LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B4K9_LEIMU
TriTrypDb:
LmxM.33.0410
Length:
420

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4K9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4K9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 408 412 PF00656 0.499
CLV_NRD_NRD_1 84 86 PF00675 0.567
CLV_NRD_NRD_1 92 94 PF00675 0.510
CLV_PCSK_KEX2_1 92 94 PF00082 0.510
CLV_PCSK_SKI1_1 103 107 PF00082 0.524
CLV_PCSK_SKI1_1 244 248 PF00082 0.436
CLV_PCSK_SKI1_1 260 264 PF00082 0.540
CLV_PCSK_SKI1_1 63 67 PF00082 0.500
CLV_PCSK_SKI1_1 72 76 PF00082 0.416
CLV_Separin_Metazoa 60 64 PF03568 0.509
DEG_APCC_DBOX_1 331 339 PF00400 0.474
DOC_CDC14_PxL_1 245 253 PF14671 0.498
DOC_USP7_MATH_1 116 120 PF00917 0.563
DOC_USP7_MATH_1 185 189 PF00917 0.570
DOC_USP7_MATH_1 213 217 PF00917 0.513
DOC_USP7_MATH_1 3 7 PF00917 0.640
DOC_USP7_MATH_1 405 409 PF00917 0.588
DOC_WW_Pin1_4 278 283 PF00397 0.584
DOC_WW_Pin1_4 398 403 PF00397 0.704
LIG_14-3-3_CanoR_1 388 395 PF00244 0.394
LIG_14-3-3_CanoR_1 63 68 PF00244 0.559
LIG_14-3-3_CanoR_1 92 100 PF00244 0.625
LIG_Actin_WH2_2 324 341 PF00022 0.559
LIG_Actin_WH2_2 33 49 PF00022 0.590
LIG_BIR_II_1 1 5 PF00653 0.671
LIG_eIF4E_1 240 246 PF01652 0.463
LIG_FHA_1 149 155 PF00498 0.503
LIG_FHA_1 245 251 PF00498 0.474
LIG_FHA_2 184 190 PF00498 0.495
LIG_FHA_2 202 208 PF00498 0.491
LIG_FHA_2 271 277 PF00498 0.625
LIG_FHA_2 342 348 PF00498 0.476
LIG_LIR_Apic_2 139 144 PF02991 0.493
LIG_LIR_Gen_1 178 185 PF02991 0.483
LIG_LIR_Nem_3 178 183 PF02991 0.472
LIG_MYND_1 57 61 PF01753 0.527
LIG_Pex14_2 180 184 PF04695 0.451
LIG_Pex14_2 78 82 PF04695 0.456
LIG_Rb_LxCxE_1 119 133 PF01857 0.520
LIG_REV1ctd_RIR_1 181 191 PF16727 0.465
LIG_SH2_CRK 195 199 PF00017 0.282
LIG_SH2_NCK_1 124 128 PF00017 0.501
LIG_SH2_NCK_1 67 71 PF00017 0.560
LIG_SH2_PTP2 141 144 PF00017 0.515
LIG_SH2_SRC 124 127 PF00017 0.504
LIG_SH2_STAP1 367 371 PF00017 0.527
LIG_SH2_STAT5 141 144 PF00017 0.584
LIG_SH2_STAT5 179 182 PF00017 0.443
LIG_SH2_STAT5 39 42 PF00017 0.549
LIG_SH2_STAT5 44 47 PF00017 0.523
LIG_SH3_3 139 145 PF00018 0.547
LIG_SH3_3 243 249 PF00018 0.435
LIG_SH3_3 396 402 PF00018 0.687
LIG_SUMO_SIM_par_1 247 253 PF11976 0.522
LIG_TRAF2_1 108 111 PF00917 0.520
LIG_TRAF2_1 144 147 PF00917 0.549
LIG_TRAF2_1 344 347 PF00917 0.485
MOD_CK1_1 255 261 PF00069 0.560
MOD_CK1_1 341 347 PF00069 0.327
MOD_CK1_1 401 407 PF00069 0.782
MOD_CK2_1 183 189 PF00069 0.497
MOD_CK2_1 201 207 PF00069 0.445
MOD_CK2_1 270 276 PF00069 0.599
MOD_CK2_1 341 347 PF00069 0.414
MOD_GlcNHglycan 1 4 PF01048 0.678
MOD_GlcNHglycan 217 220 PF01048 0.470
MOD_GlcNHglycan 254 257 PF01048 0.613
MOD_GSK3_1 164 171 PF00069 0.525
MOD_GSK3_1 315 322 PF00069 0.634
MOD_GSK3_1 401 408 PF00069 0.753
MOD_GSK3_1 42 49 PF00069 0.594
MOD_N-GLC_1 46 51 PF02516 0.590
MOD_NEK2_1 175 180 PF00069 0.441
MOD_NEK2_1 183 188 PF00069 0.395
MOD_NEK2_1 338 343 PF00069 0.563
MOD_NEK2_1 46 51 PF00069 0.512
MOD_NEK2_2 233 238 PF00069 0.431
MOD_PIKK_1 136 142 PF00454 0.535
MOD_PIKK_1 168 174 PF00454 0.563
MOD_PIKK_1 250 256 PF00454 0.534
MOD_PIKK_1 387 393 PF00454 0.489
MOD_PIKK_1 91 97 PF00454 0.617
MOD_PKA_2 221 227 PF00069 0.466
MOD_PKA_2 3 9 PF00069 0.625
MOD_PKA_2 338 344 PF00069 0.566
MOD_PKA_2 387 393 PF00069 0.609
MOD_PKA_2 91 97 PF00069 0.594
MOD_Plk_1 168 174 PF00069 0.452
MOD_Plk_1 367 373 PF00069 0.510
MOD_Plk_1 42 48 PF00069 0.527
MOD_Plk_2-3 164 170 PF00069 0.504
MOD_Plk_2-3 196 202 PF00069 0.333
MOD_Plk_4 116 122 PF00069 0.576
MOD_Plk_4 175 181 PF00069 0.496
MOD_Plk_4 367 373 PF00069 0.532
MOD_ProDKin_1 278 284 PF00069 0.589
MOD_ProDKin_1 398 404 PF00069 0.707
MOD_SUMO_rev_2 101 108 PF00179 0.574
MOD_SUMO_rev_2 81 88 PF00179 0.540
TRG_DiLeu_BaEn_1 150 155 PF01217 0.268
TRG_DiLeu_BaEn_1 299 304 PF01217 0.675
TRG_ENDOCYTIC_2 124 127 PF00928 0.400
TRG_ENDOCYTIC_2 195 198 PF00928 0.542
TRG_ENDOCYTIC_2 240 243 PF00928 0.413
TRG_ER_diArg_1 331 334 PF00400 0.493
TRG_NES_CRM1_1 147 161 PF08389 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK09 Leptomonas seymouri 59% 93%
A0A0S4KNI9 Bodo saltans 21% 100%
A0A1X0P8J5 Trypanosomatidae 32% 100%
A0A3S7X7H5 Leishmania donovani 91% 100%
A4HAF5 Leishmania braziliensis 73% 100%
A4I9L1 Leishmania infantum 91% 100%
Q4Q3G7 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS