Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4J8_LEIMU

TriTrypDb:

LmxM.33.0300

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B4J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4J8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0030515	snoRNA binding	5	12
GO:0034511	U3 snoRNA binding	6	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.549
CLV_C14_Caspase3-7	635	639	PF00656	0.764
CLV_C14_Caspase3-7	65	69	PF00656	0.696
CLV_NRD_NRD_1	112	114	PF00675	0.629
CLV_NRD_NRD_1	18	20	PF00675	0.581
CLV_NRD_NRD_1	205	207	PF00675	0.552
CLV_NRD_NRD_1	276	278	PF00675	0.315
CLV_NRD_NRD_1	328	330	PF00675	0.483
CLV_NRD_NRD_1	361	363	PF00675	0.441
CLV_NRD_NRD_1	37	39	PF00675	0.530
CLV_NRD_NRD_1	410	412	PF00675	0.458
CLV_NRD_NRD_1	465	467	PF00675	0.608
CLV_NRD_NRD_1	564	566	PF00675	0.508
CLV_NRD_NRD_1	587	589	PF00675	0.600
CLV_NRD_NRD_1	690	692	PF00675	0.754
CLV_PCSK_KEX2_1	112	114	PF00082	0.629
CLV_PCSK_KEX2_1	18	20	PF00082	0.561
CLV_PCSK_KEX2_1	204	206	PF00082	0.589
CLV_PCSK_KEX2_1	361	363	PF00082	0.441
CLV_PCSK_KEX2_1	410	412	PF00082	0.458
CLV_PCSK_KEX2_1	465	467	PF00082	0.608
CLV_PCSK_KEX2_1	509	511	PF00082	0.767
CLV_PCSK_KEX2_1	564	566	PF00082	0.474
CLV_PCSK_KEX2_1	690	692	PF00082	0.739
CLV_PCSK_KEX2_1	732	734	PF00082	0.736
CLV_PCSK_KEX2_1	756	758	PF00082	0.688
CLV_PCSK_KEX2_1	9	11	PF00082	0.554
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.792
CLV_PCSK_PC1ET2_1	690	692	PF00082	0.757
CLV_PCSK_PC1ET2_1	732	734	PF00082	0.733
CLV_PCSK_PC1ET2_1	756	758	PF00082	0.685
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.593
CLV_PCSK_SKI1_1	206	210	PF00082	0.432
CLV_PCSK_SKI1_1	234	238	PF00082	0.568
CLV_PCSK_SKI1_1	270	274	PF00082	0.514
CLV_PCSK_SKI1_1	278	282	PF00082	0.351
CLV_PCSK_SKI1_1	365	369	PF00082	0.735
CLV_PCSK_SKI1_1	6	10	PF00082	0.652
CLV_PCSK_SKI1_1	61	65	PF00082	0.757
CLV_PCSK_SKI1_1	723	727	PF00082	0.731
CLV_PCSK_SKI1_1	729	733	PF00082	0.729
CLV_PCSK_SKI1_1	753	757	PF00082	0.694
DEG_APCC_DBOX_1	410	418	PF00400	0.563
DEG_APCC_DBOX_1	587	595	PF00400	0.625
DEG_Nend_Nbox_1	1	3	PF02207	0.608
DOC_CYCLIN_RxL_1	204	211	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.491
DOC_MAPK_gen_1	176	185	PF00069	0.497
DOC_MAPK_gen_1	204	210	PF00069	0.545
DOC_MAPK_gen_1	277	285	PF00069	0.545
DOC_MAPK_gen_1	410	417	PF00069	0.450
DOC_MAPK_gen_1	673	680	PF00069	0.684
DOC_MAPK_gen_1	703	713	PF00069	0.794
DOC_MAPK_MEF2A_6	179	187	PF00069	0.517
DOC_MAPK_MEF2A_6	410	417	PF00069	0.581
DOC_MAPK_MEF2A_6	525	533	PF00069	0.589
DOC_MAPK_MEF2A_6	575	583	PF00069	0.519
DOC_PP1_RVXF_1	268	275	PF00149	0.484
DOC_PP1_RVXF_1	410	417	PF00149	0.292
DOC_PP2B_LxvP_1	579	582	PF13499	0.510
DOC_USP7_MATH_1	192	196	PF00917	0.594
DOC_USP7_MATH_1	213	217	PF00917	0.532
