START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4K0_LEIMU

TriTrypDb:

LmxM.33.0320

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4K0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0008289	lipid binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.640
CLV_NRD_NRD_1	284	286	PF00675	0.437
CLV_NRD_NRD_1	318	320	PF00675	0.602
CLV_NRD_NRD_1	346	348	PF00675	0.726
CLV_PCSK_KEX2_1	201	203	PF00082	0.482
CLV_PCSK_KEX2_1	284	286	PF00082	0.437
CLV_PCSK_KEX2_1	318	320	PF00082	0.484
CLV_PCSK_KEX2_1	336	338	PF00082	0.542
CLV_PCSK_KEX2_1	346	348	PF00082	0.726
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.482
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.542
CLV_PCSK_SKI1_1	284	288	PF00082	0.422
CLV_PCSK_SKI1_1	305	309	PF00082	0.747
CLV_PCSK_SKI1_1	326	330	PF00082	0.704
CLV_PCSK_SKI1_1	346	350	PF00082	0.703
CLV_PCSK_SKI1_1	81	85	PF00082	0.597
CLV_PCSK_SKI1_1	96	100	PF00082	0.290
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DOC_MAPK_gen_1	78	88	PF00069	0.500
DOC_PIKK_1	161	169	PF02985	0.554
DOC_PP1_RVXF_1	120	127	PF00149	0.538
DOC_PP1_RVXF_1	351	358	PF00149	0.663
DOC_PP1_RVXF_1	82	89	PF00149	0.560
DOC_PP4_FxxP_1	126	129	PF00568	0.250
DOC_PP4_FxxP_1	98	101	PF00568	0.408
DOC_USP7_MATH_1	22	26	PF00917	0.648
DOC_USP7_UBL2_3	14	18	PF12436	0.662
DOC_WW_Pin1_4	116	121	PF00397	0.408
DOC_WW_Pin1_4	256	261	PF00397	0.397
DOC_WW_Pin1_4	297	302	PF00397	0.462
LIG_14-3-3_CanoR_1	110	116	PF00244	0.502
LIG_14-3-3_CanoR_1	183	187	PF00244	0.538
LIG_APCC_ABBAyCdc20_2	284	290	PF00400	0.459
LIG_FHA_1	110	116	PF00498	0.465
LIG_FHA_1	220	226	PF00498	0.536
LIG_FHA_1	264	270	PF00498	0.508
LIG_FHA_1	46	52	PF00498	0.465
LIG_FHA_2	213	219	PF00498	0.475
LIG_FHA_2	87	93	PF00498	0.591
LIG_Integrin_RGD_1	337	339	PF01839	0.456
LIG_LIR_Gen_1	105	115	PF02991	0.447
LIG_LIR_Gen_1	194	203	PF02991	0.380
LIG_LIR_Gen_1	54	63	PF02991	0.501
LIG_LIR_Nem_3	105	111	PF02991	0.426
LIG_LIR_Nem_3	180	184	PF02991	0.462
LIG_LIR_Nem_3	194	198	PF02991	0.298
LIG_LIR_Nem_3	54	59	PF02991	0.510
LIG_Pex14_1	177	181	PF04695	0.481
LIG_Pex14_1	263	267	PF04695	0.463
LIG_Pex14_2	267	271	PF04695	0.451
LIG_PTB_Apo_2	50	57	PF02174	0.492
LIG_PTB_Phospho_1	50	56	PF10480	0.524
LIG_SH2_CRK	145	149	PF00017	0.513
LIG_SH2_CRK	184	188	PF00017	0.558
LIG_SH2_GRB2like	138	141	PF00017	0.502
LIG_SH2_NCK_1	145	149	PF00017	0.517
LIG_SH2_NCK_1	184	188	PF00017	0.558
LIG_SH2_PTP2	56	59	PF00017	0.316
LIG_SH2_SRC	211	214	PF00017	0.353
LIG_SH2_SRC	288	291	PF00017	0.605
LIG_SH2_STAP1	138	142	PF00017	0.428
LIG_SH2_STAP1	145	149	PF00017	0.412
LIG_SH2_STAT5	158	161	PF00017	0.602
