LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B4J3_LEIMU
TriTrypDb:
LmxM.33.0250
Length:
383

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4J3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4J3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 106 110 PF00656 0.512
CLV_C14_Caspase3-7 179 183 PF00656 0.512
CLV_C14_Caspase3-7 308 312 PF00656 0.585
CLV_NRD_NRD_1 137 139 PF00675 0.482
CLV_NRD_NRD_1 173 175 PF00675 0.404
CLV_NRD_NRD_1 301 303 PF00675 0.722
CLV_NRD_NRD_1 366 368 PF00675 0.529
CLV_NRD_NRD_1 38 40 PF00675 0.768
CLV_PCSK_KEX2_1 141 143 PF00082 0.463
CLV_PCSK_KEX2_1 173 175 PF00082 0.427
CLV_PCSK_KEX2_1 211 213 PF00082 0.671
CLV_PCSK_KEX2_1 301 303 PF00082 0.705
CLV_PCSK_KEX2_1 316 318 PF00082 0.455
CLV_PCSK_KEX2_1 366 368 PF00082 0.510
CLV_PCSK_KEX2_1 38 40 PF00082 0.768
CLV_PCSK_KEX2_1 54 56 PF00082 0.527
CLV_PCSK_KEX2_1 72 74 PF00082 0.492
CLV_PCSK_PC1ET2_1 141 143 PF00082 0.463
CLV_PCSK_PC1ET2_1 211 213 PF00082 0.671
CLV_PCSK_PC1ET2_1 316 318 PF00082 0.617
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.519
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.492
CLV_PCSK_SKI1_1 116 120 PF00082 0.547
CLV_PCSK_SKI1_1 138 142 PF00082 0.601
CLV_PCSK_SKI1_1 44 48 PF00082 0.502
CLV_PCSK_SKI1_1 81 85 PF00082 0.570
DEG_SPOP_SBC_1 125 129 PF00917 0.510
DOC_CKS1_1 101 106 PF01111 0.662
DOC_CYCLIN_yCln2_LP_2 203 209 PF00134 0.602
DOC_USP7_MATH_1 249 253 PF00917 0.603
DOC_USP7_MATH_1 26 30 PF00917 0.731
DOC_USP7_MATH_1 266 270 PF00917 0.532
DOC_USP7_MATH_1 324 328 PF00917 0.641
DOC_USP7_MATH_2 2 8 PF00917 0.662
DOC_WW_Pin1_4 10 15 PF00397 0.616
DOC_WW_Pin1_4 100 105 PF00397 0.638
DOC_WW_Pin1_4 107 112 PF00397 0.635
DOC_WW_Pin1_4 197 202 PF00397 0.589
DOC_WW_Pin1_4 244 249 PF00397 0.686
DOC_WW_Pin1_4 276 281 PF00397 0.613
LIG_14-3-3_CanoR_1 19 25 PF00244 0.646
LIG_14-3-3_CanoR_1 242 248 PF00244 0.716
LIG_14-3-3_CanoR_1 321 331 PF00244 0.535
LIG_14-3-3_CanoR_1 349 356 PF00244 0.495
LIG_14-3-3_CanoR_1 81 86 PF00244 0.624
LIG_Clathr_ClatBox_1 295 299 PF01394 0.615
LIG_CtBP_PxDLS_1 345 349 PF00389 0.518
LIG_eIF4E_1 290 296 PF01652 0.621
LIG_EVH1_1 277 281 PF00568 0.529
LIG_FHA_1 150 156 PF00498 0.374
LIG_FHA_1 198 204 PF00498 0.613
LIG_FHA_1 231 237 PF00498 0.564
LIG_LIR_Apic_2 99 104 PF02991 0.645
LIG_LIR_Gen_1 161 168 PF02991 0.481
LIG_LIR_Nem_3 161 165 PF02991 0.531
LIG_LIR_Nem_3 99 105 PF02991 0.650
LIG_SH2_CRK 102 106 PF00017 0.664
LIG_SH2_CRK 162 166 PF00017 0.487
LIG_SH2_CRK 290 294 PF00017 0.661
LIG_SH2_NCK_1 162 166 PF00017 0.581
LIG_SH2_NCK_1 290 294 PF00017 0.621
LIG_SH2_SRC 180 183 PF00017 0.642
LIG_SH2_STAP1 147 151 PF00017 0.518
LIG_SH2_STAP1 22 26 PF00017 0.546
LIG_SH2_STAP1 267 271 PF00017 0.643
LIG_SH2_STAT5 102 105 PF00017 0.669
