Pyr_redox_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyridine nucleotide-disulphide oxidoreductase, putative

Species:

Leishmania mexicana

UniProt:

E9B4J5_LEIMU

TriTrypDb:

LmxM.33.0270

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B4J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4J5

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019418	sulfide oxidation	4	1
GO:0044237	cellular metabolic process	2	1
GO:0070221	sulfide oxidation, using sulfide:quinone oxidoreductase	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0070224	sulfide:quinone oxidoreductase activity	5	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.211
CLV_C14_Caspase3-7	266	270	PF00656	0.492
CLV_C14_Caspase3-7	367	371	PF00656	0.499
CLV_NRD_NRD_1	188	190	PF00675	0.542
CLV_NRD_NRD_1	198	200	PF00675	0.577
CLV_NRD_NRD_1	2	4	PF00675	0.730
CLV_NRD_NRD_1	547	549	PF00675	0.667
CLV_NRD_NRD_1	564	566	PF00675	0.637
CLV_NRD_NRD_1	592	594	PF00675	0.575
CLV_NRD_NRD_1	67	69	PF00675	0.518
CLV_PCSK_KEX2_1	188	190	PF00082	0.542
CLV_PCSK_KEX2_1	198	200	PF00082	0.577
CLV_PCSK_KEX2_1	2	4	PF00082	0.730
CLV_PCSK_KEX2_1	547	549	PF00082	0.667
CLV_PCSK_KEX2_1	592	594	PF00082	0.589
CLV_PCSK_KEX2_1	69	71	PF00082	0.490
CLV_PCSK_KEX2_1	715	717	PF00082	0.661
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.447
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.661
CLV_PCSK_SKI1_1	163	167	PF00082	0.597
CLV_PCSK_SKI1_1	171	175	PF00082	0.547
CLV_PCSK_SKI1_1	64	68	PF00082	0.539
CLV_PCSK_SKI1_1	741	745	PF00082	0.696
CLV_Separin_Metazoa	154	158	PF03568	0.346
CLV_Separin_Metazoa	645	649	PF03568	0.522
CLV_Separin_Metazoa	65	69	PF03568	0.734
DEG_APCC_DBOX_1	2	10	PF00400	0.542
DEG_APCC_DBOX_1	267	275	PF00400	0.477
DEG_APCC_DBOX_1	740	748	PF00400	0.494
DEG_COP1_1	769	778	PF00400	0.427
DEG_Nend_UBRbox_1	1	4	PF02207	0.534
DEG_SCF_FBW7_1	324	331	PF00400	0.574
DOC_CKS1_1	325	330	PF01111	0.644
DOC_CYCLIN_yCln2_LP_2	517	523	PF00134	0.377
DOC_MAPK_gen_1	105	112	PF00069	0.419
DOC_MAPK_gen_1	198	206	PF00069	0.287
DOC_MAPK_gen_1	2	11	PF00069	0.543
DOC_MAPK_gen_1	565	575	PF00069	0.294
DOC_MAPK_gen_1	68	78	PF00069	0.615
DOC_MAPK_HePTP_8	196	208	PF00069	0.363
DOC_MAPK_HePTP_8	563	575	PF00069	0.440
DOC_MAPK_MEF2A_6	198	206	PF00069	0.363
DOC_MAPK_MEF2A_6	566	575	PF00069	0.434
DOC_PP2B_LxvP_1	517	520	PF13499	0.373
DOC_PP2B_LxvP_1	521	524	PF13499	0.380
DOC_PP4_FxxP_1	346	349	PF00568	0.562
DOC_PP4_FxxP_1	773	776	PF00568	0.419
DOC_USP7_MATH_1	183	187	PF00917	0.211
DOC_USP7_MATH_1	239	243	PF00917	0.419
DOC_USP7_MATH_1	306	310	PF00917	0.592
DOC_USP7_MATH_1	332	336	PF00917	0.613
DOC_USP7_MATH_1	82	86	PF00917	0.513
DOC_USP7_UBL2_3	13	17	PF12436	0.487