LIG_SH2_STAT5	203	206	PF00017	0.378
LIG_SH2_STAT5	211	214	PF00017	0.311
LIG_SH2_STAT5	254	257	PF00017	0.352
LIG_SH2_STAT5	56	59	PF00017	0.316
LIG_SH3_3	149	155	PF00018	0.523
LIG_SH3_3	25	31	PF00018	0.431
LIG_SUMO_SIM_par_1	111	116	PF11976	0.451
LIG_TYR_ITIM	286	291	PF00017	0.603
MOD_CDC14_SPxK_1	119	122	PF00782	0.540
MOD_CDK_SPxK_1	116	122	PF00069	0.517
MOD_CK1_1	256	262	PF00069	0.504
MOD_CK1_1	293	299	PF00069	0.676
MOD_CK1_1	314	320	PF00069	0.672
MOD_CK1_1	330	336	PF00069	0.700
MOD_CK1_1	72	78	PF00069	0.590
MOD_CK2_1	128	134	PF00069	0.416
MOD_CK2_1	86	92	PF00069	0.523
MOD_GlcNHglycan	184	187	PF01048	0.505
MOD_GlcNHglycan	332	335	PF01048	0.778
MOD_GlcNHglycan	71	74	PF01048	0.471
MOD_GSK3_1	219	226	PF00069	0.530
MOD_GSK3_1	293	300	PF00069	0.677
MOD_GSK3_1	307	314	PF00069	0.643
MOD_N-GLC_1	116	121	PF02516	0.423
MOD_N-GLC_1	311	316	PF02516	0.687
MOD_N-GLC_1	52	57	PF02516	0.526
MOD_N-GLC_2	141	143	PF02516	0.565
MOD_NEK2_1	329	334	PF00069	0.541
MOD_NEK2_1	4	9	PF00069	0.623
MOD_NEK2_1	52	57	PF00069	0.478
MOD_NEK2_1	69	74	PF00069	0.487
MOD_OFUCOSY	252	257	PF10250	0.491
MOD_PKA_2	109	115	PF00069	0.495
MOD_PKA_2	136	142	PF00069	0.503
MOD_PKA_2	182	188	PF00069	0.542
MOD_PKA_2	219	225	PF00069	0.480
MOD_Plk_1	311	317	PF00069	0.551
MOD_Plk_1	52	58	PF00069	0.486
MOD_Plk_2-3	61	67	PF00069	0.481
MOD_Plk_4	250	256	PF00069	0.385
MOD_Plk_4	263	269	PF00069	0.429
MOD_Plk_4	311	317	PF00069	0.713
MOD_Plk_4	52	58	PF00069	0.551
MOD_ProDKin_1	116	122	PF00069	0.412
MOD_ProDKin_1	256	262	PF00069	0.404
MOD_ProDKin_1	297	303	PF00069	0.465
MOD_SUMO_rev_2	345	355	PF00179	0.657
MOD_SUMO_rev_2	72	79	PF00179	0.379
TRG_DiLeu_BaEn_1	344	349	PF01217	0.690
TRG_DiLeu_BaEn_4	344	350	PF01217	0.735
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.343
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.532
TRG_DiLeu_LyEn_5	344	349	PF01217	0.690
TRG_ENDOCYTIC_2	145	148	PF00928	0.517
TRG_ENDOCYTIC_2	288	291	PF00928	0.605
TRG_ENDOCYTIC_2	56	59	PF00928	0.503
TRG_ER_diArg_1	135	138	PF00400	0.530
TRG_ER_diArg_1	284	286	PF00400	0.437
TRG_ER_diArg_1	346	348	PF00400	0.648
TRG_NES_CRM1_1	164	176	PF08389	0.523
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.703
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J3	Leptomonas seymouri	70%	100%
A0A0S4KHG7	Bodo saltans	38%	100%
A0A1X0P8H6	Trypanosomatidae	42%	100%
A0A3R7MF23	Trypanosoma rangeli	39%	100%
A0A3S7X7C6	Leishmania donovani	90%	100%
A4H7D8	Leishmania braziliensis	77%	100%
A4I9K2	Leishmania infantum	90%	100%
D0A1W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4Q3H6	Leishmania major	89%	100%
V5DIM4	Trypanosoma cruzi	43%	100%