LeishMANIAdb
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RIIa domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RIIa domain-containing protein
Gene product:
Regulatory subunit of type II PKA R-subunit, putative
Species:
Leishmania mexicana
UniProt:
E9B4J4_LEIMU
TriTrypDb:
LmxM.33.0260
Length:
106

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4J4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4J4

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_PP2B_LxvP_1 12 15 PF13499 0.457
LIG_14-3-3_CanoR_1 21 29 PF00244 0.593
LIG_BRCT_BRCA1_1 96 100 PF00533 0.438
LIG_FHA_1 20 26 PF00498 0.667
LIG_FHA_2 2 8 PF00498 0.732
LIG_FHA_2 28 34 PF00498 0.524
LIG_FHA_2 38 44 PF00498 0.491
LIG_LIR_Gen_1 7 17 PF02991 0.457
LIG_LIR_Nem_3 7 12 PF02991 0.458
LIG_SH2_CRK 9 13 PF00017 0.460
LIG_SH2_STAT5 61 64 PF00017 0.500
LIG_SH2_STAT5 94 97 PF00017 0.438
LIG_SH3_3 81 87 PF00018 0.366
LIG_TRAF2_1 40 43 PF00917 0.443
LIG_TRAF2_1 71 74 PF00917 0.438
MOD_CK2_1 1 7 PF00069 0.735
MOD_CK2_1 27 33 PF00069 0.508
MOD_CK2_1 37 43 PF00069 0.477
MOD_GSK3_1 46 53 PF00069 0.618
MOD_N-GLC_1 7 12 PF02516 0.458
MOD_NEK2_1 17 22 PF00069 0.718
MOD_PIKK_1 89 95 PF00454 0.405
MOD_PKA_2 20 26 PF00069 0.614
MOD_Plk_1 7 13 PF00069 0.567
TRG_DiLeu_BaEn_4 42 48 PF01217 0.492
TRG_ENDOCYTIC_2 9 12 PF00928 0.462
TRG_Pf-PMV_PEXEL_1 78 83 PF00026 0.494

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBU2 Leptomonas seymouri 63% 100%
A0A0S4IPS5 Bodo saltans 33% 100%
A0A3S7X7D0 Leishmania donovani 88% 88%
A4HAE4 Leishmania braziliensis 82% 100%
A4I9J6 Leishmania infantum 88% 88%
D0A1V5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 88%
Q4Q3I2 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS