Pyr_redox_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyridine nucleotide-disulphide oxidoreductase, putative

Species:

Leishmania mexicana

UniProt:

E9B4J5_LEIMU

TriTrypDb:

LmxM.33.0270

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

E9B4J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4J5

Function

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Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019418	sulfide oxidation	4	1
GO:0044237	cellular metabolic process	2	1
GO:0070221	sulfide oxidation, using sulfide:quinone oxidoreductase	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	1
GO:0016491	oxidoreductase activity	2	7
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.211
CLV_C14_Caspase3-7	266	270	PF00656	0.492
CLV_C14_Caspase3-7	367	371	PF00656	0.499
CLV_NRD_NRD_1	188	190	PF00675	0.542
CLV_NRD_NRD_1	198	200	PF00675	0.577
CLV_NRD_NRD_1	2	4	PF00675	0.730
CLV_NRD_NRD_1	547	549	PF00675	0.667
CLV_NRD_NRD_1	564	566	PF00675	0.637
CLV_NRD_NRD_1	592	594	PF00675	0.575
CLV_NRD_NRD_1	67	69	PF00675	0.518

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A2	Leptomonas seymouri	55%	95%
A0A3Q8IMW0	Leishmania donovani	92%	100%
A4HAE5	Leishmania braziliensis	82%	100%
A4I9J7	Leishmania infantum	93%	100%
Q4Q3I1	Leishmania major	90%	100%

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