Fuz_longin_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trafficking protein Mon1, putative

Species:

Leishmania mexicana

UniProt:

E9B4J7_LEIMU

TriTrypDb:

LmxM.33.0290

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B4J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4J7

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006623	protein targeting to vacuole	5	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0007034	vacuolar transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072665	protein localization to vacuole	6	11
GO:0072666	establishment of protein localization to vacuole	5	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.602
CLV_NRD_NRD_1	244	246	PF00675	0.447
CLV_NRD_NRD_1	407	409	PF00675	0.397
CLV_NRD_NRD_1	666	668	PF00675	0.668
CLV_PCSK_KEX2_1	243	245	PF00082	0.448
CLV_PCSK_KEX2_1	407	409	PF00082	0.397
CLV_PCSK_KEX2_1	666	668	PF00082	0.668
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.556
CLV_PCSK_SKI1_1	213	217	PF00082	0.570
CLV_PCSK_SKI1_1	249	253	PF00082	0.523
CLV_PCSK_SKI1_1	31	35	PF00082	0.402
CLV_PCSK_SKI1_1	41	45	PF00082	0.439
CLV_PCSK_SKI1_1	510	514	PF00082	0.713
DEG_APCC_DBOX_1	212	220	PF00400	0.573
DEG_SPOP_SBC_1	547	551	PF00917	0.595
DOC_CKS1_1	298	303	PF01111	0.537
DOC_CKS1_1	432	437	PF01111	0.600
DOC_CKS1_1	570	575	PF01111	0.635
DOC_PP1_RVXF_1	508	514	PF00149	0.686
DOC_PP2B_LxvP_1	187	190	PF13499	0.574
DOC_PP2B_LxvP_1	413	416	PF13499	0.525
DOC_PP4_FxxP_1	583	586	PF00568	0.648
DOC_PP4_FxxP_1	590	593	PF00568	0.715
DOC_USP7_MATH_1	169	173	PF00917	0.601
DOC_USP7_MATH_1	505	509	PF00917	0.717
DOC_USP7_MATH_1	547	551	PF00917	0.611
DOC_USP7_MATH_1	615	619	PF00917	0.750
DOC_WW_Pin1_4	147	152	PF00397	0.505
DOC_WW_Pin1_4	196	201	PF00397	0.602
DOC_WW_Pin1_4	297	302	PF00397	0.540
DOC_WW_Pin1_4	431	436	PF00397	0.592
DOC_WW_Pin1_4	447	452	PF00397	0.705
DOC_WW_Pin1_4	51	56	PF00397	0.546
DOC_WW_Pin1_4	515	520	PF00397	0.601
DOC_WW_Pin1_4	569	574	PF00397	0.587
DOC_WW_Pin1_4	582	587	PF00397	0.577
DOC_WW_Pin1_4	644	649	PF00397	0.560
LIG_14-3-3_CanoR_1	109	116	PF00244	0.581
LIG_14-3-3_CanoR_1	324	330	PF00244	0.427
LIG_14-3-3_CanoR_1	345	353	PF00244	0.427
LIG_14-3-3_CanoR_1	493	502	PF00244	0.616
LIG_14-3-3_CanoR_1	559	568	PF00244	0.583
LIG_14-3-3_CanoR_1	620	625	PF00244	0.576
LIG_14-3-3_CanoR_1	666	672	PF00244	0.501
LIG_Actin_WH2_2	528	546	PF00022	0.633
LIG_APCC_ABBA_1	64	69	PF00400	0.504
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_CSL_BTD_1	337	340	PF09270	0.420
LIG_EABR_CEP55_1	282	291	PF12180	0.580
LIG_EH_1	587	591	PF12763	0.687
LIG_EH1_1	653	661	PF00400	0.600
LIG_EH1_1	669	677	PF00400	0.672
LIG_eIF4E_1	275	281	PF01652	0.503
LIG_FHA_1	226	232	PF00498	0.605
LIG_FHA_1	234	240	PF00498	0.521
LIG_FHA_1	347	353	PF00498	0.320
LIG_FHA_1	437	443	PF00498	0.666
