AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania mexicana

UniProt:

E9B4K2_LEIMU

TriTrypDb:

LmxM.33.0340

Length:

802

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B4K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4K2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.597
CLV_C14_Caspase3-7	607	611	PF00656	0.708
CLV_C14_Caspase3-7	791	795	PF00656	0.591
CLV_MEL_PAP_1	56	62	PF00089	0.399
CLV_NRD_NRD_1	215	217	PF00675	0.484
CLV_NRD_NRD_1	290	292	PF00675	0.445
CLV_NRD_NRD_1	43	45	PF00675	0.377
CLV_NRD_NRD_1	510	512	PF00675	0.302
CLV_NRD_NRD_1	544	546	PF00675	0.205
CLV_NRD_NRD_1	583	585	PF00675	0.431
CLV_NRD_NRD_1	648	650	PF00675	0.411
CLV_PCSK_KEX2_1	215	217	PF00082	0.564
CLV_PCSK_KEX2_1	290	292	PF00082	0.445
CLV_PCSK_KEX2_1	343	345	PF00082	0.487
CLV_PCSK_KEX2_1	43	45	PF00082	0.377
CLV_PCSK_KEX2_1	510	512	PF00082	0.304
CLV_PCSK_KEX2_1	544	546	PF00082	0.206
CLV_PCSK_KEX2_1	648	650	PF00082	0.414
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.487
CLV_PCSK_SKI1_1	126	130	PF00082	0.400
CLV_PCSK_SKI1_1	163	167	PF00082	0.421
CLV_PCSK_SKI1_1	28	32	PF00082	0.404
CLV_PCSK_SKI1_1	344	348	PF00082	0.443
CLV_PCSK_SKI1_1	424	428	PF00082	0.469
CLV_PCSK_SKI1_1	43	47	PF00082	0.378
CLV_PCSK_SKI1_1	649	653	PF00082	0.419
CLV_PCSK_SKI1_1	755	759	PF00082	0.370
DEG_APCC_DBOX_1	332	340	PF00400	0.612
DEG_APCC_DBOX_1	343	351	PF00400	0.652
DEG_APCC_DBOX_1	509	517	PF00400	0.469
DEG_COP1_1	135	145	PF00400	0.615
DEG_Nend_UBRbox_2	1	3	PF02207	0.498
DEG_SPOP_SBC_1	426	430	PF00917	0.655
DEG_SPOP_SBC_1	616	620	PF00917	0.626
DOC_ANK_TNKS_1	475	482	PF00023	0.573
DOC_CDC14_PxL_1	348	356	PF14671	0.642
DOC_CYCLIN_yClb5_NLxxxL_5	653	662	PF00134	0.531
DOC_MAPK_gen_1	343	350	PF00069	0.637
DOC_MAPK_gen_1	448	457	PF00069	0.591
DOC_MAPK_gen_1	507	516	PF00069	0.510
DOC_MAPK_gen_1	544	554	PF00069	0.488
DOC_MAPK_MEF2A_6	510	518	PF00069	0.504
DOC_PP1_RVXF_1	483	489	PF00149	0.517
DOC_PP2B_LxvP_1	679	682	PF13499	0.584
DOC_PP4_FxxP_1	273	276	PF00568	0.709
DOC_PP4_FxxP_1	477	480	PF00568	0.595
DOC_SPAK_OSR1_1	476	480	PF12202	0.565
DOC_USP7_MATH_1	316	320	PF00917	0.651
DOC_USP7_MATH_1	384	388	PF00917	0.631
DOC_USP7_MATH_1	399	403	PF00917	0.653
DOC_USP7_MATH_1	556	560	PF00917	0.469
DOC_USP7_MATH_1	603	607	PF00917	0.669
DOC_USP7_MATH_1	616	620	PF00917	0.684
DOC_USP7_MATH_1	702	706	PF00917	0.593
DOC_USP7_MATH_1	763	767	PF00917	0.492
DOC_USP7_UBL2_3	409	413	PF12436	0.640
DOC_WW_Pin1_4	3	8	PF00397	0.412
DOC_WW_Pin1_4	363	368	PF00397	0.595
DOC_WW_Pin1_4	58	63	PF00397	0.645
