CARD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4J2_LEIMU

TriTrypDb:

LmxM.33.0240

Length:

1336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	3
GO:0042981	regulation of apoptotic process	6	3
GO:0043067	regulation of programmed cell death	5	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0065007	biological regulation	1	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1053	1057	PF00656	0.539
CLV_C14_Caspase3-7	1164	1168	PF00656	0.589
CLV_C14_Caspase3-7	1200	1204	PF00656	0.504
CLV_C14_Caspase3-7	351	355	PF00656	0.543
CLV_C14_Caspase3-7	460	464	PF00656	0.524
CLV_C14_Caspase3-7	484	488	PF00656	0.548
CLV_C14_Caspase3-7	586	590	PF00656	0.526
CLV_NRD_NRD_1	104	106	PF00675	0.570
CLV_NRD_NRD_1	1253	1255	PF00675	0.535
CLV_NRD_NRD_1	1303	1305	PF00675	0.502
CLV_NRD_NRD_1	295	297	PF00675	0.720
CLV_NRD_NRD_1	312	314	PF00675	0.551
CLV_NRD_NRD_1	345	347	PF00675	0.776
CLV_NRD_NRD_1	381	383	PF00675	0.759
CLV_NRD_NRD_1	579	581	PF00675	0.516
CLV_NRD_NRD_1	653	655	PF00675	0.599
CLV_NRD_NRD_1	669	671	PF00675	0.544
CLV_NRD_NRD_1	81	83	PF00675	0.511
CLV_NRD_NRD_1	951	953	PF00675	0.486
CLV_PCSK_KEX2_1	104	106	PF00082	0.570
CLV_PCSK_KEX2_1	1074	1076	PF00082	0.631
CLV_PCSK_KEX2_1	1247	1249	PF00082	0.502
CLV_PCSK_KEX2_1	1253	1255	PF00082	0.532
CLV_PCSK_KEX2_1	157	159	PF00082	0.582
CLV_PCSK_KEX2_1	295	297	PF00082	0.717
CLV_PCSK_KEX2_1	312	314	PF00082	0.439
CLV_PCSK_KEX2_1	345	347	PF00082	0.776
CLV_PCSK_KEX2_1	381	383	PF00082	0.738
CLV_PCSK_KEX2_1	52	54	PF00082	0.545
CLV_PCSK_KEX2_1	579	581	PF00082	0.574
CLV_PCSK_KEX2_1	653	655	PF00082	0.629
CLV_PCSK_KEX2_1	80	82	PF00082	0.508
CLV_PCSK_KEX2_1	950	952	PF00082	0.492
CLV_PCSK_PC1ET2_1	1074	1076	PF00082	0.631
CLV_PCSK_PC1ET2_1	1247	1249	PF00082	0.488
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.582
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.525
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.508
CLV_PCSK_PC7_1	649	655	PF00082	0.585
CLV_PCSK_SKI1_1	1055	1059	PF00082	0.535
CLV_PCSK_SKI1_1	1266	1270	PF00082	0.565
CLV_PCSK_SKI1_1	204	208	PF00082	0.599
CLV_PCSK_SKI1_1	280	284	PF00082	0.426
CLV_PCSK_SKI1_1	49	53	PF00082	0.552
CLV_PCSK_SKI1_1	559	563	PF00082	0.487
CLV_PCSK_SKI1_1	574	578	PF00082	0.515
CLV_PCSK_SKI1_1	900	904	PF00082	0.664
CLV_Separin_Metazoa	600	604	PF03568	0.513
CLV_Separin_Metazoa	61	65	PF03568	0.419
DEG_APCC_DBOX_1	1172	1180	PF00400	0.509
