Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B4K6_LEIMU

TriTrypDb:

LmxM.33.0380

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 4
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4K6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.622
CLV_NRD_NRD_1	138	140	PF00675	0.511
CLV_NRD_NRD_1	7	9	PF00675	0.552
CLV_PCSK_KEX2_1	138	140	PF00082	0.511
CLV_PCSK_KEX2_1	7	9	PF00082	0.552
CLV_PCSK_PC7_1	3	9	PF00082	0.556
CLV_PCSK_SKI1_1	308	312	PF00082	0.658
DEG_APCC_DBOX_1	299	307	PF00400	0.609
DEG_APCC_DBOX_1	7	15	PF00400	0.571
DEG_COP1_1	250	259	PF00400	0.694
DEG_Nend_UBRbox_4	1	3	PF02207	0.616
DEG_ODPH_VHL_1	11	22	PF01847	0.564
DOC_CYCLIN_RxL_1	27	38	PF00134	0.489
DOC_MAPK_DCC_7	255	265	PF00069	0.677
DOC_MAPK_DCC_7	7	16	PF00069	0.622
DOC_MAPK_gen_1	337	343	PF00069	0.632
DOC_MAPK_gen_1	7	16	PF00069	0.585
DOC_MAPK_MEF2A_6	10	18	PF00069	0.629
DOC_PP1_RVXF_1	306	312	PF00149	0.667
DOC_PP4_FxxP_1	228	231	PF00568	0.622
DOC_USP7_MATH_1	112	116	PF00917	0.494
DOC_USP7_MATH_1	23	27	PF00917	0.574
DOC_USP7_MATH_1	231	235	PF00917	0.617
DOC_USP7_MATH_1	362	366	PF00917	0.590
DOC_USP7_MATH_1	430	434	PF00917	0.539
DOC_USP7_MATH_1	52	56	PF00917	0.640
DOC_WW_Pin1_4	154	159	PF00397	0.557
DOC_WW_Pin1_4	250	255	PF00397	0.742
DOC_WW_Pin1_4	258	263	PF00397	0.617
DOC_WW_Pin1_4	47	52	PF00397	0.653
LIG_14-3-3_CanoR_1	141	146	PF00244	0.447
LIG_14-3-3_CanoR_1	285	294	PF00244	0.707
LIG_BIR_III_2	193	197	PF00653	0.536
LIG_BIR_III_4	44	48	PF00653	0.663
LIG_BRCT_BRCA1_1	432	436	PF00533	0.538
LIG_CtBP_PxDLS_1	262	266	PF00389	0.671
LIG_EH1_1	110	118	PF00400	0.468
LIG_FHA_1	117	123	PF00498	0.367
LIG_FHA_1	129	135	PF00498	0.454
LIG_FHA_1	23	29	PF00498	0.487
LIG_FHA_1	271	277	PF00498	0.630
LIG_FHA_1	281	287	PF00498	0.586
LIG_FHA_1	393	399	PF00498	0.561
LIG_FHA_1	420	426	PF00498	0.654
LIG_FHA_1	87	93	PF00498	0.522
LIG_FHA_1	97	103	PF00498	0.492
LIG_FHA_2	326	332	PF00498	0.559
LIG_FHA_2	369	375	PF00498	0.681
LIG_FHA_2	380	386	PF00498	0.724
LIG_FHA_2	443	449	PF00498	0.563
LIG_Integrin_isoDGR_2	46	48	PF01839	0.668
LIG_LIR_Gen_1	144	151	PF02991	0.484
LIG_LIR_LC3C_4	115	118	PF02991	0.420
LIG_NRBOX	17	23	PF00104	0.569
LIG_SH2_STAP1	143	147	PF00017	0.502
LIG_SH2_STAT5	124	127	PF00017	0.398
LIG_SH2_STAT5	143	146	PF00017	0.488
LIG_SH2_STAT5	171	174	PF00017	0.528
LIG_SH2_STAT5	275	278	PF00017	0.757
LIG_SH2_STAT5	388	391	PF00017	0.575
LIG_SH2_STAT5	96	99	PF00017	0.579
LIG_SH3_1	327	333	PF00018	0.669
LIG_SH3_1	361	367	PF00018	0.629
LIG_SH3_1	412	418	PF00018	0.636
LIG_SH3_3	193	199	PF00018	0.577
LIG_SH3_3	251	257	PF00018	0.700
LIG_SH3_3	327	333	PF00018	0.616
LIG_SH3_3	33	39	PF00018	0.699