DOC_USP7_UBL2_3	663	667	PF12436	0.502
DOC_WW_Pin1_4	135	140	PF00397	0.346
DOC_WW_Pin1_4	318	323	PF00397	0.492
DOC_WW_Pin1_4	324	329	PF00397	0.576
DOC_WW_Pin1_4	330	335	PF00397	0.620
DOC_WW_Pin1_4	362	367	PF00397	0.616
DOC_WW_Pin1_4	390	395	PF00397	0.524
DOC_WW_Pin1_4	702	707	PF00397	0.589
DOC_WW_Pin1_4	766	771	PF00397	0.450
DOC_WW_Pin1_4	776	781	PF00397	0.421
LIG_14-3-3_CanoR_1	297	303	PF00244	0.496
LIG_14-3-3_CanoR_1	337	346	PF00244	0.542
LIG_14-3-3_CanoR_1	360	366	PF00244	0.497
LIG_14-3-3_CanoR_1	58	67	PF00244	0.662
LIG_14-3-3_CanoR_1	634	643	PF00244	0.335
LIG_14-3-3_CanoR_1	698	706	PF00244	0.542
LIG_Actin_WH2_2	345	362	PF00022	0.505
LIG_Actin_WH2_2	37	55	PF00022	0.416
LIG_Actin_WH2_2	83	101	PF00022	0.513
LIG_BRCT_BRCA1_1	28	32	PF00533	0.477
LIG_CaM_NSCaTE_8	355	362	PF13499	0.492
LIG_Clathr_ClatBox_1	514	518	PF01394	0.370
LIG_EVH1_2	285	289	PF00568	0.396
LIG_FHA_1	208	214	PF00498	0.404
LIG_FHA_1	255	261	PF00498	0.527
LIG_FHA_1	33	39	PF00498	0.359
LIG_FHA_1	343	349	PF00498	0.563
LIG_FHA_1	41	47	PF00498	0.345
LIG_FHA_1	533	539	PF00498	0.384
LIG_FHA_1	782	788	PF00498	0.503
LIG_FHA_2	129	135	PF00498	0.419
LIG_FHA_2	264	270	PF00498	0.487
LIG_FHA_2	362	368	PF00498	0.463
LIG_FHA_2	496	502	PF00498	0.370
LIG_FHA_2	565	571	PF00498	0.438
LIG_FHA_2	635	641	PF00498	0.334
LIG_FHA_2	99	105	PF00498	0.346
LIG_LIR_Apic_2	345	349	PF02991	0.559
LIG_LIR_Apic_2	687	693	PF02991	0.509
LIG_LIR_Apic_2	734	740	PF02991	0.312
LIG_LIR_Apic_2	771	776	PF02991	0.432
LIG_LIR_Gen_1	229	237	PF02991	0.346
LIG_LIR_Gen_1	47	55	PF02991	0.436
LIG_LIR_Gen_1	477	487	PF02991	0.454
LIG_LIR_Gen_1	578	589	PF02991	0.392
LIG_LIR_Gen_1	669	678	PF02991	0.403
LIG_LIR_LC3C_4	231	235	PF02991	0.419
LIG_LIR_Nem_3	229	233	PF02991	0.346
LIG_LIR_Nem_3	420	425	PF02991	0.390
LIG_LIR_Nem_3	47	52	PF02991	0.513
LIG_LIR_Nem_3	477	482	PF02991	0.461
LIG_LIR_Nem_3	578	584	PF02991	0.386
LIG_LIR_Nem_3	611	615	PF02991	0.404
LIG_LIR_Nem_3	669	674	PF02991	0.392
LIG_LIR_Nem_3	755	761	PF02991	0.448
LIG_LIR_Nem_3	769	775	PF02991	0.432
LIG_LIR_Nem_3	777	781	PF02991	0.420
LIG_PALB2_WD40_1	351	359	PF16756	0.488
LIG_PCNA_yPIPBox_3	451	461	PF02747	0.425
LIG_PDZ_Class_3	789	794	PF00595	0.552
LIG_Pex14_1	401	405	PF04695	0.422
LIG_Pex14_2	479	483	PF04695	0.443
LIG_PTB_Apo_2	742	749	PF02174	0.423
LIG_Rb_pABgroove_1	494	502	PF01858	0.459
LIG_SH2_CRK	230	234	PF00017	0.346
LIG_SH2_CRK	428	432	PF00017	0.429
LIG_SH2_CRK	436	440	PF00017	0.378
LIG_SH2_CRK	512	516	PF00017	0.418
LIG_SH2_CRK	612	616	PF00017	0.407
LIG_SH2_GRB2like	427	430	PF00017	0.509
LIG_SH2_NCK_1	125	129	PF00017	0.419
LIG_SH2_NCK_1	594	598	PF00017	0.384
LIG_SH2_NCK_1	690	694	PF00017	0.551