DEG_APCC_DBOX_1	1324	1332	PF00400	0.505
DEG_APCC_DBOX_1	372	380	PF00400	0.554
DEG_APCC_DBOX_1	482	490	PF00400	0.480
DEG_APCC_DBOX_1	711	719	PF00400	0.579
DEG_SPOP_SBC_1	114	118	PF00917	0.606
DEG_SPOP_SBC_1	305	309	PF00917	0.617
DOC_CYCLIN_RxL_1	155	165	PF00134	0.586
DOC_MAPK_gen_1	292	302	PF00069	0.556
DOC_MAPK_gen_1	555	563	PF00069	0.654
DOC_MAPK_gen_1	728	737	PF00069	0.530
DOC_MAPK_MEF2A_6	503	510	PF00069	0.467
DOC_PP1_RVXF_1	156	163	PF00149	0.422
DOC_USP7_MATH_1	1009	1013	PF00917	0.552
DOC_USP7_MATH_1	1078	1082	PF00917	0.621
DOC_USP7_MATH_1	114	118	PF00917	0.571
DOC_USP7_MATH_1	1162	1166	PF00917	0.633
DOC_USP7_MATH_1	1239	1243	PF00917	0.554
DOC_USP7_MATH_1	21	25	PF00917	0.480
DOC_USP7_MATH_1	323	327	PF00917	0.414
DOC_USP7_MATH_1	540	544	PF00917	0.635
DOC_USP7_MATH_1	706	710	PF00917	0.430
DOC_USP7_MATH_1	841	845	PF00917	0.549
DOC_USP7_MATH_1	96	100	PF00917	0.567
DOC_USP7_MATH_1	988	992	PF00917	0.509
DOC_USP7_UBL2_3	52	56	PF12436	0.472
DOC_WW_Pin1_4	800	805	PF00397	0.653
DOC_WW_Pin1_4	978	983	PF00397	0.541
LIG_14-3-3_CanoR_1	1210	1215	PF00244	0.539
LIG_14-3-3_CanoR_1	1221	1231	PF00244	0.487
LIG_14-3-3_CanoR_1	125	129	PF00244	0.452
LIG_14-3-3_CanoR_1	1266	1275	PF00244	0.551
LIG_14-3-3_CanoR_1	20	30	PF00244	0.499
LIG_14-3-3_CanoR_1	235	241	PF00244	0.449
LIG_14-3-3_CanoR_1	280	289	PF00244	0.473
LIG_14-3-3_CanoR_1	394	398	PF00244	0.548
LIG_14-3-3_CanoR_1	596	602	PF00244	0.602
LIG_14-3-3_CanoR_1	615	619	PF00244	0.507
LIG_14-3-3_CanoR_1	64	69	PF00244	0.497
LIG_14-3-3_CanoR_1	643	651	PF00244	0.573
LIG_14-3-3_CanoR_1	847	856	PF00244	0.461
LIG_14-3-3_CanoR_1	890	899	PF00244	0.645
LIG_14-3-3_CanoR_1	950	960	PF00244	0.444
LIG_Actin_WH2_2	1165	1182	PF00022	0.561
LIG_Actin_WH2_2	1233	1249	PF00022	0.564
LIG_Actin_WH2_2	996	1013	PF00022	0.490
LIG_BIR_III_4	860	864	PF00653	0.550
LIG_CaM_IQ_9	1240	1256	PF13499	0.667
LIG_Clathr_ClatBox_1	856	860	PF01394	0.553
LIG_deltaCOP1_diTrp_1	1117	1122	PF00928	0.598
LIG_FHA_1	1016	1022	PF00498	0.478
LIG_FHA_1	1203	1209	PF00498	0.376
LIG_FHA_1	1226	1232	PF00498	0.432
LIG_FHA_1	1236	1242	PF00498	0.382
LIG_FHA_1	1267	1273	PF00498	0.549
LIG_FHA_1	166	172	PF00498	0.497
LIG_FHA_1	411	417	PF00498	0.548
LIG_FHA_1	449	455	PF00498	0.601
LIG_FHA_1	470	476	PF00498	0.525
LIG_FHA_2	1048	1054	PF00498	0.597
LIG_FHA_2	1176	1182	PF00498	0.537
LIG_FHA_2	1265	1271	PF00498	0.603
LIG_FHA_2	132	138	PF00498	0.484