LIG_SH3_3	361	367	PF00018	0.592
LIG_SH3_3	412	418	PF00018	0.655
LIG_SUMO_SIM_par_1	261	267	PF11976	0.602
LIG_TRAF2_1	177	180	PF00917	0.777
LIG_TRAF2_1	414	417	PF00917	0.633
LIG_TRAF2_1	85	88	PF00917	0.507
MOD_CDK_SPK_2	250	255	PF00069	0.704
MOD_CK1_1	154	160	PF00069	0.560
MOD_CK1_1	174	180	PF00069	0.477
MOD_CK1_1	258	264	PF00069	0.652
MOD_CK1_1	289	295	PF00069	0.657
MOD_CK1_1	298	304	PF00069	0.586
MOD_CK1_1	50	56	PF00069	0.583
MOD_CK2_1	174	180	PF00069	0.776
MOD_CK2_1	325	331	PF00069	0.562
MOD_CK2_1	368	374	PF00069	0.686
MOD_CK2_1	379	385	PF00069	0.725
MOD_CK2_1	436	442	PF00069	0.526
MOD_GlcNHglycan	153	156	PF01048	0.509
MOD_GlcNHglycan	257	260	PF01048	0.757
MOD_GlcNHglycan	364	367	PF01048	0.612
MOD_GlcNHglycan	52	55	PF01048	0.786
MOD_GlcNHglycan	69	72	PF01048	0.462
MOD_GlcNHglycan	73	76	PF01048	0.494
MOD_GSK3_1	112	119	PF00069	0.476
MOD_GSK3_1	124	131	PF00069	0.549
MOD_GSK3_1	150	157	PF00069	0.505
MOD_GSK3_1	163	170	PF00069	0.608
MOD_GSK3_1	264	271	PF00069	0.633
MOD_GSK3_1	276	283	PF00069	0.636
MOD_GSK3_1	294	301	PF00069	0.657
MOD_GSK3_1	321	328	PF00069	0.539
MOD_GSK3_1	392	399	PF00069	0.524
MOD_GSK3_1	67	74	PF00069	0.552
MOD_GSK3_1	86	93	PF00069	0.518
MOD_N-GLC_1	166	171	PF02516	0.667
MOD_NEK2_1	116	121	PF00069	0.408
MOD_NEK2_1	150	155	PF00069	0.466
MOD_NEK2_1	22	27	PF00069	0.513
MOD_NEK2_1	276	281	PF00069	0.626
MOD_NEK2_1	32	37	PF00069	0.640
MOD_NEK2_1	368	373	PF00069	0.496
MOD_NEK2_1	436	441	PF00069	0.549
MOD_NEK2_1	86	91	PF00069	0.524
MOD_PIKK_1	231	237	PF00454	0.601
MOD_PIKK_1	286	292	PF00454	0.679
MOD_PIKK_1	321	327	PF00454	0.494
MOD_PIKK_1	419	425	PF00454	0.645
MOD_PIKK_1	86	92	PF00454	0.518
MOD_PKA_2	286	292	PF00069	0.683
MOD_PKB_1	139	147	PF00069	0.458
MOD_Plk_1	166	172	PF00069	0.665
MOD_Plk_1	86	92	PF00069	0.474
MOD_Plk_4	167	173	PF00069	0.504
MOD_Plk_4	23	29	PF00069	0.578
MOD_Plk_4	32	38	PF00069	0.601
MOD_Plk_4	60	66	PF00069	0.617
MOD_ProDKin_1	154	160	PF00069	0.560
MOD_ProDKin_1	250	256	PF00069	0.739
MOD_ProDKin_1	258	264	PF00069	0.619
MOD_ProDKin_1	47	53	PF00069	0.650
MOD_SUMO_for_1	183	186	PF00179	0.676
MOD_SUMO_rev_2	407	414	PF00179	0.626
TRG_DiLeu_BaEn_1	78	83	PF01217	0.556
TRG_DiLeu_BaEn_2	431	437	PF01217	0.487
TRG_DiLeu_BaEn_4	87	93	PF01217	0.498
TRG_ENDOCYTIC_2	145	148	PF00928	0.505
TRG_ER_diArg_1	137	139	PF00400	0.485
TRG_ER_diArg_1	7	10	PF00400	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P8	Leptomonas seymouri	54%	86%
A0A0S4ILN1	Bodo saltans	30%	100%
A0A3Q8IF83	Leishmania donovani	89%	81%
A4HAF2	Leishmania braziliensis	77%	100%
A4I9K8	Leishmania infantum	90%	81%
Q4Q3H0	Leishmania major	88%	100%