LIG_SH2_NCK_1	778	782	PF00017	0.494
LIG_SH2_SRC	125	128	PF00017	0.419
LIG_SH2_SRC	594	597	PF00017	0.461
LIG_SH2_SRC	690	693	PF00017	0.413
LIG_SH2_STAP1	230	234	PF00017	0.346
LIG_SH2_STAP1	594	598	PF00017	0.384
LIG_SH2_STAP1	754	758	PF00017	0.463
LIG_SH2_STAT5	10	13	PF00017	0.548
LIG_SH2_STAT5	424	427	PF00017	0.401
LIG_SH2_STAT5	486	489	PF00017	0.373
LIG_SH2_STAT5	537	540	PF00017	0.413
LIG_SH2_STAT5	668	671	PF00017	0.395
LIG_SH2_STAT5	758	761	PF00017	0.449
LIG_SH2_STAT5	774	777	PF00017	0.422
LIG_SH3_2	12	17	PF14604	0.540
LIG_SH3_3	133	139	PF00018	0.419
LIG_SH3_3	279	285	PF00018	0.453
LIG_SH3_3	442	448	PF00018	0.398
LIG_SH3_3	505	511	PF00018	0.391
LIG_SH3_3	656	662	PF00018	0.589
LIG_SH3_3	717	723	PF00018	0.471
LIG_SH3_3	9	15	PF00018	0.507
LIG_SUMO_SIM_anti_2	129	138	PF11976	0.419
LIG_SUMO_SIM_par_1	209	216	PF11976	0.336
LIG_SUMO_SIM_par_1	42	47	PF11976	0.436
LIG_SUMO_SIM_par_1	513	518	PF11976	0.377
LIG_TYR_ITIM	510	515	PF00017	0.452
LIG_TYR_ITIM	756	761	PF00017	0.444
LIG_ULM_U2AF65_1	188	193	PF00076	0.211
LIG_WRC_WIRS_1	671	676	PF05994	0.397
MOD_CDK_SPxxK_3	330	337	PF00069	0.499
MOD_CK1_1	209	215	PF00069	0.394
MOD_CK1_1	222	228	PF00069	0.282
MOD_CK1_1	242	248	PF00069	0.183
MOD_CK1_1	347	353	PF00069	0.528
MOD_CK1_1	485	491	PF00069	0.362
MOD_CK1_1	59	65	PF00069	0.673
MOD_CK1_1	608	614	PF00069	0.474
MOD_CK1_1	649	655	PF00069	0.545
MOD_CK1_1	701	707	PF00069	0.589
MOD_CK2_1	336	342	PF00069	0.591
MOD_CK2_1	361	367	PF00069	0.464
MOD_CK2_1	564	570	PF00069	0.519
MOD_CK2_1	59	65	PF00069	0.673
MOD_CK2_1	98	104	PF00069	0.306
MOD_GlcNHglycan	180	183	PF01048	0.510
MOD_GlcNHglycan	275	278	PF01048	0.635
MOD_GlcNHglycan	306	309	PF01048	0.801
MOD_GlcNHglycan	334	337	PF01048	0.783
MOD_GlcNHglycan	385	388	PF01048	0.808
MOD_GlcNHglycan	471	474	PF01048	0.701
MOD_GlcNHglycan	487	490	PF01048	0.448
MOD_GlcNHglycan	529	532	PF01048	0.592
MOD_GlcNHglycan	615	618	PF01048	0.618
MOD_GlcNHglycan	650	654	PF01048	0.738
MOD_GlcNHglycan	84	87	PF01048	0.513
MOD_GlcNHglycan	93	96	PF01048	0.513
MOD_GSK3_1	215	222	PF00069	0.389
MOD_GSK3_1	324	331	PF00069	0.497
MOD_GSK3_1	332	339	PF00069	0.617
MOD_GSK3_1	344	351	PF00069	0.597
MOD_GSK3_1	383	390	PF00069	0.539
MOD_GSK3_1	40	47	PF00069	0.467
MOD_GSK3_1	409	416	PF00069	0.406
MOD_GSK3_1	485	492	PF00069	0.340
MOD_GSK3_1	666	673	PF00069	0.393
MOD_GSK3_1	698	705	PF00069	0.599
MOD_N-GLC_1	142	147	PF02516	0.546
MOD_N-GLC_1	219	224	PF02516	0.543
MOD_NEK2_1	1	6	PF00069	0.535
MOD_NEK2_1	166	171	PF00069	0.363
MOD_NEK2_1	206	211	PF00069	0.363
MOD_NEK2_1	316	321	PF00069	0.514
MOD_NEK2_1	32	37	PF00069	0.346
MOD_NEK2_1	403	408	PF00069	0.439
MOD_NEK2_1	414	419	PF00069	0.445
MOD_NEK2_1	482	487	PF00069	0.375