DOC_WW_Pin1_4	595	600	PF00397	0.617
LIG_14-3-3_CanoR_1	124	129	PF00244	0.673
LIG_14-3-3_CanoR_1	131	141	PF00244	0.641
LIG_14-3-3_CanoR_1	265	273	PF00244	0.678
LIG_14-3-3_CanoR_1	43	53	PF00244	0.618
LIG_14-3-3_CanoR_1	448	453	PF00244	0.613
LIG_14-3-3_CanoR_1	462	467	PF00244	0.466
LIG_14-3-3_CanoR_1	485	489	PF00244	0.555
LIG_14-3-3_CanoR_1	555	561	PF00244	0.445
LIG_14-3-3_CanoR_1	744	754	PF00244	0.549
LIG_14-3-3_CanoR_1	789	794	PF00244	0.599
LIG_Actin_WH2_2	523	541	PF00022	0.484
LIG_AP2alpha_1	672	676	PF02296	0.526
LIG_APCC_ABBA_1	560	565	PF00400	0.469
LIG_APCC_ABBA_1	713	718	PF00400	0.465
LIG_BIR_III_4	164	168	PF00653	0.591
LIG_BIR_III_4	567	571	PF00653	0.469
LIG_BRCT_BRCA1_1	121	125	PF00533	0.579
LIG_BRCT_BRCA1_1	269	273	PF00533	0.757
LIG_BRCT_BRCA1_1	453	457	PF00533	0.523
LIG_CaM_IQ_9	576	592	PF13499	0.613
LIG_CAP-Gly_1	794	802	PF01302	0.643
LIG_deltaCOP1_diTrp_1	115	125	PF00928	0.670
LIG_eIF4E_1	102	108	PF01652	0.650
LIG_FHA_1	12	18	PF00498	0.277
LIG_FHA_1	485	491	PF00498	0.555
LIG_FHA_1	497	503	PF00498	0.502
LIG_FHA_1	547	553	PF00498	0.455
LIG_FHA_1	720	726	PF00498	0.516
LIG_FHA_1	746	752	PF00498	0.546
LIG_FHA_1	785	791	PF00498	0.522
LIG_FHA_2	269	275	PF00498	0.682
LIG_FHA_2	521	527	PF00498	0.469
LIG_FXI_DFP_1	563	567	PF00024	0.269
LIG_GBD_Chelix_1	505	513	PF00786	0.280
LIG_HCF-1_HBM_1	726	729	PF13415	0.583
LIG_LIR_Apic_2	270	276	PF02991	0.716
LIG_LIR_Apic_2	288	292	PF02991	0.643
LIG_LIR_Gen_1	101	111	PF02991	0.622
LIG_LIR_Gen_1	312	321	PF02991	0.614
LIG_LIR_Gen_1	451	458	PF02991	0.573
LIG_LIR_Gen_1	564	572	PF02991	0.459
LIG_LIR_Gen_1	670	679	PF02991	0.539
LIG_LIR_Gen_1	683	689	PF02991	0.529
LIG_LIR_Gen_1	794	802	PF02991	0.592
LIG_LIR_Nem_3	101	107	PF02991	0.603
LIG_LIR_Nem_3	115	121	PF02991	0.702
LIG_LIR_Nem_3	122	128	PF02991	0.629
LIG_LIR_Nem_3	208	212	PF02991	0.633
LIG_LIR_Nem_3	312	317	PF02991	0.625
LIG_LIR_Nem_3	379	385	PF02991	0.643
LIG_LIR_Nem_3	451	455	PF02991	0.532
LIG_LIR_Nem_3	487	491	PF02991	0.519
LIG_LIR_Nem_3	564	569	PF02991	0.459
LIG_LIR_Nem_3	670	675	PF02991	0.531
LIG_LIR_Nem_3	683	688	PF02991	0.531
LIG_LIR_Nem_3	794	799	PF02991	0.583
LIG_LYPXL_S_1	350	354	PF13949	0.445
LIG_LYPXL_yS_3	351	354	PF13949	0.648
LIG_MLH1_MIPbox_1	269	273	PF16413	0.726
LIG_MLH1_MIPbox_1	453	457	PF16413	0.523
LIG_NRBOX	12	18	PF00104	0.325
LIG_PDZ_Class_3	797	802	PF00595	0.679
LIG_Pex14_2	114	118	PF04695	0.628
LIG_Pex14_2	125	129	PF04695	0.620
LIG_Pex14_2	30	34	PF04695	0.296
LIG_Pex14_2	452	456	PF04695	0.526
LIG_Pex14_2	672	676	PF04695	0.526