LIG_FHA_1	452	458	PF00498	0.546
LIG_FHA_1	459	465	PF00498	0.724
LIG_FHA_1	497	503	PF00498	0.696
LIG_FHA_1	623	629	PF00498	0.586
LIG_FHA_2	109	115	PF00498	0.587
LIG_FHA_2	207	213	PF00498	0.557
LIG_FHA_2	381	387	PF00498	0.400
LIG_FHA_2	576	582	PF00498	0.631
LIG_FHA_2	624	630	PF00498	0.390
LIG_LIR_Apic_2	429	435	PF02991	0.548
LIG_LIR_Apic_2	581	586	PF02991	0.650
LIG_LIR_Gen_1	272	281	PF02991	0.453
LIG_LIR_Nem_3	129	134	PF02991	0.372
LIG_LIR_Nem_3	272	276	PF02991	0.370
LIG_LIR_Nem_3	336	341	PF02991	0.310
LIG_LIR_Nem_3	373	378	PF02991	0.430
LIG_LIR_Nem_3	397	402	PF02991	0.346
LIG_LIR_Nem_3	412	417	PF02991	0.481
LIG_LIR_Nem_3	420	426	PF02991	0.485
LIG_LIR_Nem_3	531	535	PF02991	0.640
LIG_NRBOX	59	65	PF00104	0.523
LIG_NRP_CendR_1	679	680	PF00754	0.634
LIG_SH2_CRK	414	418	PF00017	0.585
LIG_SH2_CRK	432	436	PF00017	0.571
LIG_SH2_CRK	468	472	PF00017	0.669
LIG_SH2_NCK_1	208	212	PF00017	0.546
LIG_SH2_SRC	414	417	PF00017	0.521
LIG_SH2_STAP1	290	294	PF00017	0.684
LIG_SH2_STAP1	325	329	PF00017	0.427
LIG_SH2_STAP1	355	359	PF00017	0.435
LIG_SH2_STAP1	362	366	PF00017	0.433
LIG_SH2_STAT3	539	542	PF00017	0.642
LIG_SH2_STAT5	106	109	PF00017	0.360
LIG_SH2_STAT5	140	143	PF00017	0.386
LIG_SH2_STAT5	173	176	PF00017	0.502
LIG_SH2_STAT5	208	211	PF00017	0.555
LIG_SH2_STAT5	275	278	PF00017	0.519
LIG_SH2_STAT5	279	282	PF00017	0.502
LIG_SH2_STAT5	351	354	PF00017	0.318
LIG_SH3_3	146	152	PF00018	0.658
LIG_SH3_3	260	266	PF00018	0.602
LIG_SH3_3	295	301	PF00018	0.686
LIG_SH3_3	338	344	PF00018	0.380
LIG_SH3_3	565	571	PF00018	0.507
LIG_SH3_3	583	589	PF00018	0.701
LIG_SH3_3	77	83	PF00018	0.693
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.351
LIG_SUMO_SIM_anti_2	638	643	PF11976	0.507
LIG_SUMO_SIM_par_1	185	191	PF11976	0.558
LIG_SUMO_SIM_par_1	235	240	PF11976	0.558
LIG_SUMO_SIM_par_1	32	37	PF11976	0.433
LIG_SUMO_SIM_par_1	439	445	PF11976	0.586
LIG_TYR_ITIM	466	471	PF00017	0.677
LIG_UBA3_1	270	277	PF00899	0.474
LIG_UBA3_1	63	70	PF00899	0.563
LIG_WRC_WIRS_1	270	275	PF05994	0.369
MOD_CDK_SPK_2	582	587	PF00069	0.656
MOD_CK1_1	108	114	PF00069	0.573
MOD_CK1_1	143	149	PF00069	0.493
MOD_CK1_1	222	228	PF00069	0.632
MOD_CK1_1	297	303	PF00069	0.414
MOD_CK1_1	328	334	PF00069	0.324
MOD_CK1_1	403	409	PF00069	0.427
MOD_CK1_1	445	451	PF00069	0.613
MOD_CK1_1	458	464	PF00069	0.679
MOD_CK1_1	515	521	PF00069	0.546
MOD_CK1_1	594	600	PF00069	0.488
MOD_CK1_1	623	629	PF00069	0.449
MOD_CK1_1	87	93	PF00069	0.586
MOD_CK2_1	108	114	PF00069	0.650
MOD_CK2_1	156	162	PF00069	0.733
MOD_CK2_1	575	581	PF00069	0.500
MOD_CK2_1	623	629	PF00069	0.603
MOD_CK2_1	69	75	PF00069	0.537
MOD_GlcNHglycan	111	114	PF01048	0.667
MOD_GlcNHglycan	159	162	PF01048	0.578
MOD_GlcNHglycan	209	212	PF01048	0.524
MOD_GlcNHglycan	392	395	PF01048	0.427
MOD_GlcNHglycan	458	461	PF01048	0.664
