Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4L0_LEIMU

TriTrypDb:

LmxM.33.0420

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4L0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.462
CLV_C14_Caspase3-7	62	66	PF00656	0.673
CLV_MEL_PAP_1	193	199	PF00089	0.579
CLV_NRD_NRD_1	167	169	PF00675	0.503
CLV_NRD_NRD_1	405	407	PF00675	0.565
CLV_NRD_NRD_1	97	99	PF00675	0.673
CLV_PCSK_KEX2_1	167	169	PF00082	0.503
CLV_PCSK_KEX2_1	405	407	PF00082	0.565
CLV_PCSK_KEX2_1	97	99	PF00082	0.670
CLV_PCSK_SKI1_1	179	183	PF00082	0.649
CLV_PCSK_SKI1_1	223	227	PF00082	0.649
CLV_Separin_Metazoa	365	369	PF03568	0.539
DEG_APCC_DBOX_1	195	203	PF00400	0.619
DEG_SCF_FBW7_2	107	113	PF00400	0.508
DEG_SPOP_SBC_1	382	386	PF00917	0.509
DOC_CKS1_1	107	112	PF01111	0.508
DOC_CKS1_1	67	72	PF01111	0.734
DOC_CKS1_1	84	89	PF01111	0.741
DOC_MAPK_gen_1	245	253	PF00069	0.585
DOC_MAPK_gen_1	388	395	PF00069	0.691
DOC_MAPK_MEF2A_6	191	199	PF00069	0.588
DOC_MAPK_MEF2A_6	247	255	PF00069	0.564
DOC_MAPK_RevD_3	154	168	PF00069	0.383
DOC_PP1_RVXF_1	366	372	PF00149	0.539
DOC_PP1_RVXF_1	56	62	PF00149	0.578
DOC_PP2B_LxvP_1	255	258	PF13499	0.608
DOC_USP7_MATH_1	144	148	PF00917	0.709
DOC_USP7_MATH_1	173	177	PF00917	0.667
DOC_USP7_MATH_1	195	199	PF00917	0.496
DOC_USP7_MATH_1	2	6	PF00917	0.668
DOC_USP7_MATH_1	209	213	PF00917	0.637
DOC_USP7_MATH_1	318	322	PF00917	0.628
DOC_USP7_MATH_1	348	352	PF00917	0.581
DOC_WW_Pin1_4	106	111	PF00397	0.704
DOC_WW_Pin1_4	171	176	PF00397	0.606
DOC_WW_Pin1_4	66	71	PF00397	0.696
DOC_WW_Pin1_4	83	88	PF00397	0.810
DOC_WW_Pin1_4	9	14	PF00397	0.598
LIG_14-3-3_CanoR_1	130	135	PF00244	0.515
LIG_14-3-3_CanoR_1	196	200	PF00244	0.606
LIG_14-3-3_CanoR_1	320	326	PF00244	0.668
LIG_14-3-3_CanoR_1	394	401	PF00244	0.672
LIG_Actin_WH2_2	186	202	PF00022	0.595
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BRCT_BRCA1_1	29	33	PF00533	0.545
LIG_Clathr_ClatBox_1	156	160	PF01394	0.598
LIG_FHA_1	143	149	PF00498	0.698
LIG_FHA_1	226	232	PF00498	0.532
LIG_FHA_1	269	275	PF00498	0.489
LIG_FHA_1	37	43	PF00498	0.642
LIG_FHA_1	377	383	PF00498	0.511
LIG_FHA_2	373	379	PF00498	0.689
LIG_FHA_2	382	388	PF00498	0.595
LIG_FHA_2	55	61	PF00498	0.647
LIG_HP1_1	195	199	PF01393	0.593
LIG_LIR_Apic_2	12	17	PF02991	0.593
LIG_LIR_Gen_1	180	189	PF02991	0.599
LIG_LIR_Nem_3	180	185	PF02991	0.616
LIG_SH2_PTP2	14	17	PF00017	0.717
LIG_SH2_SRC	14	17	PF00017	0.645
LIG_SH2_STAT3	230	233	PF00017	0.606
LIG_SH2_STAT5	14	17	PF00017	0.733
LIG_SH2_STAT5	230	233	PF00017	0.606
LIG_SH2_STAT5	38	41	PF00017	0.544
LIG_SH3_1	10	16	PF00018	0.631
LIG_SH3_1	167	173	PF00018	0.699
LIG_SH3_3	10	16	PF00018	0.706
LIG_SH3_3	104	110	PF00018	0.754
LIG_SH3_3	167	173	PF00018	0.774