LIG_FHA_2	241	247	PF00498	0.596
LIG_FHA_2	283	289	PF00498	0.625
LIG_FHA_2	441	447	PF00498	0.471
LIG_FHA_2	458	464	PF00498	0.557
LIG_FHA_2	609	615	PF00498	0.587
LIG_FHA_2	873	879	PF00498	0.558
LIG_FHA_2	968	974	PF00498	0.514
LIG_GBD_Chelix_1	1214	1222	PF00786	0.556
LIG_GBD_Chelix_1	415	423	PF00786	0.561
LIG_LIR_Gen_1	516	526	PF02991	0.359
LIG_LIR_Gen_1	870	880	PF02991	0.559
LIG_LIR_LC3C_4	504	508	PF02991	0.392
LIG_LIR_Nem_3	33	37	PF02991	0.493
LIG_LIR_Nem_3	473	479	PF02991	0.499
LIG_LIR_Nem_3	516	521	PF02991	0.360
LIG_LIR_Nem_3	575	581	PF02991	0.407
LIG_LIR_Nem_3	870	876	PF02991	0.567
LIG_LYPXL_SIV_4	43	51	PF13949	0.492
LIG_LYPXL_yS_3	34	37	PF13949	0.500
LIG_MYND_1	808	812	PF01753	0.713
LIG_NRBOX	1327	1333	PF00104	0.500
LIG_NRBOX	875	881	PF00104	0.550
LIG_PCNA_yPIPBox_3	787	797	PF02747	0.452
LIG_Pex14_1	701	705	PF04695	0.530
LIG_SH2_NCK_1	1069	1073	PF00017	0.585
LIG_SH2_NCK_1	44	48	PF00017	0.364
LIG_SH2_STAP1	1069	1073	PF00017	0.564
LIG_SH2_STAP1	44	48	PF00017	0.443
LIG_SH2_STAT3	1020	1023	PF00017	0.497
LIG_SH2_STAT3	192	195	PF00017	0.519
LIG_SH2_STAT5	1020	1023	PF00017	0.497
LIG_SH3_3	893	899	PF00018	0.495
LIG_SUMO_SIM_anti_2	874	882	PF11976	0.550
LIG_SUMO_SIM_par_1	228	234	PF11976	0.488
LIG_SUMO_SIM_par_1	713	720	PF11976	0.585
LIG_TRAF2_1	1012	1015	PF00917	0.387
LIG_TRAF2_1	1050	1053	PF00917	0.592
LIG_TRAF2_1	1061	1064	PF00917	0.505
LIG_TRAF2_1	1161	1164	PF00917	0.612
LIG_TRAF2_1	1224	1227	PF00917	0.486
LIG_TRAF2_1	1242	1245	PF00917	0.501
LIG_TRAF2_1	194	197	PF00917	0.616
LIG_TRAF2_1	360	363	PF00917	0.599
LIG_TRAF2_1	499	502	PF00917	0.649
LIG_TRAF2_1	774	777	PF00917	0.544
LIG_UBA3_1	715	719	PF00899	0.588
LIG_UBA3_1	72	80	PF00899	0.444
LIG_WRC_WIRS_1	1331	1336	PF05994	0.541
MOD_CK1_1	116	122	PF00069	0.573
MOD_CK1_1	1183	1189	PF00069	0.501
MOD_CK1_1	131	137	PF00069	0.387
MOD_CK1_1	1330	1336	PF00069	0.545
MOD_CK1_1	318	324	PF00069	0.574
MOD_CK1_1	543	549	PF00069	0.674
MOD_CK1_1	761	767	PF00069	0.605
MOD_CK1_1	803	809	PF00069	0.700
MOD_CK1_1	889	895	PF00069	0.633
MOD_CK1_1	981	987	PF00069	0.585
MOD_CK2_1	100	106	PF00069	0.565
MOD_CK2_1	1009	1015	PF00069	0.381
MOD_CK2_1	1047	1053	PF00069	0.599
MOD_CK2_1	1078	1084	PF00069	0.621
MOD_CK2_1	1175	1181	PF00069	0.555
MOD_CK2_1	1220	1226	PF00069	0.538
MOD_CK2_1	1239	1245	PF00069	0.431
MOD_CK2_1	1264	1270	PF00069	0.612
MOD_CK2_1	131	137	PF00069	0.412
MOD_CK2_1	1330	1336	PF00069	0.481
