CK1_1	487	493	PF00069	0.544
MOD_CK1_1	511	517	PF00069	0.688
MOD_CK1_1	613	619	PF00069	0.493
MOD_CK2_1	388	394	PF00069	0.582
MOD_CK2_1	511	517	PF00069	0.653
MOD_CK2_1	518	524	PF00069	0.609
MOD_CK2_1	570	576	PF00069	0.578
MOD_CK2_1	596	602	PF00069	0.605
MOD_GlcNHglycan	118	121	PF01048	0.547
MOD_GlcNHglycan	206	209	PF01048	0.265
MOD_GlcNHglycan	219	222	PF01048	0.374
MOD_GlcNHglycan	243	247	PF01048	0.336
MOD_GlcNHglycan	261	264	PF01048	0.288
MOD_GlcNHglycan	265	268	PF01048	0.278
MOD_GlcNHglycan	281	284	PF01048	0.587
MOD_GlcNHglycan	290	293	PF01048	0.500
MOD_GlcNHglycan	3	6	PF01048	0.618
MOD_GlcNHglycan	324	327	PF01048	0.290
MOD_GlcNHglycan	379	382	PF01048	0.404
MOD_GlcNHglycan	461	464	PF01048	0.640
MOD_GlcNHglycan	465	468	PF01048	0.603
MOD_GlcNHglycan	486	489	PF01048	0.543
MOD_GlcNHglycan	49	52	PF01048	0.280
MOD_GlcNHglycan	573	576	PF01048	0.532
MOD_GlcNHglycan	612	615	PF01048	0.525
MOD_GlcNHglycan	710	713	PF01048	0.596
MOD_GlcNHglycan	91	94	PF01048	0.286
MOD_GSK3_1	103	110	PF00069	0.477
MOD_GSK3_1	204	211	PF00069	0.461
MOD_GSK3_1	259	266	PF00069	0.491
MOD_GSK3_1	274	281	PF00069	0.539
MOD_GSK3_1	352	359	PF00069	0.470
MOD_GSK3_1	385	392	PF00069	0.569
MOD_GSK3_1	410	417	PF00069	0.534
MOD_GSK3_1	455	462	PF00069	0.606
MOD_GSK3_1	465	472	PF00069	0.593
MOD_GSK3_1	483	490	PF00069	0.541
MOD_GSK3_1	493	500	PF00069	0.495
MOD_GSK3_1	518	525	PF00069	0.602
MOD_GSK3_1	552	559	PF00069	0.607
MOD_GSK3_1	566	573	PF00069	0.570
MOD_GSK3_1	590	597	PF00069	0.568
MOD_GSK3_1	602	609	PF00069	0.609
MOD_GSK3_1	708	715	PF00069	0.569
MOD_N-GLC_1	327	332	PF02516	0.272
MOD_N-GLC_1	493	498	PF02516	0.588
MOD_N-GLC_1	597	602	PF02516	0.542
MOD_N-GLC_2	124	126	PF02516	0.473
MOD_N-GLC_2	473	475	PF02516	0.602
MOD_NEK2_1	1	6	PF00069	0.553
MOD_NEK2_1	179	184	PF00069	0.429
MOD_NEK2_1	186	191	PF00069	0.498
MOD_NEK2_1	242	247	PF00069	0.345
MOD_NEK2_1	274	279	PF00069	0.477
MOD_NEK2_1	342	347	PF00069	0.337
MOD_NEK2_1	352	357	PF00069	0.401
MOD_NEK2_1	566	571	PF00069	0.595
MOD_NEK2_1	89	94	PF00069	0.460
MOD_NEK2_2	244	249	PF00069	0.421
MOD_PIKK_1	165	171	PF00454	0.527
MOD_PIKK_1	461	467	PF00454	0.674
MOD_PIKK_1	642	648	PF00454	0.424
MOD_PKA_1	107	113	PF00069	0.547
MOD_PKA_1	294	300	PF00069	0.482
MOD_PKA_2	106	112	PF00069	0.513
MOD_PKA_2	122	128	PF00069	0.456
MOD_PKA_2	15	21	PF00069	0.382
MOD_PKA_2	274	280	PF00069	0.493
MOD_PKA_2	294	300	PF00069	0.603
MOD_PKA_2	388	394	PF00069	0.552
MOD_PKA_2	425	431	PF00069	0.653
MOD_PKA_2	642	648	PF00069	0.424
MOD_PKA_2	700	706	PF00069	0.449
MOD_Plk_1	153	159	PF00069	0.396
MOD_Plk_1	371	377	PF00069	0.543
MOD_Plk_1	493	499	PF00069	0.564
MOD_Plk_1	545	551	PF00069	0.602
MOD_Plk_1	552	558	PF00069	0.584
MOD_Plk_4	210	216	PF00069	0.485
MOD_Plk_4	295	301	PF00069	0.470
MOD_Plk_4	371	377	PF00069	0.472
MOD_Plk_4	606	612	PF00069	0.488
MOD_ProDKin_1	37	43	PF00069	0.541
MOD_ProDKin_1	408	414	PF00069	0.619
MOD_ProDKin_1	426	432	PF00069	0.512
MOD_ProDKin_1	455	461	PF00069	0.577
MOD_ProDKin_1	509	515	PF00069	0.631
MOD_ProDKin_1	518	524	PF00069	0.583
MOD_ProDKin_1	602	608	PF00069	0.573
MOD_ProDKin_1	706	712	PF00069	0.499
MOD_ProDKin_1	81	87	PF00069	0.483
MOD_SUMO_rev_2	330	340	PF00179	0.472
MOD_SUMO_rev_2	529	538	PF00179	0.558
MOD_SUMO_rev_2	689	698	PF00179	0.444
TRG_DiLeu_BaEn_1	625	630	PF01217	0.465
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.463
TRG_ENDOCYTIC_2	343	346	PF00928	0.325
TRG_ENDOCYTIC_2	636	639	PF00928	0.462
TRG_ENDOCYTIC_2	98	101	PF00928	0.499
TRG_ER_diArg_1	294	296	PF00400	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGC4	Leishmania donovani	24%	100%
A0A3Q8IKN8	Leishmania donovani	91%	100%
A0A3R7NL29	Trypanosoma rangeli	34%	97%
A0A3S7XBP3	Leishmania donovani	23%	100%
A4HAG2	Leishmania braziliensis	76%	100%
A4HDT7	Leishmania braziliensis	24%	100%
A4I135	Leishmania infantum	24%	100%
A4I9L7	Leishmania infantum	90%	100%
A4IDR0	Leishmania infantum	23%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q0T1	Leishmania major	23%	100%
Q4Q3G1	Leishmania major	89%	100%
Q4QAA4	Leishmania major	24%	100%