DOC_USP7_MATH_1	363	367	PF00917	0.689
DOC_USP7_MATH_1	371	375	PF00917	0.678
DOC_USP7_MATH_1	44	48	PF00917	0.747
DOC_USP7_MATH_1	453	457	PF00917	0.698
DOC_USP7_MATH_1	484	488	PF00917	0.496
DOC_USP7_MATH_1	519	523	PF00917	0.793
DOC_USP7_MATH_1	685	689	PF00917	0.708
DOC_USP7_MATH_1	714	718	PF00917	0.762
DOC_USP7_MATH_1	72	76	PF00917	0.696
DOC_USP7_MATH_1	741	745	PF00917	0.558
DOC_USP7_UBL2_3	5	9	PF12436	0.595
DOC_USP7_UBL2_3	689	693	PF12436	0.645
DOC_USP7_UBL2_3	752	756	PF12436	0.683
DOC_WW_Pin1_4	365	370	PF00397	0.727
DOC_WW_Pin1_4	42	47	PF00397	0.667
LIG_14-3-3_CanoR_1	61	70	PF00244	0.714
LIG_BIR_III_2	518	522	PF00653	0.703
LIG_BIR_III_4	616	620	PF00653	0.775
LIG_BRCT_BRCA1_1	544	548	PF00533	0.358
LIG_Clathr_ClatBox_1	605	609	PF01394	0.717
LIG_FHA_1	166	172	PF00498	0.508
LIG_FHA_1	175	181	PF00498	0.402
LIG_FHA_1	287	293	PF00498	0.517
LIG_FHA_1	298	304	PF00498	0.412
LIG_FHA_2	230	236	PF00498	0.650
LIG_FHA_2	238	244	PF00498	0.631
LIG_FHA_2	333	339	PF00498	0.406
LIG_FHA_2	428	434	PF00498	0.543
LIG_FHA_2	47	53	PF00498	0.704
LIG_FHA_2	509	515	PF00498	0.678
LIG_FHA_2	633	639	PF00498	0.770
LIG_FHA_2	97	103	PF00498	0.528
LIG_LIR_Apic_2	523	529	PF02991	0.486
LIG_LIR_Nem_3	260	265	PF02991	0.498
LIG_LIR_Nem_3	485	491	PF02991	0.490
LIG_MAD2	207	215	PF02301	0.554
LIG_PCNA_PIPBox_1	309	318	PF02747	0.489
LIG_Rb_pABgroove_1	658	666	PF01858	0.735
LIG_RPA_C_Fungi	116	128	PF08784	0.628
LIG_SH2_CRK	488	492	PF00017	0.363
LIG_SH2_SRC	357	360	PF00017	0.651
LIG_SH2_SRC	479	482	PF00017	0.449
LIG_SH2_STAP1	479	483	PF00017	0.363
LIG_SH2_STAT5	138	141	PF00017	0.600
LIG_SH2_STAT5	181	184	PF00017	0.450
LIG_SH2_STAT5	249	252	PF00017	0.353
LIG_SH3_3	209	215	PF00018	0.469
LIG_SH3_3	373	379	PF00018	0.695
LIG_SH3_3	412	418	PF00018	0.578
LIG_SUMO_SIM_anti_2	553	558	PF11976	0.439
LIG_SUMO_SIM_par_1	181	186	PF11976	0.525
LIG_SUMO_SIM_par_1	308	313	PF11976	0.540
LIG_SUMO_SIM_par_1	530	536	PF11976	0.475
LIG_TRAF2_1	612	615	PF00917	0.681
LIG_TRAF2_1	618	621	PF00917	0.724
LIG_TYR_ITIM	477	482	PF00017	0.385
LIG_UBA3_1	272	278	PF00899	0.548
LIG_ULM_U2AF65_1	564	569	PF00076	0.563
MOD_CK1_1	186	192	PF00069	0.577
MOD_CK1_1	224	230	PF00069	0.550
MOD_CK1_1	245	251	PF00069	0.433
MOD_CK1_1	45	51	PF00069	0.779
MOD_CK1_1	457	463	PF00069	0.706
MOD_CK1_1	709	715	PF00069	0.726
MOD_CK2_1	257	263	PF00069	0.489
MOD_CK2_1	291	297	PF00069	0.369
MOD_CK2_1	332	338	PF00069	0.412
MOD_CK2_1	427	433	PF00069	0.528
MOD_CK2_1	636	642	PF00069	0.711
MOD_Cter_Amidation	507	510	PF01082	0.713
MOD_Cter_Amidation	586	589	PF01082	0.557
MOD_GlcNHglycan	13	16	PF01048	0.568
MOD_GlcNHglycan	189	192	PF01048	0.586
MOD_GlcNHglycan	215	218	PF01048	0.512
MOD_GlcNHglycan	373	376	PF01048	0.627