LIG_SH2_STAT5 96 99 PF00017 0.634
LIG_SH3_2 111 116 PF14604 0.685
LIG_SH3_3 108 114 PF00018 0.703
LIG_SH3_3 275 281 PF00018 0.557
LIG_SH3_3 340 346 PF00018 0.535
LIG_SH3_3 82 88 PF00018 0.656
LIG_SH3_CIN85_PxpxPR_1 111 116 PF14604 0.653
LIG_SH3_CIN85_PxpxPR_1 339 344 PF14604 0.554
LIG_TRAF2_1 176 179 PF00917 0.608
LIG_TRAF2_1 326 329 PF00917 0.634
LIG_WW_3 113 117 PF00397 0.611
LIG_WW_3 222 226 PF00397 0.583
MOD_CDK_SPxxK_3 100 107 PF00069 0.662
MOD_CDK_SPxxK_3 109 116 PF00069 0.691
MOD_CK1_1 163 169 PF00069 0.530
MOD_CK1_1 231 237 PF00069 0.737
MOD_CK1_1 322 328 PF00069 0.523
MOD_CK2_1 244 250 PF00069 0.593
MOD_Cter_Amidation 36 39 PF01082 0.615
MOD_DYRK1A_RPxSP_1 244 248 PF00069 0.591
MOD_GlcNHglycan 272 275 PF01048 0.749
MOD_GlcNHglycan 29 32 PF01048 0.780
MOD_GlcNHglycan 321 324 PF01048 0.571
MOD_GlcNHglycan 6 9 PF01048 0.744
MOD_GSK3_1 10 17 PF00069 0.615
MOD_GSK3_1 160 167 PF00069 0.490
MOD_GSK3_1 244 251 PF00069 0.714
MOD_GSK3_1 266 273 PF00069 0.670
MOD_GSK3_1 373 380 PF00069 0.529
MOD_GSK3_1 77 84 PF00069 0.647
MOD_GSK3_1 96 103 PF00069 0.623
MOD_N-GLC_1 47 52 PF02516 0.583
MOD_NEK2_1 230 235 PF00069 0.608
MOD_NEK2_2 249 254 PF00069 0.672
MOD_PIKK_1 225 231 PF00454 0.631
MOD_PIKK_1 324 330 PF00454 0.674
MOD_PKA_2 20 26 PF00069 0.751
MOD_PKA_2 243 249 PF00069 0.679
MOD_PKA_2 365 371 PF00069 0.547
MOD_PKB_1 317 325 PF00069 0.645
MOD_Plk_1 160 166 PF00069 0.534
MOD_Plk_1 249 255 PF00069 0.687
MOD_Plk_1 267 273 PF00069 0.686
MOD_Plk_4 160 166 PF00069 0.477
MOD_Plk_4 291 297 PF00069 0.617
MOD_Plk_4 96 102 PF00069 0.643
MOD_ProDKin_1 10 16 PF00069 0.616
MOD_ProDKin_1 100 106 PF00069 0.641
MOD_ProDKin_1 107 113 PF00069 0.634
MOD_ProDKin_1 197 203 PF00069 0.588
MOD_ProDKin_1 244 250 PF00069 0.688
MOD_ProDKin_1 276 282 PF00069 0.609
MOD_SUMO_for_1 140 143 PF00179 0.496
MOD_SUMO_rev_2 51 56 PF00179 0.594
TRG_DiLeu_BaEn_2 328 334 PF01217 0.634
TRG_ENDOCYTIC_2 102 105 PF00928 0.662
TRG_ENDOCYTIC_2 162 165 PF00928 0.524
TRG_ER_diArg_1 173 175 PF00400 0.427
TRG_ER_diArg_1 19 22 PF00400 0.605
TRG_ER_diArg_1 255 258 PF00400 0.676
TRG_ER_diArg_1 301 304 PF00400 0.720
TRG_NLS_Bipartite_1 301 320 PF00514 0.595
TRG_NLS_MonoExtC_3 137 142 PF00514 0.487
TRG_NLS_MonoExtN_4 136 142 PF00514 0.491
TRG_Pf-PMV_PEXEL_1 153 157 PF00026 0.618
TRG_Pf-PMV_PEXEL_1 258 262 PF00026 0.630
TRG_Pf-PMV_PEXEL_1 370 375 PF00026 0.608

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK05 Leptomonas seymouri 60% 92%
A0A1X0P9W7 Trypanosomatidae 38% 100%
A0A3R7K419 Trypanosoma rangeli 35% 98%
A0A3S5H7V7 Leishmania donovani 94% 100%
A4HAE3 Leishmania braziliensis 82% 100%
A4I9J5 Leishmania infantum 94% 100%
Q4Q3I3 Leishmania major 90% 100%
V5B266 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS