Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4L1_LEIMU

TriTrypDb:

LmxM.33.0430

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4L1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.794
CLV_NRD_NRD_1	134	136	PF00675	0.602
CLV_NRD_NRD_1	198	200	PF00675	0.472
CLV_PCSK_KEX2_1	179	181	PF00082	0.484
CLV_PCSK_KEX2_1	206	208	PF00082	0.540
CLV_PCSK_KEX2_1	33	35	PF00082	0.516
CLV_PCSK_KEX2_1	74	76	PF00082	0.837
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.484
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.528
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.516
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.788
CLV_PCSK_PC7_1	202	208	PF00082	0.500
DEG_APCC_DBOX_1	3	11	PF00400	0.489
DEG_Nend_UBRbox_3	1	3	PF02207	0.661
DOC_CDC14_PxL_1	13	21	PF14671	0.477
DOC_CYCLIN_RxL_1	3	11	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.466
DOC_MAPK_gen_1	4	12	PF00069	0.484
DOC_MAPK_JIP1_4	43	49	PF00069	0.458
DOC_MAPK_MEF2A_6	4	12	PF00069	0.484
DOC_PP2B_LxvP_1	120	123	PF13499	0.513
DOC_PP2B_LxvP_1	47	50	PF13499	0.478
DOC_PP4_FxxP_1	22	25	PF00568	0.543
DOC_USP7_MATH_1	101	105	PF00917	0.615
DOC_USP7_UBL2_3	257	261	PF12436	0.724
DOC_WW_Pin1_4	135	140	PF00397	0.625
DOC_WW_Pin1_4	172	177	PF00397	0.625
DOC_WW_Pin1_4	21	26	PF00397	0.667
DOC_WW_Pin1_4	77	82	PF00397	0.714
LIG_14-3-3_CanoR_1	207	211	PF00244	0.672
LIG_BRCT_BRCA1_1	41	45	PF00533	0.566
LIG_Clathr_ClatBox_1	7	11	PF01394	0.476
LIG_FHA_2	215	221	PF00498	0.518
LIG_FHA_2	83	89	PF00498	0.785
LIG_LIR_Apic_2	11	17	PF02991	0.461
LIG_LIR_Gen_1	11	19	PF02991	0.462
LIG_LIR_Nem_3	11	15	PF02991	0.472
LIG_SH2_CRK	201	205	PF00017	0.478
LIG_SH2_GRB2like	166	169	PF00017	0.441
LIG_SH2_SRC	166	169	PF00017	0.441
LIG_SH2_STAP1	166	170	PF00017	0.436
LIG_SH2_STAT3	23	26	PF00017	0.694
LIG_SH2_STAT5	14	17	PF00017	0.483
LIG_SH2_STAT5	46	49	PF00017	0.581
LIG_SH2_STAT5	9	12	PF00017	0.477
LIG_SH3_3	120	126	PF00018	0.575
LIG_SH3_3	29	35	PF00018	0.611
LIG_SH3_3	38	44	PF00018	0.461
LIG_SUMO_SIM_par_1	94	100	PF11976	0.743
LIG_UBA3_1	15	20	PF00899	0.591
MOD_CDK_SPxxK_3	172	179	PF00069	0.583
MOD_CK1_1	209	215	PF00069	0.546
MOD_CK1_1	58	64	PF00069	0.558
MOD_CK2_1	212	218	PF00069	0.538
MOD_CK2_1	245	251	PF00069	0.731
MOD_CK2_1	84	90	PF00069	0.711
MOD_Cter_Amidation	72	75	PF01082	0.712
MOD_GlcNHglycan	36	39	PF01048	0.745
MOD_GlcNHglycan	60	63	PF01048	0.548
MOD_GSK3_1	243	250	PF00069	0.580
MOD_GSK3_1	58	65	PF00069	0.568
MOD_GSK3_1	77	84	PF00069	0.645
MOD_GSK3_1	97	104	PF00069	0.554
MOD_N-GLC_1	130	135	PF02516	0.517
MOD_NEK2_1	235	240	PF00069	0.553
MOD_PIKK_1	209	215	PF00454	0.528
MOD_PKA_1	206	212	PF00069	0.652
MOD_PKA_1	33	39	PF00069	0.506
MOD_PKA_2	113	119	PF00069	0.449
MOD_PKA_2	206	212	PF00069	0.673
MOD_PKA_2	33	39	PF00069	0.524
MOD_ProDKin_1	135	141	PF00069	0.628
MOD_ProDKin_1	172	178	PF00069	0.624
MOD_ProDKin_1	21	27	PF00069	0.674
MOD_ProDKin_1	77	83	PF00069	0.716
TRG_DiLeu_BaEn_1	11	16	PF01217	0.456
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.502
TRG_ENDOCYTIC_2	201	204	PF00928	0.474
TRG_ENDOCYTIC_2	46	49	PF00928	0.581
TRG_ENDOCYTIC_2	9	12	PF00928	0.477
TRG_ER_diArg_1	157	160	PF00400	0.593
TRG_ER_diArg_1	184	187	PF00400	0.486
TRG_ER_diArg_1	4	7	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKH0	Leptomonas seymouri	52%	100%
A0A3S7X7E6	Leishmania donovani	90%	100%
A4HAF7	Leishmania braziliensis	75%	100%
Q4Q3G5	Leishmania major	90%	100%