MOD_CK2_1	169	175	PF00069	0.534
MOD_CK2_1	240	246	PF00069	0.590
MOD_CK2_1	440	446	PF00069	0.439
MOD_CK2_1	64	70	PF00069	0.498
MOD_CK2_1	660	666	PF00069	0.598
MOD_CK2_1	693	699	PF00069	0.569
MOD_CK2_1	705	711	PF00069	0.559
MOD_CK2_1	733	739	PF00069	0.761
MOD_CK2_1	967	973	PF00069	0.502
MOD_GlcNHglycan	1000	1003	PF01048	0.470
MOD_GlcNHglycan	1164	1167	PF01048	0.637
MOD_GlcNHglycan	1183	1186	PF01048	0.412
MOD_GlcNHglycan	16	19	PF01048	0.587
MOD_GlcNHglycan	254	257	PF01048	0.619
MOD_GlcNHglycan	317	320	PF01048	0.513
MOD_GlcNHglycan	323	326	PF01048	0.425
MOD_GlcNHglycan	496	499	PF01048	0.520
MOD_GlcNHglycan	629	632	PF01048	0.585
MOD_GlcNHglycan	661	665	PF01048	0.493
MOD_GlcNHglycan	812	815	PF01048	0.607
MOD_GlcNHglycan	817	821	PF01048	0.485
MOD_GlcNHglycan	849	852	PF01048	0.508
MOD_GlcNHglycan	860	864	PF01048	0.548
MOD_GlcNHglycan	892	895	PF01048	0.643
MOD_GlcNHglycan	98	101	PF01048	0.623
MOD_GSK3_1	1	8	PF00069	0.547
MOD_GSK3_1	1063	1070	PF00069	0.691
MOD_GSK3_1	113	120	PF00069	0.491
MOD_GSK3_1	1171	1178	PF00069	0.548
MOD_GSK3_1	1179	1186	PF00069	0.480
MOD_GSK3_1	1202	1209	PF00069	0.415
MOD_GSK3_1	1221	1228	PF00069	0.516
MOD_GSK3_1	1235	1242	PF00069	0.428
MOD_GSK3_1	124	131	PF00069	0.449
MOD_GSK3_1	1266	1273	PF00069	0.390
MOD_GSK3_1	1288	1295	PF00069	0.602
MOD_GSK3_1	165	172	PF00069	0.529
MOD_GSK3_1	236	243	PF00069	0.462
MOD_GSK3_1	263	270	PF00069	0.477
MOD_GSK3_1	333	340	PF00069	0.537
MOD_GSK3_1	436	443	PF00069	0.422
MOD_GSK3_1	536	543	PF00069	0.687
MOD_GSK3_1	733	740	PF00069	0.583
MOD_GSK3_1	859	866	PF00069	0.466
MOD_GSK3_1	886	893	PF00069	0.608
MOD_GSK3_1	96	103	PF00069	0.557
MOD_N-GLC_1	1306	1311	PF02516	0.489
MOD_N-GLC_1	264	269	PF02516	0.421
MOD_NEK2_1	1179	1184	PF00069	0.525
MOD_NEK2_1	1288	1293	PF00069	0.567
MOD_NEK2_1	147	152	PF00069	0.553
MOD_NEK2_1	164	169	PF00069	0.573
MOD_NEK2_1	236	241	PF00069	0.484
MOD_NEK2_1	264	269	PF00069	0.586
MOD_NEK2_1	282	287	PF00069	0.430
MOD_NEK2_1	332	337	PF00069	0.623
MOD_NEK2_1	733	738	PF00069	0.563
MOD_NEK2_1	758	763	PF00069	0.621
MOD_NEK2_1	779	784	PF00069	0.558
MOD_NEK2_1	872	877	PF00069	0.496
MOD_PIKK_1	1039	1045	PF00454	0.563
MOD_PIKK_1	1155	1161	PF00454	0.679
MOD_PIKK_1	1171	1177	PF00454	0.453
MOD_PIKK_1	1192	1198	PF00454	0.511
MOD_PIKK_1	166	172	PF00454	0.513
MOD_PIKK_1	240	246	PF00454	0.590
MOD_PIKK_1	313	319	PF00454	0.606
MOD_PIKK_1	595	601	PF00454	0.578
MOD_PIKK_1	643	649	PF00454	0.567
MOD_PK_1	64	70	PF00069	0.498
MOD_PK_1	693	699	PF00069	0.571
MOD_PKA_1	345	351	PF00069	0.548
MOD_PKA_1	951	957	PF00069	0.467
MOD_PKA_2	1092	1098	PF00069	0.521
MOD_PKA_2	1179	1185	PF00069	0.546
MOD_PKA_2	1220	1226	PF00069	0.580
MOD_PKA_2	124	130	PF00069	0.449
MOD_PKA_2	165	171	PF00069	0.524
MOD_PKA_2	221	227	PF00069	0.696
MOD_PKA_2	345	351	PF00069	0.548
MOD_PKA_2	393	399	PF00069	0.735
MOD_PKA_2	595	601	PF00069	0.578
MOD_PKA_2	606	612	PF00069	0.514
MOD_PKA_2	614	620	PF00069	0.505
MOD_PKA_2	810	816	PF00069	0.688
MOD_PKA_2	889	895	PF00069	0.633
MOD_PKA_2	951	957	PF00069	0.453
MOD_PKB_1	845	853	PF00069	0.451
MOD_Plk_1	1225	1231	PF00069	0.597
MOD_Plk_1	1306	1312	PF00069	0.491
MOD_Plk_1	5	11	PF00069	0.592
MOD_Plk_1	549	555	PF00069	0.560
MOD_Plk_1	572	578	PF00069	0.508
MOD_Plk_1	693	699	PF00069	0.615
MOD_Plk_2-3	1264	1270	PF00069	0.574
MOD_Plk_2-3	457	463	PF00069	0.577
MOD_Plk_2-3	968	974	PF00069	0.503
MOD_Plk_4	1210	1216	PF00069	0.494
MOD_Plk_4	124	130	PF00069	0.395
MOD_Plk_4	1327	1333	PF00069	0.565
MOD_Plk_4	221	227	PF00069	0.575
MOD_Plk_4	6	12	PF00069	0.674
MOD_Plk_4	872	878	PF00069	0.562
MOD_ProDKin_1	800	806	PF00069	0.656
MOD_ProDKin_1	978	984	PF00069	0.538
MOD_SUMO_for_1	902	905	PF00179	0.669
MOD_SUMO_rev_2	1130	1136	PF00179	0.684
MOD_SUMO_rev_2	1242	1249	PF00179	0.498
MOD_SUMO_rev_2	246	253	PF00179	0.453
MOD_SUMO_rev_2	906	916	PF00179	0.777
TRG_DiLeu_BaEn_1	124	129	PF01217	0.471
TRG_DiLeu_BaEn_1	502	507	PF01217	0.436
TRG_DiLeu_BaEn_1	711	716	PF01217	0.574
TRG_DiLeu_BaEn_2	791	797	PF01217	0.468
TRG_DiLeu_BaEn_4	1226	1232	PF01217	0.432
TRG_DiLeu_BaEn_4	367	373	PF01217	0.538
TRG_DiLeu_BaEn_4	456	462	PF01217	0.577
TRG_ENDOCYTIC_2	34	37	PF00928	0.500
TRG_ENDOCYTIC_2	38	41	PF00928	0.515
TRG_ER_diArg_1	1229	1232	PF00400	0.593
TRG_ER_diArg_1	289	292	PF00400	0.630
TRG_ER_diArg_1	578	580	PF00400	0.517
TRG_ER_diArg_1	653	655	PF00400	0.590
TRG_ER_diArg_1	845	848	PF00400	0.462
TRG_ER_diArg_1	950	952	PF00400	0.492
TRG_Pf-PMV_PEXEL_1	1266	1270	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	936	940	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	943	947	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H4	Leptomonas seymouri	42%	94%
A0A3Q8IF73	Leishmania donovani	90%	100%
A4HAE2	Leishmania braziliensis	75%	100%
A4I9J4	Leishmania infantum	90%	100%
Q4Q3I4	Leishmania major	87%	100%