MOD_GlcNHglycan	505	508	PF01048	0.687
MOD_GlcNHglycan	550	553	PF01048	0.638
MOD_GlcNHglycan	561	564	PF01048	0.622
MOD_GlcNHglycan	612	615	PF01048	0.740
MOD_GlcNHglycan	71	74	PF01048	0.638
MOD_GlcNHglycan	92	95	PF01048	0.651
MOD_GSK3_1	105	112	PF00069	0.549
MOD_GSK3_1	143	150	PF00069	0.624
MOD_GSK3_1	233	240	PF00069	0.548
MOD_GSK3_1	436	443	PF00069	0.581
MOD_GSK3_1	447	454	PF00069	0.596
MOD_GSK3_1	494	501	PF00069	0.770
MOD_GSK3_1	74	81	PF00069	0.770
MOD_N-GLC_1	346	351	PF02516	0.302
MOD_N-GLC_1	357	362	PF02516	0.302
MOD_NEK2_1	1	6	PF00069	0.718
MOD_NEK2_1	219	224	PF00069	0.535
MOD_NEK2_1	294	299	PF00069	0.425
MOD_NEK2_1	34	39	PF00069	0.470
MOD_NEK2_1	346	351	PF00069	0.411
MOD_NEK2_1	390	395	PF00069	0.427
MOD_NEK2_1	442	447	PF00069	0.684
MOD_NEK2_1	512	517	PF00069	0.674
MOD_NEK2_2	140	145	PF00069	0.465
MOD_NEK2_2	505	510	PF00069	0.718
MOD_OFUCOSY	253	258	PF10250	0.479
MOD_PIKK_1	392	398	PF00454	0.321
MOD_PIKK_1	42	48	PF00454	0.626
MOD_PIKK_1	512	518	PF00454	0.666
MOD_PIKK_1	78	84	PF00454	0.759
MOD_PKA_2	108	114	PF00069	0.564
MOD_PKA_2	403	409	PF00069	0.427
MOD_PKA_2	610	616	PF00069	0.609
MOD_PKA_2	665	671	PF00069	0.676
MOD_Plk_1	225	231	PF00069	0.664
MOD_Plk_1	357	363	PF00069	0.346
MOD_Plk_1	397	403	PF00069	0.381
MOD_Plk_1	637	643	PF00069	0.619
MOD_Plk_2-3	380	386	PF00069	0.445
MOD_Plk_4	126	132	PF00069	0.434
MOD_Plk_4	191	197	PF00069	0.418
MOD_Plk_4	623	629	PF00069	0.670
MOD_Plk_4	637	643	PF00069	0.614
MOD_ProDKin_1	147	153	PF00069	0.511
MOD_ProDKin_1	196	202	PF00069	0.600
MOD_ProDKin_1	297	303	PF00069	0.541
MOD_ProDKin_1	431	437	PF00069	0.598
MOD_ProDKin_1	447	453	PF00069	0.705
MOD_ProDKin_1	51	57	PF00069	0.537
MOD_ProDKin_1	515	521	PF00069	0.601
MOD_ProDKin_1	569	575	PF00069	0.584
MOD_ProDKin_1	582	588	PF00069	0.581
MOD_ProDKin_1	644	650	PF00069	0.556
MOD_SUMO_for_1	96	99	PF00179	0.532
MOD_SUMO_rev_2	288	297	PF00179	0.596
MOD_SUMO_rev_2	486	491	PF00179	0.661
TRG_DiLeu_BaEn_1	30	35	PF01217	0.587
TRG_DiLeu_BaEn_4	380	386	PF01217	0.356
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.692
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.664
TRG_ENDOCYTIC_2	414	417	PF00928	0.559
TRG_ENDOCYTIC_2	423	426	PF00928	0.485
TRG_ENDOCYTIC_2	468	471	PF00928	0.672
TRG_ER_diArg_1	244	246	PF00400	0.454
TRG_ER_diArg_1	407	409	PF00400	0.413
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.681
TRG_Pf-PMV_PEXEL_1	673	678	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKG6	Leptomonas seymouri	54%	96%
A0A1X0P9E4	Trypanosomatidae	28%	94%
A0A3S7X7E3	Leishmania donovani	90%	100%
A0A422N7B5	Trypanosoma rangeli	24%	96%
A4H7E1	Leishmania braziliensis	78%	100%
A4I9J9	Leishmania infantum	90%	100%
D0A1V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4Q3H9	Leishmania major	88%	100%
V5BM77	Trypanosoma cruzi	25%	93%