MOD_GlcNHglycan	457	460	PF01048	0.728
MOD_GlcNHglycan	522	525	PF01048	0.747
MOD_GlcNHglycan	638	642	PF01048	0.740
MOD_GlcNHglycan	65	68	PF01048	0.693
MOD_GlcNHglycan	695	698	PF01048	0.745
MOD_GlcNHglycan	716	719	PF01048	0.771
MOD_GlcNHglycan	726	729	PF01048	0.755
MOD_GlcNHglycan	74	77	PF01048	0.605
MOD_GSK3_1	183	190	PF00069	0.566
MOD_GSK3_1	213	220	PF00069	0.420
MOD_GSK3_1	238	245	PF00069	0.547
MOD_GSK3_1	257	264	PF00069	0.431
MOD_GSK3_1	288	295	PF00069	0.348
MOD_GSK3_1	42	49	PF00069	0.580
MOD_GSK3_1	451	458	PF00069	0.699
MOD_GSK3_1	59	66	PF00069	0.688
MOD_GSK3_1	632	639	PF00069	0.547
MOD_GSK3_1	702	709	PF00069	0.725
MOD_GSK3_1	72	79	PF00069	0.579
MOD_LATS_1	276	282	PF00433	0.449
MOD_N-GLC_1	224	229	PF02516	0.341
MOD_N-GLC_1	389	394	PF02516	0.505
MOD_N-GLC_1	451	456	PF02516	0.444
MOD_N-GLC_1	76	81	PF02516	0.483
MOD_NEK2_1	131	136	PF00069	0.518
MOD_NEK2_1	187	192	PF00069	0.611
MOD_NEK2_1	237	242	PF00069	0.567
MOD_NEK2_1	255	260	PF00069	0.363
MOD_NEK2_1	265	270	PF00069	0.344
MOD_NEK2_1	34	39	PF00069	0.694
MOD_NEK2_1	389	394	PF00069	0.543
MOD_NEK2_1	748	753	PF00069	0.722
MOD_NEK2_1	83	88	PF00069	0.545
MOD_OFUCOSY	157	162	PF10250	0.545
MOD_PIKK_1	25	31	PF00454	0.672
MOD_PIKK_1	348	354	PF00454	0.442
MOD_PKA_1	329	335	PF00069	0.525
MOD_PKA_2	229	235	PF00069	0.567
MOD_PKA_2	702	708	PF00069	0.749
MOD_PKA_2	714	720	PF00069	0.708
MOD_Plk_1	183	189	PF00069	0.590
MOD_Plk_1	237	243	PF00069	0.561
MOD_Plk_1	363	369	PF00069	0.651
MOD_Plk_1	389	395	PF00069	0.503
MOD_Plk_1	709	715	PF00069	0.785
MOD_Plk_1	96	102	PF00069	0.651
MOD_Plk_2-3	238	244	PF00069	0.592
MOD_Plk_4	245	251	PF00069	0.417
MOD_Plk_4	288	294	PF00069	0.309
MOD_Plk_4	377	383	PF00069	0.573
MOD_Plk_4	389	395	PF00069	0.412
MOD_ProDKin_1	365	371	PF00069	0.722
MOD_ProDKin_1	42	48	PF00069	0.668
MOD_SUMO_rev_2	52	60	PF00179	0.610
TRG_ENDOCYTIC_2	479	482	PF00928	0.361
TRG_ENDOCYTIC_2	488	491	PF00928	0.319
TRG_ER_diArg_1	17	19	PF00400	0.658
TRG_ER_diArg_1	204	206	PF00400	0.620
TRG_ER_diArg_1	361	363	PF00400	0.441
TRG_ER_diArg_1	563	565	PF00400	0.492
TRG_NLS_Bipartite_1	739	760	PF00514	0.748
TRG_NLS_MonoCore_2	688	693	PF00514	0.691
TRG_NLS_MonoExtC_3	688	693	PF00514	0.648
TRG_NLS_MonoExtC_3	728	733	PF00514	0.731
TRG_NLS_MonoExtN_4	689	696	PF00514	0.674
TRG_NLS_MonoExtN_4	753	760	PF00514	0.631
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A4	Leptomonas seymouri	68%	99%
A0A0S4JJZ2	Bodo saltans	39%	100%
A0A1X0P8I5	Trypanosomatidae	43%	100%
A0A3S5IQN4	Trypanosoma rangeli	44%	100%
A0A3S7X7G1	Leishmania donovani	91%	100%
A4H7E0	Leishmania braziliensis	80%	99%
A4I9K0	Leishmania infantum	91%	100%
D0A1V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q3H8	Leishmania major	90%	100%
V5BRS0	Trypanosoma cruzi	41%	100%