MOD_NEK2_1	532	537	PF00069	0.377
MOD_NEK2_1	564	569	PF00069	0.448
MOD_NEK2_1	731	736	PF00069	0.458
MOD_NEK2_1	760	765	PF00069	0.459
MOD_NEK2_1	98	103	PF00069	0.375
MOD_NEK2_2	355	360	PF00069	0.491
MOD_NEK2_2	670	675	PF00069	0.396
MOD_PIKK_1	26	32	PF00454	0.517
MOD_PIKK_1	629	635	PF00454	0.487
MOD_PIKK_1	698	704	PF00454	0.548
MOD_PKA_2	1	7	PF00069	0.536
MOD_PKA_2	167	173	PF00069	0.419
MOD_PKA_2	336	342	PF00069	0.507
MOD_PKA_2	527	533	PF00069	0.392
MOD_PKA_2	564	570	PF00069	0.463
MOD_PKA_2	59	65	PF00069	0.677
MOD_Plk_1	410	416	PF00069	0.405
MOD_Plk_1	577	583	PF00069	0.389
MOD_Plk_2-3	577	583	PF00069	0.389
MOD_Plk_4	285	291	PF00069	0.452
MOD_Plk_4	40	46	PF00069	0.436
MOD_Plk_4	410	416	PF00069	0.405
MOD_Plk_4	417	423	PF00069	0.386
MOD_Plk_4	482	488	PF00069	0.357
MOD_Plk_4	495	501	PF00069	0.300
MOD_Plk_4	522	528	PF00069	0.429
MOD_Plk_4	577	583	PF00069	0.389
MOD_Plk_4	768	774	PF00069	0.440
MOD_ProDKin_1	135	141	PF00069	0.346
MOD_ProDKin_1	318	324	PF00069	0.497
MOD_ProDKin_1	330	336	PF00069	0.620
MOD_ProDKin_1	362	368	PF00069	0.616
MOD_ProDKin_1	390	396	PF00069	0.517
MOD_ProDKin_1	702	708	PF00069	0.587
MOD_ProDKin_1	766	772	PF00069	0.450
MOD_ProDKin_1	776	782	PF00069	0.422
MOD_SUMO_rev_2	159	165	PF00179	0.330
MOD_SUMO_rev_2	94	101	PF00179	0.363
TRG_DiLeu_BaEn_1	477	482	PF01217	0.463
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.396
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.445
TRG_ENDOCYTIC_2	230	233	PF00928	0.346
TRG_ENDOCYTIC_2	428	431	PF00928	0.424
TRG_ENDOCYTIC_2	436	439	PF00928	0.377
TRG_ENDOCYTIC_2	512	515	PF00928	0.419
TRG_ENDOCYTIC_2	594	597	PF00928	0.389
TRG_ENDOCYTIC_2	612	615	PF00928	0.406
TRG_ENDOCYTIC_2	671	674	PF00928	0.389
TRG_ENDOCYTIC_2	754	757	PF00928	0.463
TRG_ENDOCYTIC_2	758	761	PF00928	0.474
TRG_ENDOCYTIC_2	778	781	PF00928	0.255
TRG_ER_diArg_1	1	3	PF00400	0.536
TRG_ER_diArg_1	188	191	PF00400	0.350
TRG_ER_diArg_1	197	199	PF00400	0.381
TRG_ER_diArg_1	534	537	PF00400	0.407
TRG_ER_diArg_1	546	548	PF00400	0.445
TRG_ER_diArg_1	58	61	PF00400	0.664
TRG_ER_diArg_1	592	594	PF00400	0.389
TRG_ER_diArg_1	67	70	PF00400	0.657
TRG_NLS_Bipartite_1	547	569	PF00514	0.485
TRG_NLS_MonoCore_2	67	72	PF00514	0.596
TRG_NLS_MonoExtC_3	564	569	PF00514	0.465
TRG_NLS_MonoExtN_4	562	569	PF00514	0.461
TRG_NLS_MonoExtN_4	68	73	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	464	469	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	548	552	PF00026	0.682
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A2	Leptomonas seymouri	55%	95%
A0A3Q8IMW0	Leishmania donovani	92%	100%
A4HAE5	Leishmania braziliensis	82%	100%
A4I9J7	Leishmania infantum	93%	100%
Q4Q3I1	Leishmania major	90%	100%