LIG_Pex14_2	685	689	PF04695	0.515
LIG_SH2_CRK	104	108	PF00017	0.613
LIG_SH2_CRK	289	293	PF00017	0.654
LIG_SH2_CRK	314	318	PF00017	0.649
LIG_SH2_CRK	491	495	PF00017	0.428
LIG_SH2_PTP2	371	374	PF00017	0.619
LIG_SH2_SRC	217	220	PF00017	0.630
LIG_SH2_STAP1	102	106	PF00017	0.599
LIG_SH2_STAP1	121	125	PF00017	0.623
LIG_SH2_STAP1	217	221	PF00017	0.691
LIG_SH2_STAT5	104	107	PF00017	0.566
LIG_SH2_STAT5	335	338	PF00017	0.609
LIG_SH2_STAT5	371	374	PF00017	0.680
LIG_SH2_STAT5	561	564	PF00017	0.469
LIG_SH2_STAT5	78	81	PF00017	0.627
LIG_SH2_STAT5	83	86	PF00017	0.617
LIG_SH3_3	1	7	PF00018	0.443
LIG_SH3_3	239	245	PF00018	0.834
LIG_SH3_3	273	279	PF00018	0.702
LIG_SH3_3	346	352	PF00018	0.646
LIG_SH3_3	527	533	PF00018	0.484
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.657
LIG_SUMO_SIM_anti_2	281	288	PF11976	0.697
LIG_SUMO_SIM_par_1	281	288	PF11976	0.697
LIG_SUMO_SIM_par_1	512	517	PF11976	0.472
LIG_SUMO_SIM_par_1	519	526	PF11976	0.469
LIG_TRAF2_1	279	282	PF00917	0.648
LIG_TRAF2_1	391	394	PF00917	0.643
LIG_TYR_ITIM	349	354	PF00017	0.645
LIG_WRC_WIRS_1	793	798	PF05994	0.585
MOD_CDC14_SPxK_1	61	64	PF00782	0.609
MOD_CDK_SPK_2	363	368	PF00069	0.572
MOD_CDK_SPxK_1	58	64	PF00069	0.647
MOD_CK1_1	177	183	PF00069	0.747
MOD_CK1_1	184	190	PF00069	0.695
MOD_CK1_1	261	267	PF00069	0.755
MOD_CK1_1	268	274	PF00069	0.728
MOD_CK1_1	304	310	PF00069	0.710
MOD_CK1_1	402	408	PF00069	0.682
MOD_CK1_1	444	450	PF00069	0.673
MOD_CK1_1	546	552	PF00069	0.477
MOD_CK1_1	595	601	PF00069	0.674
MOD_CK1_1	6	12	PF00069	0.419
MOD_CK1_1	618	624	PF00069	0.713
MOD_CK1_1	627	633	PF00069	0.687
MOD_CK1_1	766	772	PF00069	0.463
MOD_CK1_1	792	798	PF00069	0.617
MOD_CK2_1	132	138	PF00069	0.593
MOD_CK2_1	268	274	PF00069	0.710
MOD_CK2_1	514	520	PF00069	0.469
MOD_GlcNHglycan	176	179	PF01048	0.500
MOD_GlcNHglycan	303	306	PF01048	0.403
MOD_GlcNHglycan	377	381	PF01048	0.429
MOD_GlcNHglycan	386	389	PF01048	0.454
MOD_GlcNHglycan	402	405	PF01048	0.420
MOD_GlcNHglycan	442	446	PF01048	0.465
MOD_GlcNHglycan	621	624	PF01048	0.537
MOD_GlcNHglycan	626	629	PF01048	0.517
MOD_GlcNHglycan	765	768	PF01048	0.343
MOD_GlcNHglycan	8	11	PF01048	0.638
MOD_GSK3_1	120	127	PF00069	0.624
MOD_GSK3_1	137	144	PF00069	0.589
MOD_GSK3_1	177	184	PF00069	0.705
MOD_GSK3_1	261	268	PF00069	0.792
MOD_GSK3_1	400	407	PF00069	0.669
MOD_GSK3_1	424	431	PF00069	0.659
MOD_GSK3_1	444	451	PF00069	0.651
MOD_GSK3_1	493	500	PF00069	0.479
MOD_GSK3_1	516	523	PF00069	0.516
MOD_GSK3_1	546	553	PF00069	0.477
MOD_GSK3_1	615	622	PF00069	0.718