LIG_SH3_3	229	235	PF00018	0.492
LIG_SH3_3	81	87	PF00018	0.776
LIG_SH3_3	90	96	PF00018	0.633
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.560
LIG_SUMO_SIM_par_1	155	160	PF11976	0.593
LIG_SUMO_SIM_par_1	248	254	PF11976	0.500
LIG_SUMO_SIM_par_1	351	358	PF11976	0.542
LIG_TRAF2_1	111	114	PF00917	0.708
LIG_WRC_WIRS_1	4	9	PF05994	0.655
MOD_CDK_SPxK_1	66	72	PF00069	0.683
MOD_CK1_1	116	122	PF00069	0.625
MOD_CK1_1	162	168	PF00069	0.613
MOD_CK1_1	268	274	PF00069	0.746
MOD_CK1_1	321	327	PF00069	0.645
MOD_CK1_1	355	361	PF00069	0.664
MOD_CK1_1	389	395	PF00069	0.763
MOD_CK1_1	66	72	PF00069	0.533
MOD_CK2_1	2	8	PF00069	0.747
MOD_CK2_1	372	378	PF00069	0.671
MOD_CK2_1	381	387	PF00069	0.597
MOD_CK2_1	54	60	PF00069	0.780
MOD_Cter_Amidation	165	168	PF01082	0.475
MOD_GlcNHglycan	123	126	PF01048	0.591
MOD_GlcNHglycan	275	278	PF01048	0.518
MOD_GlcNHglycan	323	326	PF01048	0.747
MOD_GlcNHglycan	47	53	PF01048	0.652
MOD_GlcNHglycan	87	90	PF01048	0.825
MOD_GSK3_1	112	119	PF00069	0.702
MOD_GSK3_1	144	151	PF00069	0.674
MOD_GSK3_1	241	248	PF00069	0.517
MOD_GSK3_1	261	268	PF00069	0.539
MOD_GSK3_1	269	276	PF00069	0.655
MOD_GSK3_1	328	335	PF00069	0.658
MOD_GSK3_1	342	349	PF00069	0.429
MOD_GSK3_1	372	379	PF00069	0.670
MOD_GSK3_1	382	389	PF00069	0.699
MOD_NEK2_1	159	164	PF00069	0.584
MOD_NEK2_1	181	186	PF00069	0.616
MOD_NEK2_1	226	231	PF00069	0.511
MOD_NEK2_1	262	267	PF00069	0.510
MOD_NEK2_1	354	359	PF00069	0.564
MOD_NEK2_1	393	398	PF00069	0.671
MOD_NEK2_2	195	200	PF00069	0.608
MOD_NEK2_2	63	68	PF00069	0.543
MOD_OFUCOSY	35	40	PF10250	0.622
MOD_PIKK_1	303	309	PF00454	0.443
MOD_PIKK_1	348	354	PF00454	0.541
MOD_PIKK_1	393	399	PF00454	0.624
MOD_PK_1	130	136	PF00069	0.328
MOD_PK_1	245	251	PF00069	0.497
MOD_PKA_2	195	201	PF00069	0.615
MOD_PKA_2	319	325	PF00069	0.663
MOD_PKA_2	389	395	PF00069	0.689
MOD_PKA_2	63	69	PF00069	0.737
MOD_Plk_4	130	136	PF00069	0.328
MOD_Plk_4	159	165	PF00069	0.663
MOD_Plk_4	226	232	PF00069	0.532
MOD_ProDKin_1	106	112	PF00069	0.702
MOD_ProDKin_1	171	177	PF00069	0.596
MOD_ProDKin_1	66	72	PF00069	0.698
MOD_ProDKin_1	83	89	PF00069	0.812
MOD_ProDKin_1	9	15	PF00069	0.605
MOD_SUMO_for_1	280	283	PF00179	0.611
MOD_SUMO_rev_2	273	282	PF00179	0.741
TRG_DiLeu_BaEn_1	365	370	PF01217	0.536
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.613
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.516
TRG_DiLeu_LyEn_5	365	370	PF01217	0.536
TRG_ER_diArg_1	405	407	PF00400	0.565
TRG_ER_diArg_1	96	98	PF00400	0.712
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW8	Leptomonas seymouri	37%	72%
A0A3S7X7D6	Leishmania donovani	87%	100%
A4HAF6	Leishmania braziliensis	71%	98%
A4I9L2	Leishmania infantum	87%	100%
Q4Q3G6	Leishmania major	88%	100%