MOD_GSK3_1	762	769	PF00069	0.535
MOD_GSK3_1	784	791	PF00069	0.563
MOD_GSK3_1	8	15	PF00069	0.399
MOD_LATS_1	42	48	PF00433	0.537
MOD_NEK2_1	137	142	PF00069	0.629
MOD_NEK2_1	210	215	PF00069	0.679
MOD_NEK2_1	301	306	PF00069	0.642
MOD_NEK2_1	592	597	PF00069	0.633
MOD_NEK2_1	700	705	PF00069	0.721
MOD_NEK2_1	71	76	PF00069	0.609
MOD_NEK2_1	746	751	PF00069	0.530
MOD_NEK2_2	404	409	PF00069	0.638
MOD_NEK2_2	484	489	PF00069	0.557
MOD_NEK2_2	550	555	PF00069	0.472
MOD_NEK2_2	556	561	PF00069	0.467
MOD_NEK2_2	78	83	PF00069	0.512
MOD_PIKK_1	177	183	PF00454	0.723
MOD_PIKK_1	630	636	PF00454	0.632
MOD_PIKK_1	719	725	PF00454	0.569
MOD_PIKK_1	739	745	PF00454	0.542
MOD_PIKK_1	746	752	PF00454	0.527
MOD_PK_1	789	795	PF00069	0.608
MOD_PKA_1	43	49	PF00069	0.571
MOD_PKA_2	174	180	PF00069	0.715
MOD_PKA_2	43	49	PF00069	0.571
MOD_PKA_2	484	490	PF00069	0.555
MOD_PKA_2	543	549	PF00069	0.465
MOD_PKA_2	603	609	PF00069	0.819
MOD_PKA_2	788	794	PF00069	0.559
MOD_Plk_1	102	108	PF00069	0.589
MOD_Plk_1	137	143	PF00069	0.617
MOD_Plk_1	268	274	PF00069	0.702
MOD_Plk_1	707	713	PF00069	0.531
MOD_Plk_1	734	740	PF00069	0.678
MOD_Plk_2-3	520	526	PF00069	0.455
MOD_Plk_2-3	636	642	PF00069	0.695
MOD_Plk_2-3	665	671	PF00069	0.590
MOD_Plk_4	102	108	PF00069	0.589
MOD_Plk_4	12	18	PF00069	0.313
MOD_Plk_4	137	143	PF00069	0.716
MOD_Plk_4	205	211	PF00069	0.553
MOD_Plk_4	268	274	PF00069	0.695
MOD_Plk_4	350	356	PF00069	0.593
MOD_Plk_4	451	457	PF00069	0.540
MOD_Plk_4	462	468	PF00069	0.578
MOD_Plk_4	484	490	PF00069	0.636
MOD_Plk_4	497	503	PF00069	0.469
MOD_Plk_4	556	562	PF00069	0.469
MOD_Plk_4	681	687	PF00069	0.535
MOD_Plk_4	702	708	PF00069	0.611
MOD_ProDKin_1	3	9	PF00069	0.411
MOD_ProDKin_1	363	369	PF00069	0.591
MOD_ProDKin_1	58	64	PF00069	0.647
MOD_ProDKin_1	595	601	PF00069	0.621
TRG_DiLeu_BaEn_2	151	157	PF01217	0.636
TRG_DiLeu_BaLyEn_6	696	701	PF01217	0.541
TRG_ENDOCYTIC_2	104	107	PF00928	0.632
TRG_ENDOCYTIC_2	314	317	PF00928	0.622
TRG_ENDOCYTIC_2	351	354	PF00928	0.648
TRG_ENDOCYTIC_2	382	385	PF00928	0.633
TRG_ER_diArg_1	214	216	PF00400	0.759
TRG_ER_diArg_1	289	291	PF00400	0.640
TRG_ER_diArg_1	43	45	PF00400	0.576
TRG_ER_diArg_1	474	477	PF00400	0.654
TRG_ER_diArg_1	509	511	PF00400	0.502
TRG_ER_diArg_1	544	547	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	590	594	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ4	Leptomonas seymouri	49%	97%
A0A3Q8IUC9	Leishmania donovani	87%	100%
A4HAE8	Leishmania braziliensis	67%	100%
A4I9K4	Leishmania infantum	87%	100%
Q4Q3H4	Leishmania major	83%	100%